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Malaria treatment policies and drug efficacy in Haiti from 1955-2012

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Material Information

Title:
Malaria treatment policies and drug efficacy in Haiti from 1955-2012
Physical Description:
Mixed Material
Language:
English
Creator:
Fricken, Michael E von
Weppelmann, Thomas A.
Hosford, Jennifer D.
Existe, Alexander
Okech, Bernard A.
Publisher:
Bio-Med Central (Journal of Pharmaceutical Policy and Practice)
Publication Date:

Notes

Abstract:
Objectives: Chloroquine (CQ), after 67 years of use in Haiti, is still part of the official treatment policy for malaria. Several countries around the world have used CQ in the past due to its low incidence of adverse events, therapeutic efficacy, and affordability, but were forced to switch treatment policy due to the development of widespread CQ resistance. The purpose of this paper was to compile literature on malaria treatment policies and antimalarial drug efficacy in Haiti over 67-year period. Methods: A systematic review of PubMed, Web of Science, and the Armed Forces Pest Management Board, was conducted to find pertinent documents on national malaria treatment policies and antimalarial drug efficacy studies in Haiti between 1955 and 2012. A total of 329 citations and abstracts were reviewed independently by two researchers, of which thirty three met the final inclusion criteria of studies occurring in Haiti between 1955 and 2012 which specifically discuss malaria treatment policies and drug efficacy. Results: Results suggest that CQ has been the predominant antimalarial drug in use from 1955 to 2012. In 2010 single dose primaquine (PQ) was added to the national treatment policy, however it is not clear whether this new policy has been put into practice. Conclusions: Although no widespread CQ resistance has been reported, some studies have detected low levels of CQ resistance. Increased surveillance and monitoring for CQ resistance should be implemented in Haiti. Keywords: Hispaniola, Haiti, Malaria treatment policy, Chemotherapy, Chloroquine, Anti-malarial drug resistance, Plasmodium falciparum, Pyrimethamine
General Note:
von Fricken et al. Journal of Pharmaceutical Policy and Practice 2013, 6:10 http://www.joppp.org/content/6/1/10; Pages 1-5
General Note:
doi:10.1186/2052-3211-6-10 Cite this article as: von Fricken et al.: Malaria treatment policies and drug efficacy in Haiti from 1955-2012. Journal of Pharmaceutical Policy and Practice 2013 6:10.

Record Information

Source Institution:
University of Florida
Holding Location:
University of Florida
Rights Management:
All rights reserved by the source institution.
Resource Identifier:
oclc -
System ID:
AA00019212:00001

  • STANDARD VIEW
  • MARC VIEW

Material Information

Title:
Malaria treatment policies and drug efficacy in Haiti from 1955-2012
Physical Description:
Mixed Material
Language:
English
Creator:
Fricken, Michael E von
Weppelmann, Thomas A.
Hosford, Jennifer D.
Existe, Alexander
Okech, Bernard A.
Publisher:
Bio-Med Central (Journal of Pharmaceutical Policy and Practice)
Publication Date:

Notes

Abstract:
Objectives: Chloroquine (CQ), after 67 years of use in Haiti, is still part of the official treatment policy for malaria. Several countries around the world have used CQ in the past due to its low incidence of adverse events, therapeutic efficacy, and affordability, but were forced to switch treatment policy due to the development of widespread CQ resistance. The purpose of this paper was to compile literature on malaria treatment policies and antimalarial drug efficacy in Haiti over 67-year period. Methods: A systematic review of PubMed, Web of Science, and the Armed Forces Pest Management Board, was conducted to find pertinent documents on national malaria treatment policies and antimalarial drug efficacy studies in Haiti between 1955 and 2012. A total of 329 citations and abstracts were reviewed independently by two researchers, of which thirty three met the final inclusion criteria of studies occurring in Haiti between 1955 and 2012 which specifically discuss malaria treatment policies and drug efficacy. Results: Results suggest that CQ has been the predominant antimalarial drug in use from 1955 to 2012. In 2010 single dose primaquine (PQ) was added to the national treatment policy, however it is not clear whether this new policy has been put into practice. Conclusions: Although no widespread CQ resistance has been reported, some studies have detected low levels of CQ resistance. Increased surveillance and monitoring for CQ resistance should be implemented in Haiti. Keywords: Hispaniola, Haiti, Malaria treatment policy, Chemotherapy, Chloroquine, Anti-malarial drug resistance, Plasmodium falciparum, Pyrimethamine
General Note:
von Fricken et al. Journal of Pharmaceutical Policy and Practice 2013, 6:10 http://www.joppp.org/content/6/1/10; Pages 1-5
General Note:
doi:10.1186/2052-3211-6-10 Cite this article as: von Fricken et al.: Malaria treatment policies and drug efficacy in Haiti from 1955-2012. Journal of Pharmaceutical Policy and Practice 2013 6:10.

Record Information

Source Institution:
University of Florida
Holding Location:
University of Florida
Rights Management:
All rights reserved by the source institution.
Resource Identifier:
oclc -
System ID:
AA00019212:00001