<%BANNER%>

Examination of Relationships Between Response Topography and the Development of Behavioral Tolerance to Effects of Cocai...

Permanent Link: http://ufdc.ufl.edu/UFE0024323/00001

Material Information

Title: Examination of Relationships Between Response Topography and the Development of Behavioral Tolerance to Effects of Cocaine with Rats and Pigeons
Physical Description: 1 online resource (106 p.)
Language: english
Creator: Weaver, Matthew
Publisher: University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: 2009

Subjects

Subjects / Keywords: behavior, cocaine, lever, licking, peck, pigeon, rat, tolerance, treadle
Psychology -- Dissertations, Academic -- UF
Genre: Psychology thesis, Ph.D.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Tolerance is the attenuation of drug effects after repeated administration. The phenomenon of tolerance is multifaceted and closely related to the problems of substance abuse and substance dependence. The development of tolerance to behavioral effects is dependent on physiological and behavioral factors. A need for behavioral mechanisms to account for tolerance is illustrated through the Before-After Test of Tolerance. In this test two groups are subjected to the same experimental contingencies and drugs, however, the Before group receives the drug prior to experimental contingencies and the After group receives the drug following the contingencies. Typically, only the Before group develops tolerance, and this outcome shows that tolerance is contingent on a learning history while under the influence of drug. The finding, known as contingent tolerance, has been replicated using a variety of drugs, experimental arrangements, and animal species. Interestingly, contingent tolerance has not been exhibited in pigeons. This species difference may be a result of using species-typical responses to test for tolerance. In contrast, similar studies using rats and non-human primates included species-arbitrary responses, and contingent tolerance has been the typical result. This dissertation addresses the role of response topography in the development of tolerance to the rate-decreasing effects of cocaine with two experiments using the Before-After Test of Tolerance. Experiment 1 required rats to use species-typical licking responses in a procedure similar to that previously had resulted in tolerance for both Before and After groups of pigeons. Experiment 2 employed pigeons and a species-arbitrary treadle-pressing response, an arrangement similar to those that have led to contingent tolerance when rats were used. Experiment 1 resulted in tolerance for both the Before and After groups, which is consistent with the idea that response topography may influence the development of tolerance. Experiment 2 resulted in tolerance for both the Before and After groups, which is inconsistent with the idea that response-topography was the confounding variable in development of contingent tolerance. The outcome, however, was consistent with previous pigeon experiments. It was therefore concluded that factors other than the operantly maintained response topography must be influencing the species differences in development of tolerance to effects of cocaine.
General Note: In the series University of Florida Digital Collections.
General Note: Includes vita.
Bibliography: Includes bibliographical references.
Source of Description: Description based on online resource; title from PDF title page.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility: by Matthew Weaver.
Thesis: Thesis (Ph.D.)--University of Florida, 2009.
Local: Adviser: Branch, Marc N.
Local: Co-adviser: Hackenberg, Timothy D.

Record Information

Source Institution: UFRGP
Rights Management: Applicable rights reserved.
Classification: lcc - LD1780 2009
System ID: UFE0024323:00001

Permanent Link: http://ufdc.ufl.edu/UFE0024323/00001

Material Information

Title: Examination of Relationships Between Response Topography and the Development of Behavioral Tolerance to Effects of Cocaine with Rats and Pigeons
Physical Description: 1 online resource (106 p.)
Language: english
Creator: Weaver, Matthew
Publisher: University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: 2009

Subjects

Subjects / Keywords: behavior, cocaine, lever, licking, peck, pigeon, rat, tolerance, treadle
Psychology -- Dissertations, Academic -- UF
Genre: Psychology thesis, Ph.D.
bibliography   ( marcgt )
theses   ( marcgt )
government publication (state, provincial, terriorial, dependent)   ( marcgt )
born-digital   ( sobekcm )
Electronic Thesis or Dissertation

