Title: Department of Medicine annual report
ALL VOLUMES CITATION PDF VIEWER THUMBNAILS PAGE IMAGE ZOOMABLE
Full Citation
STANDARD VIEW MARC VIEW
Permanent Link: http://ufdc.ufl.edu/UF00090036/00003
 Material Information
Title: Department of Medicine annual report
Physical Description: Serial
Language: English
Creator: College of Medicine, University of Florida
Publisher: College of Medicine, University of Florida
Place of Publication: Jacksonville, Fla.
Publication Date: 2008-2009
 Record Information
Bibliographic ID: UF00090036
Volume ID: VID00003
Source Institution: University of Florida
Holding Location: University of Florida
Rights Management: All rights reserved by the source institution and holding location.

Downloads

This item has the following downloads:

Dept-of-Medicine-08-09-Annual-Report ( PDF )


Full Text





DEPARTMENT OF MEDICINE


Academic Year 2008-2009


UF


UNIVERSITY of
FLOOR IDA
College of Medicine
facdk ?1'ilI'









Table of Contents DeDartment of Medicine


TABLE OF CONTENTS
ACADEMIC YEAR 2009 (7/08 6/09)


I. Statement from the Chairman

II. Department Organizational Overview
a. Administration
b. Division Chiefs
c. Residents/Fellows

III. Graduate Medical Education
a. Internal Medicine Residency Training Program
b. Subspecialty Fellowship Program
c. Student Education Programs

IV. Department Research

V. Individual Divisions
a. Cardiology
b. Endocrinology
c. Gastroenterology
d. General Internal Medicine
e. Hematology & Medical Oncology
f. Infectious Disease
g. Nephrology and Hypertension
h. Pulmonary, Critical Care & Sleep Medicine
i. Rheumatology



















Department of Medicine
University of Florida
College of Medicine Jacksonville
653-1 West 8th Street, L20
Jacksonville FL 32209
904-244-8846
www.hscj.ufl.edu/im/


Annual Report AY 2009 Department of Medicine


Table of Contents


Department of Medicine


Annual Report AY 2009


Department of Medicine





Department Chair: Arshaa Mooradian. MD


STATEMENT FROM THE CHAIRMAN
ACADEMIC YEAR 2009 (7/08 6/09)

Dear Colleagues and Friends:

I am happy to share with you the Annual Report of the Department of Medicine at the University of Florida
College of Medicine Jacksonville for the academic year July 2008 through June 2009. I will briefly describe
the departmental accomplishments for the past year.

Patient care: The Department expanded clinical activities and achieved 106% of the budgeted revenues.
The faculty members continued to excel in clinical productivity exceeding the 75% percentile of MGMA RVU
benchmarks. The Department was successful in attracting talented faculty in all of its divisions. The steady
increase in the number of admissions to the Medicine service reached 14,277 admissions during the FY09.
Continued improvements in clinical operations helped cost containment and enhanced efficiency and our
outpatient care experienced growth and improvement in patient satisfaction scores.

Education: Faculty members of the Department continue to excel in their mission of educating students and
residents. There were 8 faculty members in the Department who received the Exemplary Teacher Award. The
scholarly productivity of the house staff increased substantially and the top prizes of the Annual Research Day
were awarded to the residents and fellows within the Department. The Residency Review Committee (RRC)
site visit resulted in 6 year full accreditation of the core program and the subspecialty fellowships that were
reviewed. Continuing Medical Education (CME) initiatives were offered by all the Divisions within the
Department.

New Fellowship programs were initiated as follows: Nephrology Fellowship started on July 1, 2007,
while Endocrinology, Pulmonary and Critical Care and Cardiac Electrophysiology Fellowships started July 1,
2008.

Research: The Department once again had an exceptionally productive year in research. There were a total
of 78 peer reviewed publications and 19 book chapters and editorials authored by faculty members. Faculty
made 49 national and regional presentations. During fiscal year 2009, 61 research awards with a direct cost
of $1,723,391 were acquired. This represents a 129.5% change compared to the previous fiscal year.

Over the last three years, the Department has grown significantly and the faculty members have excelled in
every aspect of the academic mission. I am proud to have the privilege of being the Chairman of such an
exceptionally productive Department.


Sincerely,



Arshag D. Mooradian, M.D.
Professor and Chairman


Annual Report AY 2009 Statement from the Chairman


Statement from the Chairman


Annual Report AY 2009


Statement from the Chairman








DEPARTMENT ORGANIZATIONAL OVERVIEW
ACADEMIC YEAR 2009 (7/08 6/09)

Arshag D. Mooradian, M.D.
Chairman, Department of Medicine

N. Stanley Nahman, M.D.
Program Director, Internal Medicine Residency and Associate Chair, Department of Medicine

Linda R. Edwards, M.D.
Associate Chair, Department of Medicine

Senthil Meenrajan, M.D.
Associate Program Director, Graduate Medical Education

Jeffrey House, D.O.
Associate Program Director, Graduate Medical Education

Carlos Palacio, M.D.
Director, Medical Student Clerkship

Irene Alexandraki, M.D.
Associate Director, Medical Student Clerkship

Christina Catalano, M.B.A.
Administrator

Nanci Morton
Administrative Manager

DIVISION CHIEFS


Cardiology

Endocrinology, Diabetes & Metabolism

Gastroenterology

General Internal Medicine

Hematology & Medical Oncology

Infectious Disease

Nephrology and Hypertension

Pulmonary, Critical Care & Sleep Medicine

Rheumatology & Clinical Immunology


Theodore Bass, M.D.

Kent R. Wehmeier, M.D.

Louis Lambiase, M.D., M.H.A.

Linda R. Edwards, M.D.

Fauzia Rana, M.D.

Michael Sands, M.D., M.P.H. &T.M.

N. Stanley Nahman, Jr., M.D.

J. Davis Cury, M.D.

Ghaith Mitri, M.D., M.M.M.


