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Permanent Link: http://ufdc.ufl.edu/UF00091266/00005
 Material Information
Title: Continuum newsletter
Physical Description: Serial
Language: English
Creator: Institute on Aging, University of Florida
Publisher: Institute on Aging, University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: Fall 2009
Copyright Date: 2009
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Bibliographic ID: UF00091266
Volume ID: VID00005
Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: All rights reserved by the source institution and holding location.

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Physical Activity to Prevent Disability
NewNIHAwardforthelnstituteonAging:Lifestylelnterventionsand
Independence For Elders (LIFE) Study












s life expectancy in the United States is rising, the maintenance of

physical independence among older Americans has emerged as a ma-
jor clinical and public health priority. The ability to move without as-
sistance is a fundamental feature of human functioning. Seniors who lose mo-
bility are less likely to remain in the community, have higher rates of morbidity,
mortality, and hospitalizations and experience a poorer quality of life. Several
studies have shown that physical activity improves physical performance, but
definitiveevidenceshowingthatmobilitydisabilitycan beprevented islacking.
A Phase 3 randomized controlled trial is needed to fill this evidence gap.
After a successful pilot study, we will now conduct a major Phase 3,
multicenterrandomized controlledtrialtocomparea moderate-intensityphys-
ical activity program to a successful aging program in 1,600 sedentary older
persons who are followed for approximately 3 years. The primary outcome is
Continued on page 2

The Clinical Translational Sciences Institute
T he National Institutes of Health recently funded the Clinical Trans-
lational Science Award (CTSA) to the University of Florida, the only
Florida university to receive this prestigious award. The CTSAs are
granted to academic health centersto revolutionize how clinical and transla-
tion research is conducted, with the ultimate goal to provide newtreatments
more efficiently and quickly to patients.
The University of Florida's Clinical Translation Sciences Institute
(CTSI) provides the new intellectual home for clinical and translational
research and training at UF, integrating and synergizing the scientific and ed-
ucational activities of 12 colleges, two academic and clinical campuses, two
Continued on page 2


Dear friends of the IOA,
In this issue, we share outstanding news
regarding the relevant expansion of our
clinical and translational research programs,
such as funding of The LIFE Study, a
definitive Phase 3 multicenter randomized
controlled trial to investigate the long-term
effects of physical activity on major mobil-
ity disability, cognition and other important
health outcomes. LIFE is the result of 10
years of research develop-
ment supported by the
Pepper Center and other
NIH grants conducted by
a team of experts across
the nation.
We are also a site
for the National Institute
on Aging funded TTrial, a
large multicenter random
ized controlled trial of Marco Pahor, M.D.
testosterone replacement
therapy in older hypogonadal men. Finally,
we lead the creation of a novel clinical
translational research program to study
age-related cognitive decline and memory
loss sponsored by The McKnight Brain
Research Foundation and the UF.This is in
addition to several awards, including RO1,
R21, K, competitive revision and supple-
ment grants, supported by the American
Recovery and Reinvestment Act and regular
NIH funds all of which will not only ad-
vance our science, but will also significantly
contributeto retain and createjobs and help
to revamp our economy.
I am so proud of our faculty, staff
and trainees who, over the past few years
have worked tirelesslyto build our programs
and position the UF Institute on Aging
at the forefront of the national arena of
geriatric and gerontological research. This
is indeed a very exciting time for the UF
Institute on Aging. F /
.c3R


W 11 11 -M~












Cognitive Aging and Memory Clinical Translational
Research Program


Physical Activity to Prevent
Disability
Continued from page 1
major mobility disability. Secondary
outcomes include cognitive function;
fall injuries; mobility disability or
death; disability in activities of daily
living; and cost-effectiveness.Tertiary
outcomes include mild cognitive im-
pairment and dementia. The physi-
cal activity intervention consists of
walking, resistance exercises, balance
exercises, stretching and behavioral
counseling.Thesuccessful aginginter-
vention consists of health education
and upper extremity stretching.
LIFE will provide definitive
evidence regarding whether physi-
cal activity is effective for prevent-
ing major mobility disability. These
results will have crucial implications
for disability prevention and will fill
an important gap in knowledge for
practicing evidence-based geriatric
medicine. The LIFE study will impact
clinical practice and public health
policy,andwill benefitindividualsand
society as a whole.
The recruitment for LIFE
will start in March 2010. More details
about the LIFE study will follow in
future issues of this publicatiorf


