AT1 Receptor Blocker Attenuates Mechanical Ventilation-Induced Atrophy and Oxidative Stress in the Diaphragm Muscle.

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Material Information

Title:
AT1 Receptor Blocker Attenuates Mechanical Ventilation-Induced Atrophy and Oxidative Stress in the Diaphragm Muscle.
Physical Description:
1 online resource (60 p.)
Language:
english
Creator:
Kwon, Oh Sung
Publisher:
University of Florida
Place of Publication:
Gainesville, Fla.
Publication Date:

Thesis/Dissertation Information

Degree:
Doctorate ( Ph.D.)
Degree Grantor:
University of Florida
Degree Disciplines:
Health and Human Performance
Committee Chair:
POWERS,SCOTTY K
Committee Co-Chair:
DODD,STEPHEN
Committee Members:
CRISWELL,DAVID S
SCARPACE,NIHAL TUMER

Subjects

Subjects / Keywords:
angiotensinii -- atrophy -- diaphragm -- losartan -- mechanicalventilation
Health and Human Performance -- Dissertations, Academic -- UF
Genre:
Health and Human Performance thesis, Ph.D.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract:
Mechanical ventilation (MV) is a method of maintaining adequate gas exchange in patients who are unable to sustain adequate alveolar ventilation on their own. Recently, our lab demonstrated that Angiotensin II (Ang II) is a possible mechanism that causes MV-induced diaphragm muscle atrophy. To determine Ang II is a required upstream signal for MV-induced diaphragm muscle atrophy and contractile dysfunction, we used AT1 receptor blocker (Losartan) and ACE inhibitor (Enalapril), which prevent the elevation of plasma Ang II levels during MV. Enalapril attenuates increased circulating Ang II levels during 12 hours prolonged MV but losartan does not. However, only losartan attenuated MV-induced diaphragm muscle atrophy. As well as, losartan attenuated MV-induced mitochondrial dysfunction, ROS production, and proteasome activity during. Therefore, Ang II does not appear to be a possible upstream mechanism to prevent MV-induced diaphragm muscle atrophy. AT1 receptor blocker, losartan has an antioxidant effect and attenuates MV-induced VIDD. Therefore, the results of our experiments could lead to human clinical trials using losartan as a therapeutic intervention to prevent VIDD.
General Note:
In the series University of Florida Digital Collections.
General Note:
Includes vita.
Bibliography:
Includes bibliographical references.
Source of Description:
Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility:
by Oh Sung Kwon.
Thesis:
Thesis (Ph.D.)--University of Florida, 2013.
Local:
Adviser: POWERS,SCOTTY K.
Local:
Co-adviser: DODD,STEPHEN.
Electronic Access:
RESTRICTED TO UF STUDENTS, STAFF, FACULTY, AND ON-CAMPUS USE UNTIL 2015-12-31

Record Information

Source Institution:
UFRGP
Rights Management:
Applicable rights reserved.
Classification:
lcc - LD1780 2013
System ID:
UFE0046197:00001