Annual Report AY 2009 Organizational Overview


Organizational Overview


Department of Medicine


Annual Report AY 2009


Organizational Overview






Organizational Overview DeDartment of Medicine


RESIDENTS/FELLOWS


Chief Residents 2008-2009


Rosalyn Alcalde, M.D.
Shilpa Reddy, D.O.

Class of 2008-2009


Ross University School of Medicine
Nova Southeastern University


Housestaff I


Medical School


Ainel Boonprakong, M.D.
Rajarshi Chakravarty, M.D.
Justin Federico, D.O.
Jawahar Gazzala, M.D.
Ankur Girdhar, M.D.
Sanjay Hegde, M.D.
Mohammad Izhar, M.D.
Syed Jafri, M.D.
Toufic Kabbani, M.D.
Jamie Kitzman, M.D.
Sudha Koduru, M.D.
Pablo Medina, M.D.
Amr Mohsen, M.D.
Hasan Riaz, M.D.
Muhammad Salahuddin, M.D.
Shawn Tai, M.D.
Jamie Woodcock, M.D.
Louise Zhou, M.D.


Housestaff II


University of Miami School of Medicine
St. George's University School of Medicine
Lake Erie College of Osteopathic Medicine
Sri Ramachandra University
All-India Institute of Medical Sciences
University of South Florida College of Medicine
Khyber Medical College
Sindh Medical College, University of Karachi
American University of Beirut
University of Florida College of Medicine
St. George's University School of Medicine
University of Florida College of Medicine
University of Alexandria Faculty of Medicine
Nishtar Medical College, Bahauddin Zakariya University
Ross University School of Medicine
Ross University School of Medicine
University of Florida College of Medicine
Ross University School of Medicine


Medical School


Sara Ahmed, M.D.
Santosh Kale, M.D.
Ravindra Maharaj, M.D.
Jasdip Matharu, M.D.
Taren Ohman, M.D.
John-Paul Pham, M.D.
Tauseef Qureshi, M.D.
Prafull Raheja, M.D.
Karishma Ramsubeik, M.D.
Naveen Seecheran, M.D.
Atman Shah, M.D.
Ho Vu, M.D.
Edward Yazigi, M.D.


Housestaff III


St. Matthews University School of Medicine
BJ Medical College University of Pune
University of West Indies Trinidad
St. George's University School of Medicine
St. George's University School of Medicine
Marshall University School of Medicine
St. George's University School of Medicine
Kasturba Medical College Mangalore University
University of West Indies Trinidad
University of West Indies Trinidad
Ross University School of Medicine
Ross University School of Medicine
Ross University School of Medicine


Medical School


Melvin Bullock, M.D.
Andrew Darlington, D.O.
Friba Faqeeri, M.D.
Somajita Ghosal, M.D.
Mohammad Asif Khan, M.D.
Carol Le, M.D.
Nimish Naik, M.D.
Thomas Nguyen, M.D.
Vinny Samuel, M.D.
Vandana Seeram, M.D.
Siva Suryadevara, M.D.
Esther Vildor-Dazil, M.D.


Medical College of Georgia
Philadelphia College of Osteopathic Medicine
Ross University School of Medicine
Calcutta National Medical College
Khyber Medical College
Medical College of Wisconsin
New York Medical College
Drexel University College of Medicine
Ross University School of Medicine
University of West Indies Trinidad
University of West Indies Trinidad
Florida State University College of Medicine


Annual Report AY 2009 Organizational Overview


Organizational Overview


Department of Medicine


Annual Report AY 2009


Organizational Overview






Organizational Overview DeDartment of Medicine


Subspecialty Fellowship Program Directors


Cardiology
Endocrinology
Gastroenterology
Interventional Cardiology
Infectious Disease
Medical Oncology
Nephrology
Pulmonary Critical Care


Steven Lavine, M.D.
Kent Wehmeier, M.D.
Louis Lambiase, M.D.
Ted Bass, M.D.
Michael Sands, M.D.
Janet Hosenpud, M.D.
Charles Heilig, M.D.
J. Davis Cury, M.D.


Subspecialty Fellow Housestaff IV

Abdul Alamir, M.D. (Endocrinology)
Bharat Gummadi, M.D. (Cardiology)
Sayer Gunn, M.D. (Medical Oncology)
Lavanya Kodali, M.D. (Nephrology)
Naeem Latif, M.D. (Medical Oncology)
Victor Lopez de Mendoza, M.D. (Nephrology)
Ajay Mhatre, M.D. (Cardiology)
Timmy Nguyen, M.D. (Medical Oncology)
Rachana Palnitkar, M.D. (Infectious Disease)
Saeed Payvar, M.D. (Cardiology)
J. Danny Pulido, M.D. (Pulmonary Critical Care)
William Salyers, M.D. (Gastroenterology)
Moiz Shafiq, M.D. (Cardiology)
Senan Sultan, M.D. (Endocrinology)
Ansley Tharpe, M.D. (Gastroenterology)
Faisal Usman, M.D. (Pulmonary Critical Care)

Subspecialty Fellow Housestaff V

Aamir Amin, M.D. (Cardiology)
Wayne Cheng, M.D. (Cardiology)
Noel Dasgupta, M.D. (Cardiology)
Taylor Dowsley, M.D. (Cardiology)
Supriya Mannepalli, M.D. (Infectious Disease)
Aasita Patel, M.D. (Cardiology)
Ivan Rascon-Aguilar, M.D. (Gastroenterology)
Haritha Sakhamuri, M.D. (Nephrology)
Amit Shah, M.D. (Cardiology)
Aja Smith-McCutchen, M.D. (Gastroenterology)
Robert Sullivan, M.D. (Nephrology)
Thomas Walsh, M.D. (Cardiology)
Robert Zaiden, M.D. (Medical Oncology)

