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Molecularly Imprinted Methacrylate Nanoparticles by Emulsion Polymerization as Drug Detoxifying Agents

Permanent Link: http://ufdc.ufl.edu/UFE0025108/00001

Material Information

Title: Molecularly Imprinted Methacrylate Nanoparticles by Emulsion Polymerization as Drug Detoxifying Agents
Physical Description: 1 online resource (53 p.)
Language: english
Creator: Greeley, Eric
Publisher: University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: 2009

Subjects

Subjects / Keywords: amitriptyline, bupivacaine, emulsion, imprinted, methacrylate, molecularly, nanoparticle, pentafluorostyrene, photoinitiation, polymer
Chemistry -- Dissertations, Academic -- UF
Genre: Chemistry thesis, M.S.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The goal is the rapid removal of a hydrophobic drug from the bloodstream in cases of overdose. This can be accomplished with molecularly imprinted polymer (MIP) nanoparticles (NPs). The nanoparticles are made from a mixture of vinyl monomers, solvent, a photoinitiator, surfactant, and drug. The reaction is carried out as a miniemulsion polymerization, under continuous stirring, and UVA illumination. The size of the nanoparticles are determined by Dynamic Light Scattering. Drug reuptake studies by UV spectroscopy are performed with a phosphate buffered saline (PBS) solution that mimics blood plasma and contains drug hydrochloride salt. The nanoparticles demonstrate high binding affinity for the drug that they were made with, as evidenced by significant loss of drug from the supernatant after pelletizing the nanoparticles by centrifugation. This gives high partition coefficient values, or Kp, in excess of 10,000 in some batches.
General Note: In the series University of Florida Digital Collections.
General Note: Includes vita.
Bibliography: Includes bibliographical references.
Source of Description: Description based on online resource; title from PDF title page.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility: by Eric Greeley.
Thesis: Thesis (M.S.)--University of Florida, 2009.
Local: Adviser: Duran, Randolph.

Record Information

Source Institution: UFRGP
Rights Management: Applicable rights reserved.
Classification: lcc - LD1780 2009
System ID: UFE0025108:00001

Permanent Link: http://ufdc.ufl.edu/UFE0025108/00001

Material Information

Title: Molecularly Imprinted Methacrylate Nanoparticles by Emulsion Polymerization as Drug Detoxifying Agents
Physical Description: 1 online resource (53 p.)
Language: english
Creator: Greeley, Eric
Publisher: University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: 2009

Subjects

Subjects / Keywords: amitriptyline, bupivacaine, emulsion, imprinted, methacrylate, molecularly, nanoparticle, pentafluorostyrene, photoinitiation, polymer
Chemistry -- Dissertations, Academic -- UF
Genre: Chemistry thesis, M.S.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: The goal is the rapid removal of a hydrophobic drug from the bloodstream in cases of overdose. This can be accomplished with molecularly imprinted polymer (MIP) nanoparticles (NPs). The nanoparticles are made from a mixture of vinyl monomers, solvent, a photoinitiator, surfactant, and drug. The reaction is carried out as a miniemulsion polymerization, under continuous stirring, and UVA illumination. The size of the nanoparticles are determined by Dynamic Light Scattering. Drug reuptake studies by UV spectroscopy are performed with a phosphate buffered saline (PBS) solution that mimics blood plasma and contains drug hydrochloride salt. The nanoparticles demonstrate high binding affinity for the drug that they were made with, as evidenced by significant loss of drug from the supernatant after pelletizing the nanoparticles by centrifugation. This gives high partition coefficient values, or Kp, in excess of 10,000 in some batches.
General Note: In the series University of Florida Digital Collections.
General Note: Includes vita.
Bibliography: Includes bibliographical references.
Source of Description: Description based on online resource; title from PDF title page.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility: by Eric Greeley.
Thesis: Thesis (M.S.)--University of Florida, 2009.
Local: Adviser: Duran, Randolph.

Record Information

Source Institution: UFRGP
Rights Management: Applicable rights reserved.
Classification: lcc - LD1780 2009
System ID: UFE0025108:00001


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