Title Page
 List of Tables
 List of Figures
 Biotic and abiotic factors in endocrine...
 Seasonal variation in plasma sex...
 The effect of capture stress on...
 Population variation in immunity...
 Developmental effects of contaminants...
 Summary and conclusions
 Biographical sketch

Title: Variation in the endocrine and immune system of juvenile alligators
Full Citation
Permanent Link: http://ufdc.ufl.edu/UF00100659/00001
 Material Information
Title: Variation in the endocrine and immune system of juvenile alligators : environmental influence on physiology
Physical Description: xiii, 143 p. ; ill.
Language: English
Creator: Rooney, Andrew A., 1969- ( Dissertant )
Guillette, Lou ( Thesis advisor )
Publisher: University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: 1998
Copyright Date: 1998
Subjects / Keywords: Zoology thesis, Ph. D   ( lcsh )
Dissertations, Academic -- Zoology -- UF   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
bibliography   ( marcgt )
theses   ( marcgt )
non-fiction   ( marcgt )
Abstract: The influence of the environment on the endocrine and immune systems has become an extreme example of the extent of human influence and human potential to disrupt biological systems. Many natural aspects of the environment (i.e., temperature, food availability, and predator interactions) modify both the endocrine and immune systems. Exposure to xenobiotic chemicals can also modify endocrine and immune parameters, especially when exposure occurs during embryonic development. Furthermore, the endocrine system is an important regulator of the immune system. Therefore, the interactions between exposure to xenobiotics in wild populations of alligators and the following variables were considered: sex hormones and seasonal variation in sex hormones, stress response, morphology of the spleen and thymus, mitogenic response, and phagocytic response. Seasonal variation in sex steroids was found in juvenile alligators. Plasma testosterone concentrations differed in contaminant-associated alligators relative to alligators from reference lake and the difference was influenced by the season. Contaminant-associated alligators also had a modified plasma corticosterone profile during capture stress; and, this modified response appears to be from an activational influence rather than a developmental effect. Several differences were also noted in immune parameters associated with the contaminated alligator population: an increase in the cortical region of the thymus, a reduction in lymphocyte presence in the spleen, and a greater proliferation response of lymphocytes. Alligators from the reference lake had sexually dimorphic characteristics in the spleen; no such difference was present in contaminant-associated alligators. Additionally, a morphological effect on the spleen and thymus was found in eggs treated with trans-nonachlor, a contaminant present in higher concentrations at the contaminated study site. In conclusion, all organisms, including the American alligator live in a dynamic environment. Changing biotic and abiotic factors--including anthropogenic changes such as the presence of contaminants--must be transduced by the endocrine and immune systems of an organism to enable homeostatic mechanisms. This research provides evidence of additional possible effects of contaminant exposure to the immune system and the endocrine-immune systems of wild, juvenile alligators. The data are particularly important because they suggest seasonality in reproductive steroidogenesis of wild, juvenile alligators.
Subject: alligator, testosterone, estradiol, corticosterone, spleen, thymus, season, stress, xenobiotics
Thesis: Thesis (Ph. D.)--University of Florida, 1998.
Bibliography: Includes bibliographical references (p. 128-142).
Statement of Responsibility: by Andrew A. Rooney.
General Note: Title from first page of PDF file.
General Note: Document formatted into pages; contains xiii, 143 p.; also contains graphics (some in color).
General Note: Vita.
 Record Information
Bibliographic ID: UF00100659
Volume ID: VID00001
Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 80443932
alephbibnum - 002424963
notis - AMD0043


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Table of Contents
    Title Page
        Page i
        Page ii
        Page iii
        Page iv
        Page v
        Page vi
        Page vii
    List of Tables
        Page viii
    List of Figures
        Page ix
        Page x
        Page xi
        Page xii
        Page xiii
    Biotic and abiotic factors in endocrine and immune function: The challenge of a modern environment
        Page 1
        Page 2
        Page 3
        Page 4
        Page 5
        Page 6
        Page 7
        Page 8
        Page 9
        Page 10
        Page 11
        Page 12
        Page 13
        Page 14
        Page 15
    Seasonal variation in plasma sex steroid concentrations in juvenile American alligators
        Page 16
        Page 17
        Page 18
        Page 19
        Page 20
        Page 21
        Page 22
        Page 23
        Page 24
        Page 25
        Page 26
        Page 27
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        Page 41
        Page 42
        Page 43
        Page 44
        Page 45
    The effect of capture stress on plasma corticosterone and testosterone in juvenile alligators from two lakes in Florida
        Page 46
        Page 47
        Page 48
        Page 49
        Page 50
        Page 51
        Page 52
        Page 53
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        Page 57
        Page 58
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        Page 60
        Page 61
        Page 62
        Page 63
    Population variation in immunity - thymus and spleen of juvenile American alligators
        Page 64
        Page 65
        Page 66
        Page 67
        Page 68
        Page 69
        Page 70
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        Page 96
        Page 97
        Page 98
        Page 99
        Page 100
    Developmental effects of contaminants on immune tissue: Thymus and spleen of American alligators
        Page 101
        Page 102
        Page 103
        Page 104
        Page 105
        Page 106
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        Page 114
        Page 115
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        Page 117
        Page 118
        Page 119
        Page 120
    Summary and conclusions
        Page 121
        Page 122
        Page 123
        Page 124
        Page 125
        Page 126
        Page 127
        Page 128
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        Page 141
        Page 142
    Biographical sketch
        Page 143
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