Subspecialty Fellow Housestaff VI

M. Kamran Aslam, M.D. (Cardiology)
Matthew Cole, M.D. (Gastroenterology)
Lori McMullan, M.D. (Cardiology)
A. Tony Ortiz, M.D. (Cardiology)


Medical School


Damascus University Faculty of Medicine
St. George's University School of Medicine
Pennsylvania State University College of Medicine
Dr. NTR University of Health Sciences
Ayub Medical College University of Peshawar
Universidad Central Del Este
Florida State University College Of Medicine
Flinders University of South Australia
Topiwala National Medical College University of Mumbai
Iran University of Medical Sciences
Universidad de Ciencias Medicas
University of Kansas School of Medicine
University of Texas Southwestern Medical School
Damascus University Faculty of Medicine
Medical College of Georgia
Allama Iqbal Medical College University of Punjab

Medical School

Texas A & M University College of Medicine
University of Florida College of Medicine
University of Wisconsin Medical School
Finch University of Health Science Chicago Medical School
Kasturba Medical College Mangalore University
University of Illinois College of Medicine
Universidad de San Carlos
PSG Institute of Medical Sciences
University of Alabama School of Medicine
Case Western Reserve University School of Medicine
Ross University School of Medicine
University of Miami School of Medicine
St. Matthews University School of Medicine

Medical School

University of Texas Southwestern Medical School
Ross University School of Medicine
Louisiana State University School of Medicine
Universidad Central del Este


Annual Report AY 2009 Organizational Overview


Organizational Overview


Department of Medicine


Annual Report AY 2009


Organizational Overview








GRADUATE MEDICAL EDUCATION
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Graduate Medical Education Program had another successful academic year highlighted by the
ACGME decision to award a 6 year accreditation cycle for the core training program and four fellowships.
In addition, progress continues in the matching of high quality of intern recruits, strong performances on
the ABIM certifying examination, successes with graduates matching into competitive fellowships, and
continued stabilization of new fellowship training programs. Each facet of the program is discussed in
the following.

Internal Medicine Residency Program: The core program was site visited by the ACGME in January
2009 and received the highest possible assessment with 6 years of full accreditation. This exciting
outcome will serve as a catalyst for our continued efforts to develop a competitive and premier training
program. The program continues to be led by Dr. N. Stanley Nahman, Jr., M.D. and in the last year,
Drs. Senthil Meenrajan and Jeff House joined as Associate Program Directors. They replaced Drs.
Arpitha Ketty and Olga Petrucelli who left the institution for other professional opportunities. The 2009
Match was a success with the mean 2-digit step one score for the matched group of 93. In addition,
and for the second year in a row, our pass rate on the ABIM certifying examination exceed 90%.
Finally, 100% of residents seeking positions successfully matched in the fellowship of their choice. 20%
percent of the fellowships were outside of the UF system. The program was well served by the two
Chief Medical Residents (CMR), Dr. Shilpa Reddy and Dr. Rosie Alcalde. Both physicians will move on to
pursue fellowship training in gastroenterology (Dr. Reddy, University of Louisville) and endocrinology
(Dr. Alcalde, UF Jacksonville). Drs. Nahman, House and Meenrajan were recognized as exemplary
teachers by the University of Florida. In research, residents submitted abstracts to the Florida ACP,
American Society of Nephrology, and Southern Section of the AFMR. Resident research accounted for 5
internal research grants, 4 published manuscripts, 8 published abstracts and 20 poster presentations.

Subspecialty Fellowship Program: Two new fellowships (Pulmonary/Critical Care and
Electrophysiology) enrolled their first fellows in July 2008, bringing the total number of postgraduate
fellowships to 9 (Cardiology, Electrophysiology, Endocrinology, Interventional Cardiology,
Gastroenterology, Infectious Disease, Medical Oncology, Nephrology and Pulmonary/Critical Care).
Cardiology, Interventional Cardiology, Infectious Disease and Medical Oncology were site visited by the
ACGME in January 2009, and all received a 6 year accreditation cycle, the strongest possible outcome
from a site visit, and a further endorsement of the high quality training opportunities available on the
UFCOM Jacksonville campus.

Student Education: Drs. Alexandraki and Palacio continue to head student education and have been
recognized for their efforts. Students continue to have rotations in inpatient and ambulatory settings.
They also complete a two week required Geriatrics Clerkship during the 4th year.


Annual Report AY 2009 Graduate Medical Education


Graduate Medical Education


Program Director: N. Stanlev Nahman. Jr MD


Annual Report AY 2009


Graduate Medical Education









LISTING OF PROGRAM LEADERSHIP

Chief Medical Residents

Shilpa Reddy, DO, Post-doctoral Associate and Chief Medical Resident
Medical School / Graduation date Nova Southeastern University 2005
Internship/residency and year University of Florida Jacksonville 2008
Chief Medical Resident University of Florida Jacksonville

Rosalyn Alcalde, MD, Post-doctoral Associate and Chief Medical Resident
Medical School / Graduation date Ross University School of Medicine 2005
Internship/residency and year University of Florida Jacksonville 2008
Chief Medical Resident University of Florida Jacksonville

Current Faculty

Irene Alexandraki, MD, Assistant Professor and Associate Student Clerkship Director
Medical School / Graduation date University of Athens 1989
Internship/residency and year Hahneman University 1998
Subspecialty training and year Infectious disease/Baylor College of Medicine 2001

Jeff House, DO, Assistant Professor and Associate Program Director
Medical School / Graduation date Nova Southeastern University 1997
Internship/residency and year University of Florida Jacksonville 2001

N. Stanley Nahman, Jr., MD, Professor and Program Director
Medical School / Graduation date Medical College of Ohio 1979
Internship/residency and year Presbyterian Hospital Denver, Mt Carmel Health, Columbus 1984
Subspecialty training and year Nephrology/The Ohio State University 1987

