Development of Intake Retention, and Excretion Fractions Used in Bioassay Programs for Metallic Nanoparticle Aerosols Pr...

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Material Information

Title:
Development of Intake Retention, and Excretion Fractions Used in Bioassay Programs for Metallic Nanoparticle Aerosols Produced in Modern Munitions Development
Physical Description:
1 online resource (88 p.)
Language:
english
Creator:
Godwin, William J
Publisher:
University of Florida
Place of Publication:
Gainesville, Fla.
Publication Date:

Thesis/Dissertation Information

Degree:
Master's ( M.S.)
Degree Grantor:
University of Florida
Degree Disciplines:
Biomedical Engineering
Committee Chair:
BOLCH,WESLEY EMMETT
Committee Co-Chair:
HINTENLANG,DAVID ERIC
Committee Members:
WU,CHANG-YU

Subjects

Subjects / Keywords:
aerosol -- aluminum -- biokinetic -- chemimba -- model -- nanoparticle -- systemic
Biomedical Engineering -- Dissertations, Academic -- UF
Genre:
Biomedical Engineering thesis, M.S.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract:
Current state-of-the-art munitions development by the United States Air Force creates potential exposure scenarios wherein soldiers and laboratory workers may inhale nanophase aerosols. The primary metals of present interest in munitions development are aluminum, boron, tantalum, titanium, and tungsten. The contained work describes efforts made to develop a software package capable of analyzing, and predicting, bioassay measurements of workers and soldiers following exposures to the munitions' aerosols. The resultant software package (chemIMBA) developed by Dr. Alan Birchall of Public Health England was created by tailoring a pre-existing software package for radioactive aerosol exposures called, Integrated Modules for Bioassay Analysis (IMBA). Biokinetic model selection, and implementation, was conducted for boron, tantalum, titanium and tungsten. For aluminum, a new systemic biokinetic model was created, and implemented within chemIMBA. Exposures to three different post-detonation blast-aerosols for soldiers in the battlefield, and laboratory workers, were simulated using the newly developed chemIMBA software. Intake Excretion Fractions, and Intake Retention Fractions, for time periods up to ten thousand days post-exposure were predicted for exposure scenarios of soldiers and laboratory workers.
General Note:
In the series University of Florida Digital Collections.
General Note:
Includes vita.
Bibliography:
Includes bibliographical references.
Source of Description:
Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility:
by William J Godwin.
Thesis:
Thesis (M.S.)--University of Florida, 2013.
Local:
Adviser: BOLCH,WESLEY EMMETT.
Local:
Co-adviser: HINTENLANG,DAVID ERIC.
Electronic Access:
RESTRICTED TO UF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE UNTIL 2014-12-31

Record Information

Source Institution:
UFRGP
Rights Management:
Applicable rights reserved.
Classification:
lcc - LD1780 2013
System ID:
UFE0046398:00001