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 Front Cover
 Table of Contents
 Statement from the chairman
 Department organizational...
 Graduate medical education
 Department research
 Individual divisions
 Back Matter
 Back Cover














Title: Department of Medicine annual report
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Title: Department of Medicine annual report
Physical Description: Serial
Language: English
Creator: College of Medicine, University of Florida
Publisher: College of Medicine, University of Florida
Place of Publication: Jacksonville, Fla.
Publication Date: 2009-2010
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Table of Contents
    Front Cover
        Page i
    Table of Contents
        Page 1
    Statement from the chairman
        Page 2
    Department organizational overview
        Page 3
        Page 4
        Page 5
    Graduate medical education
        Page 6
        Page 7
        Page 8
        Page 9
        Page 10
    Department research
        Page 11
        Page 12
    Individual divisions
        Page 13
        Page 14
        Page 15
        Page 16
        Page 17
        Page 18
        Page 19
        Page 20
        Page 21
        Page 22
        Page 23
        Page 24
        Page 25
        Page 26
        Page 27
        Page 28
        Page 29
        Page 30
        Page 31
        Page 32
        Page 33
        Page 34
        Page 35
        Page 36
        Page 37
        Page 38
        Page 39
        Page 40
        Page 41
        Page 42
        Page 43
        Page 44
        Page 45
        Page 46
        Page 47
        Page 48
        Page 49
        Page 50
        Page 51
        Page 52
        Page 53
        Page 54
        Page 55
        Page 56
        Page 57
    Back Matter
        Page 58
        Page 59
        Page 60
    Back Cover
        Page 61
Full Text





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Department of Medicine


TABLE OF CONTENTS
ACADEMIC YEAR 2010 (7/09 6/10)


I. Statement from the Chairman

II. Department Organizational Overview
a. Administration
b. Division Chiefs
c. Residents/Fellows

III. Graduate Medical Education
a. Internal Medicine Residency Training Program
b. Subspecialty Fellowship Program
c. Student Education Programs

IV. Department Research

V. Individual Divisions
a. Cardiology
b. Endocrinology, Diabetes & Metabolism
c. Gastroenterology
d. General Internal Medicine
e. Hematology & Medical Oncology
f. Infectious Diseases
g. Nephrology & Hypertension
h. Pulmonary, Critical Care & Sleep Medicine
i. Rheumatology & Clinical Immunology



















Department of Medicine
University of Florida
College of Medicine Jacksonville
653-1 West 8th Street, L20
Jacksonville FL 32209
904-244-8846
www.hscj.ufl.edu/im/


Annual Report AY 2010 Department of Medicine


Table of Contents


Annual Report AY 2010


Department of Medicine





Department Chair: Arshag Mooradian, MD


STATEMENT FROM THE CHAIRMAN
ACADEMIC YEAR 2010 (7/09 6/10)

Dear Colleagues and Friends:

I am pleased to provide you the Annual Report of the Department of Medicine at the University of
Florida College of Medicine Jacksonville for the academic year July 2009 through June 2010. I will
briefly describe the departmental accomplishments for the past year.

Patient care: The Department had an exceptionally productive year. Clinical volumes in all disciplines
were strong and allowed the Department to finish up the year with a profit of $767,513 compared to the
projected bottom line of only $5,434. The clinical excellence of the faculty was coupled with continued
improvements in clinical operations and improvements in patient satisfaction scores. Our goal is to
continue to provide the kind of care for patients that we would want for our family members.

Education: The Department continues to excel in its mission of educating students and residents.
There were unprecedented 14 faculty members in the Department who received the Exemplary Teacher
Award. The scholarly productivity of the house staff increased substantially and several of the top prizes
of the Annual Research Day were awarded to the residents and fellows within the Department. We saw
the successful site visit and subsequent accreditation of Nephrology Fellowship for 4 years. Continuing
Medical Education (CME) initiatives were offered by all the Divisions within the Department including a
highly successful Internal Medicine review symposium, annual Nephrology symposium and musculo-
skeletal ultra sound course launched with the participation of national and international thought leaders.

Research: The Department once again had an exceptionally productive year in research. There were a
tota of 143 peer reviewed publications and 27 book chapters and editorials authored by faculty
members. Faculty made 95 national and regional presentations. During the academic year 2010, we had
88 research awards.

Overall, the Department has excelled in every aspect of the academic mission. I am proud to have the
privilege of being the Chairman of such an exceptionally productive Department.


Sincerely,



Arshag D. Mooradian, M.D.
Professor and Chairman


Annual Report AY 2010 Statement from the Chairman


Statement from the Chairman


Annual Report AY 2010


Statement from the Chairman





Organizational Overview


DEPARTMENT ORGANIZATIONAL OVERVIEW
ACADEMIC YEAR 2010 (7/09 6/10)

Arshag D. Mooradian, M.D.
Chairman, Department of Medicine

N. Stanley Nahman, Jr., M.D.
Program Director, Internal Medicine Residency and Associate Chair, Department of Medicine

Linda R. Edwards, M.D.
Associate Chair, Department of Medicine

Senthil Meenrajan, M.D.
Associate Program Director, Graduate Medical Education

Jeffrey House, D.O.
Associate Program Director, Graduate Medical Education

Carlos Palacio, M.D.
Director, Medical Student Clerkship

Irene Alexandraki, M.D.
Associate Director, Medical Student Clerkship

Christina Catalano, M.B.A.
Administrator

Nanci Morton
Administrative Manager

DIVISION CHIEFS


Cardiology

Endocrinology, Diabetes & Metabolism

Gastroenterology

General Internal Medicine

Hematology & Medical Oncology

Infectious Disease

Nephrology & Hypertension

Pulmonary, Critical Care & Sleep Medicine

Rheumatology & Clinical Immunology


Theodore Bass, M.D.

Kent R. Wehmeier, M.D.

Ravi Kottoor, M.D. Interim

Linda R. Edwards, M.D.

Fauzia Rana, M.D.

Michael Sands, M.D., M.P.H. &T.M.

N. Stanley Nahman, Jr., M.D.

James D. Cury, M.D.

Ghaith Mitri, M.D., M.M.M.


Annual Report AY 2010 Organizational Overview


Department of Medicine


Annual Report AY 2010


Organizational Overview






Organizational Overview


RESIDENTS/FELLOWS


Chief Residents 2009-2010

Andrew Darlington, D.O.
Nimish Naik, M.D.


Class of 2009-2010


Housestaff I
Ramandeep Bambrah, M.D.
Chandrikha Chandrasekharan, M.D.
Emily Christman, M.D.
Michelle Diaz, M.D.
Nasima Jafferjee, M.D.
Sarada Jaimungal, M.D.
Arezo Karmand, M.D.
Cristian Landa, M.D.
Ann Lee, M.D.
Joel Martinez-Ramirez, M.D.
Frederic Nguyen, M.D.
Reshma Ramlal, M.D.
Vinoo Ramsaran, M.D.
Rohan Samson, M.D.
Miloni Shroff, M.D.
Amita Singh, M.D.
Ryan Wilson, M.D.

Housestaff II
Justin Federico, D.O.
Jawahar Gazzala, M.D.
Ankur Girdhar, M.D.
Sanjay Hegde, M.D.
Mohammad Izhar, M.D.
Syed Jafri, M.D.
Brandon Kinney, M.D.
Sudha Koduru, M.D.
Hasan Riaz, M.D.
Muhammad Salahuddin, M.D.
Shawn Tai, M.D.
Louise Zhou, M.D.

Housestaff III
Sara Ahmed, M.D.
Santosh Kale, M.D.
Ravindra Maharaj, M.D.
Jasdip Matharu, M.D.
Taren Ohman, M.D.
John-Paul Pham, M.D.
Tauseef Qureshi, M.D.
Prafull Raheja, M.D.
Karishma Ramsubeik, M.D.
Naveen Seecheran, M.D.
Atman Shah, M.D.
Ho Vu, M.D.
Edward Yazigi, M.D.


Medical School


Philadelphia College of Osteopathic Medicine
New York Medical College



Medical School
Ross University School of Medicine
Tamil Nadu Dr MGR Medical University
Georgetown University School of Medicine
University of Miami School of Medicine
University of Florida College of Medicine
University of the West Indies, Trinidad
Ross University School of Medicine
Ross University School of Medicine
Ross University School of Medicine
University of Puerto Rico School of Medicine, San Juan
University of Florida College of Medicine
University of the West Indies, Trinidad
University of the West Indies, Trinidad
Tamil Nadu Dr MGR Medical University
Mahatma Gandhi Mission's Medical College
M.P. Shah Medical College
Ross University School of Medicine

Medical School
Lake Erie College of Osteopathic Medicine
Sri Ramachandra University
All-India Institute of Medical Sciences
University of South Florida College of Medicine
Khyber Medical College
Sindh Medical College, University of Karachi
University of Texas Medical School at San Antonio
St. George's University School of Medicine
Nishtar Medical College, Bahauddin Zakariya University
Ross University School of Medicine
Ross University School of Medicine
Ross University School of Medicine

Medical School
St. Matthews University School of Medicine
BJ Medical College University of Pune
University of West Indies Trinidad
St. George's University School of Medicine
St. George's University School of Medicine
Marshall University School of Medicine
St. George's University School of Medicine
Kasturba Medical College Mangalore University
University of West Indies Trinidad
University of West Indies Trinidad
Ross University School of Medicine
Ross University School of Medicine
Ross University School of Medicine


Annual Report AY 2010 Organizational Overview


Department of Medicine


Annual Report AY 2010


Organizational Overview






Organizational Overview


Subspecialty Fellowship Program Directors
Cardiac Electrophysiology
Cardiology
Endocrinology
Gastroenterology
Interventional Cardiology
Infectious Disease
Medical Oncology
Nephrology
Pulmonary Critical Care

Subspecialty Fellow Housestaff IV
Junaid Ahmed, M.D. Cardiology
Rosalyn Alcalde, M.D. Endocrinology
Jeffrey Blackburn, M.D. Cardiology
Suzanne Brulte, M.D. Nephrology
C. Bruce Cochrane, M.D. Infectious Disease
Jelica Janicijevic, M.D. Cardiology
Herman Kado, M.D. Cardiology
Mohammad Asif Khan, M.D. Medical Oncology
Emad Naem, M.D. Endocrinology
Suraj Naik, M.D. Gastroenterology
Thomas Nguyen, M.D. Nephrology
Vinny Samuel, M.D. Pulmonary Critical Care
Vandana Seeram, M.D. Pulmonary Critical Care
Nina Singh, M.D. Gastroenterology
Siva Suryadevara, M.D. Cardiology

Subspecialty Fellow Housestaff V
Abdul Alamir, M.D. Endocrinology
Bharat Gummadi, M.D. Cardiology
Lavanya Kodali, M.D. Nephrology
Naeem Latif, M.D. Medical Oncology
Victor Lopez de Mendoza, M.D. Nephrology
Ajay Mhatre, M.D. Cardiology
Timmy Nguyen, M.D. Medical Oncology
Rachana Palnitkar, M.D. Infectious Disease
Saeed Payvar, M.D. Cardiology
J. Danny Pulido, M.D. Pulmonary Critical Care
William Salyers, M.D. Gastroenterology
Moiz Shafiq, M.D. Cardiology
Senan Sultan, M.D. Endocrinology
Ansley Tharpe, M.D. -Gastroenterology
Faisal Usman, M.D. Pulmonary Critical Care

Subspecialty Fellow Housestaff VI
Aamir Amin, M.D. Cardiology
Wayne Cheng, M.D. Cardiology
Noel Dasgupta, M.D. Cardiology
Taylor Dowsley, M.D. Cardiology
Aasita Patel, M.D. Cardiology
Ivan Rascon-Aguilar, M.D. Gastroenterology
Amit Shah, M.D. Cardiology
Aja Smith-McCutchen, M.D. Gastroenterology
Thomas Walsh, M.D. Cardiology

Subspecialty Fellow Housestaff VII
Scott Beach, M.D. Interventional Cardiology
Anil Matthew, M.D. Cardiac Electrophysiology
Vijay Ramu, M.D. Cardiac Electrophysiology
Stuart Smalheiser, M.D. Interventional Cardiology


Steven Hsu, M.D.
Steven Lavine, M.D.
Kent Wehmeier, M.D.
Ravindranath Kottoor, M.D.
Ted Bass, M.D.
Michael Sands, M.D.
Dat Pham, M.D.
Charles Heilig, M.D.
J. Davis Cury, M.D.


Medical School
Creighton University School of Medicine
Ross University School of Medicine
University of South Carolina School of Medicine
University of Alabama School of Medicine
University of Miami School of Medicine
Temple University School of Medicine
Wayne State University School of Medicine
Khyber Medical College
University of Damascus
University of Texas Southwestern Medical School
Drexel University College of Medicine
Ross University School of Medicine
University of West Indies Trinidad
University of Florida College of Medicine
University of West Indies Trinidad

Medical School
Damascus University Faculty of Medicine
St. George's University School of Medicine
Dr. NTR University of Health Sciences
Ayub Medical College University of Peshawar
Universidad Central Del Este
Florida State University College Of Medicine
Flinders University of South Australia
Topiwala National Medical College University of Mumbai
Iran University of Medical Sciences
Universidad de Ciencias Medicas
University of Kansas School of Medicine
University of Texas Southwestern Medical School
Damascus University Faculty of Medicine
Medical College of Georgia
Allama Iqbal Medical College University of Punjab

Medical School
Texas A & M University College of Medicine
University of Florida College of Medicine
University of Wisconsin Medical School
Finch University of Health Science Chicago Medical School
University of Illinois College of Medicine
Universidad de San Carlos
University of Alabama School of Medicine
Case Western Reserve University School of Medicine
University of Miami School of Medicine

Medical School
Louisiana State University School of Medicine
Wayne State University School of Medicine
Bangalore University Medical College
University of Miami School of Medicine


Annual Report AY 2010 Organizational Overview


Department of Medicine


Annual Report AY 2010


Organizational Overview





Program Director: N. Stanley Nahman, Jr., MD


GRADUATE MEDICAL EDUCATION
ACADEMIC YEAR 2010 (7/09 6/10)


Highlights

During the past academic year, the Graduate Medical Education (GME) Division continued to grow and
flourish. Some of the highlights during this time include the appointment of new GME leadership, the
maturation of recently developed fellowships. The faculty remains committed to providing residents with
outstanding educational opportunities as well as mentoring trainees in their research endeavors. The
Internal Medicine Program had another successful recruiting period and welcomed new group of high
quality interns. The residents were also successful in attaining a high pass rate on the ABIM exam,
matching into competitive fellowships both local and abroad, and producing scholarly activity. The major
components of the GME Division program are detailed below.

Internal Medicine Residency Program: Following the core program's successful site visit by the ACGME
in January 2009 the training program has continued in a very positive trajectory. Graduates from the
2009 class continued the trend of successful ABIM certification and the 2010 class had an extremely
successful year in fellowship match. Over the past 6 years the program benefited from strong leadership
by Dr. Stan Nahman, who devoted most of his time and energy into taking this program to higher levels.
However, this past year marks a year of transition in leadership in the division. In April, Dr. Nahman
resigned to take a new position in Georgia and Dr. Jeff House was assigned the role of program director.
As well Dr. Meenrajan left us this spring and as a result two new associate program directors, Doctors
Christina Bailey and Carlos Palacio, were appointed and assumed their new duties in the late spring.
The program had strong leadership from the chief residents Andy Darlington and Nimish Naik. Both
have now completed their year as chief residents and have pursued fellowships in cardiology and
nephrology respectively. Drs. Nahman, House and Meenrajan were all recognized as exemplary
teachers by the University of Florida. The residents made a strong showing yet again at the fall and
spring Florida ACP chapter meeting by placing second in Doctors Dilemma competition. In research,
residents submitted abstracts to the Florida ACP, the National ACP, American Society of Nephrology, and
Southern Section of the AFMR. Resident research accounted for 2 internal research grants, 6 published
manuscripts, 11 published abstracts and 19 poster presentations.

Subspecialty Fellowship Program: The two newest fellowships (Pulmonary/critical care and
electrophysiology) continued to mature over the past year and began preparations for their site visits in
the next academic year. These, along with the 7 other fellowships (Cardiology, Endocrinology,
Interventional Cardiology, Gastroenterology, Infectious Disease, Medical Oncology, and Nephrology)
maintain to recruit high quality trainees and most of them continue to enjoy the maximum 6 year
accreditation cycle. New leaders are emerged in these programs as most of them transition to a position
of having assistant/associate program directors. These new directors include Drs. Dat Pham (Medical
Oncology Program Director), Nilmarie Guzman (Infectious Disease Assistant Program Director), Ravi
Kottoor (GI Program Director), Juan Munoz (GI Assistant Program Director), Mae Sheikh-Ali
(Endocrinology Assistant Program Director), Abubakr Bajwa (Pulmonary/Critical Care Assistant Program
Director), Daniel H. Katz (Electrophysiology Assistant Program Director), and Charles Heilig (Nephrology
Program Director).

Student Education: Medical student clerkship continues to be directed by Drs. Alexandraki and Palacio.
Students continue to have rotations in inpatient and ambulatory setting. Fourth year subinternships on
the wards and on subspecialty rotations were popular both from University of Florida Students as well as
students from abroad.


Annual Report AY 2010 Graduate Medical Education


Graduate Medical Education


Annual Report AY 2010


Graduate Medical Education






Program Director: N. Stanley Nahman, Jr., MD


LISTING OF PROGRAM LEADERSHIP

New Faculty

Andrew Darlington, Post-doctoral Associate and Chief Medical Resident
Medical School / Graduation date Nova Southeastern University 2006
Internship/residency and year University of Florida Jacksonville 2009
Chief Medical Resident University of Florida Jacksonville

Nimish Naik, MD, Post-doctoral Associate and Chief Medical Resident
Medical School / Graduation date Ross University School of Medicine 2006
Internship/residency and year University of Florida Jacksonville 2009
Chief Medical Resident University of Florida Jacksonville

Current Faculty

Irene Alexandraki, MD, Assistant Professor and Associate Student Clerkship Director
Medical School / Graduation date University of Athens 1989
Internship/residency and year Hahneman University 1998
Subspecialty training and year Infectious disease/Baylor College of Medicine 2001

Jeff House, DO, Assistant Professor and Associate Program Director
Medical School / Graduation date Nova Southeastern University 1997
Internship/residency and year University of Florida Jacksonville 2001

N. Stanley Nahman, Jr., MD, Professor and Program Director
Medical School / Graduation date Medical College of Ohio 1979
Internship/residency and year Presbyterian Hospital Denver, Mt Carmel Health, Columbus 1984
Subspecialty training and year Nephrology/The Ohio State University 1987

Carlos Palacio, MD, Associate Professor and Student Clerkship Director
Medical School / Graduation date University of Miami 1993
Internship/residency and year University of Florida Jacksonville 1996

Senthil Meenrajan, MD, Assistant Professor and Associate Program Director
Medical School / Graduation date Madras Medical College 1997
Internship/residency and year Robert Packer Hospital 2004
Subspecialty training and year Geriatrics/Oregon Health and Science University 2005


SCHOLARLY ACTIVITY

Sorted by category (grants, presentations, published abstracts, and manuscripts), and by year within each
category. Residents are underlined.

Grants

2009 University of Florida Dean's Fund for Residents and Fellow Research Grant, 2009: "Impact & Costs of
Emergency Department Care of Nursing Home Patients."
PI: Louise Zhou. MD; CoPI/mentor: Senthil Meenrajan, MD

2009 University of Florida Dean's Fund for Residents and Fellow Research Grant, 2009: "The Effects of Pioglitazone
on Platelet Function Profiles in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease" PI: Siva
Suryadevara, MD; CoPI/mentor: N. Stanley Nahman, Jr, MD

Presentations

2009 Mohsen A, Zhou L. Impact and Costs of Emergency Department Care of Nursing Home Patients. Florida ACP.
Fall 2009.


Annual Report AY 2010 Graduate Medical Education


Graduate Medical Education


Annual Report AY 2010


Graduate Medical Education





Graduate Medical Education Program Director: N. Stanley Nahman, Jr., MD

2009 Shah AU. Myocarditis masquerading as a STEMI. Poster Presentation Florida ACP. Fall 2009.

2009 Salahuddin M. Spindle Cell Carcinoma: a rare and challenging disease entity. Poster Presentation Florida
ACP. Fall 2009.

2009 Reddv SC, Ramsubeik K, Federico JR, Goodwich R, Palacio C, Vega K). Do HbA1C levels correlate with
delayed gastric emptying in diabetic patients? Gastroenterology 2009; 134 (supplement 1): A490. (Poster
presentation, DDW 2009)

2009 Chisholm S, Khoury JE, Jamal MM, Vega KJ. The frequency of confirmed Barrett's esophagus varies by
ethnicity and gender. Gastrointest Endosc 2009; 69: AB359. (Poster presentation, DDW 2009)

2009 Mohsen A, Zhou L, Meenrajan S. Impact and Costs of Emergency Department Care of Nursing Home
Patients. Oral Presentation FLACP Fall 2009.

2009 Shah A. Myocarditis masquerading as a STEMI. Poster Presentation FLACP Fall 2009.

2009 Salahuddin M, Shah A, Edwards L. Spindle Cell Carcinoma: a rare and challenging disease entity. Poster
Presentation FLACP Fall 2009.

2010 Salahuddin M, Sakhamuri H, Maddirala S, Elfayoumy S, Wludyka P, Britt K, Masnita-Iusan C, Heilig C, Nahman
NSJr. Comparison of time to bacteremia in HIV infected hemodialysis patients from the 1996 and 2004
USRDS Datasets. Poster Presentation AFMR Southern Section February 2010.

2010 Mohsen A, Zhou L, Meenrajan S. Emergency department care in evaluation of nursing home patients. Poster
Presentation AFMR Southern Section February 2010.

2010 Shah A, Rana F,_Buzaianu M. Comparative study of the clinical and tumor characteristics in women with
breast cancer of different age groups. Oral Presentation FLACP Spring 2010.

2010 Koduru S. Abiotrophia endocarditis presenting as non-st elevation myocardial infarction. Oral Presentation
FLACP Spring 2010.

2010 Riaz H, Latif N. Auto-immune hemolytic anemia and Hodgkin's disease. Poster Presentation FLACP Spring
2010.

2010 Mohsen A, Zhou L, Meenrajan S. Emergency department care in evaluation of nursing home patients. Poster
Presentation National ACP Toronto 2010.

Published abstracts

2009 Oureshi T, Nauven T, Nahman Jr NS, Urquidi V. In vitro cytotoxicity of Gadolinium Contrast Medium NE
Florida Medicine Vol. 6, No 2. 2009

2009 Khan M, Shah A, House J. Symptomatic Hypermagnesemia Due to Oral Milk of Magnesia in the Absence of
Renal Failure.. NE Florida Medicine Vol. 6, No 2. 2009

2009 Reddv SC, Meenrajan S. Immunity Factor in Resistant or Recurrent Clostridium Difficile. NE Florida Medicine
Vol. 6, No 2. 2009

2009 Darlincton A, Desai B, Bass T, Nahman Jr NS, Angiolillo D. The Analysis of Thrombotic Profiles in Patients with
End-stage Renal Disease. NE Florida Medicine Vol. 6, No 2. 2009

2009 Reddv SC, Ramsubeik K, Federico JR, Goodwich R, Palacio C, Vega KJ. Do HbA1C levels correlate with
delayed gastric emptying in diabetic patients? Gastroenterology 2009; 134 (supplement 1): A490.


