Group Title: BMC Neuroscience
Title: High frequency oscillations in limbic rat model for temporal lobe epilepsy
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 Material Information
Title: High frequency oscillations in limbic rat model for temporal lobe epilepsy
Series Title: BMC Neuroscience
Physical Description: Archival
Creator: Talathi,Sachin
Hwang,Dong-Uk
Ditto,William
Myers,Stephen
Simonotto,Jennifer
Carney,Paul
Norman,Wendy
Publication Date: 2007
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General Note: Start pageP145
General Note: M3: 10.1186/1471-2202-8-S2-P145
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Bibliographic ID: UF00099996
Volume ID: VID00001
Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: Open Access: http://www.biomedcentral.com/info/about/openaccess/
Resource Identifier: issn - 1471-2202

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BMC Meuroscience BioMed C



Poster presentation

High frequency oscillations in limbic rat model for temporal lobe
epilepsy
Sachin S Talathil, Dong-Uk Hwang*1, William Ditto', Stephen Myers1,
Jennifer Simonottol, Paul R Carney1,2,3,4 and Wendy Norman3


Address: 'Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA, 2Department of Neuroscience, University of
Florida, Gainesville, FL 32611, USA, 3Department of Pediatrics, University of Florida, Gainesville, FL 32611, USA and 4Department of Neurology,
University of Florida, Gainesville, FL 32611, USA
Email: Dong-Uk Hwang* dhwang@bme.ufl.edu
* Corresponding author



from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007
Toronto, Canada. 7-12 July 2007

Published: 6 July 2007
BMC Neuroscience 2007, 8(Suppl 2):P145 doi:10.1 186/1471-2202-8-S2-P145



2007 Talathi et al; licensee BioMed Central Ltd.


Recently a number of groups [1,21 have reported on the
existence of pathological High frequency oscillations
(HFO's) (oscillations in the frequency range of 80-200
Hz, termed as Ripple band and oscillations in the fre-
quency range of 200 Hz and above, termed as Fast Ripple
band) in the epileptic brain both in in-vivo and in-vitro
experiments. Our goal in this study is to study the statisti-
cal modulation of HFOs during epileptogenesis in order
to characterize their function in progression to seizures in
the epileptic brain.

In this study we define a HFO event as a subset of wave
having significant high frequency component with low
wave amplitude. HFO are detected from data recorded at
a sampling rate of 12000 Hz for the entire duration of epi-
leptogenesis which lasts anywhere from about 3-6 weeks.

Statistical analysis on the HFO suggest that occurrence of
HFO's occur primarily during the 12 hour dark cycle
whereas the HFO's primarily seem to occur during the 12
hour day cycle in the control rat The video recording
shows that the rat is primarily in active and exploratory
state during the dark cycle. These observations suggest
that HFO in epileptic rats are correlated with the state of
arousal.


Spatial correlation of HFOs in different regions of the
brain is also investigated with cross-correlogram. Com-
parison of cross-correlogram of the post-stimulus HFO in
the epileptic rat to the pre stimulus HFO (control) sug-
gests modification in the circuitry in the hippocampus,
evidence for which in in-vitro experiments were provided
by [3].

References
I. Engel J Jr, Wilson CL, Bragin A: Advances in understanding the
process of epileptogenesis based on patient material: what
can the patient tell us? Epilepsia 2003, 44(suppl 12):60-71.
2. Bragin A, Engel J, Wilson CL, Fried I, Buzsaki G: High frequency
oscillations in human brain. Hippocampus 1999, 9:137-142.
3. Avoli M, D'Antuono M, Louvel J, Kohling R, Biagini G, Pumain R,
D'Arcangelo G, Tancredi V: Network and pharmacological
mechanisms leading to epileptiform synchronization in the
limbic system in vitro. Prog Neurobiol 2002, 68:167-207.


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