Citation
Identification of Inflammatory Markers Associated with Alzheimers Disease

Material Information

Title:
Identification of Inflammatory Markers Associated with Alzheimers Disease
Creator:
Swilley, Erica Lee
Publisher:
University of Florida
Publication Date:
Language:
English

Thesis/Dissertation Information

Degree:
Master's ( M.S.)
Degree Grantor:
University of Florida
Degree Disciplines:
Epidemiology
Committee Chair:
Zhao,Jinying
Committee Co-Chair:
Hu,Hui
Committee Members:
Qin,Huaizhen
Graduation Date:
5/1/2020

Subjects

Subjects / Keywords:
alzheimers
clusterin
crp
disease
inflammatory
marker
mmp
pai
Genre:
Unknown ( sobekcm )

Notes

General Note:
Understanding the complex pathways and biological risk factors of Alzheimers Disease is the first step in developing an effective therapy Recent research indicates there is growing evidence suggesting the bodys immunological defenses such as increased inflammatory protein concentration in plasma is associated with Alzheimers disease However, the association between these inflammatory proteins and Alzheimers Disease have not been previously explored within this study population This analysis investigates the association between five inflammatory markers Clusterin Matrix Metalloproteinase Tissue inhibitor of Metalloproteinase C reactive protein and Plasminogen activator inhibitor that have previously been theorized to influence development of alzheimers disease or alzheimers dementia Our study included participants of the alzheimers disease neuroimaging initiative phase one who had data for four hundred patients diagnosed with mild cognitive impairment two hundred patients diagnosed with alzheimers and two hundred cognitively normal controls The inflammatory marker data was collected from a subset of this original population fifty eight cognitively normal three hundred ninety six mild cognitive impairment and one hundred and twelve alzheimers patients Our study participants were between the ages of fifty five and ninety years old and majority were males We conducted logistic regression and ordinal regression analyses to test the association between the markers and alzheimers disease We adjusted our model for known risk factors such as age race gender APOE and education Our study found that only one inflammatory protein was significantly associated with alzheimers disease

Record Information

Source Institution:
University of Florida
Holding Location:
University of Florida
Rights Management:
All applicable rights reserved by the source institution and holding location.
Embargo Date:
5/31/2021

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