Annual Report AY 2010


Graduate Medical Education





Program Director: N. Stanley Nahman, Jr., MD


2009 Chisholm S, Khoury JE, Jamal MM, Vega KJ. The frequency of confirmed Barrett's esophagus varies by
ethnicity and gender. Gastrointest Endosc 2009; 69: AB359.


Published manuscripts

2009 Chisholm S, Gummadi B, Vega KJ, House J. Sandostatin causing reversible thrombocytopenia. Eur J
Gastroenterol Hepatol. 2009 Apr;21(4):474-5.

2009 Vega KJ, Chisholm S, Jamal MM. Comparison of reflux esophagitis and its complications between African
Americans and non-Hispanic whites. WorldJGastroenterol2009 June 21; 15(23): 2878-2881

2009 Ramsubeik K, Maharai R, Mitri G. When the diagnosis of Rheumatologic disease does not follow the book.
Journal of Musculoskeletal Medicine. 2009 Jan; 26(1): 11-14.

2009 Ramsubeik K, Griffiths H, Mitri G. Arthritis in a patient with severe psoriasis: Narrowing the differential. Journal
of Musculoskeletal medicine. 2009 Aug; 26(9): 334-342.

2009 Girdhar A, Zaiden R. A 54-year-old man with right opaque hemithorax and worsening shortness of breath.
Respiration. 2010;79(2):157-9. Epub 2009 Aug 29.

2010 Ramsubeik K, Maharai R, Reddv S, Khan M. Is early TPN in hyperemesis gravidarum worth the risk?
Northeast Florida Medicine. 2010; 61(2): 44.


HONORS AND AWARDS


Ryan Wilson, MD

Ravi Maharaj, MD

Dave Cury, MD


Intern of the Year

Resident of the Year

Teacher of the Year


Exemplary Teachers: (arranged alphabetically)
Drs. Irene Alexandraki, Doug B. Chapman, Donald A. Conetta, Malcolm T. Foster, Jeffrey G House,
Robert J. Kim, Steven J. Lavine, Ghania Masri, Senthil R. Meenrajan, Alan B Miller, Juan C Munoz,
Pramod K. Reddy, Manish Relan, and Elisa M. Sottile.

Ravi Maharaj was awarded the Exemplary Teacher Award for residents.


Clinical Teacher of the Year & Excellence in Student Education Award:
Andrew Darlington was the recipient of the Edward Jelks for Outstanding Resident Clinician of the Year.

Linda Edwards received the Louis Russo Award for Outstanding Professionalism in Medicine.

Naveen Seecheran was honored as the ACP Resident of the Year in 2010.


ENDOWMENTS AND GIFTS

The Anne and Max Michael, Jr. Education Fund Established 2006, by Anne Michael


2010

2010

2010


Graduate Medical Education


Annual Report AY 2010


Graduate Medical Education






Program Director: N. Stanley Nahman, Jr., MD


POST-GRADUATE ACTIVITIES OF CMR AND SENIOR RESIDENTS


Graduate


Professional Status


Location


Outgoing Chiefs
Andrew Darlington, DO

Nimish Naik, MD



Graduating residents
1. John-Paul Pham, MD


2. Naveen Seecheran, MD


3. Sara Ahmed, MD
4. Santosh Kale, MD
5. Ravindra Maharaj, MD
6. Jasdip Matharu, MD
7. Taren Ohman, MD
8. Tauseef Qureshi, MD
9. Prafull Raheja, MD


10. Karishma Ramsubeik, MD


11. Atman Shah, MD


Ho Vu, MD
Edward Yazigi, MD


Fellowship, Cardiology 2011

Fellowship, Nephrology 2011




Chief Medical Resident 2010
Fellowship, Cardiology 2011
Chief Medical Resident 2010
Fellowship, Cardiology 2011
Hospitalist
Hospitalist
Fellowship, Geriatrics
Fellowship, Pulmonary/Critical Care
Fellowship, Oncology
Fellowship, Pulmonary/Critical Care
Fellowship, Heart Failure 2010
Fellowship, Cardiology 2011
Fellowship, Geriatrics 2010
Fellowship, Rheumatology 2011
Hospitalist 2010
Fellowship, Oncology 2011
Fellowship, Medical Oncology
Hospitalist


University of Florida Jacksonville

University of Pittsburgh




University of Florida Jacksonville
University of Wisconsin-Milwaukee
University of Florida Jacksonville
University of Vermont
New York, NY
Memphis, TN
University of Miami
University of Florida Jacksonville
University of Florida Jacksonville
University of Florida Jacksonville
University of Texas Southwestern
University of Louisville
University of Miami
University of Wisconsin-Madison
Jacksonville, FL
University of Nevada
University of Florida Jacksonville
Jacksonville, FL


Annual Report AY 2010 Graduate Medical Education


Graduate Medical Education


Annual Report AY 2010


Graduate Medical Education





Director of Research: Michael Haas, PhD


DEPARTMENT RESEARCH
ACADEMIC YEAR 2010 (7/09 6/10)

The Department continues to support clinical and basic science research. Figure 1 shows external
research funding (federal, state, industry, and foundation) administered by the University of Florida. In
the fiscal year July 2009- June 2010 (Figure 1), there was a significant reduction in the amount of
external funding awarded to Department of Medicine investigators. A partial explanation for this may be
the departure of several faculty members the previous year. However, there are promising trends
showing that the number of UF-funded investigators (Figure 2) has increased each year as well as the
number of UF-funded projects (Figure 3).

The Divisions of Nephrology & Hypertension,
SGastroenterology, and Endocrinology, Diabetes and
Metabolism currently have fully-operational research
2000 c n laboratories located in the UF-Jacksonville Medical
Research Building. However, there have been a few
Invesi.3m.t n changes in the basic science faculty. New faculty
member, Minghui Xiang, Ph.D. (Nephrology &
Hypertension), currently occupies laboratory space
previously held by Virginia Urquidi, Ph.D., who
sponse departed from the Division of Nephrology &
Hypertension. Other investigators with laboratories
i located in the Medical research building include
20i0o 28ins 20 a s th Charles Heilig, M.D. (Nephrology & Hypertension),
Figrng.l Ttlanl rese d lar Xiaoyu Li, M.D., Ph.D. (Gastroenterology), and
Michael J. Haas, Ph.D. (Endocrinology).














Monthly research conferences were presented by internal end external speakers covering topics such as
the cloning of ion transporters involved in hypertension to molecular epidemiology of AIDS in Africa.

Opportunities for residents and sub-specialty fellows to participate in clinical and basic science research
have expanded. A series of five-lectures covering clinical study design, basic statistics for clinical
investigators, and methods in basic science research were presented to residents and fellows. Several
residents and fellows have received research funding from the Deans Fund Research Grant, which is
sponsored by the Dean's office and subject to peer-review. Several residents and fellows have also been
involved in basic science research in the Medical Research Building and have submitted abstracts to
national meetings such as the Endocrine Society and the American Diabetes Association annual
meetings, and presented locally at Research Day. At Research Day, several Department of Medicine
residents and fellows received awards for their and their mentor's efforts. An outstanding 1/3 (29 of


Department Research


Annual Report AY 2010


Department Research





Director of Research: Michael Haas, PhD


103) of the platform and poster presentations were given by residents and fellows from the Department
of Medicine. Senan Sultan, M.D. (fellow, Endocrinology), and Thomas Walsh, M.D. (resident),
received fourth and fifth place prizes, respectively, for their platform presentations. For poster
presentations, Aasita Patel, M.D. (resident), and Abdul-Razzak Alamir, M.D. (fellow,
Endocrinology), received second and fifth place prizes, respectively.


Annual Report AY 2010 Department Research


Department Research


Annual Report AY 2010


Department Research







DIVISION OF CARDIOLOGY
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The division of Cardiology had a strong bottom line in FY 10. Cardiology finished the year with a
positive bottom line on the professional side (physician budget) as well as the hospital side. The Shands
Cardiovascular budget, which has eight cost centers, had a positive contribution margin for FY 10.

In July 09, the Electrophysiology fellowship program began with two fellows. In FY 10, Cardiology
graduated the first two fellows in the Electrophysiology program. In FY 11, two new Electrophysiology
fellows with join the program.

The division continues to practice in Lake City and St. Mary's, Georgia. Both of these practices are
strong practices that not only contribute positively to the UF budget but also to the Shands budget with
downstream revenue. We continued our practice in Live Oak and hope to add more diagnostic testing to
this area. We made plans in FY 10 to expand the St. Mary's clinic in regards to a new building in a new
location. The new facility will be larger which will allow Cardiology to expand the volume of patients
seen daily. The estimated time of completion on the building is 4th quarter FY 12. Lake Shore Hospital
was acquired by HMA in late FY 10, with HMA owning 60% of the shares. Cardiology is working closely
with HMA and the current Lake Shore administrator to continue the partnership with Lake Shore and
possibly expand Cardiovascular Services in Lake City.

The Peripheral Vascular Program continues to be strong under the leadership of Dr. Luis Guzman. Dr.
Danny Vo, Vascular Surgery, joined Cardiology as a .2 FTE in FY 10. The Peripheral Vascular Case
volume increased in FY 10, with Drs. Guzman and Vo both performing cases in our peripheral room.

The number of referrals Cardiology received from outside the Jacksonville area has increased over the
past year. These are mostly high acuity cases needing high risk coronary intervention. Dr. Bass has
expanded his referral base by performing high risk angioplasty on patients who have been turned down
for surgical treatment. In FY 10, Shands purchased the Impella 2.5 for Cardiology. This device is a
minimally invasive, catheter-based cardiac assist device designed to directly unload the LV and reduce
myocardial work and oxygen consumption. This allows the Interventional Cardiologist more protected
time while performing high risk cases. This program ( high risk cases) along with the new device will be
marketed heavily in FY 11 in the North Florida/South Georgia and Central Florida areas.

In FY 10, Cardiology had a marketing campaign that highlighted our two Spanish speaking Cardiologist.
We marketed Dr. Guzman and Angiolillo to community physicians and the Spanish communities. We will
continue this campaign in FY 11 as we see the Spanish community growing in the Jacksonville area and
there being more of a demand for physicians who speak Spanish.

Dr. Lyndon Box has worked very aggressively this year with the local EMS to develop protocols for
STEMI patients, develop educational programs for EMT's regarding STEMI's and work with EMS on state
and national legislation issues regarding dedicated PCI hospitals. He also has been instrumental in
working with local EMS on standardizing the Electronic EKG transmission systems for Ambulances. We
purchased systems for local EMS program to place in their ambulances so that EKG's could be
transmitted directly to the physician/hospital from the field. All devices have been installed and the in-
house system in currently installed in the Emergency Department. This new system has had a positive
effect on door to balloon times. The streamlined process has exceeded current CMS targets (average
time for this calendar year 58 mins; CMS goal is <90 minutes). Volume of patients being treated for
STEMI in our facility has been constant and is currently on pace to increase this year despite multiple
publications documenting a national decline in the frequency of STEMI by as much as 50%. Dr Box,
Physician Champion of the STEMI program, has been recognized with appointments to the American


Cardiology


Division Chief: Theodore Bass, MD


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


Heart Association Mission Lifeline Task Force for Florida and the Southeastern Affiliate. He is currently
chairman of the PCI facility sub-committee. The program has received over $10,000 in grant funding
which will be used to expand the program. Investigator initiated research is under way with IRB
approval and expected publication in the next 6 months. The program was awarded its first industry
sponsored trial and will be participating in the TRANSLATE-ACS study. In FY 10 we also hired a STEMI
coordinator to our group to help facilitate the STEMI outreach /community program.

Customer Service: In regards to Customer Service, Cardiology has made many improvements in
Customer Service in FY 10. New policies and procedures have been put in place to decrease the
registration time for patients in clinic. New policies have also been put in place to decrease the wait
time for patients who are having a diagnostic/interventional procedure performed. In 4th Quarter FY 10,
the Cath lab and EP lab received an award from the Internal Outcomes Instrument Survey (IOI tool used
for pt. satisfaction) for our scores in providing excellent services and decreased wait times.

The Cardiology Inpatient Unit (CCU) continued to have strong patient satisfaction scores. CCU
continues to be above the 85% percentile in patient satisfaction scores.

Cardiology Goals for FY 11 are as follows:

Hire a Cardiologist to develop /lead a Women's Cardiovascular Health Program
Continue to grow research in all areas of Cardiology
Enhance relationship with VA in regards to referrals for testing as well as collaboration
with their cardiologist
Collaborate with Emergency Department on a Chest Pain Center.
Work with hospital to establish a true Heart Failure program.
Expand services in St. Mary with new office facility and new location
Further relationship with Lake Shore Hospital in collaboration with HMA (Health
Management Associates).
Expand High Risk Angioplasty program, use of Impella 2.5

Patient Care: The vascular complication rate from the EP lab is well below goal. The infection rates
from UTI and central lines in the CCU remain at zero for the year. Cath lab complications remain well
below national standards for diagnostic procedures. With the heavy volume of the echo lab, incomplete
studies before patient discharge continue to decline.

Education: We receive between 400-500 applications per year for five available spots in our General
Cardiology Fellowship Program. Applications are screened eighteen months prior to the start of the
program. This past year we received 520 applicants thru ERAS (Electronic Residency Application
Service) of which 56 were selected for interview. Individuals are invited based on medical school,
quality of the medical residency, USME scores, research performed, and letters of recommendations.
Faculty evaluates candidates based on interpersonal skills, academic potential, and clinical potential.

Cardiovascular Fellowship Program: 15 fellows; 5 per year for 3 years; 5 graduates per year: this past
year 4 continued in private practice and 1 continued at another academic institution as a non-invasive
cardiologist with a specialty in echocardiography training; >10 publications, >10 presentations this
calendar year. Interventional Cardiovascular Program: 2 fellows per year (1 year fellowship). Clinical
Electrophysiology Fellowship: 2 fellows per year (1 year fellowship)

Research: We have clinical trials: ~25 active studies in various fields of cardiovascular diseases (ACS,
PCI, EP, HF). Academic productivity: since 2008, ~70 peer-reviewed manuscripts, >100 presentations at
national and international meetings, and 2 books.


Cardiology


Annual Report AY 2010


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Division Chief: Theodore Bass, MD


LISTING OF FACULTY MEMBERS

Dominick Angiolillo, M.D. Ph.D., Assistant Professor
Medical School / Graduation date The Catholic University of the Sacred Heart Medical School, Italy 1997
Internship/residency and year The Catholic University of the Sacred Heart Medical School, Italy 1997
Subspecialty training and year University Hospital of Salamanca, Spain/The Policlinico 1998
Agostino Gemelli University Hospital, Italy/San Carlos 2003
University Hospital


Theodore Bass, M.D., Professor and Division Chief
Medical School / Graduation date Brown University 1976
Internship/residency and year Mayo Clinic 1979
Subspecialty training and year Boston University 1981




Lyndon Box, M.D., Assistant Professor
Medical School / Graduation date University of Mississippi Birmingham, Alabama 2001
Internship/residency and year Carraway Methodist Medical Center/Oregon Health Sciences 2002
University 2004
Subspecialty training and year University of Florida Jacksonville, Florida 2008



Douglas Chapman, M.D., Assistant Professor
Medical School / Graduation date Chicago Medical School 1984
Internship/residency and year University of Missouri 1987
Subspecialty training and year Michael Reese Hospital 1990




I Donald Conetta, M.D., Associate Professor
Medical School / Graduation date Duke University 1970
Internship/residency and year Georgetown University 1975
Subspecialty training/year University of Florida 1977



Luis Guzman, M.D., Assistant Professor
Medical School / Graduation date University of Buenos Aires, Argentina 1982
Internship/residency and year Churruca-Visca Hospital, Argentina 1986
Subspecialty training and year Instituto Cardiovascular Buenos Aires, Argentina 1989




[ ISteve Hsu, M.D., Associate Professor
Medical School / Graduation date Washington University 1990
Internship/residency and year Thomas Jefferson University 1993
Subspecialty training and year Thomas Jefferson University 1997


Annual Report AY 2010 Cardiology


Cardiology


Annual Report AY 2010


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Division Chief: Theodore Bass, MD


LE I


LlJ


LJI1


Daniel Katz, M.D., Assistant Professor
Medical School / Graduation date New Jersey Medical School Newark, New Jersey 1997
Internship/residency and year Brown University Rhode Island 2000
Subspecialty training and year Albert Einstein College of Medicine Bronx, New York 2006



Robert Kim, M.D., Assistant Professor
Medical School / Graduation date Tufts University School of Medicine Boston, MA 1998
Internship/residency and year St. Elizabeth's Medical Center Boston, MA/ 2001
University of MA Medical Center-Worcester, MA 2004
Subspecialty training and year Dartmouth-Hitchcock Medical Center Lebanon, NH 2008


Steven Lavine, M.D., Associate Professor
Medical School / Graduation date Temple University 1976
Internship/residency and year Temple University 1979
Subspecialty training and year Temple University 1981



Alan Miller, M.D., Professor
Medical School / Graduation date University of Pittsburgh 1966
Internship/residency and year Mount Sinai 1968
Internship/residency and year George Washington University 1971
Subspecialty training and year Cleveland Metropolitan Hospital 1973


David Nabert, M.D., Associate Professor
Medical School / Graduation date UMDNJ New Jersey Medical School 1988
Internship/residency and year Hackensack University Medical Center 1991
Subspecialty training and year Ochsner Medical Foundation 1999



Joseph Pensabene, M.D., Assistant Professor
Medical School / Graduation date The Chicago Medical School 1984
Internship/residency and year Overlook Hospital 1987
Subspecialty training and year Cardiovascular Disease, Northwestern Memorial Hospital 1990
Subspecialty training and year Interventional Cardiology, UCLA Medical Center 1991
Subspecialty training and year Cardiac CT and Cardiac MRI, University of Florida Jacksonville 2006

Robert Percy, M.D., Associate Professor
Medical School / Graduation date University of Mississippi 1973
Internship/residency and year University of Mississippi 1977
Subspecialty training and year Joslin Clinic 1979
Subspecialty training and year Mass General Hospital 1981


Martin Zenni, M.D., Associate Professor
Medical School / Graduation date University of Chicago 1986
Internship/residency and year Tufts University 1989
Subspecialty training and year Harvard Medical School 1992


Annual Report AY 2010 Cardiology


Cardiology


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


PUBLICATIONS

Peer reviewed publications:
Marfn F, Gonzalez-Conejero R, Capranzano P, Bass TA, Roldan V, Angiolillo DJ. Pharmacogenetics in cardiovascular
antithrombotic therapy. J Am Coil Cardiol. 2009;54(12):1041-57.

Ferreiro JL, Angiolillo DJ. Antiplatelet therapy: Clopidogrel plus PPIs-a dangerous combination? Nat Rev Cardiol.
2009;6(6):392-4.

Ferreiro JL, G6mez-Hospital JA, Cequier AR, Angiolillo DJ, Roura G, Teruel L, Maristany J, G6mez-Lara J, Jara F, Bass TA,
Esplugas E. Use of Impella Recover LP 2.5 in elective high risk percutaneous coronary intervention. Int J Cardiol. 2009
Sep 2. [Epub ahead of print]

Ferreiro JL, Ueno M, Angiolillo DJ. Cangrelor: a review on its mechanism of action and clinical development. Expert Rev
Cardiovasc Ther. 2009 Oct;7(10):1195-201.

Escaned J, Flores A, Garcfa-Pavia P, Segovia J, Jimenez J, Aragoncillo P, Salas C, Alfonso F, Hernandez R, Angiolillo DJ,
Jim6nez-Quevedo P, BaNuelos C, Alonso-Pulp6n L, Macaya C. Assessment of microcirculatory remodeling with
intracoronary flow velocity and pressure measurements: validation with endomyocardial sampling in cardiac allografts.
Circulation. 2009 Oct 20;120(16):1561-8.

Angiolillo, DJ. New antiplatelet agents. Clinical Advances in Hematology and Oncology 2009; 7 (9), 584-587.

Capodanno D, Angiolillo DJ. Platelet monitoring for PCI. Hamostaseologie. 2009;29:376-80.

Serebruany VL, Mouelhi ME, Pfannkuche HJ, Rose K, Marro M, Angiolillo DJ. Investigations on 5-HT4 Receptor Expression
and Effects of Tegaserod on Human Platelet Aggregation In Vitro. Am J Ther. 2009 Sep 22. [Epub ahead of print]

Angiolillo DJ, Ferreiro JL. Platelet Adenosine Diphosphate P2Y12 Receptor Antagonism: Benefits and Limitations of
Current Treatment Strategies and Future Directions. Rev Esp Cardiol. 2010; 63:60-76.

Angiolillo DJ, Capodanno D, Goto S. Platelet Thrombin Receptor Antagonism and Atherothrombosis. Eur Heart J
2010;31:17-28.

Angiolillo DJ, Bernardo E, Capodanno D, Vivas D, Sabat6 M, Ferreiro JL, Ueno M, Jimenez-Quevedo P, Alfonso F, Bass TA,
Macaya C, Fernandez-Ortiz A. Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients
with Coronary Artery Disease on Dual Antiplatelet Therapy. J Am Coil Cardiol 2010; 55:1139-46.

Kandzari DE, Angiolillo DJ, Price MJ, Teirstein PS. Identifying the 'Optimal' Duration of Dual Antiplatelet Therapy
Following Drug-Eluting Stent Revascularization. JACC Int 2009;2:1279-85.

Capodanno D, Dharmashankar K, Angiolillo DJ. Mechanism of action and clinical development of ticagrelor, a novel
platelet ADP P2Y12 receptor antagonist. Expert Rev Cardiovasc Ther. 2010;8:151-8.

Harrington RA, Stone GW, McNulty S, White HD, Lincoff AM, Gibson CM, Pollack CV, Montalescot G, Mahaffey KW,
Kleiman N, Goodman S, Amine M, Angiolillo DJ, Becker R, Chew D, French W, Leisch F, Parikh K, Skerjanec S, Bhatt DL.
P2Y12 inhibition with cangrelor compared with clopidogrel acute coronary syndromes PCI: CHAMPION PCI results. N Engl
J Med 2009;361:2318-29.

Capodanno D, Angiolillo DJ. In most DES Patients, the duration of dual antiplatelet therapy should be one year (or even
indefinitely). Giornale Italiano Cardiol Inv 2010; 1: 12-15.

Angiolillo DJ, Ueno M, Goto S. Basic principles of platelet biology and clinical implications. Circ J 2010;74: 597 607.

Ferreiro JL, Sibbing D, Angiolillo DJ. Platelet Function Testing and Risk of Bleeding Complications. Thromb Haem 2010(in
press).

Ferreiro JL, Angiolillo DJ. Diabetes and antiplatelet therapy in acute coronary syndrome. Circulation 2010 (in press).

Capodanno D, Angiolillo DJ. Diabetes mellitus: the scary killer haunting silently. Eurointervent 2010 (in press).


Cardiology


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


Angiolillo DJ, Saucedo JF, DeRaad R, Frelinger AL, Gurbel PA, Costigan TM, Jakubowski JA, Ojeh CK, Effron MB.
Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary
syndromes: Results of the SWitching Anti Platelet (SWAP) Study. J Am Coil Cardiol 2010 (in press).

