Age and HIV Effects on Cerebral White Matter and Cognitive Functioning

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Material Information

Title:
Age and HIV Effects on Cerebral White Matter and Cognitive Functioning
Physical Description:
1 online resource (72 p.)
Language:
english
Creator:
Seider, Talia R
Publisher:
University of Florida
Place of Publication:
Gainesville, Fla.
Publication Date:

Thesis/Dissertation Information

Degree:
Master's ( M.S.)
Degree Grantor:
University of Florida
Degree Disciplines:
Psychology, Clinical and Health Psychology
Committee Chair:
COHEN,RONALD A
Committee Co-Chair:
WIENS,BRENDA A
Committee Members:
PRICE,CATHERINE ELIZABETH
PEREIRA,DEIDRE B

Subjects

Subjects / Keywords:
aging -- cognitive -- fractional -- hiv -- hyperintensities -- matter -- white
Clinical and Health Psychology -- Dissertations, Academic -- UF
Genre:
Psychology thesis, M.S.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract:
The Human Immunodeficiency Virus-1 (HIV) and aging are both known risk factors for cerebral white matter deterioration and declines in neurocognitive functioning. This study investigated HIV effects on white matter and cognitive functioning in the context of aging. 103 HIV seropositive (HIV+) and 63 seronegative (HIV-) individuals without dementia aged 23-79 received neurocognitive assessments and magnetic resonance imaging (MRI). Fractional anisotropy (FA) was used to assess white matter integrity and white matter hyperintensities (WMH) were quantified to measure degree of white matter damage. Linear regression predicted FA and WMH from age, HIV status, and the age by HIV interaction. Correlational analyses analyzed the relationship between WMH and FA. HIV-associated clinical factors predicted WMH and FA in separate linear regression models to further investigate HIV effects on white matter structure. Finally, the associations of neurocognitive variables with WMH and with FA were analyzed using multivariate and univariate regressions, respectively. A significant age by HIV interaction revealed a significant effect of age on WMH volume for HIV+ participants only. WMH volume was negatively correlated with FA in frontal and parietal regions, and this relationship was stronger when examining only subjects with HIV. Greater HIV disease severity and Hepatitis C coinfection were associated with greater WMH volumes but not with FA. Finally, WMH volume was negatively associated with scores on speeded psychomotor testing, FA was positively associated with learning and memory, and associations were stronger in HIV+ participants only versus the group as a whole. Age and HIV interact to produce cerebral white matter damage. WMH and FA are associated with different aspects of cognitive functioning. WMH and FA are more strongly related to each other and to cognitive functioning in HIV+ participants, suggesting that they are showing greater age-related changes than controls. Possible mechanisms are discussed and future directions addressed.
General Note:
In the series University of Florida Digital Collections.
General Note:
Includes vita.
Bibliography:
Includes bibliographical references.
Source of Description:
Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility:
by Talia R Seider.
Thesis:
Thesis (M.S.)--University of Florida, 2014.
Local:
Adviser: COHEN,RONALD A.
Local:
Co-adviser: WIENS,BRENDA A.
Electronic Access:
RESTRICTED TO UF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE UNTIL 2015-05-31

Record Information

Source Institution:
UFRGP
Rights Management:
Applicable rights reserved.
Classification:
lcc - LD1780 2014
System ID:
UFE0046778:00001