Carlos Palacio, MD, Associate Professor and Student Clerkship Director
Medical School / Graduation date University of Miami 1993
Internship/residency and year University of Florida Jacksonville 1996

Senthil Meenrajan, MD, Assistant Professor and Associate Program Director
Medical School / Graduation date Madras Medical College 1997
Internship/residency and year Robert Packer Hospital 2004
Subspecialty training and year Geriatrics/Oregon Health and Science University 2005

PUBLICATIONS

Sullivan R*, Reddy S*, Elfayoumy S, Wludyka P, Britt K, Maddirala S, Cuhaci B, Mars R, Cu G, Urquidi V, Lambiase L,
Nahman Jr NS: Hepatitis C and Cirrhosis as Risk Factors for Bacteremia in Hemodialysis Patients. J Invest Med,
56:452, 2008.
Maddirala S, Elfayoumy S, Wludyka P, Bullock K, Britt K, Reddy S*, Cuhaci B, Mars R, Cu G, Urquidi V, Lambiase L,
Nahman Jr NS. Bacteremia in Patients with HIV and Hepatitis C: Analysis of the DMMS Study. J Invest Med, 56:421,
2008.
Darlinaton A*, Suzuski Y, Desai B, Rozum L, Bass T, Nahman Jr NS, Angiolillo D. Analysis of Thrombotic Profiles in
Patients with End Stage Renal Disease Undergoing Hemodialysis. JInvest Med, 56:415, 2008.
Gupta R*, Kattoor R, Vega KJ, Petrucelli O, Nahman Jr NS. Overuse of Acid Suppression Therapy in Hospitalized
Patients and Interventions Designed to Improve Prescribing Habits. JInvestMed, 56:436, 2008.
Mohsen. A.*. Meenrajan, S. Case Report: A rare Case of Metastatic Hepatocellular Carcinoma. NE Florida Medicine
Vol. 6, No 2. 2009
Qureshi, T.*, Nguyen, T*. Nahman, N.S., Urquidi, V. In vitro cytotoxicity of Gadolinium Contrast Medium NE Florida
Medicine Vol. 6, No 2. 2009

Khan. M.* Shah. A.* House, J. Symptomatic Hypermagnesemia Due to Oral Milk o fMagnesia in the Absence of Renal
Failure.. NE Florida Medicine Vol. 6, No 2. 2009


Graduate Medical Education


Program Director: N. Stanlev Nahman. Jr MD


Annual Report AY 2009


Graduate Medical Education








Reddy, S.* Meenrajan, S. Immunity Factor in Resistant or Recurrent Clostridium Difficile. NE Florida Medicine Vol. 6,
No 2. 2009
Darlinaton, A.* Desai, B. Bass, T. Nahman, N.S., Angiolillo, D. The Analysis of Thrombotic Profiles in Patients with
End-stage Renal Disease. NE Florida Medicine Vol. 6, No 2. 2009
indicates a resident


HONORS AND AWARDS

Justin Federico, DO Intern of the Year 2009

Andrew Darlington, Resident of the Year 2009
DO

Luis Laos, MD Teacher of the Year 2009


Exemplary Teachers: (arranged alphabetically)

Drs. Irene Alexandraki, Dominick Angiolillo, Linda Edwards, Malcolm Foster, Jeffrey House, Senthil
Meenrajan, N. Stanley Nahman Jr., and Elisa Sottile.

Andrew Darlington was awarded the Exemplary Teacher Award for residents.


Clinical Teacher of the Year & Excellence in Student Education Award:

Andrew Darlington was the recipient of the Edward Jelks for Outstanding Resident Clinician of the Year.

Linda Edwards received the Louis Russo Award for Outstanding Professionalism in Medicine.

Nimish Naik was honored as the ACP Resident of the Year in 2009.




ENDOWMENTS AND GIFTS

The Anne and Max Michael, Jr. Education Fund Established 2006, by Anne Michael


GRANTS AND CONTRACTS

Principal Investigator Sponsor/Title
Thomas Nguyen University of Florida Dean's Fund for Residents and Fellow Research Grant, 2008: "A Retrospective Analysis
of Risk Factors in DSRD."
Siva Suryadevara University of Florida Dean's Fund for Residents and Fellow Research Grant, 2009: "The effects of
Pioglitazone on platelet function in patients with Type 2 diabetes mellitus & coronary artery disease."
Amr Mohsen University of Florida Dean's Fund for Residents and Fellow Research Grant, 2009: "Impact & Costs of
Emergency Department Care of Nursing Home Patients."


Annual Report AY 2009 Graduate Medical Education


Graduate Medical Education


Program Director: N. Stanlev Nahman. Jr MD


Annual Report AY 2009


Graduate Medical Education






G


POST-GRADUATE ACTIVITIES OF CMR AND SENIOR RESIDENTS


Graduate


Professional status


Location


Outgoing Chiefs
Shilpa Reddy, DO
Rosalyn Alcalde, MD


Graduating residents
1. Andrew Darlington, DO

2. Nimish Naik, MD

3. Friba Faqeeri, MD
4. Somajita Ghosal, MD
5. Melvin Bullock, MD

6. Carol Le, MD
7. Mohammad Asif Khan, MD
8. Thomas Nguyen, MD
9. Vinny Samuel, MD
10. Vandana Seeram, MD
11. Siva Suryadevara, MD
12. Esther Vildor-Dazil, MD


Fellowship, Gastroenterology 2009
Fellowship, Endocrinology 2009




Chief Medical Resident,
Fellowship, Cardiology 2010
Chief Medical Resident
Fellowship, Nephrology 2010
Private Practice
Private Practice
Hospitalist
Fellowship, Gastroenterology, 2010
Private Practice
Fellowship, Oncology 2009
Fellowship, Nephrology 2009
Fellowship, Pulmonary/Critical Care 2009
Fellowship, Pulmonary/Critical Care 2009
Fellowship, Cardiology 2009
Private Practice