Ueno M, Ferreiro JL, Angiolillo DJ. Mechanism of action and clinical development of platelet thrombin receptor
antagonists. Expert Rev Cardiovasc Ther. 2010 (in press).

Vivas D, Angiolillo DJ. Platelet P2Y12 Receptor Inhibition: An Update on Clinical Drug Development. Am J Cardiov Drugs
2010 (in press)

Capodanno D, Angiolillo DJ. Antithrombotic therapy in the elderly. J Am Coil Cardiol 2010 (in press).

Storey RF, Angiolillo DJ, Patil SBG, Desai B, Ecob R, Husted S, Emanuelsson H, Cannon CP, Becker RC, Wallentin L.
Inhibitory Effects of Ticagrelor Compared to Clopidogrel on Platelet Function in Patients with Acute Coronary Syndromes:
the PLATO PLATELET Substudy. J Am Coil Cardiol 2010 (in press).

Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker RC, Bhatt DL, Cattaneo M, Collet JP, Cuisset T, Gachet
C, Montalescot G, Jennings LK, Kereiakes D, Sibbing D, Trenk D, Van Werkum JW, Paganelli F, Price MJ, Waksman R,
Gurbel PA. Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to ADP. J Am Coil
Cardiol 2010 (in press).

Angiolillo DJ. Antithrombotic Management in Patients Undergoing Coronary Stent Implantation Requiring Chronic Oral
Anticoagulation: How to Balance Safety and Efficacy? Catheter Cardiovasc Interv. 2010;75:943-5.

Tomasello SD, Angiolillo DJ, Goto S. Inhibiting PAR-1 in the prevention and treatment of atherothrombotic events. Expert
Opinion On Investigational Drugs 2010 (in press).

Ueno M, Ferreiro JL, Angiolillo DJ. Update on the clinical development of cangrelor. Expert Rev Cardiovasc Ther. 2010 (in press)

Capodanno D, Angiolillo DJ. Impact of Race and Gender on Antithrombotic Therapy. Thromb Haem 2010 (in press).

Ueno M, Rao SV, Angiolillo DJ. Elinogrel: Pharmacological principles, pre-clinical and early phase clinical testing. Future
Cardiology 2010 (in press).

Dasgupta,N; Chapman,D; Preeclampsia Associated with Carotid Occlusion and Stroke in a Young Woman; Journal of
Stroke and Cerebrovascular Diseases; Vol 19, No. 2 (March-April), 2010: pp 163-164.

David E. Kandzari, Antonio Colombo, Seung-Jung Park, Carl L. Tommaso, Stephen G. Ellis, Luis A. Guzman, Paul S.
Teirstein, Corrado Tamburino, John Ormiston, Gregg W. Stone, George D. Dangas, Jeffrey J. Popma, Theodore A. Bass
on behalf of the American College of Cardiology Interventional Scientific Council. Revascularization for Unprotected Left
Main Disease: Evolution of the Evidence Basis to Redefine Treatment Standards. J Am Coil Cardiol 2009;54 1576-1588.

Dasgupta NR, Guzman, L. A. and Chapman DB. Pre-eclampsia associated carotid dissection and stroke in a young
woman. J of Stroke and Cerebrovascular Disease 2010;19:163-64.

Guzman, L. A. Timing to Coronary Intervention in Patients with NSTEMI: We should intervene within 6 hours. Rev
Argentina Cardiol 2010 (in press. Argentine Journal of Cardiology).

Luis A Guzman. Glycoprotein IIb/IIIa Inhibitors to Facilitate Percutaneous Intervention in ST-Elevation Myocardial
Infarction. The Sooner not Necessarily the Better. Editorial. (in press. Circulation Journal).

Fisher, J. Katz, D. The Psychological Impact of Implantable Cardioverter-Defibrillator Recalls. PACE; August, 2009
32:1012-1016.

Zile MR, Gaasch WH, Anand, IS, Haass M, Little WC, Miller AB et al: Mode of death in patients with heart failure and a
preserved ejection fraction:Results from the Irbesartan in Heart Failure with Preserved Ejection Fraction Study (
I_PRESERVE ) Trial Circulation 2010; 121: 1393-1405.

O"Connor CM, Miller AB, Blair J et al :Causes of death and rehospitalization in patients hospitalized with worsening heart
failure and reduced left ventricular ejection fraction:Reseults from efficacy of vasopressin antagonism in heart failure
outcome study with tolvaptan (Everest) program. Amer Heart J 2010 in press.


Cardiology


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


Ibrihim E, Johnson KR, Miller AB et al: Measuring aortic pulse wave velocity using high field cardiovascular MRI:
comparison of techniques. J Cardiovascular MRI 2010 in press.

Anand IS, Hetzel SJ, Miller AB et al: Baseline systolic blood pressure and outcomes in patients with heart failure and
preserved ejection fraction-results from the I-preserve trial. JACC 2010 in press.

Teerlink JR, Zile MR, White M, Miller AB et al: Acute coronary syndromes inpatients with heart failure and preserved
ejection fraction-a harbinger of death? JACC 2010 in press.

Pena I, Boxer R, Schocken D, Felker GM, Dupree C, Miller AB et al: Elderly patients are less likely to receive evidence
based medications indicated for systolic heart failure: results from the study of anemia in a heart failure population
(STAMINA-HFP) registry. JACC 2010 in press.

Book chapters:
Angiolillo DJ, Costa M, Guzman L. Book: Cardiovascular Interventions SOLACI. 2nd Edition Title: In-stent Restenosis.
Treatment approach. Editor: A Souza, MD, F Buitron, MD, E Ban Hayashi and E Souza, MD. Publisher: Atheneu. 2009

Berrocal D, Guzman L. Book: Cardiovascular Interventions SOLACI. 2nd Edition Title: Invasive Strategy in Patients with
Non-ST Elevations Acute Coronary Syndromes. Editor: A Souza, MD, F Buitron, MD, E Ban Hayashi and E Souza, MD.
Publisher: Atheneu. 2009

Guzman L., Book: Evidence in Cardiology. 6th Edition. Title: Evidence Based Medicine in Percutaneous Coronary
Angioplasty. Editors: C. Tajer, M.D., H. Doval, M.D.; Publisher Atlante. 2010; In press.

Ferreiro JL, Angiolillo DJ. Platelet reactivity and coronary stenosis. in CORONARY STENOSIS. IMAGING, STRUCTURE AND
PHYSIOLOGY, edited by Javier Escaned and Patrick Serruys 2010 in press).

Angiolillo DJ, Giugliano R, Simon DI. Antithrombotic therapy in acute coronary syndrome. Hurst's The Heart, 13edition
Edited by Fuster V et al. 2010 (in press).

Angiolillo DJ. Biography of prasugrel. nowPharma Ltd London, UK (2010 in press).

Ancheta IB, Chiong J, Miller AB et al: The impact of B-type natriuretic peptide depression and NYHA classification on
quality of life in patients with chronic heart failure. J Card Failure 2009;15 no 6, S120

Abstract presentations at national and international meetings only:
(Faculty have been involved in '100 invited presentations at regional, national and international meetings)

Capranzano P, Ferreiro JL, Kodlipet D, Alissa R, Darlington A, Charlton R, Desai B, Guzman LA, Bass TA, Angiolillo DJ.
Comparative assessment of platelet P2Y12 signaling in type 2 diabetes mellitus versus non diabetic subjects. European
Society of Cardiology 2009.

Angiolillo DJ, Bernardo E, Capranzano P, Sabate M, Jimenez-Quevedo P, Alfonso F, Hernandez-Antolin R, Bass TA,
Macaya C, Fernandez-Ortiz A. Impact of renal function on clopidogrel-induced antiplatelet effects in diabetes mellitus
patients with coronary artery disease. European Society of Cardiology 2009.

Rossini R, Musumeci G, Lettieri G, Nijaradze L, Biondi Zoccai GG, Romano L, Lortkipanidze L, Cicorella F, Gavazzi F,
Angiolillo DJ. Prevalence, predictors, and long-term prognosis of discontinuation of oral antiplatelet therapy after DES
implantation. European Society of Cardiology 2009.

Rossini R, Musumeci G, Lettieri G, Lortkipanidze L, Romano L, Nijaradze L, Izzo F, Biondi Zoccai GG, Gavazzi F, Angiolillo
DJ. Prevalence and predictors of bleeding in patients on prolonged dual oral antiplatelet therapy undergoing DES
implantation. European Society of Cardiology 2009.

Rossini R, Nijaradze L, Musumeci G, Lettieri G, Biondi Zoccai GG, Cicorella F, Lortkipanidze L, Romano L, Gavazzi F,
Angiolillo DJ. Safety of proton-pump inhibitors in patients on oral antiplatelet therapy with aspirin and clopidogrel after
DES implantation. European Society of Cardiology 2009.


Cardiology


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


Bernardo Garcia E, Angiolillo DJ, Jimenez-Quevedo P, Fernandez-Ortiz A, Alfonso F, Hernandez-Antolin R, Macaya C,
Sabate M. Increased Ig E and complement component C3 levels in diabetic patients after drug eluting stent implantation.
European Society of Cardiology 2009.

T. Nijaradze, R. Rossini, C. Lettieri, G. Musumeci, N. Lortkipanidze, V. Sirbu, N. Cicorella, M. Romano, G. Biondi Zoccai, L.
Mihalcsik, R. Rosiello, D.J. Angiolillo, A. Gavazzi. Proton-Pump Inhibitors In Patients On Dual Antiplatelet Therapy After
Des Implantation. ICCAD 2009.

N. Lortkipanidze, R. Rossini, G. Musumeci, C. Lettieri, T. Nijaradze, A. Izzo, G. Biondi Zoccai, N. Cicorella, V. Sirbu, M.
Romano, R. Rosiello, D.J. Angiolillo, A. Gavazzi Bleeding In Patients On Dual Oral Antiplatelet Therapy Undergoing Des
Implantation. ICCAD 2009.

R. Rossini, G. Musumeci, C. Lettieri, T. Nijaradze, G. Biondi Zoccai, M. Romano, N. Lortkipanidze, N. Cicorella, A. Izzo, V.
Sirbu, R. Rosiello, D.J. Angiolillo, A. Gavazzi Dual Antiplatelet Therapy Discontinuation After Des Implantation. ICCAD
2009.

R. Rossini, C. Lettieri, G. Musumeci, G. Biondi Zoccai, T. Nijaradze, M. Romano, N. Lortkipanidze, N. Cicorella, V. Sirbu,
A. Izzo, A. Gavazzi, D.J. Angiolillo. Discontinuation of oral antiplatelet therapy after DES implantation: prevalence,
predictors and long-term prognosis. Transcatheter Cardiovascular Therapeutics 2009.

C. Lettieri, R. Rossini, G. Musumeci, M. Romano, N. Lortkipanidze, T. Nijaradze, G Biondi Zoccai, A. Izzo, N. Cicorella, V.
Sirbu, R. Rosiello, L. Fiocca, L. Mihalcsik, G Guagliumi, D.J. Angiolillo, O. Valsecchi, A. Gavazzi. Bleeding in patients on
prolonged dual oral antiplatelet therapy undergoing DES implantation. GISE 2009.

R. Rossini, G. Musumeci, C. Lettieri, T. Nijaradze, G. Biondi Zoccai, N. Lortkipanidze, N. Cicorella, M. Romano, A. Izzo, G.
Tarantini, V. Sirbu, R. Rosiello, G. Guagliumi, D.J. Angiolillo, O. Valsecchi, A. Gavazzi Antiplatelet therapy discontinuation
after DES implantation: prevalence, predictors and long-term prognosis. GISE 2009.

T. Nijaradze, R. Rossini, C. Lettieri, G. Musumeci, G. Biondi Zoccai, M. Romano, N. Lortkipanidze, N. Cicorella, V. Sirbu,
A. Izzo, L. Mihalcsik, R. Rosiello, G. Guagliumi, D.J. Angiolillo, O. Valsecchi, A. Gavazzi. Proton-pump inhibitors in patients
on dual antiplatelet therapy after DES implantation. GISE 2009.

N. Lortkipanidze, G. Musumeci, R. Rossini C. Lettieri, T. Nijaradze, M. Romano, N. Cicorella, G Biondi Zoccai, V. Sirbu,
A. Izzo, G. Tarantini, D.J. Angiolillo, O. Valsecchi, A. Gavazzi. Bleeding in patients on dual oral antiplatelet therapy
undergoing DES implantation: prevalce and predictors. GISE 2009.

R. Rossini, C. Lettieri, G. Musumeci, T. Nijaradze, G. Biondi Zoccai, N. Lortkipanidze, N. Cicorella, M. Romano, L.
Mihalcsik, A. Izzo, R. Rosiello, G. Tarantini, D.J. Angiolillo, A. Gavazzi. Proton-pump inhibitors in patients on dual
antiplatelet therapy after DES implantation. GISE 2009.

Angiolillo DJ, Badimon J, Saucedo JF, Frelinger AL, Michelson AD, Jakubowski JA, Ojeh CK, Baker B, Zhu B, Effron MB.
Comparison of prasugel with clopidogrel on platelet function in coronary artery disease patients with type 2 diabetes
mellitus third Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS-3). American Heart Association, Orlando,
Florida, 2009.

Wilson SR, Angiolillo DJ, Frelinger AL, O'Donoghue M, Neumann FJ, Michelson AD, Miller DL, Luo J, McCabe CH, Antman
EM, Braunwald E, Wiviott S. Assessment of Platelet Function in Diabetes Mellitus: Observations from The PRINCIPLE-TIMI
44 Trial. American Heart Association, Orlando, Florida, 2009.

Saucedo JF, Angiolillo DJ, DeRaad R, Frelinger AL, Gurbel PA, Costigan TM, Jakubowski JA, Ojeh CK, Effron MB for the
SWAP Investigators Decrease in Poor Responders on Switching from Clopidogrel to Prasugrel: Results from the SWitching
Anti Platelet (SWAP) Study. American Heart Association, Orlando, Florida, 2009.

Storey RF, Patil SBG, Ecob R, Angiolillo DJ, Wallentin L. More rapid and consistent inhibition of platelet aggregation is
achieved by loading with ticagrelor compared to clopidogrel in patients with acute coronary syndromes: results from the
PLATO PLATELET substudy. American Heart Association, Orlando, Florida, 2009.

Storey RF, Angiolillo DJ, Patil SBG, Desai B, Husted S, Emanuelsson H, Cannon CP, Harrington R, Wallentin L.
Maintenance treatment with ticagrelor yields greater and more consistent inhibition of platelet function compared to
clopidogrel in patients with acute coronary syndromes: results from the PLATO PLATELET study. American Heart
Association, Orlando, Florida, 2009.


Cardiology


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


Ferreiro Gutierrez JL, Capranzano P, Dharmashankar K, Capodanno D, Ueno M, Charlton RK, Bass TA, Angiolillo DJ.
Comparaci6n del estado basal de activaci6n de la via iniciada en el receptor P2Y12 en pacientes diab6ticos versus no
diab6ticos. Spanish Society of Cardiology 2009.

Ferreiro Gutierrez JL, Capranzano P, Ueno M, Dharmashankar K, Capodanno D, Charlton RK, Bass TA, Angiolillo DJ.
Concordancia entire diferentes tests de funci6n plaquetar a la hora de definir una respuesta sub6ptima al tratamiento con
clopidogrel. Spanish Society of Cardiology 2009.

Ferreiro Gutierrez JL, Capranzano P, Ueno M, Capodanno D, Dharmashankar K, Desai B, Bass TA, Angiolillo DJ. El
cilostazol produce una inhibici6n del receptor P2Y12 mayor que una dosis alta clopidogrel en pacientes con DM y
respuesta sub6ptima al clopidogrel. Spanish Society of Cardiology 2009.
Ferreiro Gutierrez JL, Capranzano P, Capodanno D, Ueno M, Dharmashankar K, Desai B, Bass TA, Angiolillo DJ.
Correlaci6n entire agregometria 6ptica y VerifyNow para medir el grado de inhibici6n del receptor P2Y12 en pacientes en
tratamiento con clopidogrel. Spanish Society of Cardiology 2009.

Bernardo Garcia E, Jim6nez Quevedo P, Angiolillo DJ, Hernando L, Hernandez Antolfn R, Fernandez Ortiz A, Macaya
Miguel C, Sabat6 M, Niveles elevados de IgE y el component C3 del complement en pacientes diab6ticos tratados con
implantaci6n de stent farmacoactivo. Spanish Society of Cardiology 2009.

Ferreiro Gutierrez JL, Darlington A, Ueno M, Capodanno D, Capranzano P, Desai B, Bass TA, Angiolillo DJ. Evaluaci6n
mediante tromboelastograffa (TEG) del perfil tromb6tico de pacientes con insuficiencia renal cr6nica en hemodialisis.
Spanish Society of Cardiology 2009.

Jose Luis Ferreiro Gutierrez, Piera Capranzano, Masafumi Ueno, Davide Capodanno, Kodlipet Dharmashankar, Andrew
Darlington, Bhaloo Desai, Ronald K. Charlton, Lyndon C. Box, Martin M. Zenni, Luis A. Guzman, MD, Theodore A. Bass,
Dominick J. Angiolillo, Cilostazol Therapy Achieves Greater P2Y12 Inhibitory Effects Compared to High Clopidogrel
Maintenance Dosing in Suboptimal Clopidogrel Responders with Diabetes Mellitus. American College of Cardiology/i2
Summit 2010. Atlanta, GA.

Masafumi Ueno, Jose Luis Ferreiro, Kodlipet Dharmashankar, Piera Capranzano, Davide Capodanno, Andrew Darlington,
Desai Bhaloo, Ronald Charlton, Lyndon Box, Martin Zenni, Luis Guzman, Theodore Bass, Dominick J. Angiolillo.
Correlation Between the VerifyNow P2Y12 Assay and Light Transmittance Aggregometry to Measure Platelet P2Y12
Receptor Inhibition in Patients on Clopidogrel Therapy. American College of Cardiology/i2 Summit 2010. Atlanta, GA.

Roberta Rossini, Corrado Lettieri, Giuseppe Biondi Zoccai, Giuseppe Musumeci, Tamar Nijaradze, Michele Romano, Nicola
Cicorella, Nikoloz Lortkipanidze, Antonio Izzo, Vasile Sirbu, Antonello Gavazzi, Dominick J. Angiolillo. Early and Late
Discontinuation of Oral Antiplatelet Therapy after DES Implantation: Prevalence, Predictors, and Long-term Prognosis.
American College of Cardiology/i2 Summit 2010. Atlanta, GA.

David Vivas, Esther Bernardo, Juan Carlos Garcia-Rubira, Dominick J. Angiolillo, Patricia Martin Rojas-Marco, Alfonso
Calle, Carlos Macaya, Antonio Fernandez-Ortiz, Effects of an Intensive Glycemic Control with Insulin on Platelet
Aggregation Profile in Patients with Acute Coronary Syndrome: the CHIPS (Control de la Hiperglucemia y Funci6n
Plaquetaria en los Sfndromes Coronarios Agudos) Study. American College of Cardiology/i2 Summit 2010. Atlanta, GA.

Davide Capodanno, Esther Bernardo, David Vivas, Jose' Luis Ferreiro, Manel Sabate', Pilar-Jimenez Quevedo, Masafumi
Ueno, Kodlipet Dharmashankar, Fernando Alfonso, Theodore Bass, Carlos Macaya, Antonio Fernandez-Ortiz, Dominick J.
Angiolillo. Impact of Chronic Kidney Disease on Platelet Function Profiles in Diabetes Mellitus Patients with Coronary
Artery Disease on Dual Antiplatelet Therapy. American College of Cardiology/i2 Summit 2010. Atlanta, GA.

Dominick Angiolillo, Esther Bernardo, Martina Zanoni, Piera Capranzano, Giovanni Malerba, Elisabetta Trabetti, Manel
Sabate', Pilar-Jimenez Quevedo, Paola Prandini, Davide Capodanno, Jose' Luis Ferreiro, Theodore Bass, Pier Franco
Pignatti, Antonio Fernandez-Ortiz Impact of IRS-1 Genotypes on Platelet Reactivity and Cardiovascular Outcomes in Type
2 Diabetes Mellitus Patients with Coronary Artery Disease. American College of Cardiology/i2 Summit 2010. Atlanta, GA.

Kodlipet C. Dharmashankar, Jose-Luis Ferreiro, Masafumi Ueno, Andrew Darlington, Davide Capodanno, Bhaloo Desai,
Ronald K. Charlton, Luis A. Guzman, Theodore A. Bass, Dominick J. Angiolillo. Inter-assay Agreement to Define
Inadequate Clopidogrel Response. American College of Cardiology/i2 Summit 2010. Atlanta, GA.

Roberta Rossini, Giuseppe Musumeci, Corrado Lettieri, Giuseppe Biondi Zoccai, Tamar Nijaradze, Nicola Cicorella, Nikoloz
Lortkipanidze, Michele Romano, Giuseppe Tarantini, Antonello Gavazzi, Dominick J. Angiolillo. Long-term Bleeding in


Cardiology


Annual Report AY 2010


Cardiology





Division Chief: Theodore Bass, MD


Patients on Prolonged Dual Oral Antiplatelet Therapy after DES Implantation: Prevalence, Predictors, and Prognostic
Implications. American College of Cardiology/i2 Summit 2010. Atlanta, GA.

Jose Luis Ferreiro Gutierrez, Andrew Darlington, Davide Capodanno, Masafumi Ueno, Piera Capranzano, Bhaloo Desai,
Kodlipet Dharmashankar, Yoshie Suzuki, Stanley Nahman, Theodore A. Bass, Dominick J. Angiolillo. Thrombotic Profile
Analysis Using Thromboelastography in End Stage Renal Disease Patients Undergoing Hemodialysis. American College of
Cardiology/i2 Summit 2010. Atlanta, GA.

Luis A Guzman, MD, Ileana L. Piia, MD. Tracy Y Wang, MD, Martha Daviglus, MD, Jose Exaire, MD, Carlos Rodriguez,
MD, Vilma Torres, MD, Shuang Li, MD, Marjorie Funk, MD, Jorge Saucedo, MD, Chris Granger, MD and Mauricio G
Cohen, MD Differences in Practice Patterns and Outcomes between Hispanics and Non-Hispanic Whites Treated for ST-
Segment Elevation Myocardial Infarction:Results from ACTION Registry Get With The Guidelines. AHA QCOR Scientific
meeting. May 2010

Ancheta IB, Chiong J, Miller AB et al: The impact of B-type natriuretic peptide depression and NYHA classification on
quality of life in patients with chronic heart failure. J Card Failure 2009;15 no 6, S120

Mathew, V. Ramu, J. Ahmed, D. Katz, S. Hsu. Adherence to guidelines for ICD implantation for primary prevention of
sudden cardiac death a retrospective study.

