Group Title: Cerebrospinal Fluid Research 2006, 3:12
Title: Review of "The Blood-Cerebrospinal Fluid Barrier" by Wei Zheng and Adam Chodobski (editors)
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Title: Review of "The Blood-Cerebrospinal Fluid Barrier" by Wei Zheng and Adam Chodobski (editors)
Series Title: Cerebrospinal Fluid Research 2006, 3:12
Physical Description: Archival
Publication Date: 39059
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Bibliographic ID: UF00100270
Volume ID: VID00001
Source Institution: University of Florida
Holding Location: University of Florida
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Cerebrospinal Fluid Research

BioMed Central

Book review

Review of "The Blood-Cerebrospinal Fluid Barrier" by Wei Zheng
and Adam Chodobski (editors)
Hazel C Jones*1,2

Address: 'Department of Pharmacology, University of Florida, Gainesville, FL 32610, USA and 2Gagle Brook House, Chesterton, Bicester, Oxon
OX26 1UF, UK
Email: Hazel C Jones*
* Corresponding author

Published: 08 December 2006
Cerebrospinal Fluid Research 2006, 3:12 doi: 10.1 186/1743-8454-3-12

Received: 17 November 2006
Accepted: 08 December 2006

This article is available from:
2006 Jones; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This multi-author volume on the blood-cerebrospinal fluid barrier summarizes past and current
research in the areas of choroid plexus and cerebrospinal fluid in health and disease.

Book details
The Blood-Cerebrospinal Fluid Barrier.
Edited by: Wei Zheng, Adam Chodobski. Chapman and
Hall/CRC, Taylor and Francis Group, Boca Raton, Florida
USA; 2005. ISBN: 0-415-32074-7 Price: 92.00 (hardback,
629 pages)

The blood-cerebrospinal fluid barrier functions together
with the blood-brain barrier and the meninges, to control
the internal environment of the brain. Sited at the choroid
plexus epithelium, it secretes the cerebrospinal fluid
(CSF), which circulates through the ventricles and around
the outside of the brain and spinal cord. Originally
assumed to pass an ultra filtrate of plasma into the brain
ventricles, the choroid plexus was subsequently shown to
secrete a homeostatically controlled electrolyte solution,
the CSF [1]. In the last twenty years the choroidal epithe-
lium has emerged as a complex organ with many addi-
tional functions that include neuroendocrine signaling,
neuroimmune and neuroinflammatory responses, drug
and toxin metabolism and transport. There is an increas-
ing awareness that improved knowledge of the role of the
choroid plexus in brain function has the potential to open
new avenues for the treatment and prevention of neuro-
logical disorders.

There has been a requirement for a comprehensive review
on the choroid plexus and blood-CSF barrier for a number
of years [2]. This multi-author book edited by Wei Zheng
and Adam Chodobski has 24 chapters and 51 contribu-
tors. The chapters have a consistent style and each one has
a complete reference list. The book fulfills an important
need for research scientists in the field of choroid plexus
and CSF and as a reference book for neuroscientists, clini-
cians and toxicologists. Section 1 is devoted to choroid
plexus development and morphology, section 2 to barrier phys-
iology and molecular biology, section 3 to the barrier in dis-
ease states and section 4 to in vivo and in vitro models of the
barrier. Many topics are covered in this book and it is pos-
sible to select only a few for mention as being of particular
interest. The proteins and lipids that make up the intercel-
lular tight junctions are being elucidated at the molecular
level, but how permeability is regulated awaits further
investigation. The physiological regulation of CSF secre-
tion is another important topic that has received much
attention and is yet to be fully elucidated, together with
the expression and role of ion transporters and channels.
Knowledge of transporters for toxic substances and for-
eign chemicals and their metabolism by the choroid
plexus is expanding rapidly, as are the fundamentals of
nucleoside and metal transport and the role of choroid
plexus peptides in hormonal signaling in the brain.

Page 1 of 2
(page number not for citation purposes)

Choroid plexus function changes with disease and aging
and knowledge of the processes involved is important for
understanding CNS disease states, such as Alzheimer's,
Parkinson's, HIV, and disorders of CSF circulation. The
final section provides the reader with a detailed review of
the techniques used for investigation of choroid plexus
function including in situ perfusion, cell culture and
whole animal methods.

In conclusion, 'The Blood-Cerebrospinal Fluid Barrier' is a
comprehensive book that covers all aspects of the subject
and should be on the bookshelf of all researchers involved
in brain barriers and brain homeostasis.

Competing interests
The authors) declare that they have no competing inter-

Authors' contributions
Sole author

I. Davson H: The Physiology of the Cerebrospinal Fluid London, Churchill;
2. Davson H, Segal MB: Physiology of the CSF and Blood-Brain Barriers Boca
Raton, Florida, USA, CRC Press; 1996.

Page 2 of 2
(page number not for citation purposes)

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