Notes

Abstract: Tolerance is the attenuation of drug effects after repeated administration. The phenomenon of tolerance is multifaceted and closely related to the problems of substance abuse and substance dependence. The development of tolerance to behavioral effects is dependent on physiological and behavioral factors. A need for behavioral mechanisms to account for tolerance is illustrated through the Before-After Test of Tolerance. In this test two groups are subjected to the same experimental contingencies and drugs, however, the Before group receives the drug prior to experimental contingencies and the After group receives the drug following the contingencies. Typically, only the Before group develops tolerance, and this outcome shows that tolerance is contingent on a learning history while under the influence of drug. The finding, known as contingent tolerance, has been replicated using a variety of drugs, experimental arrangements, and animal species. Interestingly, contingent tolerance has not been exhibited in pigeons. This species difference may be a result of using species-typical responses to test for tolerance. In contrast, similar studies using rats and non-human primates included species-arbitrary responses, and contingent tolerance has been the typical result. This dissertation addresses the role of response topography in the development of tolerance to the rate-decreasing effects of cocaine with two experiments using the Before-After Test of Tolerance. Experiment 1 required rats to use species-typical licking responses in a procedure similar to that previously had resulted in tolerance for both Before and After groups of pigeons. Experiment 2 employed pigeons and a species-arbitrary treadle-pressing response, an arrangement similar to those that have led to contingent tolerance when rats were used. Experiment 1 resulted in tolerance for both the Before and After groups, which is consistent with the idea that response topography may influence the development of tolerance. Experiment 2 resulted in tolerance for both the Before and After groups, which is inconsistent with the idea that response-topography was the confounding variable in development of contingent tolerance. The outcome, however, was consistent with previous pigeon experiments. It was therefore concluded that factors other than the operantly maintained response topography must be influencing the species differences in development of tolerance to effects of cocaine.
General Note: In the series University of Florida Digital Collections.
General Note: Includes vita.
Bibliography: Includes bibliographical references.
Source of Description: Description based on online resource; title from PDF title page.
Source of Description: This bibliographic record is available under the Creative Commons CC0 public domain dedication. The University of Florida Libraries, as creator of this bibliographic record, has waived all rights to it worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law.
Statement of Responsibility: by Matthew Weaver.
Thesis: Thesis (Ph.D.)--University of Florida, 2009.
Local: Adviser: Branch, Marc N.
Local: Co-adviser: Hackenberg, Timothy D.

Record Information

Source Institution: UFRGP
Rights Management: Applicable rights reserved.
Classification: lcc - LD1780 2009
System ID: UFE0024323:00001


This item has the following downloads:


Full Text

PAGE 13

.

PAGE 20

or at least with only as many as are needed to assure the general applicability of the results

PAGE 29

Method Subjects Rattus norvegicus Apparatus

PAGE 30

Procedure Training.

PAGE 31

Baseline Drug Regimen.

PAGE 33

Drug Procedure. Data Analysis.

PAGE 34

Hill equation) Bottom Top ED50 Top Bottom Hill slope Top Bottom Hill

PAGE 35

slope ED50

PAGE 37

Results and Discussion

PAGE 46

296 0 50 100 150 13 10173042Drug Dose (mg/kg)Percent of Saline Responding289 Acute Chronic 1 3 10173042Hill Slope Drug Dose (mg/kg)

PAGE 47

291Dosage Cocaine (mg/kg) CS13 10173042Percent of Saline Responding 0 25 50 75 100 125 150 290 289 Percent of Saline Responding 0 25 50 75 100 125 150 293Dosage Cocaine (mg/kg) CS13 10173042

PAGE 48

292Dosage Cocaine (mg/kg) CS 0.1 13 10173042Percent of Saline Responding 0 25 50 75 100 125 150 296Dosage Cocaine (mg/kg) CS 0.1 13 10173042

PAGE 49

Before AC 0.1 13 101742Percent of Saline Responding 0 20 40 60 80 100 120 140 160 Acute Chronic AfterDosage Cocaine (mg/kg) AC 0.1 13 101742

PAGE 50

Acute S 0.1 13 101742Percent of Saline Responding 0 20 40 60 80 100 120 140 160 Before Group After Group ChronicDosage Cocaine (mg/kg) S 0.1 13 101742

PAGE 54

Method Subjects Columba livia ad l ibitum Apparatus

PAGE 56

Procedure Training. Base line

PAGE 57

Drug Regimen.