Kim et al. Management and Clinical Outcomes of Acute Cardiac Tamponade Complicating Electrophysiology Procedures:
A Single Center Case Series. Pacing and Clinical Electrophysiology (in press)

Lavine SJ, Walsh T. Prediction of left ventricular filling pressures in patients with preserved left ventricular systolic
function and diastolic dysfunction. J Am Soc Echocardiogr 2010, in press. American Society of echocardiography
Scientific sessions, Presented in San Diego, CA, June 2010

Lavine SJ. Longitudinal Systolic and Diastolic dysfunction in chronic aortic regurgitation. J Am Soc Echocardiogr 2010, in
press. American Society of echocardiography Scientific sessions, Presented in San Diego, CA, June 2010


CLINICAL ACTIVITIES


CONTRACTS AND GRANTS


Competitive grant
1. Esther and King Biomedical Research program:
$377,000


Annual Report AY 2010 Cardiology


Inpatient activity AY 09/10
CV In PT admissions 2,311
Observations 445

Outpatient activity
Physician clinic visits *15,306
Cardiac ultrasounds 10,727
Cardiac nuclear studies 3,350
EKGs 56,746
Stress tests 5,198
Heart caths ** 2,563
EP procedures *** 498
Device placements ****218
Cardiac rehab visits 3,108
*Attending and Fellows: Jacksonville Clinic ***EP Prodecures: Ablations = 158,
= 10, 870, Lake Shore = 1,448, Live Oak = Cardioversions = 36, EP's = 226, Lead
190, St Marys = 2,920 Extractions = 78

**Cath Only = 1,596, Coronary = 699, ****Device placements: ICD's = 105
Peripheral = 268 Pacemakers = 113


Investigator initiated industry sponsored grants
1. Physio Control/Medtronic- $500
2. Sanofi-Aventis $5,000
3. BMS/Sanofi-aventis $125,000


Cardiology


Annual Report AY 2010


Cardiology





Endocrinology, Diabetes and Metabolism


DIVISION OF ENDOCRINOLOGY, DIABETES AND METABOLISM
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The Division of Endocrinology, Diabetes and Metabolism had a year of rapid growth and development in
all areas of the academic mission of the University of Florida. The most significant event was graduation
of two endocrinology fellows after the ACGME approval of the Endocrinology Fellowship Training
Program July 2008. Clinically, major events included expansion of clinical services and in research, the
endocrinology laboratories initiated new in vitro investigations into hormonal action with expansion of
the facilities. Academically, the division submitted multiple publications and contributed immensely to
the University's educational mission, to many training programs at the University of Florida as well as
non-university affiliated health care providers.

Patient care: The division provides inpatient and outpatient consultation for the University of Florida
College of Medicine, Jacksonville campus and satellite offices as well as for referring physicians in the
Northeast Florida /Southern Georgia region and beyond. Dr. Joe Chehade, Dr. Arshag Mooradian, Dr.
Mae Sheikh-Ali and Dr. Kent Wehmeier are the core clinical faculty. The division addresses clinical
endocrinology problems related to hypothalamus, pituitary, thyroid, pancreas, adrenal and sex hormone
gland dysfunction. Patients with metabolic disorders including diabetes mellitus, metabolic syndrome,
obesity, anorexia, hypercholesterolemia, calcium and metabolic diseases such as osteoporosis and
vitamin D deficiency are evaluated and treated. The division's main clinical operations occur at
University of Florida Endocrinology and Diabetes at Emerson Medical Plaza. The number and variety of
consultations continue to rise rapidly. Patients are also evaluated at the Shands Jacksonville Ambulatory
Care Center (ACC). The most important advances this year were the acquisition of a continuous glucose
monitoring device for evaluating metabolic control in patients with diabetes. Dr. Chehade and Dr. Mae
Sheikh-Ali perform analyses of the glucose monitoring data to make recommendations regarding
diabetes management. Diabetes care has been strengthened by the partnering of outpatient diabetes
education with the Division of Endocrinology. Meredith Smith, MS, RD, LD provides onsite education at
the UF Emerson location for diabetes management, carbohydrate counting and medical nutrition therapy
(MNT.) The dynamic testing clinic has also opened this year to allow enhanced evaluation of adrenal and
pituitary disease.

On the inpatient service, many more patients are served by endocrinology consultation. The division has
also been instrumental in the institution and implementation of a standardized order form for the insulin
therapy in hospitalized patients. To provide excellence in the care of patients with pituitary disease, Dr.
Michael Petr in the Division of Neurosurgery, Dr. Iman Naseri in the Division of Otolaryngology, Dr.
Donna Hill in the Department of Ophthalmology and Dr. Robert Malyapa in the Department of Radiation
Oncology have partnered together with the Division of Endocrinology as a network of specialists devoted
to the care of these patients. Dr. Sunil Sharma of the Department of Surgery is opening an office next
door to the office at UF Emerson. This will be a new avenue of consultation and growth for the division.
The division also presented evaluation and management techniques in the areas of thyroid disease and
osteoporosis to UF Family Practice clinics to facilitate optimal care of patients with these conditions.

Education: The most significant event this year was graduation of two endocrinology fellows, Dr.
Abdul-Razzak Alamir and Dr. Senan Sultan, after ACGME approval of the Endocrinology fellowship in May
2008. The program received a 2 year provisional accreditation, in July 2008 with four fellows under the
direction of Dr. Wehmeier. Dr. Rosalyn Alcalde, a graduate of the UF College of Medicine core medicine
program, and Dr. Emad Naem joined the division July 1st of 2009 and have been active clinically and
with scholarly publications. All four fellows have made substantive contributions to the clinical care,
education and research mission of the division. The division is actively preparing for full accreditation
with an upcoming site visit.


Division Chief: Kent Wehmeier, MD


Annual Report AY 2010


Endocrinology, Diabetes and Metabolism





Endocrinology, Diabetes and Metabolism


In residency education, Dr. Wehmeier continues as rotation director of relevant educational programs for
Endocrinology. He is the primary liaison between the Core Residency Program and the division, and is a
member of the Resident Education Committee.

In the educational program of University of Florida Medical Students, Dr. Joe Chehade, Dr. Mae Sheikh-
Ali and Dr. Wehmeier participated in preceptoring clinics in endocrinology and coordinated lectures for
the University of Florida medical students and residents in medicine and emergency medicine. Core
lectures were also delivered to the obstetrics/gynecology and medicine residents. The division continues
to provide monthly report cards to the Department of Medicine for the purposes of performance
improvement in the area of insulin utilization. The division's endocrinology grand rounds provided an
avenue for speakers at UF Jacksonville and Gainesville to share knowledge and enhance collaboration
between various disciplines at UF. The 2010 Update in Internal Medicine was another venue that
division faculty contributed to the educational mission.

LISTING OF FACULTY MEMBERS

Joe Chehade, M.D., Associate Professor
Medical School / Graduation date St. Joseph University School of Medicine, Beirut-Lebanon 1992
Internship/residency and year Staten Island University Hospital 1997
Subspecialty training and year Saint Louis University School of Medicine 1997



Michael Haas, Ph.D., Research Associate Professor
Graduate School/Graduation date University of Nebraska Medical Center 1991
Post-Graduate Training and year McArdle Laboratory for Cancer Research 1994




Arshag D. Mooradian, M.D. Professor and Chairman, Department of Medicine
Medical School / Graduation date American University of Beirut 1980
Internship/residency and year American University of Beirut 1982
Subspecialty training and year University of Minnesota 1985



Mae Sheikh-Ali, M.D., Assistant Professor
Medical School / Graduation date Damascus University School Medicine 1999
Internship/residency and year Drexel University College Of Medicine 2005
Subspecialty training and year Mayo Clinic, Jacksonville, Florida 2007



* Kent Wehmeier, M.D., Associate Professor and Division Chief
Medical School / Graduation date University of Missouri-Columbia 1988
Internship/residency and year Barnes-Jewish Hospital, Washington University 1991
Subspecialty training and year Saint Louis University School of Medicine 1993


L A I


Annual Report AY 2010 Endocrinology, Diabetes and Metabolism


Division Chief: Kent Wehmeier, MD


Annual Report AY 2010


Endocrinology, Diabetes and Metabolism





Endocrinology, Diabetes and Metabolism


PUBLICATIONS
Caplan L, Pittman CB, Zeringue AL(including Wehmeier KR), et al. An oberservational study of musculoskeletal pain
among patients receiving bisphosphonate therapy. Mayo Clin Proc. 2010 Apr;85(4):341-8. Epub 2010 Mar 15.

Chehade JM, Sheikh-Ali M, Alexandraki I, House J, Mooradian AD. The effect of health care provider education on
diabetes management of hospitalized patients. International Int J Clin Pract. 2010, (in Press).

Chehade JM, Lim W, Silverberg AB, Mooradian AD. The incidence of Hashimoto's disease in nodular goitre: the
concordance in serological and cytological findings. Int J Clin Pract. 2010 Jan;64(1):29-33.

Chehade JM, Sultan S. Evaluation of pituitary mass. BMJ Epocrates Website. 2009. Available at:
https://online.epocrates.com/u/29111124/Evaluation+of+pituitary+mass Accessed September 2, 2009.

Sheikh-Ali M, Chehade JM, Mooradian AD. The Antioxidant Paradox in Diabetes Mellitus. American Journal of
Therapeutics. In Press.

Haren MT, Siddiqui AM, Armbrecht HJ (including Haas MJ), et al. Testosterone modulates gene expression pathways
regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle. Int J Androl. 2010
(in press).

Haas M3, Mooradian AD. Therapeutic interventions to enhance apolipoprotein A-I mediated cardioprotection. Drugs.
2010 (in press).

Alcalde R, Sheikh-Ali M. Growth Hormone Deficiency. BMJ Epocrates Website 2010, (in press).

Sheikh-Ali M, Sultan S, Alamir A, Hass M3, Mooradian AD. Hyperglycemia-induced endoplasmic reticulum stress in
endothelial cells. Nutrition. 2010 (in press).

Haas M3, Wong N, Mooradian, AD. Regulation of high-density lipoprotein by inflammatory cytokines: establishing links
between autoimmunity and cardiovascular disease. Diabetes Metab Res Rev. 2010;26:90-99.

Sheikh-Ali M, Sultan S, Alamir A, Hass MJ, Mooradian AD. Hyperglycemia-induced endoplasmic reticulum stress in
endothelial cells. Nutrition. 2010 (in press).

Alcalde R, Sheikh-Ali M. Growth Hormone Deficiency. BMJ Epocrates Website 2010, (in press).

Wehmeier KR. Pseudohypoparathyroidism. BMJ Epocrates Website. 2009. Available at:
https://online.epocrates.com/noFrame/showPage.do?method=diseases&MonographId=1150&ActiveSectionId= 11.
Accessed August 17, 2009.

Sheikh-Ali M, Chehade JM. A Rational Approach to Initiation of Insulin Therapy in Older Adults. Geriatrics and Aging.
2009; vol 12, no. 3: 135-140.

Alamir A, Sheikh-Ali M. Thyroid function testing. BMJ Epocrates Website 2009. Available at:
https://online.epocrates.com/u/29111121/Thyroid+function+testing Accessed November 11, 2009.

.Sheikh-Ali M, Sultan S, Alamir A, Haas MJ, Mooradian AD. Effects of antioxidants on glucose-induced oxidative stress
and endoplasmic reticulum stress in endothelial cells. Diabetes Res Clin Pract. Nov. 2009;87:161-166.

Alamir A, Sheikh-Ali M. Thyroid function testing. BMJ Epocrates Website 2009. Available at:
https://online.epocrates.com/u/29111121/Thyroid+function+testing Accessed November 11, 2009.

Chehade JM, Sultan S. Evaluation of pituitary mass. BMJ Epocrates Website. 2009. Available at:
https://online.epocrates.com/u/29111124/Evaluation+of+pituitary+mass Accessed September 2, 2009.

Reddy P, Mooradian AD. Clinical utility of anion gap in deciphering acid-base disorders. International Journal of Clinical
Practice 63: 1516-1525, 2009.

Reddy P, Mooradian AD. Diagnosis and management of hyponatremia in hospitalized patients. International Journal of
Clinical Practice 63: 1494-1508, 2009.

Annual Report AY 2010 25 Endocrinology, Diabetes and Metabolism


Division Chief: Kent Wehmeier, MD






Endocrinology, Diabetes and Metabolism


Chaitman BR, Hardison RM, Adler D, Gebhart S, Grogan M, Ocampo S, Sopko G, Ramires JA, Schneider D, Frye RL, and
the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group (Mooradian AD). The
Bypass Angioplasty Revascularization Investigation 2 Diabetes Randomized Trial of different treatment strategies in type
2 diabetes mellitus with Stable ischemic heart disease: Impact of treatment strategy on cardiac mortality and myocardial
infarction. Circulation 120:2529- 2540, 2009.

Hlatky MA, Boothroyd DB, Melsop KA, Kennedy L, Rihal C, Rogers WJ, Venkitachalam L, Brooks MM, for the Bypass
Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Study Group (Mooradian AD site PI). Economic
outcomes of treatment strategies for type 2 diabetes mellitus and coronary artery disease in the bypass angioplasty
revascularization investigation 2 diabetes trial. Circulation 120:2550-2558, 2009.

Chehade JM, Sheikh-Ali. M, Mooradian AD. The role of micronutrients in managing diabetes mellitus. Diabetes
Spectrum 22:214-218, 2009.

Mooradian AD, Meenrajan S. The business of academic medicine is a business like no other: A perspective. The Health
Care Manager 28:344-350, 2009.

Pop-Busui R, Lombardero M, Lavis V, Forker A, Green J, Korytkowski M, Sobel BE, Jones TLZ, and the BARI 2D Study
Group (Mooradian AD site PI). Relation of severe coronary artery narrowing to insulin or thiazolidinedione use in
patients with type 2 diabetes mellitus. American Journal of Cardiology 104: 52-58, 2009.

Albu JB, Lu J, Mooradian AD, Krone R, Nesto RW, Porter M, Rana JS, Rogers WJ, Sobel BE, Gottlieb S for the BARI 2D
Study Group. Relationships of obesity and fat distribution with atherothrombotic risk factors. Baseline results from the
BARI 2D trial. Obesity 2010 May;18(5):1046-54..

Haas M3, Mooradian AD. Regulation of high-density lipoprotein by inflammatory cytokines: Establishing links between
immune dysfunction and cardiovascular disease. Diabetes & Metabolism Research and Reviews 26: 90-99, 2010

Alexandraki A, Mooradian AD. Barriers related to mammography use for breast cancer screening among minority
women. Journal of the National Medical Association 102:206- 218, 2010.

Escobedo J, Rana JS, Lombardero MS, Albert SG, Davis AM, Kennedy FP, Mooradian AD, Robertson DG, Srinivas VS,
Gebhart SSP, for the BARI 2D Study Group. Association between albuminuria and duration of diabetes and myocardial
dysfunction and peripheral arterial disease among patients with stable coronary artery disease in the BARI 2D study.
Mayo Clin Proc. 85:41-46, 2010.

McBane RD, Hardison RM, Sobel BE, BARI 2D Study Group (A. Mooradian). Comparison of plasminogen activator
inhibitor-i, tissue type plasminogen activator antigen, fibrinogen, and D- dimer levels in various age decades in patients
with type 2 diabetes mellitus and stable coronary artery disease (from the BARI 2D Trial). Am. J of Cardiol. 105:17-24,
2010.

Book chapters:
Wilson GR, Alexandraki I, Samraj G, Mooradian AD. Endocrinology. In Textbook of Family Medicine. RE Rakel and DP
Rakel (eds) 8th edition, Elsevier, Philadelphia, PA, 2010 in press

Presentations:
Mooradian AD. Obesity in the elderly. 10th Annual Conference in obesity, University of Southern Florida, Orlando, FL,
2009.

Mooradian AD. Dietary guidelines for diabetes. 10th Annual Conference in obesity, University of Southern Florida,
Orlando, FL, 2009.

Mooradian AD. Diabetes in the Elderly. Endocrine Society meetings San Diego CA, June 2010.

Chehade JM, Haas M3, Mooradian AD. Induction of apolipoprotein A-I gene expression by Glucagon-Like Peptide-1
and Exendin-4. The Endocrine Society Annual Meeting, June 19-22, 2010, San Diego, CA (poster & oral presentation).


Annual Report AY 2010 Endocrinology, Diabetes and Metabolism


Division Chief: Kent Wehmeier, MD


Annual Report AY 2010


Endocrinology, Diabetes and Metabolism






Endocrinology, Diabetes and Metabolism


Sheikh-Ali M, Raheja P, Hass M3, Mooradian AD. Sex steroid-dependent inhibition of hyperglycemia-induced
endoplasmic reticulum stress in endothelial cells. American Association of Clinical Endocrinologists Annual Meeting, April
21-25, 2010, Boston, MA (oral presentation).

Mooradian AD. Diabetic dyslipidemia. Update in Internal Medicine. Atlantic Beach, FL 2010.

Naem E, Sheikh-Ali M. Papillary thyroid microcarcinoma associated with benign thyroid tissue in the delphian lymph
node. American Association of Clinical Endocrinologists Annual Meeting, April 21-25, 2010, Boston, MA (poster
presentation).

Wehmeier, K and Naem E. Worsening Hypothyroidism Related Myoptahy Caused by Ezetimibe Therapy. University of
Florida-Jacksonville Research Day, May 2010, Jacksonville, FL (poster presentation).


CLINICAL ACTIVITIES


Inpatient Activity FY 09/10
Number of IP Consults 548

Outpatient Activity
Clinic Visits 6280
Thyroid Biopsies 159


GRANTS AND CONTRACTS


Principal Sponsor/Title Project period Total direct
Investigator costs
Abdul Alamir, MD Endocrine Fellows Foundation 08/09 20,000.00
Abdul Alamir, MD Deans Fund Research Award for Residents and Fellows 08/09 5,000.00
Mae Sheikh-Ali, MD Novo Nordisk Protocol 5/10-11/10 40,997
Kent R. Wehmeier, MD Novo Nordisk Protocol 8/9-6/10 46,473


Annual Report AY 2010 Endocrinology, Diabetes and Metabolism


Division Chief: Kent Wehmeier, MD


Annual Report AY 2010


Endocrinology, Diabetes and Metabolism





Interim Division Chief: Ravi Kottoor, M.D.


DIVISION OF GASTROENTEROLOGY
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The Division of Gastroenterology had an extraordinary 2009-2010 fiscal year. Clinically, the division saw
outpatients at the on-campus Ambulatory Care Center (ACC), Emerson Gastroenterology Clinic
(Emerson), Shands Jail Clinic, UF Jacksonville Faculty Clinic, Beaches Digestive Clinic, and the Southside
Digestive Clinic. Ambulatory motility studies, capsule endoscopy, and diagnostic breath tests were
performed at Emerson. Endoscopy procedures were performed at Shands Jacksonville Medical Center
and the Medical Partners Surgery Center at Emerson. The research operation saw us acquiring several
industry sponsored grants. Dr. Kenneth Vega who was an Associate Professor in our division left in
November 2009 to accept a position as Associate Professor at the University of Oklahoma, Oklahoma
City, OK.

Patient Care: The patient care aspect of the academic mission is pursued by the division through three
clinics at University of Florida, the provision of inpatient consult services at Shands Jacksonville, inpatient
and outpatient GI services at Baptist Medical Center Beaches and St. Luke's Hospital. The division
continues to be the leader in Northern Florida in the treatment of viral hepatitis and staffs a
gastrointestinal motility laboratory. We provide two special clinics per week caring for patients with
inflammatory bowel disease and two Hepatology clinics per week to focus on patients with liver disease.

Education: The division was involved in teaching for the residency program. Dr. Ravi Kottoor
coordinated ambulatory clinics as well as in patient rotations for medical residents. The faculty has
presented several topics of interests during the Internal Medicine Grand Rounds. Dr. Juan Munoz and
Dr. Samir Habashi are particularly interested in the education of therapeutic endoscopy, EUS and ERCP
procedures to fellows.

The division conducts a Gastroenterology Fellowship Program which consists of two fellows per year for
three years. The program continues its 100% board passing rate by previous year's graduates. After a
site visit conducted by the ACGME in July 2008, the program was granted accreditation for the next
three and a half years.

Research: Divisional research activities include basic and clinical studies on a variety of
gastroenterology diseases by our faculty members. We have set up a basic molecular Virology lab lead
by Dr. Xiaoyu Li. His research has been focused on interactions of host innate immunity and hepatitis C
virus. His work was presented in regional, national and international conferences. His work was
published in Viral Research and is available on-line as of August 29, 2009. Most faculty members have
published papers on a wide range of topics with Dr. Juan Munoz leading in the number of publications in
peer reviewed journals. A clinical study is being conducted by Dr. Juan Munoz in the ablation of Barrett's
Esophagus to be included in the HALO registry to monitor these patients. Another prospective study
being conducted is by Dr. Ravi Kottoor on a fecal marker for inflammatory bowel disease.

LISTING OF FACULTY MEMBERS

Robert Bass, M.D., Assistant Professor
Medical School / Graduation date Medical College of Georgia 1988
Internship/residency and year University of South Alabama 1991
Subspecialty training and year University of Florida Jacksonville 1993


Gastroenterology


Annual Report AY 2010


Gastroenterology





Interim Division Chief: Ravi Kottoor, M.D.


Samir Habashi, M.D., Assistant Professor
Medical School / Graduation date Ain-Shams University, Cairo, Egypt 1985
Internship/residency and year University of Florida Jacksonville 2003
Subspecialty training and year University of Florida Jacksonville 2007




Ravi Kottoor, M.D., Associate Professor and Interim Division Chief
Medical School / Graduation date Kasturba Medical College, India 1970
Internship/residency and year Ottawa Civic Hospital 1974
Subspecialty training and year Dalhousie University, Canada 1975




Xiaoyu Li, M.D., Ph.D., Assistant Professor
Medical School / Graduation date Harbin Medical University, China 1983
Internship/residency and year Mt Sinai School of Medicine 2004
Subspecialty training and year University of Florida 2007
Graduate degree and year State University of New York 2001



Juan Munoz, M.D., Assistant Professor
Medical School / Graduation date Universidada Complutense, Spain 1991
Internship/residency and year University of Florida Jacksonville 2001
Subspecialty training and year University of Florida Jacksonville 2004




Paul Sievert, M.D., Assistant Professor
Medical School / Graduation date University of Miami 1996
Internship/residency and year Medical College of Virginia 1999
Subspecialty training and year University of Florida Jacksonville 2003





PUBLICATIONS

Gupta R, Garg P, Kottoor R, Munoz JC, Jamal MM, Lambiase LR, Vega K3. Overuse of acid suppression therapy in
hospitalized patients. South Med J. 2010 March;103(3):207-11.

Munoz JC. Esophageal stenting In Patients with Advanced Esophageal Cancer. Northeast Florida Medicine Vol 61, Page
33-36. No 1, Spring 2010. www.DCMSonline.orc

Munoz, JC, Rascon-Aguilar I, Lambiase LR, Awad ZT, Vega K3. Extraction of surgical clip induced "lollipop"
choledocholithiasis. Endoscopy. 2010; 42 Suppl 2:e15-6. Epub Jan 13.

Smith AS, Cole M, Vega K3, Munoz JC. Palliation of malignant rectal obstruction from invasive prostate cancer with
multiple overlapping self-expanding metal stents. South Med J. 2009 Dec 102(12): 1257-9.

Munoz JC, Pudhota S, Tharpe A. Preventing an unfortunate polypectomy attempt in a large broad-based, smooth, and
soft polypoid elevation of the colonic wall. Gastroenterology. 2010 Jan;138(1):e3-4. Epub 2009 Nov 21.

Munoz JC, Salyers W. Upper gastrointestinal bleeding in a 47-year old. eMedicine case presentation. 14 Oct 2009.


Annual Report AY 2010 Gastroenterology


Gastroenterology


Annual Report AY 2010


Gastroenterology






Interim Division Chief: Ravi Kottoor, M.D.


