Proof of Principle

MISSING IMAGE

Material Information

Title:
Proof of Principle Image Registration, Structure Volumes and Cognitive Associations
Physical Description:
1 online resource (40 p.)
Language:
english
Creator:
Schwab, Nadine A
Publisher:
University of Florida
Place of Publication:
Gainesville, Fla.
Publication Date:

Thesis/Dissertation Information

Degree:
Master's ( M.S.)
Degree Grantor:
University of Florida
Degree Disciplines:
Psychology, Clinical and Health Psychology
Committee Chair:
PRICE,CATHERINE ELIZABETH
Committee Co-Chair:
BOGGS,STEPHEN R
Committee Members:
PERLSTEIN,WILLIAM MICHAEL
MCCRAE,CHRISTINA SMITH

Subjects

Subjects / Keywords:
parkinsons
Clinical and Health Psychology -- Dissertations, Academic -- UF
Genre:
Psychology thesis, M.S.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract:
Background: Brain magnetic resonance image (MRI) registration alters structure orientation, size, and/or shape. Purpose: To examine whether linear registration methods (image transformation to 6, 9, and 12 degrees of freedom) alter structural volume and cognitive associations for a commonly segmented structure, the caudate nucleus in a group of patients with Parkinson's disease (PD) and demographically matched non-PD peers. Hypotheses: Structure volumes and cognitive associations would differ by image registration, with greater abnormalities observed for the 9 and 12 degree of freedom registrations. Methods: Eighty MRI brain scans from older adults with and without Parkinson's disease were registered using 6, 9, and 12 degrees of freedom. Volumetric masks of the caudate nucleus were compared in each registration condition. Controlling for intracranial and brain volume, caudate nucleus volumes were correlated to measures of general cognitive ability, mental flexibility, and confrontation naming. Results: Nine- and 12-degree registered volumes were significantly larger than native and 6-degree volumes. Only the 9 and 12-degree caudate nucleus volume registrations were significantly associated with our cognitive variables of interest. Our dissociating cognitive measure was strongly not correlated to caudate nucleus volumes. Conclusion: Linear registration techniques altered volumetric and cognitive-structure associations. Investigators are encouraged to report degree of registration.
General Note:
In the series University of Florida Digital Collections.
General Note:
Includes vita.
Bibliography:
Includes bibliographical references.
Source of Description:
Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility:
by Nadine A Schwab.
Thesis:
Thesis (M.S.)--University of Florida, 2014.
Local:
Adviser: PRICE,CATHERINE ELIZABETH.
Local:
Co-adviser: BOGGS,STEPHEN R.
Electronic Access:
RESTRICTED TO UF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE UNTIL 2015-05-31

Record Information

Source Institution:
UFRGP
Rights Management:
Applicable rights reserved.
Classification:
lcc - LD1780 2014
System ID:
UFE0046776:00001