approximately 1 in 7 adults
over 65 years old experiences
moderate to severecognitive
and memory impairment, which ad-
verselyimpacts independence. Clini-
cal and translational research on
interventionstoremediateorprevent
these highly prevalent age-related
conditions is in its early stage.
The Institute on Aging is
now hosting the newly established
Cognitive Aging and Memory Clini-
cal Translational Research Program
(CAM-CTRP). The program is
supported by the endowed fund
of the McKnight Brain Research
Foundation and by the UF. The
primary goal of the CAM-CTRP is
to address a critical gap in research
by developing a cutting-edge inter-
disciplinary clinical translational
research program, which translates
basic science discoveries regarding
cognitive aging and memory into
clinical applications to slow, avert or


restore the age-related cognitive
decline. The CAM-CTRP capital-
izes on the existing strengths of the
Institute on Aging/Pepper Center
Cores, the UF McKnight Brain
Institute, the Clinical Transla-
tional Sciences Institute (CTSI), the
Departments of Neurology, Neu-
roscience, Psychiatry and Aging
and Geriatric Research, other UF
institutes and colleges, and of the
rich UF grant funding portfolio in
the arena of aging, brain, cognition
and memory.
The CAM-CTRP is de-
signed to be positioned at the
forefront of the national arena of
aging, cognition and memory re-
search by using an interdisciplinary
approach that traverses the entire
spectrum of biomedical investiga-
tion. The search for the Program
Director is in progress. We will pro-
vide more news aboutthis program
in future issues of this publication


The Clinical Translational Sciences Institute
Continued from page 1
regional healthcare systems and the Interactions Program.
67 counties of the State of Florida. UF has a rich environment of
We are proud to announce distinguished colleges, state-of-the-
that the Institute on Aging (IOA) is art research facilities and statewide
a part of the CTSI infrastructure health education and health delivery
and plays key leadership roles in the systems.These resources position UF
CTSI. Dr. Pahor directs the KL2 and the IOA at the forefront of insti-
mentored research career develop- tutions to train the next generation
ment program for junior faculty. of clinical and translational investi-
He is also the director of the IOA gatorsand tohelpovercometwoma-
Clinical Research Unit of the CTSI jor obstacles in our nation's clinical
Participant and Clinical Interactions research enterprise: the translation
Program. The IOA is part of the of of basic science discoveries to early
the CTSI infrastructure, and thereby investigations in humans, and the
it is fully integrated into the network translation of clinical research into
of the eight Clinical Research Units better medical practice and health-
of the CTSI Participant and Clinical care delivery.-l












Legs vs. Arms Event Raises
the Institute on Aging


Crescent Beach Legs vs. Arms event participants
(from left) Dr. Yvette Bazikian, Dr. Christiaan Leeu-
wenburgh, Leif Stringer and Carolyn Goddard
Stellar volunteer Carolyn God-
dard organized and presented
the first Memorial Day week-
end Legs vs. Arms beach competi-
tion, which was to include sea kayak-
ing ("Arms") and a three-mile run on
the beach ("Legs"). Carolyn's son,
Leif Stringer, orchestrated the race.
Due to inclement weather,
the kayaking was cancelled. The run,
however,was a greatsucess, and race
winners received spa gift certificates.


Funds & Awareness for


Carolyn hopes that Legs vs.
Arms will become an annual event
that will attract more local spon-
sors like the ones at this year's event,
which indluded: The Stringer Fam-
ily; Experience the Island; Island
Center Crescent Beach; Dave Wal-
drop, Inc.; and Napoli Pizza and
Reserve Age.
Dr. Christiaan Leeuwen-
burgh, Chief of the Division of Biol-
ogy and Aging, had this to say about
the event and its support of the Insti-
tute: "Despite the poor weather, the
turnout was great. Most importantly,
the participants were fully engaged
and enjoyed the relaxed run on the
beach at their own pace. Family and
friends watched children run and
play on the beach and in the ocean.
Carolyn and Leif prepared and
ran a flawless event. I hope to do it
again next year." t