Abstracts and Presentations:
Smith A, Munoz 3C, Kottoor R. Ambient music nature therapy as an adjunct to colonoscopy. University of Florida-
Jacksonville, Research day, poster presentation May 2010.

Rascon I, Munoz 3C. Are ACE inhibitors and ARB's protective against liver fibrosis in patients with hepatitis C. University
of Florida-Jacksonville. Research day, poster presentation May 2010.

Luyu Yao*, David R. Nelson, Chen Liu, and Xiaoyu Li. Inhibitory effects of IRF-3 on hepatitis C viral replication. Oral
presentation at APASL, Beijing, China. Aug 2010

Smith A, Munoz 3C, Vega K. Palliation of Malignant Rectal Obstruction from Invasive Prostate Cancer with Multiple
Overlapping Self-Expanding Metal Stents. University of Florida/Jacksonville Shands. Research day, poster presentation
October 2009 Abstracts

Salyers WJ. Munoz JC. Appendiceal Mercury Sequestration. America College of Gastroenterology Annual Scientific
Meeting. Poster presentation, Oct 2009.

Xiaoyu Li and Eckard Wimmer. Inhibition of hepatitis C virus IRES-mediated translation by oligonucleotides. Virus
Research. 146(1-2):29-35 Nov 2009

Luyu Yao*, Huijia Dong, Haizhen Zhu, David R. Nelson, Chen Liu, Louis Lambiase, and Xiaoyu Li. Inhibitory effects of
1-8U gene on hepatitis C Viral IRES-mediated translation. Submitted to Antimicrobial Agents and Chemotherapy, 2009

Luyu Yao*, David R Nelson, Chen Liu, and Xiaoyu Li. 2009. Inhibition of Hepatitis C viral (HCV) replication by in vivo
dimerization of IFN regulatory factor-3 (IRF3). Manuscripts in preparation.

Luyu Yao* and Xiaoyu Li. 2009. Inhibitory effects of HnRNP M gene on hepatitis C Viral translation and its relation with
Interferon treatment. Manuscript in preparation.

Book Chapters and Monographs:
Munoz JC, Laos L. Foreign Body Ingestion. https://online.epocrates.com/u/29111050/Foreign+body+ingestion. British
Medical Journal Publishing Group. Last updated: 20 Nov 2009.


Munoz JC, Reddy S. Mallory-Weiss Tear. https://online.epocrates.com/u/29321145/MalloryWeistear. British Medical Journal
Publishing Group. Last update: 01 Oct 2009.


HONORS AND AWARDS

Dr. Juan Carlos Munoz was the recipient of the University of Florida Exemplary Teachers Award 2010.

The University of Florida College of Medicine-Jacksonville congratulates Dr. Robert Bass on being named one of
Jacksonville Magazine's Top Docs for the last nine years.


CLINICAL ACTIVITIES


Inpatient Activity AY 09/10
Number of IP Consults 1398
Shands Jacksonville Inpatient Procedures 1656
Baptist Beaches Inpatient Procedures 87
St. Lukes Inpatient Procedures 9
Outpatient Activity
Clinic Visits 14786
Shands Jacksonville Outpatient Procedures 4760
Baptist Beaches Outpatient Procedures 729
Jacksonville Beach Surgery Center Outpatient Procedures 622
Jacksonville Surgery Center 854
Medical Partners Surgery Center 1088


Annual Report AY 2010 Gastroenterology


Gastroenterology


Annual Report AY 2010


Gastroenterology






Interim Division Chief: Ravi Kottoor, M.D.


GRANTS AND CONTRACTS


Principal Study Title Project Sponsor Award
Investigator Period Amount
Kottoor, R A Phase III, Randomized, Placebo-Controlled, Blinded, Multicenter Study of the 5/27/2009 Millennium $2,000.00
Induction and Maintenance of Clinical Response and Remission by MLN0002 in Patients present Pharmaceuticals
with Moderate to Severe Ulcerative Colitis
Kottoor R A Phase III, Randomized, Placebo-Controlled, Blinded, Multicenter Study of the 6/26/2008 Millennium $6,133.00
Induction and Maintenance of Clinical Response and Remission by Vedolizumab present Pharmaceuticals
(MLN0002) in Patients with Moderate to Severe Crohn's Disease
KottoorR A Phase III, Open-label Study to Determine the Long-term Safety and Efficacy of 5/27/2009 Millennium $2,000.00
Vedolizumab (MLN0002) in Patients with Ulcerative Colitis and Crohn's Disease present Pharmaceuticals
Kottoor R A Phase III Multicenter, Randomized, Placebo-controlled, Double-blind Study to 8/28/2008 Centocor Inc. $2,435.20
Evaluate the Safety and Efficacy of Golimumab Maintenance Therapy, Administered present
Subcutaneously, in Subjects with Moderately to Severely Active Ulcerative Colitis
Kottoor R A Phase IIb, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group 8/7/2009 Johnson & $7,714.20
Study to Evaluate the Efficacy and Safety of Ustekinumab Therapy in Subjects with present Johnson Inc.
Moderately to Severely Active Crohn's Disease Previously Treated with TNF Antagonist
Therapy
Kottoor R A Phase II/III Multicenter, Randomized, Placebo-controlled, Double-blind Study to 8/28/2008 Centocor Inc. $3,814.40
Evaluate the Safety and Efficacy of Golimumab Induction Therapy, Administered 4/17/2010
Intravenously, in Subjects with Moderately to Severely Active Ulcerative Colitis
Kottoor R A randomized, double-blind, placebo-controlled, parallel group, multi-center study to 5/16/2008 Pfizer Inc. $655.00
investigate the safety and efficacy of CP-690,550 in subjects with moderate to severe 8/11/2009
Crohn's Disease
Kottoor R A Multi-center, Investigator-blinded, Randomized, 12-month, Parallel-group, Non- 3/12/2008 Procter & $2,030.00
inferiority Study to Compare the Efficacy of 1.6 to 2.4g Asacol Therapy QD Versus 11/14/2009 Gamble
Divided Dose (BID) in the Maintenance of Remission of Ulcerative Colitis Company
Kottoor R A Prospective Study Quantitating Fecal TNF-ALPHA In Active IBD Compared To Other 1/15/2008- UCB, Inc $12,031.24
Forms Of Acute Enterocolitis present
Kottoor R A Phase 3, Randomized, Double-Blind, Placebo Controlled, Multicenter Study to Assess 2/19/2010 Salix Pending
the Efficacy and Safety of Budesonide Foam (2mg/25ml BID for 2 Weeks, Followed By present Pharmaceuticals
2mg/25ml QD for 4 Weeks) Versus Placebo In Subjects With Active Mild to Moderate
Ulcerative Proctitis or Proctosigmoiditis
Lambiase L Protocol 0000810: An Open-Label Clinical Study Evaluating the Long Term Safety of 10/16/2007 Alnara $8,531.20
ALTU-135 in the Treatment of Patients with Exocrine Pancreatic Insufficiency ue to 8/23/2009 Pharmaceuticals
Chronic Pancreatitis or Pancreatectomy
Lambiase L A Phase 3, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of 2/19/2007 Duke University $36,053.04
Li, Xiaoyu Albumin Interferon Alfa-2b in Combination with Ribavirin Compared with Peginterferon 12/31/2009 & Human
Alfa-2a in Combination with Ribavirin in Interferon Alfa Naive Subjects with Chronic Genome
Hepatitis C Genotype 1. ACHIEVE-1 Sciences
Lambiase L A Phase 3, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of 2/19/2007 Duke University $97.90
Li, Xiaoyu Albumin Interferon Alfa-2b (alb-IFN) in Combination with Ribavirin Compared with 12/31/2009 & Human
Peginterferon Alfa-2a (PEGASYS or PEG-IFNa2a) in Combination with Ribavirin in Genome
Interferon Alfa Naive Subjects with Chronic Hepatitis C Genotype 2 or 3. ACHIEVE-2/3 Sciences
Lambiase L Randomized, Multicenter, Double-Blinded, Phase IV Study Evaluating the Efficacy (as 12/19/2006 Hoffman-La $1,990.71
Li, Xiaoyu Measured by Sustained Virological Response) and Safety of 360 mcg Induction Dosing 6/15/2010 Roche Ltd.
of Pegasys in Combination with Higher Copegus Doses in Treatment-naive Patients
with Chronic Hepatitis C Genotype 1 Virus Infection of High Viral Titer and Baseline
Body Weight Greater than or Equal to 85 kg
Li, Xiaoyu A Phase II, Randomized, Double-Blind, Placebo-Controlled Study To Evaluate The 7/14/2009 Pfizer Inc. $3,468.04
Safety And Efficacy Of Filibuvir Plus Pegylated Interferon Alfa-2A And Ribavirin In present
Treatment Naive, HCV Genotype 1 Infected Subjects
Li, Xiaoyu Randomised, placebo-controlled, multi-centre study to assess the efficacy and safety of 8/19/2009 Glaxosmithkline $1,600.00
eltrombopag in thrombocytopenic subjects with hepatitis C virus (HCV) infection who present Ltd.
are otherwise eligible to initiate antiviral therapy (peginterferon alfa-2b plus ribavarin)
Li, Xiaoyu A Phase III, Safety & Efficacy Study Of Boceprevir In Previous Untreated Subjects With 8/1/2008 Schering Plough $2,167.20
Chronic Hepatitis C Genotype 1 present Research Inst.
Li, Xiaoyu Boceprevir/Peginterferon/ Ribavirin for the Treatment of Chronic Hepatitis C in 7/20/2009 Schering Plough $17,315.92
Treatment-Naive Subjects: A Comparison of Erythropoietin Versus Ribavirin Dose present Research Inst.
Reduction for the Management of Anemia
Munoz J HALO: Patient Registry: Ablation of Barrett's Esophagus 4/15/2010 BARRx Medical, Pending
present Inc.
Munoz J COPD patients diagnosed with gastro esophageal reflux disease have decreased rates 6/1/2008 Takeda Pharm. $3,084.80
Vega K of COPD exacerbations after treatment with high dose Proton pump inhibitor therapy present UF Dean's
(esomeprazole or lansoprazole) Grant
Munoz J Expression of esophageal tight junction proteins & RNA in African American & Non- 10/27/2008 UF Research $1,820.35
Vega K hispanic whites present Foundation
Munoz J Identification of esophageal stem & progenitor cell markers in African American & Non- 10/27/2008 UF Research $5,461.06
Vega K hispanic whites present Foundation
Munoz J Open label, 6-12 mo. safety & efficacy study of levodopa-carbidopa intestinal gel in 6/3/2009 Solvay $720.00
Huang Z levodopa-responsive subjects w/ advanced Parkinson's disease & severe motor- present Pharmaceuticals
fluctuations


Gastroenterology


Annual Report AY 2010


Gastroenterology





Division Chief: Linda Edwards, MD


DIVISION OF GENERAL INTERNAL MEDICINE
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The division continues a robust inpatient and outpatient practice and is an integral part of the
educational experience for the Internal Medicine residency.

Patient Care: The Division of General Internal Medicine is comprised of 14 members, including the two
chief medical residents. The full time faculty are certified by the American Board of Internal Medicine.
The clinical care provided by members of the division include the provision of inpatient care as the
attending for the four inpatient teaching services, outpatient care at three locations; the ACC, Faculty
Clinic and the UF Internal Medicine Clinic at Emerson, an inpatient Internal Medicine consultation service
and medical evaluation of patients admitted to the Psychiatry service. The division has continued with
steady growth in its outpatient practice as the physicians in the group have established themselves as
excellent clinicians. One of the highlights of the outpatient practice is the JaxHATS (Jacksonville Health
and Transition Services) Clinics held on Tuesday and Thursday mornings. Dr. Linda Edwards, in
conjunction with Dr. David Wood, a general pediatrician, have established this clinic that provides a
medical home for adolescents and young adults with special health care needs who are transitioning
from their pediatricians to adult providers. In addition to these clinical activities, our geriatrician serves
as the medical director for Lakeside Nursing and Rehabilitation Center.

Education: The division provides faculty supervision of residents on the four general internal medicine
inpatient teaching services, inpatient medicine consultation service and geriatrics. The division also
provides faculty supervision and mentoring of all categorical medicine residents in their outpatient
continuity practice and urgent care clinics.

Dr. Jeff House was appointed the Program Director for the Internal Medicine residency program in the
Spring of 2010. Drs. Alexandraki and Palacio continued to serve as Associate Clerkship Director and
Clerkship Director for medical students from Gainesville who rotate on the Internal Medicine service
(inpatient and outpatient). Drs. Edwards, Alexandraki, Meenrajan and Palacio served as key clinical
faculty for the Core Training Program in Internal Medicine and are members of the Resident Education
Committee.

Drs. Alexandraki, Masri and Sottile serve as peer reviewers for the University of Florida Health Science
Center/Jacksonville faculty development program. Dr. Sottile also serves as a facilitator and is the co-
developer of the "Teaching Residents to Teach"-a 6-8 hour intradepartmental seminar offered each year
at the University of Florida Health Science Center/Jacksonville. This has now been expanded to include
subspecialty residents as well.

All members of the division participate in morning report and have presented at the noon conference
core curriculum series held daily as well as the Friday afternoon ambulatory didactic sessions and Board
review.

The division is also an integral part of the education program for 3rd and 4th year medical students from
the University of Florida. Our faculty serve as preceptors for students in both the inpatient setting a well
as in the outpatient practice. Student evaluations of their experience are excellent and are reflected in
the number of exemplary teacher awards given to faculty within the division.

Quality: Dr. Jeff House coordinates monthly M&M/QA for the training program. He serves as the Chair
of the Medical Performance Improvement Committee (MPIC) and reports to the Performance
Improvement Committee-the institutional body that oversees quality and safety for the Shands
Jacksonville campus. Dr. Manish Relan serves as the quality officer for the Division of GIM. The division


General Internal Medicine


Annual Report AY 2010


General Internal Medicine





Division Chief: Linda Edwards, MD


continues to participate and exceed CMS expectations for PQRI documentation in diabetes care
(measurement of Alc, LDL and BP). Dr. Relan is working with the hospital quality team to review and
assess our readmission rates and bounce backs.

Research: Research in the division varies among the faculty. Many of the faculty have mentored
residents in their research projects and have assisted them in submitting and being awarded grants from
the Dean's Fund for Research.


LISTING OF FACULTY MEMBERS


Irene Alexandraki, M.D., M.P.H., Assistant Professor
Medical School / Graduation date University of Athens, Greece
Internship/residency and year Hahnemann University Hospital
Subspecialty training and year Baylor College of Medicine (Infectious Disease)
Post-graduate training and year University of North Florida (Masters in Public Health)



Linda Edwards, M.D., Associate Professor, Associate Chairman and Division Chief
Medical School / Graduation date East Carolina University
Internship/residency and year Jacksonville Health Education Programs


1989
1998
2001
2009




1981
1985


Malcolm Foster, M.D., Professor
Medical School / Graduation date
Internship/residency and year
Subspecialty training and year




Alan Halperin, M.D., Professor
Medical School / Graduation date
Internship/residency and year


Bowman Gray School of Medicine
University of Florida, Gainesville
University of Florida, Gainesville (Infectious Disease)





University of Kansas
University of Wisconsin


1963
1966
1967





1971
1974






1997
2001






1989
1992
1994


Jeffrey House, D.O., Assistant Professor
Medical School / Graduation date Nova Southeastern College of Osteopathic Medicine
Internship/residency and year University of Florida Jacksonville





Ghania Masri, M.D., Assistant Professor
Medical School / Graduation date Damascus University, Syria
Internship and year Cleveland Clinic Foundation
Residency and year Case Western Reserve University


LLJ


Annual Report AY 2010 General Internal Medicine


General Internal Medicine


Annual Report AY 2010


General Internal Medicine





Division Chief: Linda Edwards, MD


r 7 1


Senthil Meenrajan, M.D. M.B.A, Assistant Professor
Medical School / Graduation date Madras Medical College, India
Internship/residency and year Robert Packer Hospital
Subspecialty training and year Oregon Health Sciences University (Geriatric Medicine)
Post-graduate training and year Canyon College (MBA: Healthcare Administration)



Carlos Palacio, M.D., M.P.H., Associate Professor
Medical School / Graduation date University of Miami
Internship/residency and year University of Florida, Jacksonville
Post-graduate training and year University of North Florida (MPH, Master of Public Health)




James Phillips, M.D., Assistant Professor
Medical School / Graduation date St. George's University, West Indies
Internship/residency and year University of Florida, Jacksonville





Pramod Reddy, M.D., Assistant Professor
Medical School / Graduation date Sri Dev Raj Urs Medical College, India
Internship/residency and year Stony Brook University Hospital





Manish Relan, M.D., Assistant Professor
Medical School / Graduation date Armed Forces Medical College, India
Internship and year Brookdale University Hospital
Residency and year Scranton Temple Residency Program




Elisa Sottile, M.D., Assistant Professor
Medical School / Graduation date Temple University School of Medicine
Internship/residency and year University of Pennsylvania


PUBLICATIONS

Textbook Chapters:
Alexandraki I, Contributing author "Commitment to Patient Confidentiality- Infectious Disease: A perspective from a General
Internist' chapter of the textbook "Professionalism in Medicine: A Case-Based Guide for Medical Students", Cambridge
University Press, New York, pages 273-275, 2010

Alexandraki I, Contributing author "Adrenal Glands", Endocrinology chapter (35), textbook "Rakel& Rakel, Textbook of Family
Medicine, 8th Edition', in press, Elsevier Publications, 2010

Monographs:
Palacio C. Rickets. BMJ publishing group point-of-care Website. (US product on epocrates.com).
Updated January 2010


General Internal Medicine


Annual Report AY 2010


General Internal Medicine


1997
2004
2005
2004




1993
1997
2007





2001
2005






1992
2000






1995
2000
2002





1993
1997





Division Chief: Linda Edwards, MD


Palacio C. Rickets. BMJ publishing group Best Practice Website.(International product on bestpractice.com)Updated
2010

Palacio C. (2008). 65-year old woman-Mrs Thompson. In SIMPLE: Simulated Internal Medicine Patient Learning
Experience Project eds. Berman and Fall. http://www.simplecases.ora. Updated January 2010

Palacio C, Fauzia R. Blast Crisis. BMJ publishing group point-of-care Website. (US product on epocrates.com) Updated
January 2010

Palacio C, Fauzia R. Blast Crisis. BMJ publishing group Best Practice Website. (International product on
bestpractice.com) Updated January 2010

Journals:
I. Alexandraki, A.D. Mooradian; Barriers Related to Mammography Use for Breast Cancer Screening Among Minority
Women. JNat/MedAssoc. 2010 Mar;102(3):206-218. PMID: 20355350

I. Alexandraki, A.D. Mooradian; Barriers Related to Mammography Use for Breast Cancer Screening Among Minority
Women. The Breast Cancer Network News for: Friday, March 5, 2010; http://www.thebcnnews.com/

I. Alexandraki, C. Palacio. Gram-negative versus Gram-positive bacteremia: what's more alarming? (invited
commentary) CritCare (in press) 2010

LN Dyrbye, AR Hollein, AJ Mechaber, K. O'Brien, M. Thomas, I. Alexandraki, K. Chang-Chretien, A. Shaheen, K. Engle,
C. Palacio, D. Torre, S. Pokala. Journal Watch from ACE (Alliance for Clinical Education): Annual review of Medical
Education Articles in Internal Medicine Journals, 2008-09. Teaching and Learning in Medicine (in press) 2010

JM Chehade, M Sheikh-Ali, I Alexandraki, J House, AD Mooradian. The Effect of Healthcare Provider Education on
Diabetes Management of Hospitalized Patients. IntJClin Pract. (in press, June) 2010

Livingood WC, Razaila L, Reuter E, Filipowicz, Butterfield, Lukens-Bull K, Edwards L, Palacio C, Wood DL. Using
Multiple Sources of Data to Assess the Prevalence of Diabetes at the Sub-County Level in Jacksonville, Florida, 2010.
Preventing Chronic Disease

Vu, H**, Vildor,E**, Reddy, S, Phillips, J, Meenrajan, S, Edwards, L, Hosenpud, Janet M.D. Case report: An
Unusual Presentation of Burkitt's Lymphoma. Southern Medical Journal Vol 102 Issue 9 2009: 961-962.

Halperin AK. Complementary and Alternative Medicine in the Management of Chronic Pain. In Jay: Clinician's Guide to
Chronic Headache and Facial Pain. Informa Healthcare USA, Inc. New York, NY. 2010; pp 208-218.

Zaiden R, Ohman T, House 3, Villas B, Rana F. Angioimmunoblastic T-cell lymphoma presenting as extensive psoriasis: a
case report and discussion. Community Oncology. 2010, Feb; 2(7):1-3.

Meenrajan S, House MedicalIllness During Travel -A Review, Northeast Florida Medicine. 2009: 60(4), 10-12.

Kahn M, Shaw A, House J. Symptomatic Hypermagnesemia Due to Oral Milk of Magnesia in the Absence of Renal
Failure, Northeast Florida Medicine. 2009, 60, No. 2.

House J. Postoperative Fever. BMJ publishing group point-of-care Website. January 2009 (US product on epocrates.com)

House J. Postoperative Fever. BMJ publishing group Best Practice Website. June 2009 (International product on
bestpractice.com)

Vega KJ, Palacio C, Lanqford-Leqq T, Watts J, Jamal MM. Gender variation in esophageal motor function: analysis of
129 healthy individuals. Digestive and Liver Disease. 2009 Dec 23. PMID: 20036202

House J, Concise review of Shoulder Pain in the Primary Care Setting. Accepted for publication.

Masri, Ghania MD, Phillips, James M. MD. Hyponatremia. BMJ Point of Care. September 2009;
www.pointofcare.bmi.com.


General Internal Medicine


Annual Report AY 2010


General Internal Medicine






Division Chief: Linda Edwards, MD


Reddy, Pramod MD. Clinical Approach to Renal Tubular Acidosis in Adult Patients. International Journal of Clinical
Practice. (Accepted for publication November 2009)

Mannepalli, S; Mitchell-Samon, L; Guzman, N; Relan, M; McCarter, YS: Mycobacterium tuberculosis osteomyelitis in a
patient with Human immunodeficiency virus / Acquired Immunodeficiency syndrome (HIV/AIDS) A clinical reminder.
Cases Journal 2010, 3:67

Abstracts/ Posters:
I. Alexandraki, J. Balls***, V. Kumar, K. Lukens-Bull, EA Zenni, D. Wood. Introducing Public Health to Internal Medicine
Residents through the Design and Implementation of an Obesity Case Module, University of Florida Medical Education
Week, Jacksonville, FL, April 2010

I. Alexandraki, C. Palacio, AD Mooradian. Impact of polypharmacy on medication adherence in low income African-
American patients, University of North Florida, Department of Public Health, Research Day, Jacksonville, FL, July 2009.

William Livingood, PhD, Luminita Razaila, MS, Elena Reuter, MPH, Rebecca Filipowicz, MPH, MS, CHES, Katryne Lukens-
Bull, MPH, Linda Edwards, MD, Carlos Palacio, MD, MPH and David L. Wood, MD, MPH Addressing diabetes
disparities through sub-county analysis of multiple data sources. Abstract 207698 Oral presentation 137th APHA Annual
Meeting (November 7-11, 2009) in Philadelphia, PA.


