Group Title: BMC Neuroscience
Title: Spike timing dependent plasticity promotes synchrony in inhibitory networks in presence of heterogeneity and noise
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Title: Spike timing dependent plasticity promotes synchrony in inhibitory networks in presence of heterogeneity and noise
Series Title: BMC Neuroscience
Physical Description: Archival
Creator: Talathi,Sachin
Haas,Julie
Publication Date: 2007
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Abstract: :
General Note: Start pageP58
General Note: M3: 10.1186/1471-2202-8-S2-P58
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Bibliographic ID: UF00099995
Volume ID: VID00001
Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: Open Access: http://www.biomedcentral.com/info/about/openaccess/
Resource Identifier: issn - 1471-2202

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Poster presentation

Spike timing dependent plasticity promotes synchrony in inhibitory
networks in presence of heterogeneity and noise
Sachin S Talathi*1,2 and Julie Haas2


Address: 'Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA and 2Institute for Nonlinear Sciences,
University of California San Diego, San Diego, CA, 92093, USA
Email: Sachin S Talathi* stalathi@bme.ufl.edu
* Corresponding author



from Sixteenth Annual Computational Neuroscience Meeting: CNS*2007
Toronto, Canada. 7-12 July 2007

Published: 6 July 2007
BMC Neuroscience 2007, 8(Suppl 2):P58 doi:10.1186/1471-2202-8-S2-P58



2007 Talathi and Haas; licensee BioMed Central Ltd.


Introduction
Recently a novel form of spike timing dependent plasticity
(STDP) was observed in GABAergic synaptic couplings in
layer II of the entorhinal cortex. Depending on the relative
timing of pre-synaptic input at time tpre and postsynaptic
excitation at time tpost the synapse is strengthened (At =
tpost-tpre>0) or weakened (At < 0). Because the observed
effect is the largest at 10 ms, the operational dynamic
range of the observed STDP rule lies in the higher gamma
frequency band (>40 Hz), a frequency range important for
several vital neuronal tasks. In this work we study the
influence of this novel STDP of inhibitory synapses on the
synchronization of two mutually coupled interneurons
(MCI) in the presence of heterogeneity and noise. We
demonstrate analytically how this synchronization is
brought about by defining the spike response curve
(SRC), which measures the nonlinear response of neuron
to pre-synaptic input. We present simulation results to
demonstrate how the unique features of the STDP
increase the robustness of synchronization even in the
presence of heterogeneity and noise.

Results
See Figure 1.

Conclusion
STDP of inhibitory synapses promotes synchrony
between two mutually coupled interneurons thereby
making it more robust against intrinsic heterogeneity in
firing frequency of the coupled neurons.


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BMC Neuroscience 2007, 8(Suppl 2):P58


A



C


-4 -3 -2 -1 0 1
Heterogeneity (H)


3 4


Figure I
Example demonstrating the enhancement in synchronization of mutually coupled interneurons through spike
timing dependent plasticity on inhibitory synapses. (a) Schematic diagram of reciprocally connected interneurons with
self-inhibition. (b) The ratio of average firing period of the two neurons is plotted as function of heterogeneity in intrinsic firing
frequency of each neuron. The ratio (diamond) represents a dynamic synapse, where STDP modulates the synaptic strength
between the coupled neurons. The ratio in (star) represents the situation when the synaptic strength is static. (c) The syn-
chronization index K is plotted as function of heterogeneity H for the two cases discussed in (b).




































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SStatic Synapse *
* Dynamic Synapse "
**

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**


**
^*
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