Retired Faculty Supports Biology of Aging Research


T he Institute on Aging recent-
ly received $30,811 through
a realized gift annuity estab-
lished by Margaret W. Hoffmann,
MD. The IOA received the gift after
Dr. Hoffmann's passing earlier this
year. Through her philanthropy, Dr.
Hoffmann has provided funds to the
Division of Biology of Aging for re-
search discoveriesto unravel mecha-
nisms of aging and to use natural
interventions to promote healthy
aging. Dr. Hoffmann was the first
female physician scientist at UF
within the Department of Pathology
in the 1960s and was very interested
in research to improve the quality of
life in elderly citizens.
"Due to Dr. Hoffman's
generosity, we will now have more


opportunities to continue to make
significant contributions to the pres-
ervation of independence for
older adults," Dr. Marco Pahor, IOA
Director, said.
Dr. Christiaan Leeuwen-
burgh, Chief of the Division of the
Biology of Aging stated: "The funds
provided by Dr. Hoffman will allow
us to support innovative research
projects, which
may lead to
practical inter-
ventions to
improve the
quality of life in
the elderly."f'


Welcome To Our New
Faculty and Staff:
Susan Nayfield, M.S., M.D., M.Sc.,
Clinical Research Division Chief, Ge-
riatric Medicine Acting Division Chief
and Associate Professor (will join us in
February 2010); Bhanuprasad Sand-
esara, MD Clinical Assistant Professor;
Thomas Buford, PhD Lecturer; Ronald
Lester, MBA, PhD Assistant Director;
Jocelyn Lee, PhD Senior Studies Co-
ordinator, Joe Nocera, PhD Research
Assistant, Lynda Pasteur, MA, Commu-
nication Consultant; Brenda Barefield
and Deborah Crenshaw Program Assis-
tants; Cardie Dielschneider and Taylor
Holt, Screeners; Jeff Knaggs, Study
Coordinator; Vanessa Horman, Recep-
tionist; and Sophy Perdomo, Student
Assistant. Hazel Lee, MS has moved to
a Biological Scientist position, and Lor-
raine Koerper to a Laboratory Techni-
cian position. Dr. Kenneth Heilman, a
renowned behavioralneurologistwhose
research interests include attentional,
emotional, and cognitive disorders was
appointed as an Investigator at the Ge-
riatric Research, Education and Clinical
Center (GRECC) at the VA.

Opportunities to
Participate In
Research Studies:
If interested in participating in one of
our current or future studies, you can
now enroll in our IRB approved recruit-
ment registry. To enroll, or to obtain
additional information about our stud-
ies, please call 1-866-386-7730 or email
Peggy Smith at psmith@aging.ufl.edu.

New Positions:
We are currently advertising several fac-
ulty and staff positions; more positions
will be posted soon. Foremployment op-
portunities, please visit the University of
Florida's website at http://jobs.ufl.edu
or email your inquiry to Camelia Pascu
at cpascu@aging.ufl.edu.









Inttt on Aging
POBx1. 00107
Gansvle FL261

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Sinstitute on
Aging

UNIVERSITY OF FLORIDA


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UF FLORIDA


Giving to the Institute on Aging
...why every dollar counts


U nlocking life's mysteries particularly the secrets of how long and how
well we live is the distinct focus of the University of Florida's Institute on
Aging. Our scientists and physicians are dedicated to achieving better un-
derstanding of the mechanisms of aging and how we can maintain or enhance our
physical independence and cognitive abilities.

Private philanthropy is so essential to our work. Your gift, regardless of size, can
make the critical difference in funding new scientific endeavors. Imagine discoveries
thatfuel positive cellular changes; identify newtherapiesthat help rehabilitate aging
bones and joints; or uncover additional pharmaceutical allies. Private philanthropy
makes all this and much more possible.

To learn more about how you can invest in a healthier and more independent to-
morrow for us all, please contact Sandra Fackler, Senior Director of Development,
at (352)265-7227 or sfackler@ufl.edu. #1


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