HONORS AND AWARDS


Irene Alexandraki, M.D.
Linda Edwards, M.D.


Malcolm Foster, M.D.


Alan Halperin, M.D.
Jeff House, D.O.
Ghania Masri, M.D.
Senthil Meenrajan, M.D.
Carlos Palacio, M.D.
Pramod Reddy, M.D.
Manish Relan, M.D.
Elisa Sottile, M.D.


University of Florida Exemplary Teacher Award 2010
President, Faculty Council HSC/Jacksonville
Louis S. Russo Award for Outstanding Professionalism 2009
Governor, Florida Chapter of the American College of Physicians
President Elect, Duval County Medical Society
Board of Directors, ACP Foundation, Vice-Chairman
University of Florida Exemplary Teacher Award 2010
Chair, Institutional Review Board, UF & SJMC
University of Florida Exemplary Teacher Award 2010
University of Florida Exemplary Teacher Award 2010
University of Florida Exemplary Teacher Award 2010
Vice-Chair, Institutional Review Board, UF and SJMC
University of Florida Exemplary Teacher Award 2010
University of Florida Exemplary Teacher Award 2010
University of Florida Exemplary Teacher Award 2010


CLINICAL ACTIVITIES

Inpatient Activity AY 09/10
Numbers of Inpatient Admissions 3060
Inpatient Days 18280
Average length of stay 5.97
Number of OBU Admissions 740
Number of SNU Admissions 740
Number of IP Consults 3029

Outpatient Activity
Clinic Visits 16827


Annual Report AY 2010 General Internal Medicine


General Internal Medicine


Annual Report AY 2010


General Internal Medicine





Hematology & Medical Oncology


DIVISION OF HEMATOLOGY & MEDICAL ONCOLOGY
ACADEMIC YEAR 2010 (7/09 6/10)


Highlights

The Division of Hematology & Medical Oncology continued its clinical and academic missions. The
division maintains an ACGME accredited Oncology fellowship training program and actively participates in
training internal medicine residents and medical students in inpatient and outpatient settings. Dr. Rana
coordinated a free Community Health Fair in collaboration with (APPNA) Association of Physicians of
Pakistani Descent of North Florida to provide blood sugar screenings, cholesterol screenings and blood
pressure checks. Free screenings and counseling were provided for breast, ovarian, cervical and prostate
cancers.

Each member of the division has a strong role in division activities. Dr. Fauzia Rana is Division Chief of
Hematology & Medical Oncology. Dr. Dat Pham continues his efforts in the Thoracic Oncology Program
and he is on the Quality Improvement Committee. He also works with the Proton Therapy Institute in
collaboration of patient care. Dr. Pham is also the Fellowship Director and continues to work closely with
the education of the fellows. Dr. Robert Zaiden is responsible for developing Multispecialty GI Cancer
Program. Dr. Zaiden is also involved in the teaching the residents and fellows. We have been successful
in hiring Dr. Naeem Latif as Assistant Professor of Medicine. Dr. Latif will join us in September 2010.

Patient care: The division continues to work closely with hematology-oncology leadership, and central
administration of the UF College of Medicine Gainesville, to coordinate the divisional mission with
growth and development of the Jacksonville Hematology/Oncology Program. This year we have already
seen a 10% increase in Analytic case data received from Tumor Registry. In July of 2009 Dr. Rana
expanded her outpatient clinic to the Emerson location. This is a Multidisciplinary clinic in conjunction
with the Breast Surgeon, Radiation Oncologist and Pathologist. With the hiring of additional faculty the
division will increase its ability to serve patients demands and to set a foundation for increasing patient
volume and to generate more revenue.

Education: The division continues to support the Internal Medicine Residency Program through
facilitation of morning report and noon conference core curriculum. The division offers a consult
experience in medical oncology to residents at all training levels. We have a weekly didactic lecture
series that gives fellows the opportunity to present cases to the faculty. Continuing support of education
to division fellows, we have a monthly Journal Club that generates discussion on various oncology
related topics throughout the year. There is a quarterly city wide joint conference between University of
Florida and Mayo Clinic of Jacksonville. This opportunity allows the fellows to present unusual cases. The
fellowship in medical oncology continues to prosper with all positions filled for July 2010 and 2011. Our
Fellowship Program has been granted accreditation for five years.

Research: The Division of Hematology& Medical Oncology is currently conducting 6 clinical trials. We
are planning to start about 5 new trials in near future. We have started collaboration with Mayo Clinic-
Jacksonville, Florida and will be conducting Cooperative Group clinical trials, besides retrospective and
prospective studies. Our PAL-2: A pilot study of the Palliative ARNP (Advanced Registered Nurse
Practitioner) Liaison Program (The PAL Program) intended to improve patients' quality of life through
targeted FACT-G driven palliative interventions study is now open to enrollment.


Annual Report AY 2010 Hematology/Oncology


Division Chief: Fauzia Rana, MD


Annual Report AY 2010


Hematology/Oncology






Hematology & Medical Oncology


LISTING OF FACULTY MEMBERS

Fauzia Rana, MD, Assistant Professor and Division Chief
Medical School / Graduation date Fatima Jinnah Medical College
Internship/residency and year University of Rochester New York
Subspecialty training and year Dana Farber Deaconess Hospital/Harvard


1982
1990
1993


Dat Pham, MD Assistant Professor
Medical School / Graduation date Uni
Internship/residency and year Uni
Subspecialty training and year Uni




Robert Zaiden, MD, Assistant Professor
Medical School / Graduation date Uni
Internship/residency and year Uni
Subspecialty training and year Uni


versity of Florida Jacksonville
versity of Florida Jacksonville
versity of Florida Jacksonville


versity of St. Matthews
versity of Florida Jacksonville
versity of Florida Jacksonville


PUBLICATIONS

Naeem Latif, MD, Fauzia Rana, MD, An unusual case of Primary Small Cell Neuroendocrine Carcinoma of the Breast, (In
Press) scheduled to be published in the 16(6) issue of the Breast Journal TBJ-00323-2009 single page, September 2010

Shah A.,_Woodcock J., Rana F., Olfactory Neuroblastoma with Hyponatremia: A Case Report, North East Florida Medicine,
Resident Research Edition of the Journal, Vol. 61, No. 2 2010, 25-26

Ankur Girdhar, Robert Zaiden, A 54-Year-Old Man with Right Opaque Hemithorax and Worsening Shortness of Breath,
Respiration 2010; 79: 157-159

Naeem Latif, MD, Fauzia Rana, MD, A Case Report of Hypereosinophilia and Sarcoma, Advances in Hematology and
Oncology, (Accepted), April 2010 to be published in December 2010

Jorge Cortes, Joseph O. Moore, Dat Pham, et al, "Control of plasma uric acid in adults at risk for tumor lysis syndrome:
Efficacy and safety of rasburicase alone and rasburicase followed by allopurinol compared with allopurinol alone: Results
of a multicenter phase III study." (Accepted) by Journal of Clinical Oncology in April 2010 for future publication

Naeem Latif, MD, Fauzia Rana, MD, The Pure Erythroleukemia: A Case Report and Literature Review, Clinical Advances in
Hematology & Oncology Volume 8, Issue 4, April 2010, 283-290

Hasan Riaz, MD, Naeem Latif, MD, Fauzia Rana, MD, Auto-Immune Hemolytic Anemia and Hodgkin's Disease, Advances
in Hematology and Oncology, (Submitted) March 2010

Naeem Latif, MD, Fauzia Rana, MD, Breast Cancer and HIV in the Era of Highly Active Antiretroviral Therapy (HAART):
The Breast Journal manuscript TBJ-00145-2010, (Accepted) March 2010, single page, to be published 2011

Naeem Latif, MD, Fauzia Rana, MD, and Troy Guthrie, MD, JAK2 mutation: impact on pathogenesis, classifications, and
management of myeloproliferative neoplasms, Community Oncology, Volume 7/Number 3, March 2010, 1-6


1997
2000
2002


2003
2007
2009


Division Chief: Fauzia Rana, MD


Annual Report AY 2010


Hematology/Oncology





Hematology & Medical Oncology


Robert Zaiden, MD, Taren Ohman, MD, Jeffrey House, DO, Bruce Villas, MD, Fauzia Rana, MD, Angioimmunoblastic T-cell
lymphoma presenting as extensive psoriasis: a case report and discussion, Community Oncology, Volume 7/ Number 2,
February 2010, 1-3

Mohammad A. Khan, MD, MRCP*; Atman Shah**, MD; Fauzia Rana, MD, An Unusual Case of Hepatitis and Polyserositis,
Northeast Florida Medicine, Vol. 60, No.4 Winter 2009, 35-36

Dimitrious P Agaliotis, MD, PhD, FACP, Consulting Staff, Department of Medicine, Baptist Health System, Robert Zaiden,
MD, Department of Hematology and Medical Oncology, University of Florida at Jacksonville; Saduman Ozturk, PA-C,
Physician Assistant, Bone Marrow Transplant Center, Florida Hospital Cancer Institute, Hemophilia, Overview, eMedicine,
Updated: Nov 24, 2009, http://emedicine.medscape.com/article/210104-print

Zaiden tR Rana F Monograph: Evaluation of Anemia, BMJ Best Practice, https://online.epocrates.com. Updated Nov. 6,
2009

Robert Zaiden, MD, Timmy Nguyen, MD, Fauzia Rana, MD, Large B-Cell Lymphoma, Consultant. Vol.4 No. 9, University of
Florida Health Science Center, Jacksonville I September 11, 2009, 593

Abstracts:
Naeem Latif, MD, Fauzia Rana, MD, Racial disparity in breast cancer in an inner-city academic institution, Annual Meeting
of the American Society of Clinical Oncology, June 4-8, 2010, single page, (Accepted), full-text versions of the publish-
only abstracts will appear on www.asco.ora and www.lco.ora in a fully searchable format.

Robert Zaiden, MD, Esophageal Carcinoma: Epidemiology and Pathogenesis, NE FL Med, Vol61 Nol Spring 2010, 10-12

Atman Shah, MD, Fauzia Rana, MD, Comparative study of the clinical and tumor characteristics in women with breast
cancer of different age groups, NE FL Medicine, Resident Research Edition of the Journal 2010, Vol.61 No. 2 2010, 19-20

R. Zaiden, F. Rana, UFCOM-JAX, Jacksonville, FL. A retrospective review of demographics and stage of presentation in
patients with ER/PR/HER2-NEU receptor negative (triple negative) breast cancer, 2009 Breast Cancer Symposium,
October 8-10, 2009, single page

S.L. Hines, F. Rana, R.B. McNeil, J. Peterson, L. Vallo, W. Tan; Mayo Clinic Florida, Jacksonville, FL; Univ of Florida,
Jacksonville, FL. Survival differences by ethnicity in triple negative breast cancer and brain metastases. 2009 Breast
Cancer Symposium, October 8-10, 2009, single page

R Zaiden, MD, D Pham, MD, Chemotherapy for Metastatic Colorectal Cancer, NE FL Med, Vol60 Nol, Spr 2009, 22-23

Presentations:
Fauzia Rana, MD, Naeem Latif, MD, HIV and Breast Cancer, University of Florida Research Day 2010, Abstract
Presentation

Fauzia Rana, MD, Naeem Latif, MD, Neoadjuvant Chemotherapy in Triple Negative Breast Cancer, University of Florida
Research Day 2010, Abstract presentation

How to work up a patient with Coagulation Disorders, Fatima Jinnah Medical College, Lahore, Pakistan, 2010

Fauzia Rana, MD, Neoadjuvant Treatment for Breast Cancer presentation for Mayo Clinic Annual Hematology/Oncology
Board Review, July 2009

Case discussion Breast Cancer, 8th Shaukat Khanum Memorial Hospital Symposium, Lahore, Pakistan, 2009


CLINICAL ACTIVITIES


Annual Report AY 2010 Hematology/Oncology


Inpatient Activity AY 09/10
Numbers of Inpatient Admissions 736
Outpatient Activity AY 09/10
Clinic Visits 5710


Division Chief: Fauzia Rana, MD


Annual Report AY 2010


Hematology/Oncology





Hematology & Medical Oncology


CONTRACTS AND GRANTS


Principal Sponsor Title Project Total
Investigator Period Direct Cost
Pham, Dat Eli Lilly Non-small cell lung cancer: the impact of ethnic origin on patients 03/30/09- $4,500.00
and being treated second line with pemered an observational study 05/14/10
Company

Pham, Dat Amgen Prospective Multi-national Observational Study to Assess Health 05/05/09- $450.00
Inc. Resource Utilization Associated with Skeletal Related Events in 05/30/10
Patients with Bone Metastases Secondary to Breast, Prostate, or Lung
Cancer, or Multiple Myeloma.

Pham, Dat GlaxoSmit A double-blind, randomized, placebo-controlled Phase III study to 04/23/07- $6,405.00
hKline assess the efficacy of recMAGE-A3 + AS15 Antigen-Specific Cancer 06/20/10
Biologicals Immunotherapeutic as adjuvant therapy in patients with resectable
S.A. MAGE-A3-positive Non-Small Cell Lung Cancer
(GSK)

Rana, Fauzia Johnson & A Randomized, Double-Blind, Placebo Controlled, Multicenter Study 5/17/09- $3,350.00
Johnson Evaluating Epoetin Alfa Initiated at 40,000 IU 4/17/10

Rana, Fauzia Wyeth A Phase 3 Randomized, Open Label Study of Neratinib Versus 3/31/09- $4,555.00
Lapatinib Plus Capecitabine for the Treatment on ErbB 2 Positive 3/26/10
Locally Advanced or Metastatic Breast Cancer.

Rana, Fauzia Celator PHASE IIb, Multicenter, Randomized, Open-label Trial of CPX-351 4/13/09- $508.00
Pharmace (Cytarabine:Daunorubicin) Liposome Injection Versus Intensive 4/28/10
uticals Inc Salvage Therapy in Adult Patients 560 Years Old with AML in First
Relapse Following an Initial CR >1 Month Duration

Rana, Fauzia Celator Phase IIB, Multicenter, Randomized, Open Label, Trial of CPX-351 4/13/09- $4,375.00
Pharmace (Cytarabine:Daunorubicin) Lipsome Injection versus cytarabine and 4/28/10
uticals Inc daunorubicin in patients with untreated AML

Rana, Fauzia Incyte A rdmzd. Dbld-bind, placebo controlled study of the jak inhibitor 5/27/09- $7,747.00
Corp. INCB018424 table admin orally to subjects with primary myelofibrosis 7/9/10

Rana, Fauzia University A Phase II Trial of Preoperative Capecitabine Plus Cisplatinum in 10/14/08- $10,000.00
of Florida Early Stage ER -, PR -, HER-2 Negative Breast Cancer 10/14/09

Rana, Fauzia Millenium A two arm non randomized multicenter phase 2 study of velcade 9/21/09- $4,408.00
(bortezomib) in combination with Rituximab, Cyclophosphamide, and 9/8/10
Prednisone with or without Doxorubicin followed by Rituximab
Maintenance in Patients with Relapsed Follicular Lymphoma

Rana, Fauzia Millenium Randomized phase 3B study of 3 treatment regimens in subjects with 5/14/08- $11,845.00
previously untreated multiple myeloma are not considered 4/8/10
candidates for high-dose chemotherapy and autologous stem cell
transplantation


Annual Report AY 2010 Hematology/Oncology


Division Chief: Fauzia Rana, MD


Annual Report AY 2010


Hematology/Oncology





Division Chief: Michael Sands, MD


DIVISION OF INFECTIOUS DISEASES
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The Division of Infectious Diseases continued its clinical and academic missions during this past year.
The division is comprised of 4 infectious diseases consultants, all of whom are dually boarded in internal
medicine and infectious diseases; 1 Nurse research coordinator and 1 travel medicine nurse. The division
provides clinical consultation in infectious diseases at the Shands Hospital/Jacksonville, Hospital Infection
Control direction of Shands Hospital, transplantation infectious diseases consultation at Shands,
outpatient travel and tropical medicine services, outpatient infectious diseases consultation, and clinical
infectious diseases research. The Division maintains an ACGME accredited Infectious Diseases fellowship
training program and actively participates in the training of internal medicine residents and medical
studies in inpatient and outpatient infectious diseases. The Division had a contract with the Duval County
Health Department (DCHD) to provide professional consultation and programmatic direction for their
HIV/AIDS, TB and STD programs and clinical care to the counties' HIV/AIDS, TB and STD patients in
DCHD specialty clinics.

Each member of the division has a strong administrative role in division activities. Dr. Sands is the
university ID Division Chief, has been the acting Medical Director of Communicable Diseases for Duval
County Health Department and ID Division Fellowship Program Director. Dr. Vandevelde directed the
Travel Medicine section. Dr. Guzman is the Chair of Hospital Infection Control for Shands Hospital, the
Division Research Director and ID Fellowship Associate Program Director. Dr. Bailey is the Associate
Program Director for the University Core Internal Medicine Residency and has been the Director of the
DCHD STD and Refugee Health sections.

Patient care:
University ID Division inpatient and hospital based activity: The division provides full time infectious
consultation throughout the Shands/Jacksonville Hospital system. During the 2009-20010 academic year,
the division performed over 748 inpatient infectious diseases consultations with subsequent follow-up at
Shands Hospital. This represented a 23% increase in in-patient consultations.

Outpatient services: The division offers outpatient ID consultation by referral at the Emerson and ACC
clinics. During the 09-10 academic year there were over 350 outpatient ID consultative visits,
representing a 38% increase in outpatient consultation volume. Travel medicine services are provided
three time per week for overseas travelers at the Faculty Clinic. Over 510 travel patients were seen
during the academic year.

Under contract with the DCHD, the division provided professional and administrative oversight and care
for the HIV/AIDS, TB, STD and refugee screening clinical services seen at the DCHD specialty clinics.
During the 09-10 academic year, ID division physicians delivered or over-sighted the care for over 2,600
HIV/AIDS patients, 5500 STD visits, 980 refugee visits and over 1700 TB visits at DCHD specialty clinics.

Education:
Grand Rounds: The division actively participates both presenting at Medical Grand Rounds and are
regular attendees. This academic year faculty gave presentations at 4 UF Grand Rounds, 1 Baptist
Medical Center Grand Rounds and 1 topical lecture at the Internal Medicine Annual Update.

Fellowship Training: The division maintains an ACGME accredited fellowship in infectious diseases with
one fellow for each of the 2 clinical fellowship years. The fellowship program had an accreditation
inspection during this past academic year and has been re-accredited on a 5 year cycle. The fellowship
training is unique in offering 2 months of clinical microbiology, dedicated research time, 2 months of
training in solid organ transplantation ID at the Mayo Clinic, 1 month training in Pediatric Infectious


Infectious Diseases


Annual Report AY 2010


Infectious Diseases





Division Chief: Michael Sands, MD


Diseases at Wolfson Childrens' Hospital and 1 month as a junior ID faculty consultant in the Shands
MICU, in addition to 15 months experience as the consult and teaching fellow on the general ID in-
patient consult service at Shands.

Our 07-09 year's Infectious Diseases fellow passed her Infectious Diseases boards and is in a full time
infectious diseases practice in the Atlanta area. Our recent graduating fellow (08-10) distinguished
herself by publication of 2 ID monographs, a journal article, selection for oral presentation of an ID case
at the Infectious Diseases Society of America's (IDSA) annual national/international meeting,
presentation of a UF Grand Rounds, selection for a specialty training fellowship month in non-
tuberculous mycobacteria at Denver Jewish Hospital and scoring in the 90th percentile on the national ID
in-service training examination. She relocated to San Francisco to join a south bay ID practice.

Resident Training: Faculty provided noon ID core curriculum conferences for the residents, ID
consultation teaching rounds, outpatient HIV/AIDS continuity clinics and resident ID board review
sessions.

Medical Student Education: Dr. Guzman presented the HIV/AIDS core content conference for UF medical
students by teleconference with UF Gainesville. Medical student rotate on the infectious diseases
consultative service.

ID Division Conference Schedule: The division maintained a full conferencing schedule with ongoing
meetings Monday and Thursday noon. Conference topics included: regularly scheduled case
conferences, ID board reviews, monthly journal club, HIV topical reviews, monthly TB cases and topical
reviews, monthly research conferences, travel and tropical medicine conferences, transplantation ID
conferences, and monthly Med/Peds ID joint conferences.

Cooperative extramural resident and fellows' training: As part of their curricula, Mayo Clinic ID fellows,
UF Intensivist fellows, UF Pediatric ID fellows and UF Podiatric-Orthopedic residents rotated on the UF ID
inpatient consultative service and in the HIV outpatient clinics.

Research: Drs Guzman and Bailey served as members of the University of Florida/Jacksonville
Institutional Review Board. The division has been responsible for performance of components of federal
and state categorical grants awarded to the DCHD for TB, HIV, refugee and STD care and epidemiologic
services. These grants are in excess of $6.5 million. Additionally the division has been instrumental in
acquiring and directing a federal Ryan White Title 3 grant of $300,000 annually for improved community
based access to care, that provides HIV/AIDS care to 250 indigent patients not otherwise brought into
care or previously lost from case.

UF research and scholarly writing included: 3 abstracts presented at UF Research Day, 2 abstracts
presented at national and statewide meetings, 1 ID monograph, 14 journal articles accepted for
publication, 7 externally funded research protocols and 1 internally developed research protocol.
Externally funded protocols include an NIH sponsored INSIGHT network observational study of pandemic
Influenza H1N1 complications.

LISTING OF FACULTY MEMBERS

SChristina Bailey, MD, Assistant Professor
Medical School / Graduation date University of Texas Health Science Center, Houston, TX 1995
Internship/residency and year University of Florida Department of Medicine, Jacksonville, FL 1998
Subspecialty training and year University of Florida Department of Medicine, Jacksonville, FL 2000


'IUJ


Annual Report AY 2010 Infectious Diseases


Infectious Diseases


Annual Report AY 2010


Infectious Diseases





Division Chief: Michael Sands, MD


Nilmarie Guzman, MD, Assistant Professor
Medical School / Graduation date Ponce School of Medicine, Ponce, PR 1996
Internship/residency and year Damas Hospital, Ponce, PR 1999
Subspecialty training and year University of Florida Health Science Center, Jacksonville, FL 2006





Michael Sands, MD, MPH&TM, FIDSA, Associate Professor and Division Chief
Medical School / Graduation date Georgetown University, Washington, DC 1972
Internship/residency and year St. Mary's Hospital, San Francisco, CA 1974
Subspecialty training and year Tulane University School of Public Health& Tropical Medicine, 1975
New Orleans, LA (MPH&TM)
Louisiana State University School of Medicine, New Orleans, LA 1977
(Infectious Diseases)
Northwestern Memorial Hospital, Dept. of Pathology, Clinical 1981
Microbiology Section (Clinical Microbiology)

Alexander Vandevelde, M.D., Associate Professor
Medical School / Graduation date University of Louvain Medical School, Belgium 1963
Internship/residency and year St. Vincent's Medical Center, Jacksonville, FL 1964
University Medical Center, Jacksonville, FL 1969
Subspecialty training and year University of Florida Medical School, Gainesville, FL 1971




PUBLICATIONS
Monograph:
Palnitkar R and YS McCarter. New algorithms for the laboratory diagnosis of Clostridium difficile. American Society for
Clinical Pathology LabQ, American Society for Clinical Pathology Press, Chicago, IL. (Manuscript in press)

Journal Publications:
Supriya Mannepalli, Levonne Mitchell-Samon, Nilmarie Guzman, Manish Relan and Yvette S McCarter. Mycobacterium
tuberculosis osteomyelitis in a patient with human immunodeficiency virus/ acquired immunodeficiency syndrome
(HIV/AIDS): a case report. Cases Journal 2010, 3:67 (23 February 2010)

M. Sands. Travel medicine as an evolving specialty. Northeast Florida Medicine 2009;60:9.

Guzman N. Vaccinations for travelers. Northeast Florida Medicine 2009; 60:13-17.

