Group Title: 7th International Conference on Multiphase Flow - ICMF 2010 Proceedings
Title: P2.15 - Red Blood Cell Aggregation and its Role in Blood Passage through a Bifurcation
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 Material Information
Title: P2.15 - Red Blood Cell Aggregation and its Role in Blood Passage through a Bifurcation Bio-Fluid Dynamics
Series Title: 7th International Conference on Multiphase Flow - ICMF 2010 Proceedings
Physical Description: Conference Papers
Creator: Chesnutt, J.K.W.
Marshall, J.S.
Publisher: International Conference on Multiphase Flow (ICMF)
Publication Date: June 4, 2010
Subject: blood flow
plasma skimming
Abstract: A new mesoscale model of red blood cells (RBCs) as discrete ellipsoidal particles subject to receptor-ligand adhesive forces (Chesnutt & Marshall 2009a) is used to examine the structure of RBC aggregates and to investigate the effects of RBC collision and aggregation on blood flow through a bifurcation. Aggregation of RBCs is important in many physiological processes such as the shear-thinning behavior of blood, the rate of oxygen consumption by the body, and the distributions of formed elements in the blood. The computational model is validated against experimental and theoretical data of RBC aggregation in shear and channel flows. The structure of aggregates formed by RBCs is analyzed by various new measures that relate RBCs which are in contact with each other and that characterize an aggregate by fitting an ellipse to the projection of the constituent cells onto a plane, and by usual measures such as average aggregate size. These structural measures are used to demonstrate that two-dimensional (2D) discrete-element simulations retain some of the important features of corresponding three-dimensional (3D) simulations. The effects of factors such as shear rate and adhesive surface energy density on the size and structure of RBC aggregates is examined and compared for 2D and 3D flows. The effect of RBC adhesion on migration of blood elements (RBCs, leukocytes, platelets) in channel flow is also investigated. The mesoscale model is then used to investigate the problem of blood flow through a bifurcating vessel with differing flow rates through each branch of the bifurcation, focusing on understanding the effects of RBC collision and adhesion on the plasma skimming phenomenon and on the rate of particle collision with vessel walls near the bifurcation point. Along the walls after the bifurcation point, the effect of collisions of RBCs with each other, compared to the absence of collisions (i.e., RBCs pass through each other without incidence), is discovered to substantially increase both the amount of time particles are in contact with walls and the downstream distance over which particles collide with walls. The effect of RBC adhesion is observed to slightly decrease the rate of particle collisions along walls after the bifurcation compared to the case without RBC adhesion. These results illustrate the importance of simulating collision and adhesion of cells for blood flow through bifurcations.
General Note: The International Conference on Multiphase Flow (ICMF) first was held in Tsukuba, Japan in 1991 and the second ICMF took place in Kyoto, Japan in 1995. During this conference, it was decided to establish an International Governing Board which oversees the major aspects of the conference and makes decisions about future conference locations. Due to the great importance of the field, it was furthermore decided to hold the conference every three years successively in Asia including Australia, Europe including Africa, Russia and the Near East and America. Hence, ICMF 1998 was held in Lyon, France, ICMF 2001 in New Orleans, USA, ICMF 2004 in Yokohama, Japan, and ICMF 2007 in Leipzig, Germany. ICMF-2010 is devoted to all aspects of Multiphase Flow. Researchers from all over the world gathered in order to introduce their recent advances in the field and thereby promote the exchange of new ideas, results and techniques. The conference is a key event in Multiphase Flow and supports the advancement of science in this very important field. The major research topics relevant for the conference are as follows: Bio-Fluid Dynamics; Boiling; Bubbly Flows; Cavitation; Colloidal and Suspension Dynamics; Collision, Agglomeration and Breakup; Computational Techniques for Multiphase Flows; Droplet Flows; Environmental and Geophysical Flows; Experimental Methods for Multiphase Flows; Fluidized and Circulating Fluidized Beds; Fluid Structure Interactions; Granular Media; Industrial Applications; Instabilities; Interfacial Flows; Micro and Nano-Scale Multiphase Flows; Microgravity in Two-Phase Flow; Multiphase Flows with Heat and Mass Transfer; Non-Newtonian Multiphase Flows; Particle-Laden Flows; Particle, Bubble and Drop Dynamics; Reactive Multiphase Flows
 Record Information
Bibliographic ID: UF00102023
Volume ID: VID00483
Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: P215-Chesnutt-ICMF2010.pdf

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