The South America Map Collection holds maps of the South American continent, generally excluding but sometimes including parts of Central American and the Caribbean basin. South America is the landmass situated in the western hemisphere and, mostly, the southern hemisphere, bordered on the west by the Pacific Ocean and on the north and east by the Atlantic Ocean; North America and the Caribbean Sea lie to the northwest. Maps of focused on Central America and the Caribbean basin including maps focused on Guyana, Suriname and French Guiana may be found in a separate Caribbean Map Collection.

Maps in this collection are held in large part by the University of Florida's Map and Imagery Library.