University of Louisville
University of Florida, Jacksonville




University of Florida, Jacksonville
University of Florida, Jacksonville
University of Florida, Jacksonville
University of Pittsburgh
Jacksonville, FL
Baltimore, MD
University of Florida, Jacksonville
University of Florida, Jacksonville
Jacksonville, Florida
University of Florida, Jacksonville
University of Florida, Jacksonville
University of Florida, Jacksonville
University of Florida, Jacksonville
University of Florida, Jacksonville
Jacksonville, FL


Annual Report AY 2009 Graduate Medical Education


Graduate Medical Education


Program Director: N. Stanley Nahman. Jr MD


Annual Report AY 2009


Graduate Medical Education














July 15, 2009


ACGME
Accreditation Council for N.S. Nahman Jr
Graduate Medical Education
Program Director Internal Medicine Residency Program
515 North State Street Univ of Florida College of Medicine/Jacksonville
Suite 2000
Chicago, IL 60654 Department of Medicine, LRC 4th floor
653-1 West 8th St, GME Box L18
Phone 312.755.5000
Faxne 312.755.7498 Jacksonville, FL 32209
www.acgme.org
Dear Dr. Nahman,

The Residency Review Committee for Internal Medicine, functioning in accordance with the
policies and procedures of the Accreditation Council for Graduate Medical Education (ACGME),
has reviewed the information submitted regarding the following program:

Internal Medicine

University of Florida College of Medicine Jacksonville Program
University of Florida College of Medicine Jacksonville
Jacksonville, FL

Program 1401121099

Based on all of the information available to it at the time of its recent meeting, the Review
Committee accredited the program as follows:

Status: Continued Accreditation
Length of Training: 3
Maximum Number of Residents: 44
Effective Date: 05/19/2009
Approximate Date of Next Survey: 05/2014 FS
Cycle Length: 5.0 Year(s)
Approximate Date For Internal Review: 11/2011


The Review Committee commended the program for its demonstrated substantial compliance with
the ACGME's Requirements for Graduate Medical Education without citations.

PROGRAM STRENGTHS

The Review Committee noted the following strengths or areas of substantial improvement since
the last review:

1. The program and faculty have implemented measures that have reversed a prior decline in
American Board of Internal Medicine pass rate.

2. The sponsoring institution and department have recently implemented several subspecialty
training programs and enriched the educational environment.

3. The department and program are commended for providing an educational program that
generates significant enthusiasm among the residents.









N. S Nahman
Page 2





It is the policy of the ACGME and of the Review Committee that each time an action is taken
regarding a change in the accreditation status of a program, the residents and applicants (those
invited for interviews) must be notified. This office must be notified of any major changes in the
organization of the program. When corresponding with this office, please identify the program by
name and number as indicated above. Changes in participating sites and changes in leadership
must be reported to the Review Committee using the ACGME Accreditation Data System.

Sincerely yours,






Karen L Lambert
Associate Executive Director
Residency Review Committee for Internal Medicine
(312)755-5785
kll@acgme.org

CC: Constance K. Haan, MD MS
Steven J. Lavine, MD
Kent R. Wehmeier
Louis R. Lambiase, MD MHA
Michael Sands, MD MPH
Janet R. Hosenpud, MD BA
Charles W. Heilig, MD BS
Theodore A. Bass, MD
Steve S. Hsu, MD
James D. Cury


Participating Site(s):
Shands Jacksonville Medical Center








DEPARTMENT RESEARCH
ACADEMIC YEAR 2009 (7/08 6/09)

Clinical and basic science effort has expanded over the past year and has been a major focus of the
department. The department has several investigators working in the UF-Jacksonville Medical Research
Building, including Michael J. Haas, Ph.D. (Endocrinology), Charles Heilig, M.D.(Nephrology &
Hypertension), Xiaoyu Li, M.D., Ph.D. (Gastroenterology), and Virginia Urquidi, Ph.D. (Nephrology
& Hypertension).

This spring, Robert C. Nuss, M.D.(Dean of the Regional Campus Jacksonville), Michael Nussbaum,
M.D. (Chair, Department of Surgery) and N. Stanley Nahman, Jr., M.D. (Chief, Division of Nephrology
& Hypertension), provided funds to purchase a real-time DNA analysis system, located in the Medical
Research Building. Since this technology is rapidly becoming the standard for such tasks as measuring
gene expression and viral copy number, this equipment dramatically improves the competitiveness of
investigators in the department

Research conferences were sponsored by the Department of Medicine on Friday afternoons. Speakers
from various departments on campus and from The Mayo Clinic Jacksonville gave presentations on
their research projects, both basic and clinical.

New residents in the Department of Medicine were invited to participate in various research projects
mentored by Department of Medicine faculty at their orientation. Lectures on clinical study design,
statistics, and basic science were provided to faculty and trainees, including sub-specialty residents.

The Department of Medicine won its share of awards at Research Day. Resident Tausef Qureshi, M.D.
was awarded second place in the platform presentation category, and resident M. Kamran Aslam,
M.D. received the fourth place prize. In the poster category, Senan Sultan, M.D. (fellow,
Endocrinology) received the third place and Abdul-Razzak Alamir, M.D. (fellow, Endocrinology)
received the 5th place prize.