Bailey C, Vandevelde A. Travelers' Diarrhea. Northeast Florida Medicine 2009; 60:18-22.

Palnitkar R. An update on malaria and insect avoidance. Northeast Florida Medicine 2009; 60:23-26.

Duprez DA, Kuller LH, Tracy R, Otvos J, Cooper DA, Hoy J, Neuhaus J, Paton NI, Friis-Moller N, Lampe F, Liappis AP,
Neaton JD for the INSIGHT SMART Study Group including Sands M. Lipoprotein particle subclasses, cardiovascular
disease and HIVinfection. Atherosclerosis 2009; 207(2):524-9.

Grund B, Neuhaus J, Phillips A for the INSIGHT SMART study group including Sands M Relative risk of death in the
SMARTstudy (letter). Lancet 2009; 9:724-5.

Rodger AJ, Fox Z, Lundgren JD, Kuller LH, Boesecke C, Gey D, Skoutelis A, Goetz MB, Phillips AN for the INSIGHT SMART
Study Group including Sands M. Activation and coagulation biomarkers are independent predictors of the development of
opportunistic disease in patients with HIV infection. J Infect Dis 2009; 200(6):973-83

Dore GJ, Soriano V, Rockstroh J, Kupfer B, Tedaldi E, Peters L, Neuhaus J, Puoti M, Klein MB, Mocroft A, Clotet B,
Lundgren JD for the SMART INSIGHT Study Group including Sands M Frequent hepatitis B virus (HBV) rebound among
HIV HBV coinfected patients following antiretroviral therapy interruption in the SMART study. AIDS 2010;24:867-65


Infectious Diseases


Annual Report AY 2010


Infectious Diseases





Division Chief: Michael Sands, MD


Lampe FC, Duprez DA, Kuller LH, Tracy R, Otvos J, Stroes E, Cooper DA, Hoy J, Paton NI, Friis-Moller N, Neuhaus J,
Liappis AP, Phillips AN for INSIGHT SMART Study Group including Sands M. Changes in lipid and lipoprotein particle
concentrations following interruption of antiretroviral therapy: a SMART sub-study. J Acquir Immun Defic Synd
2010;54:275-84

Neuhaus J, Jacobs Jr. DR, Baker JV, Calmy A, Duprez D, La Rosa A, Kuller LH, Pett SL, Ristola M, Ross MJ, Shlipak MG,
Tracy R, Neaton JD for the INSIGHT SMART including Sands M, MESA and CARDIA Research Groups. Markers of
inflammation, coagulation and renal function are elevated in adults with HIV infection. J Infect Dis 2010;201:1788-95

Neuhaus J, Angus B, Kowalska JD, La Rosa A, Sampson J, Wentworth D, Mocroft A for SMART including Sands M and
ESPRIT Study Groups. Risk of all-cause mortality associated with non-fatal AIDS and serious non-AIDS events among
adults infected with HIV. AIDS 2010;24:697-706

Abstracts presented at meetings:
Nilmarie Guzman, MD, Multiple co-authors from CDC. UF &Shands. and other Jacksonville area hospitals. Prevalence of
Healthcare-Associated Infections in Acute Care Hospitals in Jacksonville, FL. Fifth Decennial Society for Healthcare
Epidemiology in America Meeting in Atlanta, GA March 2010

Christina Bailey, Michael Sands. IDSA (Infectious Diseases Society of America) Poster presentation Neisseria gonorrhea in
an Era of Inceasing Antimicrobial Resistance Oct 2009, Philadelphia

Bailey C. et al. STD National Conference. Poster: Community-Based STD Clinic for LGBT Youth (13-23)- A Collaberative
Approach that finds high rates of positivity Oct 2009 Atlanta

CLINICAL ACTIVITIES


Inpatient activity AY 09/10
Consults 750
Outpatient activity
UF Travel Medicine 510
ID Consultation Clinic 350
DCHD HIV/AIDS patients 2600
STD visits 5500
Refugee visits 980
TB visits 1700


GRANTS AND CONTRACTS
Principal Sponsor/Title
Investigator
Guzman CEFTO-SSK-4001 A prospective, multi-center, observational registry involving patients hospitalized with
complicated skin and soft tissue infections (cSSTI) for IV antibiotic therapy
Guzman Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Two- Stage Study to Assess the Efficacy and
Safety of Crofelemer 125mg, 250mg, and 500mg Orally Twice Daily for the Treatment of HIV-Associated
Diarrhea (ADVENT Trial) (NP303-101)
Guzman CDC sponsored Jacksonville Healthcare-Associated Infections Prevalence Survey 2009
Guzman A prospective, multicenter, investigator-blinded, randomized, comparative study to estimate the safety,
tolerability and efficacy of NXL104/ceftazidime vs. imipenem cilastatin followed by appropriate oral therapy in
the treatment of complicated urinary tract Infections in hospitalized ( adultsNXL104/2001)
Guzman A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of
Ritonavir-Boosted Elvitegravir (EVG/r) Versus Raltegravir (RAL) Each Administered With a Background Regimen
in HIV-1 Infected, Antiretroviral Treatment-Experienced Adults" (GS-US-183-0145)
Guzman The SWIFT Study: A Prospective, Randomized, Open-Label Phase IV Study to Evaluate the Rationale of
Switching from Fixed-Dose Abacavir (ABC)/Lamivudine (3TC) to Fixed-Dose Tenofovir DF (TDF)/Emtricitabine
(FTC) in Virologically-Suppressed, HIV-1 Infected Patients Maintained on a Ritonavir-Boosted Protease
Inhibitor-Containing Antiretroviral Regimen (GS-US-164-0216)
Sands An International Observational Study to Characterize Adults Who are Hospitalized with Complications of
Influenza A Pandemic H1N1A Multicenter NIH sponsored Study of the International Network for Strategic
Initiatives in Global HIV Trials (INSIGHT) (FLU 003 Study)


Infectious Diseases


Annual Report AY 2010


Infectious Diseases





Division Chief: N. Stanley Nahman, Jr., MD


DIVISION OF NEPHROLOGY AND HYPERTENSION
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The graduation of the first Nephrology Fellow Class included two fellows, both of whom passed their
ABIM Nephrology Board Exam in the Fall of 2009. In addition, this year brought the hiring of Dr. Minghui
Xiang as Assistant Professor in Research, from Johns Hopkins University. Dr. Xiang recently received
four years of research funding from the American Heart Association to investigate a sodium/hydrogen
transporter he cloned and its potential role in hypertension. Other new recruits this summer included Dr.
Ashwani Gupta as Assistant Professor and Dr. Leighton James as Associate Professor. Dr. Gupta has
clinical research training in the anemia of end stage renal disease under Dr. Anthony Beserab, an
internationally recognized clinical researcher in this field. Dr. Gupta's contributions will enhance the
clinical research effort in the Nephrology Division. Dr. James is a nationally recognized diabetes
researcher from the University of Texas, Southwestern, and will also make substantial contributions to
the teaching program for the fellows. Dr. Stanley Nahman was awarded an Exemplary Teacher Award
this year for his efforts with the residents. Finally, University of Florida Hero Awards for clinical care were
received by Dr. Victor Lopez de Mendoza and Dr. Charles Heilig. Dr. Stanley Nahman and Dr. Gil Cu
moved to other institutions/practices toward the end of the year and Dr. Charles Heilig was named the
new chief of the division.

Fistula First Program: In conjunction with Dr. Bruce Sommer of the Surgery Dept., this project has led
to substantial improvement in the percentage of hemodialysis patients who dialyze with an arterio-
venous fistula (the preferred access) as opposed to use of a catheter or an A-V graft for dialysis. The
percentage of our HD outpatients at Shands Jacksonville dialyzing with a native A-V fistula (the preferred
access) has been 32 36% during this academic year. In comparison, only 17% dialyzed with a native
A-V fistula in 2007 prior to initiation of the Fistula First Program here.

Hemodialvsis Quality Improvement Initiative for Nephroloav Fellows. Analysis and management of
dialysis adequacy and anemia in ESRD patients on hemodialysis. This project is ongoing for the fellows.

Nephroloav & Hypertension Year/l Update, Jacksonville, FL.: This year's meeting organized by the UF-
Jacksonville Division of Nephrology was held at the Hyatt Regency Hotel in Jacksonville with good
attendance from local healthcare professionals. This yearly meeting provides education and CME credits
for doctors, nurses and others involved in the care of patients with renal disease.

Noninvasive Assessment of Dialysis Access Blood Flow Rates: Development in progress, led by Dr.
Ronald Mars. Serial assessments of dialysis access blood flow rates will be used to detect anatomic
problems which can be managed preemptively to avoid clotting and loss of valuable fistulas & grafts.
This monitoring is also important to maintain compliance with current dialysis management
recommendations from Medicare.

Simulation Laboratory Experience: Future fellow training experiences to be arranged with the Dept. of
Medicine for intravascular line placement and renal biopsy.

Faculty Recruitment: Dr. Minghui Xiang arrived in January 2010 from Johns Hopkins University. He is a
PhD researcher with a background in physiology and molecular biology. He recently cloned a new
sodium-hydrogen antiporter which he is investigating in the pathogenesis of hypertension. Dr. Xiang
was awarded a new 4-year American Heart Association Grant to pursue his investigations. Two
additional new faculty members arrived this summer: Dr. Ashwani Gupta from Henry Ford Hospital in
Detroit, now an Assistant Professor, and Dr. Leighton James from the University of Texas-Southwestern
in Dallas, now an Associate Professor. Dr. Gupta will develop a clinical research program. Dr. James will


Nephrology and Hypertension


Annual Report AY 2010


Nephrology and Hypertension





Division Chief: N. Stanley Nahman, Jr., MD


continue to pursue his basic science studies into the pathogenesis of diabetic kidney disease in the
Nephrology Laboratories here.

Patient Care: The Nephrology Clinical Services remain very busy, with a hemodialysis population of
nearly 300 patients cared for by the UF-Jacksonville Nephrology Division. There are two outpatient
hemodialysis units, plus a Peritoneal Dialysis Clinic which serves approximately 30 patients. The
outpatient dialysis units are located at Shands Jacksonville & at the Gateway Dialysis Unit in Jacksonville.
Clinics at Shands Jacksonville include General Nephrology Clinics, an Anemia Clinic, a Vascular Access
Clinic, Transplant Clinic, Fellows Continuity Clinic, and a Correctional Facility Clinic (CFC). In addition
there is a busy inpatient Consult Service with a running census of 35-50 patients. UF-Jacksonville
physicians have cared for an increasing population of patients with renal disease over the last 15 years.

Education: ACGME accreditation was approved for the Nephrology Fellowship Program for four more
years. There are two new fellows each year, with a 2-year fellowship program. The Division presents all
the ACGME-required clinical education topics for the fellows. The University of Florida-Jacksonville
Nephrology Fellowship Program continued its Transplant Service rotation for the senior fellows at Mayo
Jacksonville, and this rotation has received very positive feedback from both institutions. This year's
Tisher Visiting Professor Lecture was given by Dr. Paul Klotman, Chairman of Medicine at the Mt. Sinai
School of Medicine. He gave lectures at both UF campuses and had lively interactions with the faculty
and fellows who presented their most recent research studies and cases. In addition, the yearly
University of Florida Jacksonville Nephrology & Hypertension Update for the Jacksonville community
was held at the Hyatt Hotel in 2/2010. It was well attended by physicians, fellows, nurses and allied
health professionals who also obtained CME credits. Outside meetings attended by the fellows included
the American Society of Nephrology, the National Kidney Foundation, the American Federation for
Medical Research and Peritoneal Dialysis (PD) University. The senior Nephrology Fellows attended PD
University which provides them with an extensive overview of the current management of peritoneal
dialysis patients, and with valuable information for their Nephrology Board Exam. All the Nephrology
Fellows participate in the American Society of Nephrology In-Training-Exam (ITE) which helps them
identify areas for additional study. In addition, a Harvard (BWH) Board Review Course on CD's is
available in the Division for the fellows to prepare for the ABIM Nephrology Board Exam. Finally, the
faculty attend and/or speak at development conferences on campus, and at local or national meetings,
including the American Society of Nephrology, American Federation for Medical Research and National
Kidney Foundation.

Research: The Nephrology Division produced 9 publications and 9 Abstracts/Presentations, with 7
Grants and Contracts active this year. The topics of the research studies spanned from clinical research
studies on infections and anemia in dialysis patients, to glucose transporter roles in renal disease, to the
pathogenesis of cancer. Although Dr. Virginia Urquidi moved her laboratory to the Memorial Sloan
Kettering Cancer Institute/Orlando, the Division recruited Dr. Minghui Xiang as Assistant Professor from
the Johns Hopkins University who specializes in kidney & hypertension research. Dr. Xiang's new
funding from the AHA began 7-1-2010. Dr. Ashwani Gupta arrived in the Nephrology Division 7-1-10
from Henry Ford Hospital and will conduct research on the anemia of dialysis patients. This will provide a
substantial boost to the clinical effort. Dr. Leighton James arrived 8-1-10 and has worked on CTGF in
diabetic nephropathy. He will also work on diabetes research with Dr. Heilig. Dr. Heilig's lab focuses on
glucose transporter regulation of glomerulosclerosis, and more recently on a potential role for Mechano -
Growth Factor (MGF) in diabetic kidney disease. The Nephrology fellows rotate through the basic
science labs as part of their research training.


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Division Chief: N. Stanley Nahman, Jr., MD


LISTING OF FACULTY MEMBERS


Gil Cu, MD, Assistant Professor
Medical School / Graduation date
Internship/residency and year
Subspecialty training and year



Charles Heilig, MD, Professor
Medical School / Graduation date
Internship/residency and year
Subspecialty training and year


University of the Philippines
Lutheran Medical Center, NY
Beth Israel Medical Center, NY




University of Minnesota
Mayo Clinic Rochester
Brigham and Women's Hospital, Harvard University


Ronald Mars, MD, Associate Professor
Medical School / Graduation date St Louis University
Internship/residency and year Emory University
Subspecialty training and year Emory University




N. Stanley Nahman, Jr, MD, Professor and Divison Chief
Medical School / Graduation date Medical College of Ohio
Internship/residency and year Presbyterian Hospital Denver, Mt Carmel Health, Columbus
Subspecialty training and year The Ohio State University




Haritha Sakhamuri, Ph.D., Assistant Professor
Medical School / Graduation date PSG Institute of Medical Sciences/India
Internship/residency and year University of Florida/Shands Jacksonville
Subspecialty training and year University of Florida/Shands Jacksonville




Virginia Urquidi, PhD, Research Associate Professor
Graduate School and year University of Bilbao, Spain
PhD Oxford University, UK
Post-doctoral training Oxford University, UK




Minghui Xiang, PhD, Research Assistant Professor
M.S. Arizona State University
Ph.D. Arizona State University
Postdoctoral training Johns Hopkins University School of Medicine


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Division Chief: N. Stanley Nahman, Jr., MD


PUBLICATIONS

Vesely E, Heilig C, Brosius III F. GLUT1 Induced cFLIP Expression Promotes Proliferation and Prevents Apoptosis in
Vascular Smooth Muscle Cells. Am. J. Physiol. Cell Physiol. 297(3): C759-65, 2009.

Wang Y, Heilig K, Minto A, Chen S, Xiang M, Dean D, Geiger R, Chang A, Pravtcheva D, Schlimme M, Deb D, Wang Y,
Quigg R, Heilig C. Nephron-Deficient FVB Mice Develop Rapidly Progressive Renal Failure & Heavy Albuminuria Involving
Excess Glomerular GLUT1 & VEGF. [E-Pub ahead of print, 11-16-09]. Laboratory Invest. 90(1): 83-97, 2010.

Wang Y, Heilig K, Chen S, Xiang M, Brosius F, Heilig C. Transgenic Overexpression of GLUT1 in Glomeruli Produces
Features of Diabetic Glomerulosclerosis. Am J Physiol Renal Physiol. 2010 Jul;299(1):F99-F111. Epub 2010 Apr 7.

Zhang H, Schin M, Saha J, Burke K, Holzman L, Filipiak W, Saunders T, Heilig C, Brosius III F. Podocyte Specific
Overexpression of GLUT1 Surprisingly Reduces Mesangial Matrix Expansion in Diabetic Nephropathy in Mice. Am J
Physiol Renal Physiol. 2010 Jul;299(1):F91-8. Epub 2010 Apr 7.

Reddy S, Sullivan R, Zaiden R, Lopez V, Naik N, Vega K, Nahman Jr NS, Alexandraki I: Hepatitis C infection and the risk
of bacteremia in hemodialysis patients with tunneled vascular access catheters. SMedJ, 102:374-377, 2009.

Schushan M, Xiang M, Bogomiakov P, Padan E, Rao R, and Ben-Tal N. Model-guided mutagenesis drives functional
studies of human NHA2, implicated in hypertension. Journal of Molecular Biology 396 (5): 1181-1196, 2010.

Goodison S, Rosser CJ, Urquidi V. Urinary proteomic profiling for diagnostic bladder cancer biomarkers. Expert Rev
Proteomics. 6(5):507-14, 2009.

Sakai Y, Goodison S, Cao W, Urquidi V, Namiki K, Porvasnik S, Urbanek C, Rosser CJ. VEGF induces expression of Bcl-2
and multiple signaling factors in microvascular endothelial cells in a prostate cancer model. World J Urol. Oct;27(5):659-
66, 2009. Epub 2009 Jun 4.

Sun Y, Urquidi V, Goodison S. Derivation of molecular signatures for breast cancer recurrence prediction using a two-
way validation approach. -Breast Cancer Res Treat. Feb;119(3):593-9, 2010. Epub 2009 Mar 17.

Abstracts and Presentations:
Barrios C, Rodriguez E, Wysocki J, Rodriguez-Pacheco F, Ye M, Kalea A. Heilig C, Batlle D. Glut-1, ACE2 and Angiotensin
II Degradation in Mesangial Cells. Circulation (abstr.), 2009.

Batlle D. et al. ACE and ACE2 glomerular expression in GLUT 1 over-expressing transgenic mice, a model of "local
glomerular diabetes." JASN (abstr.), 2009.

Deb D, Heilig K, Nahman NS, Heilig C. Prevention of diabetes-induced signaling agent and matrix expression by
glomerular antisense GLUT1 in vivo and by mesangial cell antisense-GLUT1 and quercetin treatment in vitro. American
Society of Nephrology, JAmer Soc Nephrol, 2009.

Sakhamuri H, Sullivan R, Foldesi-Freeman A, Masnita C, Wludyka P, Nahman Jr NS, Heilig C. Effects of above goal
hematocrit levels in a hemodialysis population Submitted. American Society of Nephrology, JAmer SocNephrol., 2009.


HONORS AND AWARDS

Minghui Xiang AHA Research Grant 4y 2010

C Heilig University of Florida Heroes Award 2010

NS Nahman, Jr Exemplary Teacher, UF College of Medicine 2009


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Division Chief: N. Stanley Nahman, Jr., MD


CLINICAL ACTIVITIES


Inpatient Activity FY 09/10

Initial IP Encounters Billed (IDX)** 1132
Inpatient Dialysis Services (IDX) 3843
**This count includes all IP admissions and IP consultations to accommodate the coding changes with CMS**
Outpatient Activity
Clinic Visits (IDX) 3667
Outpatient Dialysis (Full Month) (IDX) 2691




GRANTS AND CONTRACTS

Principal Sponsor/Title Project Total direct
Investigator period costs
Heilig C Dialysis Clinic Inc / Mechanisms of GLUT 1-induced glomerulosclerosis 10/08 $436,733
(projects C-2957 and C-3000) 8/12
Urquidi V Florida Breast Cancer Coalition Research Foundation 2009-2010 $75,000
Urquidi V The PRAME gene in Tumor Progression
Urquidi V NCI-NIH/ Identification and functional analysis of metastasis proteins 9/04-8/09 $1,250,000
Urquidi V NCI-NIH/Towards a non-invasive molecular test for bladder cancer 9/07 8/12 $1,450,000
Urquidi V University of Florida Dean's Fund Faculty Research Grant/ The role of MMP8 8/07 9/10 $30,000
protein isoforms in migration and invasion capabilities of breast cancer cells
Nahman J, NS Dialysis Clinic Inc/Update in Nephrology & Hypertension 2/10 $20,000
Sommer B, Fistula first program/Dialysis Clinic Inc 3/07 2/10 $225,000
Nahman Jr NS
(Co-PI)


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Pulmonary, Critical Care and Sleep Medicine


DIVISION OF PULMONARY, CRITICAL CARE AND SLEEP MEDICINE
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The Division of Pulmonary, Critical Care and Sleep Medicine has had a productive year with addition of 2
new faculty members (Dr. Adil Shujaat and Dr. Nauman Chaudary) and now a full complement of six
fellows in training. The fellowship training program has been very popular with over 300 applications for
the two available positions per year. The first two fellows will be graduating in June 2011. The RRC site
visit is scheduled for September 2nd 2010. Clinically we have expanded the services to diagnose and treat
pleural diseases and hope to add cardiopulmonary exercise testing to the list of vast services provided by
our division. Academically we are involved in multiple international randomized controlled trials in the
arena of pulmonary arterial hypertension. The fellows under the mentorship of faculty are conducting a
number of retrospective clinical studies. The division has had a number of publications and abstracts
presented in national and international conferences.

Patient care: The division faculty staffs a number of specialized clinics. The Asthma Clinic under the
supervision of Dr. Cury is part of the American Lung Association Asthma Clinical Research Network. The
Network has only 18 sites in the country and in collaboration with Nemours Clinic continues to be
involved in state of the art clinical research. Pulmonary Hypertension and Interstitial Lung Disease Clinic
has become a regionally known referral center with patients being referred from Georgia and central and
south Florida. As member of Pulmonary Hypertension Association it continues to be a center of
excellence. The fellow's continuity clinic is staffed by at least 5 fellows once a week and staffed by
faculty. The number of pulmonary function tests performed has also accordingly increased. The test
reports are now available on Allscript and Portal enhancing access to results by primary care physicians.
Thoracic Oncology Clinic continues its multidisciplinary approach to patients with Thoracic malignancy.
The initiation of medical thoracoscopy under supervision of Dr. Shujaat will provide additional crucial role
in this context and we will be one of the few places to offer this service in the state. Interventional
bronchoscopy service offers numerous therapeutic options to patients with malignant and non malignant
airway diseases. We have started placement of feducial gold markers for proton therapy in lung cancer.
The involvement of the division is crucial to provision of this novel approach.

