Citation
Molecularly Imprinted Methacrylate Nanoparticles by Emulsion Polymerization as Drug Detoxifying Agents

Material Information

Title:
Molecularly Imprinted Methacrylate Nanoparticles by Emulsion Polymerization as Drug Detoxifying Agents
Creator:
Greeley, Eric
Place of Publication:
[Gainesville, Fla.]
Publisher:
University of Florida
Publication Date:
Language:
english
Physical Description:
1 online resource (53 p.)

Thesis/Dissertation Information

Degree:
Master's ( M.S.)
Degree Grantor:
University of Florida
Degree Disciplines:
Chemistry
Committee Chair:
Duran, Randolph
Committee Members:
Enholm, Eric J.
Smith, Benjamin W.
Graduation Date:
8/8/2009

Subjects

Subjects / Keywords:
Drug interactions ( jstor )
Ions ( jstor )
Molecular interactions ( jstor )
Molecules ( jstor )
Monomers ( jstor )
Nanoparticles ( jstor )
Polymerization ( jstor )
Polymers ( jstor )
Reuptake ( jstor )
Solvents ( jstor )
Chemistry -- Dissertations, Academic -- UF
amitriptyline, bupivacaine, emulsion, imprinted, methacrylate, molecularly, nanoparticle, pentafluorostyrene, photoinitiation, polymer
Genre:
Electronic Thesis or Dissertation
born-digital ( sobekcm )
Chemistry thesis, M.S.

Notes

Abstract:
The goal is the rapid removal of a hydrophobic drug from the bloodstream in cases of overdose. This can be accomplished with molecularly imprinted polymer (MIP) nanoparticles (NPs). The nanoparticles are made from a mixture of vinyl monomers, solvent, a photoinitiator, surfactant, and drug. The reaction is carried out as a miniemulsion polymerization, under continuous stirring, and UVA illumination. The size of the nanoparticles are determined by Dynamic Light Scattering. Drug reuptake studies by UV spectroscopy are performed with a phosphate buffered saline (PBS) solution that mimics blood plasma and contains drug hydrochloride salt. The nanoparticles demonstrate high binding affinity for the drug that they were made with, as evidenced by significant loss of drug from the supernatant after pelletizing the nanoparticles by centrifugation. This gives high partition coefficient values, or Kp, in excess of 10,000 in some batches. ( en )
General Note:
In the series University of Florida Digital Collections.
General Note:
Includes vita.
Bibliography:
Includes bibliographical references.
Source of Description:
Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Thesis:
Thesis (M.S.)--University of Florida, 2009.
Local:
Adviser: Duran, Randolph.
Statement of Responsibility:
by Eric Greeley.

Record Information

Source Institution:
University of Florida
Holding Location:
University of Florida
Rights Management:
Copyright Greeley, Eric. Permission granted to the University of Florida to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Resource Identifier:
489120275 ( OCLC )
Classification:
LD1780 2009 ( lcc )

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. 63. 64. J. Molec.