PUBLICATIONS

Peer reviewed publications (2008-2009)
1. Ferreiro JL, Angiolillo DJ. Antiplatelet therapy: Clopidogrel plus PPIs-a dangerous combination? Nat Rev Cardiol.
2009 Jun;6(6):392-4.
2. Suzuki N, Angiolillo DJ, Tannenbaum MA, Driesman MH, Smith C, Bikkina M, Meckel CR, Morales CE, Xenopoulos
NP, Coletta JE, Bezerra HG, Bass TA, Costa MA. Strategies for drug-eluting stent treatment of bifurcation
coronary artery disease in the United States: insights from the e-Cypher S.T.L.L.R.trial. Catheter Cardiovasc
Interv. 2009 Jun 1;73(7):890-7.
3. Cola C, Brugaletta S, Yuste VM, Campos B, Angiolillo DJ, Sabat6 M. Diabetes mellitus: a prothrombotic state
implications for outcomes after coronary revascularization. Vasc Health Risk Manag. 2009;5(1):101-19.
4. Michelson AD, Frelinger AL 3rd, Braunwald E, Downey WE, Angiolillo DJ, Xenopoulos NP, Jakubowski JA, Li Y,
Murphy SA, Qin J, McCabe CH, Antman EM, Wiviott SD; for the TRITON-TIMI 38 Investigators.
Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. Eur
Heart J. 2009 May 12. [Epub ahead of print].
5. Capranzano P, Ferreiro JL, Angiolillo DJ. Prasugrel in acute coronary syndrome patients undergoing percutaneous
coronary intervention. Expert Rev Cardiovasc Ther. 2009 Apr; 7(4):361-9.
6. Price MJ, Berger PB, Angiolillo DJ, Teirstein PS, Tanguay JF, Kandzari DE, Cannon CP, Topol EJ. Evaluation of
individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet
reactivity: design and rationale of the GRAVITAS trial. Am Heart J. 2009 May;157(5):818-24, 824.el.
7. Angiolillo DJ. Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future
directions. Diabetes Care. 2009 Apr; 32(4):531-40.
8. Capodanno D, Angiolillo DJ. Contemporary issues on clopidogrel therapy: a critical appraisal. Intern Emerg Med.
2009 Jun;4(3):195-8.


Department Research


Department of Medicine


Annual Report AY 2009


Department Research








9. Angiolillo DJ. Platelet function testing in clinical practice: are we ready for prime time? Rev Esp Cardiol. 2009
Feb;62(2):113-6.
10. Tamburino C, Angiolillo DJ, Capranzano P, Di Salvo M, Ussia G, La Manna A,Guzman LA, Galassi AR, Bass TA.
Long-term clinical outcomes after drug-eluting stent implantation in unprotected left main coronary artery
disease. Catheter Cardiovasc Interv. 2009 Feb 15;73(3):291-8.
11. Angiolillo DJ, Bhatt DL, Gurbel PA, Jennings LK. Advances in antiplatelet therapy: agents in clinical development.
Am J Cardiol. 2009 Feb 2; 103(3 Suppl):40A-51A.
12. Angiolillo DJ. Variability in responsiveness to oral antiplatelet therapy. Am J Cardiol. 2009 Feb 2; 103(3
Suppl):27A-34A.
13. Angiolillo DJ. Emerging insights on antiplatelet therapy. Introduction. Am J Cardiol. 2009 Feb 2; 103(3
Suppl):1A-3A.
14. Biasucci LM, Liuzzo G, Della Bona R, Leo M, Biasillo G, Angiolillo DJ, Abbate A, Rizzello V, Niccoli G, Giubilato S,
Crea F. Different apparent prognostic value of hsCRP in type 2 diabetic and nondiabetic patients with acute
coronary syndromes. Clin Chem. 2009 Feb; 55(2):365-8.
15. Rossini R, Musumeci G, Lettieri C, Molfese M, Mihalcsik L, Mantovani P, Sirbu V, Bass TA, Della Rovere F, Gavazzi
A, Angiolillo DJ. Long-term outcomes in patients undergoing coronary stenting on dual oral antiplatelet treatment
requiring oral anticoagulant therapy. Am J Cardiol. 2008 Dec 15; 102(12):1618-23.
16. Angiolillo DJ, Suryadevara S, Capranzano P, Zenni MZ, Guzman LA, Bass TA. Antiplatelet drug response
variability and the role of platelet function testing: a practical guide for interventional cardiologists. Catheter
Cardiovasc Interv. 2009 Jan 1; 73(1):1-14.
17. Angiolillo DJ, Capranzano P, Desai B, Shoemaker SB, Charlton R, Zenni MM, Guzman LA, Bass TA. Impact of
P2Y(12) Inhibitory Effects Induced by Clopidogrel on Platelet Procoagulant Activity in Type 2 Diabetes Mellitus
Patients. Thromb Res. 2008 Nov 12. [Epub ahead of print]
18. Angiolillo DJ, Suryadevara S, Capranzano P, Bass TA. Prasugrel: a novel platelet ADP P2Y12 receptor antagonist.
A review on its mechanism of action and clinical development. Expert Opin Pharmacother. 2008 Nov;
9(16):2893-900.
19. Jim6nez-Quevedo P, Suzuki N, Corros C, Ferrer C, Angiolillo DJ, Alfonso F, Hernandez-Antolfn R, BaNuelos C,
Escaned J, Fernandez C, Costa M, Macaya C, Bass T, Sabat6 M. Vessel shrinkage as a sign of atherosclerosis
progression in type 2 diabetes: a serial intravascular ultrasound analysis. Diabetes. 2009;58(1):209-14.
20. Antonios N, Angiolillo DJ, Silliman S. Hypertriglyceridemia and ischemic stroke. Eur Neurol. 2008;60(6):269-78.
21. Tamburino C, Angiolillo DJ, Capranzano P, Dimopoulos K, La Manna A, Barbagallo R, Tagliareni F, Mangiafico S,
Guzman LA, Galassi AR, Bass TA. Complete versus incomplete revascularization in patients with multivessel
disease undergoing percutaneous coronary intervention with drug-eluting stents. Catheter Cardiovasc Interv.
2008;72(4):448-56.
22. Carlson ER, Percy RF, Angiolillo DJ, Conetta DA. Prognostic significance of troponin T elevation in patients
without chest pain. Am J Cardiol. 2008;102(6):668-71.
23. Wiviott SD, Braunwald E, Angiolillo DJ, Meisel S, Dalby AJ, Verheugt FW, Goodman SG, Corbalan R, Purdy DA,
Murphy SA, McCabe CH, Antman EM; TRITON-TIMI 38 Investigators. Greater clinical benefit of more intensive
oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in
therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38.
Circulation. 2008;118(16):1626-36.
24. Angiolillo DJ, Guzman LA. Clinical overview of promising nonthienopyridine antiplatelet agents. Am Heart J. 2008
Aug;156(2 Suppl):S23-8.
25. Angiolillo DJ, Bates ER, Bass TA. Clinical profile of prasugrel, a novel thienopyridine. Am Heart J. 2008 Aug;156(2
Suppl):S16-22.
26. Angiolillo DJ, Capranzano P. Pharmacology of emerging novel platelet inhibitors. Am Heart J. 2008 Aug;156(2
Suppl):S10-5.
27. Angiolillo DJ, Guzman LA, Bass TA. Current antiplatelet therapies: benefits and limitations. Am Heart J. 2008
Aug;156(2 Suppl):S3-9.
28. Angiolillo DJ, Bates ER. Platelet inhibitor therapy: current perspectives and emerging novel agents: introduction.
Am Heart J. 2008 Aug;156(2 Suppl):S1-2.
29. Angiolillo DJ, Capranzano P, Goto S, Aslam M, Desai B, Charlton RK, Suzuki Y, Box LC, Shoemaker SB, Zenni MM,
Guzman LA, Bass TA. A randomized study assessing the impact of cilostazol on platelet function profiles in
patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-
2 study. Eur Heart J. 2008 Sep;29(18):2202-11.
30. Valgimigli M, Campo G, de Cesare N, Vranckx P, Hamon M, Angiolillo DJ, Sabate M, Ferrari F, Furgieri A,
Tumscitz C, Repetto A, Colangelo S, Meliga E, Kubbajeh M, Parrinello G, Percoco G, Ferrari R. Tailoring treatment
with tirofiban in patients showing resistance to aspirin and/or resistance to clopidogrel (3T/2R). Rationale for the
study and protocol design. Cardiovasc Drugs Ther. 2008 Aug;22(4):313-20.
31. Giles T, Miller AB, Elkayam,U et al: Pioglitizone use in early heart failure, J of Card failure 2008; 14: 445-452.