In critical care, the division continues to offer management for non-trauma neurological cases on a
regular basis. The division is involved in the multidisciplinary critical care committee which meets
monthly and focuses on quality improvement and streamlining the care of critically ill. The critical care
team provides services to neurosurgery, cardiology and neurology patients. At least two retrospective
analyses of two different cohorts of patient have shown that the actual intensive care unit mortality is
significantly less than APACHE II predicted mortality. Prospective data collection and analysis in this area
are planned. The new faculty members are now certified in performing bedside percutaneous
tracheostomy and endobronchial ultrasound guided bronchoscopy.

The division plans to initiate a sleep medicine presence at Emerson clinic location with Dr. Bajwa,
providing opportunities to collaborate with Dr. Sunil Sharma (Bariatric Surgery) and Dr. Tribod Fattahi
(OMFS). This presence will also provide an avenue for expansion of Sleep Medicine Services. The
inpatient pulmonary consult service continues to be busy and with a full complement of fellows is able to
provide care and consultation in a timely and efficient manner. The regular availability of fluoroscopy
slots every day will not only help increase the number of bronchoscopic procedures offered by the
division but also enhance efficiency and timely provision of such procedure.

Education: The division continues to play an active role in educational core lecture series including
Grand Rounds and Updates in Internal Medicine 2010. The division faculty also has an active role in the
educational lectures for a variety of residency programs including emergency medicine, obstetrics,
internal medicine and trauma critical care. Dr. Cury was honored with teacher of the year award. The


Division Chief: James D. Cury, MD


Annual Report AY 2010


Pulmonary, Critical Care & Sleep Medicine





Pulmonary, Critical Care and Sleep Medicine


pulmonary and critical care fellowship program was given a 2 year provisional accreditation in 2008 and
the RRC visit is schedule for September 2nd 2010. Under the leadership of Dr. Cury as program director
the preparation for the site visit are complete. He is also actively involved in the residency education
committee. Dr. Bajwa acts as the assistant program director and along with Dr. Cury is responsible for
coordinating the educational activities for the fellowship. The fellows are regularly mentored by a faculty
member in preparation and presentation of lectures.

The addition of Dr. Tauseef Qureshi and Dr. Jasdip Matharu now provides a full complement of six
fellows to the division. All the previous fellows have passed their internal medicine board certification
examination with Dr. Qureshi, Dr. Matharu and Dr. Seeram planning to take the examination in August
2010. The fellows are involved with nursing and infection control committees and provide regular input
in various quality improvement programs.

The citywide interventional bronchoscopy workshop organized by Dr. Pulido and hosted by our division
at the CSESR was a success with participants from a number of local practices including fellows from
Mayo Clinic. The division also hosts Mayo Clinic pulmonary and critical care fellows during their one
month inpatient pulmonary consult rotation at Shands hospital.

The faculty has and continues to mentor and supervise family medicine residents from the Navy
residency program during their rotation in medical intensive care unit and have always received a very
positive feedback from the leadership of that program. In addition, we have been active in training nurse
practitioners and physician assistants not only from the university of Florida sponsored training programs
but also for the nurse practitioners preparing to be a part of the neuro-critical care program.

Research: The Pulmonary Hypertension and Interstitial Lung Disease program under Dr. Bajwa has
attracted a number of industry sponsored international trials which are actively recruiting patients.
Marinella Lipinski acts as research coordinator. Dr. Bajwa as a co-investigator with Dr. Elsayed from the
Department of Radiology, have secured a Dean and Esther King Foundation Biomedical research Grant
for evaluation of the relationship between right ventricular myocardial mechanics and pulmonary artery
vessel and flow dynamics in pulmonary artery hypertension by MRI. Dr Faisal Usman and Dr Danny
Pulido both have presented abstracts in American College of Chest Physicians and American Thoracic
Society annual meetings. The faculty has a number of publications in peer review journals and a number
of manuscripts in preparation. Close collaboration with the Department of Radiology and Proton Therapy
Institute is key to future protocols and publications. Both Dr. Cury and Dr. Bajwa are involved in Proton
Therapy for lung cancer protocols. A recent manuscript in collaboration with Dr. Bradford Hoppe from
the proton therapy institute titled "Early outcomes of concurrent proton therapy with chemotherapy in
patients with lung cancer" has been submitted to publication.

LISTING OF FACULTY MEMBERS

Abubakr Bajwa, M.D., Assistant Professor
Medical School / Graduation date King Edward Medical College 1999
Internship/residency and year University of South Dakota 2003
Subspecialty training and year Mayo Graduate School of Medicine 2007



Nauman Chaudary, M.D., Assistant Professor
Medical School / Graduation date University of Miami 1981
Internship/residency and year Barnes Hospital/Washington 1984
Subspecialty training and year Washington University 1987


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Division Chief: James D. Cury, MD


Annual Report AY 2010


Pulmonary, Critical Care & Sleep Medicine





Pulmonary, Critical Care and Sleep Medicine


James D. Cury, M.D., Associate Professor and Division Chief
Medical School / Graduation date University of Miami 1981
Internship/residency and year Barnes Hospital/Washington 1984
Subspecialty training and year Washington University 1987



Adil Shujaat, M.D., Assistant Professor
Medical School / Graduation date King Edward Medical College 1998
Internship/residency and year St.Luke's Roosevelt Hospital Center 2003
Subspecialty training and year St.Luke's Roosevelt Hospital Center 2006







PUBLICATIONS

Anatoliotakis N, Chisholm S, Moncur L, Ketty A, Cury J. A hypotensive 22 year old man with chest pain, cough and an
abnormal chest radiograph. Chest 2009;135:228-32.

Kramer D, Arasi L, Cancbal J, Bajwa AA. Automated prone positioning and axial rotation in critically ill non-trauma
patients with ARDS. J Intensive Care Med. 2010 Mar-Apr;25(2):121-5.

Usman F, Pulido J, Bajwa AA, Cury JD, Laos L. A 19 year old boy with exertional dyspnea. In press Respiratory
Medicine CME. doi:10.1016/j.rmedc.2009.09.009

Girdhar A, Singh A, Bajwa AA. An unusual cause of pulmonary artery hypertension in a patient with chronic obstructive
airway disease. In press Respiratory Medicine CME. doi:10.1016/j.rmedc.2010.04.002.

Pulido JD, Usman F, Cury JD, Bajwa AA, Koch K, Laos L. Modification of percutaneous tracheostomy by direct
visualisation of endotracheal tube positioning with Glidescope prior to performing procedure. Chest 2009 136: 1S

Shah A, Bajwa AA, Khan A. Mounier-Kuhn syndrome masquerading as obstructive lung disease. In press Respiratory
Medicine CME. doi:10.1016/j.rmedc.2009.05.009.

Bajwa AA, Usman F, Cury JD, Wolfsen D, Laos L. A 62-Year-Old Woman With Dyspnea, Leukocytosis, and Diffuse
Ground-Glass Opacities. Chest June 2010 137:1470-1473; doi:10.1378/chest.09-2602

Keller CA, Pulido JD, Erasmus D. Asymptomatic Deep Vein Thrombosis: A Common Finding Revealed By Screening
Ultrasound Duplex Sonography Following Lung Transplantation. Am. J. Respir. Crit. Care Med. 2010. 181: A4315.

Usman F, Pulido JD, Bajwa AA. Echocardiographic Findings in Critically III Patient with AIDS. Am. J. Respir. Crit. Care
Med., Apr 2009; 179: A5509.

Abstracts and Presentations:
Usman F, Pulido JD, Bajwa AA. Echocardiographic Findings in Critically Ill Patient with AIDS. American Thoracic
Society San Diego 2009. Oral and Poster presentation.

Keller CA, Pulido JD, Erasmus D. Asymptomatic Deep Vein Thrombosis: A Common Finding Revealed By Screening
Ultrasound Duplex Sonography Following Lung Transplantation. Amer. Thoracic Soc., New Orleans 2010. Poster
Presentation.

Chaudary N. Hanta Virus Pulmonary syndrome treated with high frequency oscillator ventilation. Poster presentation.
University of Florida- Jacksonville, Research Day 2010.

Chaudary N. Correlation between radionuclide cerebral flow scan and clinical brain death and its impact on organ
donation. Poster presentation. University of Florida- Jacksonville, Research Day 2010.


Division Chief: James D. Cury, MD


Annual Report AY 2010


Pulmonary, Critical Care & Sleep Medicine






Pulmonary, Critical Care and Sleep Medicine


HONORS AND AWARDS


James D Cury, M.D.


University of Florida Teacher of the year


CLINICAL ACTIVITIES


Inpatient activity AY 09/10
Inpatient Pulmonary admissions 373
Inpatient Days 3429
Average length of stay 9.19
Number of IP Consults 1004
Outpatient activity
Clinical Visits 2748
Procedures
Bronchoscopies 559
Sleep Studies 698


Annual Report AY 2010 Pulmonary, Critical Care & Sleep Medicine


2009


Division Chief: James D. Cury, MD


Annual Report AY 2010


Pulmonary, Critical Care & Sleep Medicine





Division of Rheumatology and Clinical Immunology


DIVISION OF RHEUMATOLOGY AND CLINICAL IMMUNOLOGY
ACADEMIC YEAR 2010 (7/09 6/10)

Highlights

The Division of Rheumatology & Clinical Immunology had a very successful and productive academic
year on multiple levels. Despite our new beginnings we have been planting many seeds for the future
and can readily see some of the fruits of our dedication to the UF COM mission, collaboration, and
teamwork under the guidance of our leadership including the deans but specifically our chairman, Dr.
Arshag Mooradian. The division had great accomplishments in patient care, research, and education.

Despite the road blocks that we encountered in trying to accomplish a joint rheumatology fellowship
program with Mayo Clinic in Jacksonville, Dr. Mitri was very instrumental in mentoring the first resident
from the UF COM Jacksonville, Dr. Karishma Ramsubeik, to accomplish her dream when she matched
with a prestigious rheumatology fellowship training program at the Medical College of Wisconsin. The
division continues its dedicated efforts to establish the first rheumatology fellowship training program in
Jacksonville, FL in order to retain our highly trained physicians and provide more rheumatologists to face
the expanding shortage in rheumatologists in the present and future. Meanwhile, we continue to work
with other training programs and the GME office at UF COM Jacksonville in order to provide the
mentoring and teaching for many students and residents, who are interested in our specialty. Dr. Kaeley
had his first extremely successful CME musculoskeletal ultrasound sound training course in Ponte Vedra,
while working with Dr. Pappa on developing a web-based rheumatology eLearning series that would be
readily available, even wirelessly, to students and physicians while at the UF COM Jacksonville campus.

We almost tripled our publications and doubled our out-patient visits compared to last year. Our faculty
members were featured in local, national, and international professional meetings and local media
channels, served on expert advisory boards and as professional journal reviewers, and in local and
professional medical societies. Currently, we offer the most up to date patient care and rheumatology
services to our patients both in the in-patient and out-patient settings.

The Division of Rheumatology & Clinical Immunology, under the leadership of Dr. Mitri, was able to build
its research unit from the grounds up. After overcoming many challenges and in a short time, the
division has almost a million US Dollar in total research budget from grants and active studies with
almost twice that amount in the pipeline.

None of this could have been accomplished without the support of our leadership at UF COM
Jacksonville, but more importantly it is a reflection to the diversity, determination, and teamwork of the
division's faculty members, whom Dr. Mitri was able to recruit in a relatively short period of time based
on their unique qualifications and cultural fit. However, the backbone to our success is the loyal and hard
working staff at our clinics, hospital, and administrative offices.

Patient care: Considering our new beginnings, major shortage in our specialty, our unique collective
expertise, and enthusiasm we were able to double our out-patient visits compared to last academic year
and maintain a steady growth. Patients with numerous medical conditions including but not limited to
many types of arthritis, lupus, scleroderma, myositis, autoimmune and systemic diseases, osteoporosis,
connective tissue diseases related to inflammation and metabolic dysfunction, soft tissue conditions and
pain such as fibromyalgia. We continue to be on the frontiers of providing the very up to date
rheumatology services and 24/7 consultations at Shands Hospital in Jacksonville, the ambulatory care
clinic, and our dedicated out-patient clinic on Emerson Street.

In the out-patient setting we provide full rheumatology coverage from Monday to Friday, where we
provide diagnostic musculoskeletal ultrasound, musculoskeletal procedures under ultrasound guidance
using state of the art 3D technology, and lately the very first non-surgical treatment of Dupuytren's


Division Chief: Ghaith Mitri, MD, MMM


Annual Report AY 2010


Rheumatology and Clinical Immunology





Division of Rheumatology and Clinical Immunology


Contractures using a biologic therapy. At our infusion suite, we can administer all the intravenous
biologics, disease modifying drugs, and osteoporosis medications.

Excellence is our only goal when it comes to patient care. Our faculty members achieved or exceeded
the average in our specialty and in comparison to others at our institution. We touch our patients' lives
during some of the most vulnerable moments they will ever encounter alone or with their loved ones. As
physicians of the UF COM Jacksonville we always strive for excellence in our practice.

Education: Education is one of the main missions at the UF COM Jacksonville. Our faculty members
have been very dedicated and creative in delivering the best of what they can offer to our students and
residents. Our achievements in education were highlighted in multiple venues.

In Internal Medicine residency education, Dr. Mitri continues as rotation director of relevant educational
programs for Rheumatology. He is the primary liaison between the Core Residency Program and the
division, and is a member of the Resident Education Committee. He also volunteers on a regular basis as
a teaching attending for Internal Medicine rounds and morning reports. In the educational program of
University of Florida medical students and residents Dr. Pappa, Dr. Kaeley, and Dr. Mitri participated in
preceptoring clinics in rheumatology and delivered core curriculum lectures for the Department of
Medicine Residency Program at the UF COM Jacksonville. All the rheumatology faculty members
participated in internal medicine grand rounds and shared the knowledge of their invited rheumatology
speakers on a regular basis.

Musculoskeletal Ultrasound for Rheumatologists Course in March 2010 at Ponte Vedra, FL was a great
success. It was accomplished under the leadership of Dr. Kaeley, who is a world-class rheumatology
ultrasonographer. This was a 3-day CME hands-on training course that uniquely utilized our state of art
simulation laboratory at the UF COM Jacksonville. It was greatly attended and featured many other
world-expert speakers. This will set the stage for many more similar courses in the future.

ELearning is an entrepreneur unique project that was pioneered by Dr. Pappa and Kaeley. The aim of
this project is to develop electronic learning content to cover basic Rheumatology Core Curriculum as
well as musculoskeletal ultrasound training material. Internal Medicine Residents need to assimilate core
knowledge rapidly in order to gain the most out of the clinical Rheumatology rotations. Other specialties
have shown interest in acquiring skills to perform musculoskeletal sonography. A need to assess
knowledge acquired was also identified. Adobe presenter was chosen to create short lectures from
PowerPoint slides that could be viewed on demand. The created content may be viewed independently
by viewing PDF files or be coupled to a deployment system such as Adobe Connect. A short series of
lectures and a demonstration of ultrasound guided injection of the knee which included a quiz at the end
were created.
LISTING OF FACULTY MEMBERS

Gurjit S Kaeley, M.B.B.S., Assistant Professor and Director of Musculoskeletal Ultrasound

Medical School/Graduation date The London Hospital Medical College, London, UK 1990
Internship/residency and year University of Tennessee College of Medicine 1996
Subspecialty training and year University of Tennessee College of Medicine 1998


S Ghaith Mitri, M.D. M.M.M., Assistant Professor and Division Chief

Medical School/Graduation date Damascus University School of Medicine 1995
Internship/residency and year Scranton Temple University 1999
Subspecialty training and year University of Pittsburg School of Medicine 2001
Post-Graduate Training and year Marshall School of Business, USC 2007


Division Chief: Ghaith Mitri, MD, MMM


Annual Report AY 2010


Rheumatology and Clinical Immunology





Division of Rheumatology and Clinical Immunology Division Chief: Ghaith Mitri, MD, MMM

Chrysoula Pappa, M.D., Assistant Professor of Medicine

Medical School/Graduation date Aristotle University of Thessaloniki 2001
Internship/residency and year Albany Medical College 2007
Subspecialty training and year Albany Medical College 2009





PUBLICATIONS

Minupalli B, Mitri GS. Dermatomyositis & Polymyositis chapter. Essential Evidence Plus, by Wiley-Blackwell. An online
medical reference tool and mobile web search. Accepted in June 2010

Kaeley GS. Training and Education in Rheumatology Ultrasound: Experiences in the USA. Book Chapter in Essential
Applications of Ultrasound in Rheumatolog. 1st Edition. 2010: Pages 345-346.

Kissin EY, Nishio J, Yang M, Backhaus M, Balint PV, Bruyn GA, Craig-Muller J, D'Agostino MA, Feoktistov A, Goyal J,
lagnocco A, Ike RW, Moller I, Naredo E, Pineda C, Schmidt WA, Swen N, Tabechian D, Wakefield RJ, Wells AF, Kaeley
GS. Self Directed Learning of Basic Musculoskeletal Ultrasound Among Rheumatologists in the United States. Arthritis
Care Research. 2010 Feb;62(2):155-60.

Kunkel G, Kaelev GS, Thiele R. Comment on: an analysis of MRI and ultrasound imaging in patients with gout who have
normal plain radiographs. Rheumatology (Oxford). 2010 Feb 19. [Epub ahead of print]

Kaeley GS. Evaluation of Seronegative Arthritis. BMJ Point-of-Care Nov 2009; www.pointofcare.bmj.com. (Last
accessed December 2009)

Kaeley GS. Cryoglobulinemia. BMJ Point-of-Care Nov 2009; www.pointofcare.bmj.com. (Last accessed December 2009)

Keen HI, Bingham CO 3rd, Bradley LA, Conaghan PG, Heald AE, Kaeley GS, Maksymowych WP, Moskowitz RW,
Schumacher HR Jr, Woodworth TE, Mease PJ. Assessing single joints in arthritis clinical trials. J Rheumatol. 2009
Sep;36(9):2092-6.

D'Agostino MA, Conaghan PG, Naredo E, Aegerter P, lagnocco A, Freeston JE, Filippucci E, Moller I, Pineda C, Joshua F,
Backhaus M, Keen HI, Kaeley G, Zisweiler HR, Schmidt WA, Balint PV, Bruyn GA, Jousse-Joulin S, Kane D, Moller I,
Szkudlarek M, Terslev L, Wakefield RJ.The OMERACT Ultrasound Task Force -- Advances and Priorities. J Rheumatol.
2009 Aug;36(8):1829-32.

Mitri G. Familial Mediterranean Fever. BMJ Point-of-Care 2009; www.pointofcare.bmi.com. Powered by Epocrates. (Topic
last updated 08/18/2009)

Ramsubeik K, Griffiths H, Mitri G. Arthritis in a patient with severe psoriasis: Narrowing the differential. J Musculoskel
Med. 2009; 26: 334-342.

Presentations:
Kaeley GS. Introduction to musculoskeletal ultrasound, ultrasonography of the hand, wrist, and shoulder. Musculoskeletal
Ultrasound Course, Salt Lake City, UT. July 2009.

Kaeley GS. Future Therapies in Osteoporosis. Idaho Rheumatology Association Annual Conference. Sun Valley, Idaho.
Sept 2009.

Kaeley GS. Sonography of the elbow, shoulder, and in spondyloarthritis. Musculoskeletal Ultrasound Course. Sun Valley,
Idaho. Sept 2009.

Kaeley GS. Ultrasonography of the hand, wrist, and elbow. Musculoskeletal Ultrasound Course for UF Rheumatology
Fellows, Gainesville, FL. November 2009.

Kaeley GS. Use of Ultrasound in Inflammatory Arthritis. UF College of Medicine Jacksonville Internal Medicine Update.
Jacksonville Beach. Florida. March 2010.

Annual Report AY 2010 56 Rheumatology and Clinical Immunology






Division of Rheumatology and Clinical Immunology


Kaeley GS. Musculoskeletal Ultrasound for Rheumatologists. Georgia Society of Rheumatology annual meeting. Hilton
Head, South Carolina. June 2010.

Kaeley GS. Use of sonography in inflammatory arthritis. Florida Society of Rheumatology annual meeting. Bonita Springs,
FL. June 2010.

Kaeley GS. Faculty Musculoskeletal Ultrasound Workshop at American College of Rheumatology annual meeting
Philadelphia, Pennsylvania. November 2009.

Kaeley GS. Diagnostic Use of Musculoskeletal Ultrasound in Clinical Practice, American College of Rheumatology
(ACR/ARHP) Annual Meeting Philadelphia, Pennsylvania. November 2009.

Kaeley GS. Invited faculty Ultrasound Lecture and Workshop American College of Rheumatology State of the art
meeting, Chicago, Illinois. April 2010.

Kaeley GS. Sonography in evaluating Spondyloarthropathies, American Institute of Ultrasound in Medicine annual
meeting, San Diego, California. March 2010.

Kaeley GS. Introduction to the basic principles of sonography, ultrasonography of Spondyloarthritis, and of the shoulder.
Musculoskeletal Ultrasound Course for Rheumatologists. UF COM CME course, Ponte Vedra Beach, FL. March 2010.

Mitri G. Fibromyalgia Diagnosis & Treatment. Northeast Florida Advance Registered Nurse Practitioners' meeting,
Jacksonville, FL. December 2009.

Mitri G. Familial Mediterranean Fever. Syrian American Medical Society (SAMS) Annual International Meeting, Damascus,
Syria. CME supported by the Cleveland Clinic. June 2010.



CLINICAL ACTIVITIES


Outpatient activity
Clinical Visits 4,306


CONTRACTS AND GRANTS


Principal Sponsor/Title Budget/
Investigator Value
Mitri G. Roche/Protocol: ML22533 (ACT-STAR) An open label, randomized study to evaluate the safety, $37,605
tolerability and efficacy of tocilizumab (TCZ) monotherapy or TCZ in combination with non-biologic
disease modifying antirheumatic drugs (DMARDS) in patients with active rheumatoid arthritis who
have an inadequate response to current non-biologic or biologic DMARDS.
Mitri G. EMD Serono/Protocol: 27646 A randomized, double blind, placebo controlled, multicenter $110,512
prospective dose finding Phase II/III study with atacicept given subcutaneously to subjects have
recently experienced a flare of systemic lupus erythematosus (SLE).
Mitri G. Actelion/Protocol: AC-052-510 A two stage observational cohort study in scleroderma patients to $239,346
evaluate screening tests and the incidence of pulmonary arterial hypertension and pulmonary
hypertention (DETECT).
Mitri G. Bristol Meyers Squibb/Protocol: IM101-235 A randomized, head to head, single blind study to $152,368
compare the efficacy and safety of subcutaneous abatacept versus subcutaneous adalimumab
both with background methotrexate in biologic naive subjects with rheumatoid arthritis.
Kaeley GS. Amgen/Protocol: 20090061 A randomized, double blind, placebo controlled, multiple dose study to $93,003
evaluate the safety, tolerability and efficacy on AMG 827 in subjects with rheumatoid arthritis and
an inadequate response to methotrexate.
Kaeley GS. Wyeth/Unrestricted grant from to develop validated Web Atlas of Sonographic Scoring of $46,500
Rheumatoid Arthritis Activity.
Kaeley GS. Biosound Esaote & Sonosite/Unrestricted equipment loans. $188,250


Division Chief: Ghaith Mitri, MD, MMM


Annual Report AY 2010


Rheumatology and Clinical Immunology







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Department of Medicine
University of Florida
College of Medicine Jacksonville
653-1 West 8th Street, L20
Jacksonville FL 32209
904-244-8846
www.hscj.ufl.edu/im/




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