Diaphragm Plasticity Following High Cervical Spinal Cord Injury and Systemic Sepsis


Material Information

Diaphragm Plasticity Following High Cervical Spinal Cord Injury and Systemic Sepsis
Physical Description:
1 online resource (226 p.)
Gill, Luther Charles, Jr.
University of Florida
Place of Publication:
Gainesville, Fla.
Publication Date:

Thesis/Dissertation Information

Doctorate ( Ph.D.)
Degree Grantor:
University of Florida
Degree Disciplines:
Rehabilitation Science
Committee Chair:
Fuller, David D
Committee Members:
Judge, Andrew
Martin, Anatole D
Davenport, Paul W


Subjects / Keywords:
cervical -- diaphragm -- plasticity
Rehabilitation Science -- Dissertations, Academic -- UF
Rehabilitation Science thesis, Ph.D.
Electronic Thesis or Dissertation
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )


Plasticity—a commonly used term in neurophysiology, now also appropriately describes the muscle fiber malleability noted following exposure to various stimuli (load, neural input) (Pette, 2001).  Classic nerve cross-union experiments performed over 50 years ago, established a new paradigm in muscle physiology (Buller et al., 1960a).  In an attempt to examine plasticity in monosynaptic reflex pathways, Buller et al. unknowingly designed ground-breaking studies revealing how direct neural modulation significantly alters skeletal muscle fiber phenotype and contractility (Buller et al., 1960a).  To date, investigating mechanisms of limb muscle plasticity has been the focus of the overwhelming majority of studies (Baldwin, 1996a, b; Baldwin et al., 1996; Buller et al., 1960a; Buller and Pope, 1977; Dubowitz, 1967; Edgerton et al., 1969; Goldspink et al., 1991a; Goldspink et al., 1992; Goldspink et al., 1991b; Goldspink et al., 1974; Loughna et al., 1990; Mommaerts et al., 1977; Vaughan and Goldspink, 1979; Watt et al., 1984; Williams et al., 1986; Williams and Goldspink, 1976).  Hence, the body of literature describing limb muscle plasticity following physiological perturbation (load, inactivity) has been well defined.  However, diaphragm muscle plasticity following physiological perturbation remains a highly debated topic  (Sieck and Mantilla, 2008).  Indeed, the specific mechanism(s) inducing diaphragm plasticity following inactivity have been controversial.  In particular, the defined mechanism(s)typically associated with limb muscle plasticity may not be applicable to diaphragm muscle (Sieck and Mantilla, 2008).  Further, several studies across various models of diaphragm inactivity have shown marked phenotypic variability following perturbation.  Considering this, investigators suggest that diaphragm phenotype may not be directly affected by inactivity alter diaphragm phenotype (Jubran and Tobin, 1997; Miyata et al., 1995).  Respiratory failure is an unfortunate consequence of diaphragm dysfunction.  As the primary inspiratory muscle necessary for sustaining life, it is essential that effective diaphragm function is maintained. Not only this, but the noted rapidity associated with diaphragm plasticity is also a major concern.  For example, significant diaphragm myofiber atrophy (30-50%) has been shown in animals and humans following a brief episode (6-18 hours) of inactivity (Levine et al., 2008).  Myofiber atrophy of this magnitude in limb muscle would only be seen following days to weeks on inactivity (Fujita et al., 2009a; Fujita et al., 2009b). Thus, elucidating the mechanism(s)associated with diaphragm plasticity are of significant clinical importance.
General Note:
In the series University of Florida Digital Collections.
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Includes vita.
Includes bibliographical references.
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Description based on online resource; title from PDF title page.
Source of Description:
This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Thesis (Ph.D.)--University of Florida, 2012.
Adviser: Fuller, David D.
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Statement of Responsibility:
by Luther Charles Gill Jr.

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lcc - LD1780 2012
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