Department Research


Department of Medicine


Annual Report AY 2009


Department Research








32. Lavine SJ, Conetta DA. Comparison of the effect of pressure loading on left ventricular size, systolic and diastolic
function in canines with left ventricular dysfunction with preserved and reduced ejection fraction. Cardiovasc
Ultrasound. 2008 Nov 18;6:57.
33. Mooradian AD. Asymptomatic hyperthyroidism in older adults? Is it a distinct clinical and laboratory entity? Drugs
& Aging 25(5):371-80, 2008.
34. Wehmeier, KR, Mazza, A, Hachem, S, Ken Ligaray K, Mooradian AD, Wong, NC, Haas MJ. Differential regulation
of apolipoprotein A-I gene Expression by vitamin D receptor modulators Biochim. Biophys. Acta 1780:264-273,
2008.
35. Wehmeier KR. The Thrifty Economy: Energy Storage and the Obesity Epidemic. Northeast Florida Medicine
59:10-17, 2008.
36. Wehmeier KR and Wood D. Evaluation and treatment of bone diseases in youth with chronic health conditions.
Northeast Florida Medicine 59:35-42, 2008.
37. American Diabetes Association, Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ,
Hoogwerf BJ, Lichtenstein AH, Mayer-Davis E, Mooradian AD, Wheeler ML. Nutrition recommendations and
interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. Jan;31
Suppl 1:S61-78, 2008.
38. BARI 2D Study Group (Mooradian A)., Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM,
Orchard TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TL, Molitch ME, Nesto RW, Sako EY, Sobel
BE. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N. Engl J Med. 360 :2503-
15, 2009
39. Kancha R. Perioperative assessment and management of the patient with pulmonary disease. Northeast Florida
Medicine, Vol 59, No.1 2008: 19-22.
40. Kancha R. Perioperative Assessment and management of patients with Diabetes. Northeast Florida Medicine, Vol
59, No. 1 2008: 23-27.
41. Maalouf R, Mosley M, James Kallail K, Kramer KM, Kumar G. A comparison of salicylic acid levels in normal
subjects after rectal versus oral dosing. Acad Emerg Med 2009 Feb;16(2):157-61.
42. Maalouf R, Mierau SB, Moore TA, Kaul A. First case report of community-acquired pneumonia due to
Tsukamurella pulmonisAnn Intern Med. 2009 Jan 20;150(2):147-8.
43. Pham D. Multidisciplinary Approach to Colorectal Cancer Treatment. Northeast Florida Medicine Vol. 60, Nol; 9:
2009
44. Zaiden R, Pham D. Chemotherapy for Metastatic Colorectal Cancer. Northeast Florida Medicine Vol. 60, No 1: 22-
23; 2009
45. Meenrajan S, Subbiah S, Pham D. Consideration in the Management of Colorectal Cancer in the Elderly.
Northeast Florida Medicine Vo. 60, Nol; 24-28; 2009
46. Reddy S, Sullivan R, Zaiden R, De Mendoza V, Naik N, Vega K, Nahman S, Alexandraki I. Hepatitis C infection
and the risk of bacteremia in hemodialysis patients with tunneled vascular access catheters. Southern Medical
Journal Volume 102, Number 4, April 2009
47. Nguyen T, Pham D. Adjuvant Chemotherapy for Colon Cancer: Northeast Florida Medicine Vol. 60, No 1; 20 -
21; 3.2009
48. Edwards L; Gauger C, Rana F. Sickle Cell Disease: Transition from Pediatric to Adult Providers; Northeast Florida
Medicine vol. 59, No. 4 December 2008
49. Rana F, Garg P, Buzaianu E, Guthrie T. Predictors of toxicity and toxicity profile of adjuvant chemotherapy in
elderly breast cancer patients. The Breast Journal. 2009.
50. Palacio C, Rana F. Blast Crisis; British Medical Journal: December 2008; online epocrates.com/u29111026
51. Zaiden R, Nguyen T. Large B Cell Lymphoma presenting as recurrent sinusitis. Accepted for publication in
Consultant
52. Cortas J, Seither K, Maziaz R, Pham D et al. Superiority of rasburicase versus allopurinol on plasma uric acid
control in adult patients with hematologic malignancies at risk of developing tumor lysis syndrome: results of a
randomized comparative phase iii study; 12:2008
53. Palnitkar RM, Sands M. Mucormycosis; Epocrates, BMJ online monograph
54. Bailey, CL Epocrates, Chancroid. BMJ online monograph
55. Bailey, CL Epocrates, Urethritis BMJ online monograph
56. Guzman, N. Leptospirosis. Epocrates BMJ online monograph
57. Guzman N. Coxiella Epocrates BMJ online monograph
58. Sands M. Vibrios other than V. cholera Epocrates BMJ online monograph
59. Sands M. Epocrates Hantaviruses in the United States. BMJ online monograph
60. Bailey, CL, Smith V, Sands M. Hepatitis B Vaccine: a seven-year study of adherence to the immunization
guidelines and efficacy in HIV-1 positive adults. Int J Infect Dis (2008) 12, e77-83
61. Alexandraki I, Sullivan R, Zaiden R, Bailey C, McCarter Y, et al. Blood culture isolates in hemodialysis vascular
catheter-related bacteremia. Am J Med Sci 336(4), 2008.