PAGE 59

Drug Procedure. Data Analysis. Results and Discussion

PAGE 78

Chronic AbstinenceCocaine Dose (mg/kg) V 1.0 3.05.610.017.0Percent of Saline Responding 0 25 50 75 100 125 150 AcuteCocaine Dose (mg/kg) V 1.0 3.05.610.017.0Percent of Saline Responding 0 25 50 75 100 125 150 Before Group After Group

PAGE 79

820: 5.6Dosage Cocaine (mg/kg) S1 3 5.61017Percent of Saline Responding 0 50 100 150 200 Acute Chronic Abstinence 660:5.6 Percent of Saline Responding 0 50 100 150 200 802: 7.4 996: 5.6Dosage Cocaine (mg/kg) S1 3 5.61017

PAGE 80

30:4.2 Percent of Saline Responding 0 25 50 75 100 125 150 549: 5.6 958: 5.6Dosage Cocaine (mg/kg) S1 3 5.61017 829Dosage Cocaine (mg/kg) S1 3 5.61017Percent of Saline Responding 0 25 50 75 100 125 150 Acute Chronic Abstinence

PAGE 81

AfterCocaine Dose (mg/kg) V 1.0 3.05.610.017.0Percent of Saline Responding 0 25 50 75 100 125 150 Acute Chronic Abstinence Before V 1.0 3.05.610.017.0

PAGE 86

t t t t

PAGE 87

t

PAGE 90

t

PAGE 98

Automatic Control, IEEE Transactions on 19 Experimental analysis of behavior, part 1. Journal of the Experimental Analysis of Behavior 10 Journal of the Experimental Analysis of Behavior 9 The laboratory rat volume II: Research application. Psychopharmacology 113 Drug Developmen t Research, 20 Pharmacology, Biochemistry, & Behavior, 30 Journal of the Experimental Analysis of Behavior, 11 A primer of behavioral pharmacology : Concepts and principles in the behavior analysis of drug action Physiology and Behavior, 7 Psychopharmacologia, 27 Journal of the Experim ental A nalysis of Behavior. 34(1

PAGE 99

Schedules of reinforcement Journal of the Experimental Analysis of Behavior 13 Science (New York, N.Y.) 171 Psychopharmacology 96 Journal of the Experimental Analysis of Behavior 39 Psychopharmacologia 41 Journal of the Experimental Analysis of Be havior 80 Journal of Comparative and Physiological Psychology 85 Learning and Motivation, 6 Journal of the Ex p erimental Analysis of Behavior, 12 Journal of the Experimental Analysis of Behavior, 476 Journal of the Experimental Analysis of Behavior 2 Laboratory Animal Science 44 Journal of the Experimental Analysis of Behavior 83

PAGE 100

Journal of the Ex p erimental Analysis of Behavior, 20 Behavioural Processes 75 Journal of the Experimental Analysis of Behavior 89 Biology of the rat Journal of the Experimental Analysis of Behavior 26 Journal of the Ex p rimental Analysis of Behavior, 11 Journal of the Experimental Analysis of Behavior 37 Pharmacological and environmental factors in the development of contingent tolerance to cocaine in pigeons Fitting models to biological data using linear and nonlinear regression: A practical guide to curve f itting Behavioural Pharmacology 4 Behavior Research Methods, Instruments & Computers 25 Journal of Pharmacological and Toxicological Methods 39 Scie nce (New York, N.Y.) 177

PAGE 101

Journal of the Experimental Analysis of Behavior, 81, 169-188. Journal of the Experimental Analysis of Behavior 82 Behavioural Pharmacology 19 Science 157 Pharmacology: Fifth edition. Psychological Review 74 Journal of the Experimental Analysis of Behavior 26 Pharmacology, Biochemistry, & Behavior, 32 Handbook of operant behavior Psychopharmac ologia, 9 Psychological Review 77 Tactics of scientific r esearch The behavior of organisms; An exper imental a nalysis Pharmacology, Biochemistry, & Behavior, 36 Journal of the Experimental Analysis of Behavior 13

PAGE 102

Handbood of operant behavior Psychological Review, 78 Journal of the Experimental Analysis of Behavior 22 NIDA Research Monograph Journal of the Experimental Analysis of Behavior, 60 Journal of the Experimental Analysis of Behavior 44 Behavioural Pharmacology 5 Journal of the Experimental Analysis of Behavior, 90 Science, 231 Journal of the Experimental Analysis of Behavior, 12, Contemporary research in operant behavior Journal of the Experimental Analysis of Behavior 26 Journal of Pharmacology & Experimental Therapeutics, 205

PAGE 103

. Behavioural Processes, 67