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Quantification of Lacune Volume in Alzheimer’s Disease and Small Vessel Vascular Dementia
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 Material Information
Title: Quantification of Lacune Volume in Alzheimer’s Disease and Small Vessel Vascular Dementia
Series Title: Journal of Undergraduate Research
Physical Description: Serial
Language: English
Creator: Kelley, Lauren
Price, Catherine ( Mentor )
Publisher: University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: 2010
Abstract: Understanding pathological markers seen on brain magnetic resonance imaging (MRI) may improve dementia diagnosis and treatment approaches. This study sought to examine total brain MRI lacunes volume in Alzheimer’s disease (AD) and small vessel vascular dementia (sVD) as well as AD and sVD group differences in lacune volume within regional white and gray matter. We hypothesized greater total lacune volume in vascular dementia, with the greatest volume in the basal ganglia. Lacune volumes were measured on brain MRIs diagnosed clinically with AD (n=42) or sVD (n=28). A trained rater (reliability, r = 0.93-0.98) measured the volume of all lacunes 2mm in diameter or larger. Separate volumes were calculated for lacunes in white and gray matter regions. Perivascular spaces were excluded. Results revealed that lacune volume did not differ between sVD and AD (mean ± s.d: AD= 9.99 ± 24.19 mm3; sVD= 9.87 ± 13.62mm3 and sVD group (t(68) = -0.11; p = 0.91); and in each region measured, the mean lacunes volume did not differ between sVD and AD white matter regions (t(68) = 0.46, p = 0.65) or those found in subcortical gray matter structures (t(68) = -0.68, p = 0.50). For all gray and white matter regions, the lacune volume was comparable and both sVD and AD patients presented with evidence of vascular disease. Future studies should examine regional lacune volume and cognition in these patient groups.
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Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
System ID: UF00091523:00582

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