Association Of Adipose Tissue Distribution With Type 2 Diabetes Among Breast Cancer Patients

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Association Of Adipose Tissue Distribution With Type 2 Diabetes Among Breast Cancer Patients
Qi, Jia
University of Florida
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Master's ( M.S.)
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University of Florida
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Unknown ( sobekcm )


General Note:
The association of adipose tissue distribution with type 2 diabetes (T2D) has been examined by previous studies, but they were not specific to women living with breast cancer whose metabolism might be different to women without breast cancer. Since several studies suggested that most of breast cancer patients would experience weight gain after diagnosis and that T2D would negatively affect the prognosis of breast cancer, it is meaningful to examine the relationship between adipose tissue distribution and T2D among breast cancer patients. Participants (n=238) diagnosed with breast cancer at 20-75 years old who received breast cancer treatment at University of Florida Health Shands Hospital from January 1, 2012 to December 31, 2017 with at least one completed and identifiable abdominal or pelvic computed tomography (CT) scan and the data of race and ethnicity were included from the electronic medical record system of the hospital. All 32 diabetic breast cancer patients included in the sample got T2D after their breast cancer diagnoses. Adipose tissue distribution [visceral fat area (VFA), subcutaneous fat area (SFA) and the ratio of VFA to SFA (VFA/SFA)] was quantified on CT images of the third lumbar vertebra (L3) using a CT image segmentation technique, and T2D status was retrieved from electronic medical records. The association of adipose tissue distribution with T2D among breast cancer women was examined using multivariable logistic regression adjusting age, race, ethnicity, muscle area (MA), and waist circumference (WC). Our results showed that breast cancer patients who had T2D were significantly 0.88 times as likely to have 10 cm2 increased SFA compared to breast cancer women without T2D (OR 0.88, 95% CI 0.81-0.96). There might be a positive association of VFA/SFA with T2D (OR 19.57, 95% CI 3.26-117.42), although the estimate was imprecise. In conclusion, the study findings suggested that subcutaneous adipose tissue (SAT) was negatively associated with T2D, and VAT/SAT [the ratio of the amount of visceral adipose tissue (VAT) to the amount of SAT] was positively associated with T2D among breast cancer patients. Further studies are warranted to confirm these associations.

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University of Florida
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University of Florida
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All applicable rights reserved by the source institution and holding location.
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