Simulation of Magnetic Particle Imaging Using Rotational Brownian Dynamics Simulations

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Material Information

Title:
Simulation of Magnetic Particle Imaging Using Rotational Brownian Dynamics Simulations
Physical Description:
1 online resource (54 p.)
Language:
english
Creator:
Dhavalikar, Rohan D
Publisher:
University of Florida
Place of Publication:
Gainesville, Fla.
Publication Date:

Thesis/Dissertation Information

Degree:
Master's ( M.S.)
Degree Grantor:
University of Florida
Degree Disciplines:
Chemical Engineering
Committee Chair:
RINALDI,CARLOS
Committee Co-Chair:
DOBSON,JON P

Subjects

Subjects / Keywords:
brownian -- imaging -- simulation
Chemical Engineering -- Dissertations, Academic -- UF
Genre:
Chemical Engineering thesis, M.S.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract:
Magnetic Particle Imaging (MPI) is an emerging biomedical imaging technique which uses the non-linear magnetization characteristics of magnetic nanoparticle tracers to obtain millimeter scale temporal and spatial resolution images. Human tissue, being diamagnetic, does not produce a background signal, meaning that the images have near-perfect contrast. Theoretical models assume the magnetic dipoles of nanoparticles used as tracers instantaneously align with the applied field which is at odds with the experimental results showing that finite relaxation affects the signal and resolution of the image. We model this relaxation effect using rotational Brownian dynamics simulations to predict the effect on the resolution and account for the shift in image location. We model the behavior of nanoparticles in response to the rapid movement of a field free point (FFP), which leads to the flipping of the saturated nanoparticles inducing a voltage in the receiving coil. The magnetic dipoles lag behind the changing field due to relaxation and hence produce a significant difference in the signal properties. We also model the magnetic particle relaxometer which is used to measure properties of tracer material by applying an oscillating field to the suspension of nanoparticles The study demonstrates the effect of Brownian relaxation on the signal strength, resolution, and image shift distance.
General Note:
In the series University of Florida Digital Collections.
General Note:
Includes vita.
Bibliography:
Includes bibliographical references.
Source of Description:
Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility:
by Rohan D Dhavalikar.
Thesis:
Thesis (M.S.)--University of Florida, 2014.
Local:
Adviser: RINALDI,CARLOS.
Local:
Co-adviser: DOBSON,JON P.
Electronic Access:
RESTRICTED TO UF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE UNTIL 2015-05-31

Record Information

Source Institution:
UFRGP
Rights Management:
Applicable rights reserved.
Classification:
lcc - LD1780 2014
System ID:
UFE0046786:00001