Department Research


Department of Medicine


Annual Report AY 2009


Department Research








62. The strategies for management of antiretroviral therapy (SMART) study group, including Sands M. Major clinical
outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the
SMART study. JID 2008; 197:1133-44.
63. The strategies for management of antiretroviral therapy (SMART) study group, including Sands M. Inferior
clinical outcomes of the CD4 cell count-guided antiretroviral treatment interruption strategy in the SMART study:
Role of CD4 cell counts and HIV RNA levels during follow-up. JID 2008;197:1145-55.
64. Bailey C, Smith V, Sands M. Hepatitis B vaccine: A seven year study of adherence to the immunization
guidelines and efficacy in HIV- 1 positive adults. DID 2008; 12:e77 e83.
65. The SMART/INSIGHT_and D:A:D Study Groups, including Sands M. Use of nucleoside reverse transcriptase
inhibitors and risk of myocardial infarction in HIV infected patients. AIDS 2008, 22:F17-F24.
66. Fox Z, Phillips A, Cohen C et al and the SMART study group including Sands M. Viral resuppression and
detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor
based regimen. AIDS 2008;22:2279-2289.
67. Vindas-Cordero J, Sands M, Sanchez W. Austrian's triad complicated by suppurative pericarditis and cardiac
tamponade: A case report and review of the literature. DID 2009;13:e23-e25.
68. Mocroft A, Wyatt C, Szczedh L, et al and the SMART study group including Sands M. Interruption of
antiretroviral therapy is associated with increased plasma cystatin C. AIDS 2009;23:71-82.
69. Afessa B, Bajwa A, Salman S, Incidence of atrial fibrillation in critically ill patient with sepsis. J Intensive Care
Med 2008 May-June; 23(3):178-83.
70. Mazidi P, Bajestani S. Khan M, Khair T, Laos L. Goodpasture's Syndrome: A Case Report and Review of
Literature: The Internet Journal of Internal Medicine. 2008, Volume 7, Number 2.
71. K. Ramsubeik, R. Maharaj, G Mitri. When diagnosis of rheumatologic disease does not "follow the book". J
Musculoskel Med. January 2009; 26(1): 11-14.
72. Bruyn GA, Naredo E, Moller I, Moragues C, Garrido J, de Bock GH, D'Agostino MA, Filippucci E, lagnocco A,
Backhaus M, Swen N, Balint PV, Pineda C, Milutinovic S, Kane DJ, Kaeley G, Narvaez JA, de Agustin J, Wakefield
RJ, Narvaez J, Schmidt WA. Reliability of ultrasonography in detecting shoulder disease in patients with
rheumatoid arthritis. Ann Rheum Dis. 2009 Mar;68(3):357-61.
73. Goodison S, Urquidi V: Breast tumor metastasis: analysis via proteomic profiling. Expert Rev Proteomics. 5:457-
67, 2008

Books, Book chapters, Editorials
1. Wehmeier KR. Disorders of Calcium Metabolism. Schmitz P, Martin K and Miller D (eds) In Internal Medicine:
Just The Facts McGraw-Hill, New York. 2008.
2. Wehmeier KR. Metabolic Bone Diseases. Schmitz P and Miller D (eds) In Internal Medicine:Just The Facts
McGraw-Hill, New York. 2008.
3. Chehade J, Mooradian AD. Drug Therapy: Current and emerging agents in hyperglycemia. In: Diabetes in Old
Age. 3nd edition, A.J, Sinclair (eds), John Wiley & Sons Ltd., 2008.
4. Alexandraki I, Contributing author "Community Acquired Pneumonia" chapter of the textbook "Internal Medicine
Essentials for Clerkship Students 2, ACP- Clerkship Directors in Internal Medicine, pages 197-199, 2009
5. Alexandraki I, Contributing author "Urinary Tract Infection" chapter of the textbook "Internal Medicine Essentials
for Clerkship Students ', ACP- Clerkship Directors in Internal Medicine, pages 180-182, 2009
6. Alexandraki I, Department of Medicine, University of Florida College of Medicine-Jacksonville. HIV-Related
Opportunistic Infections (2009) [Internet], eds. BMJ Point of Care. http://group.bmj.com/products/evidence-
centre/bmj-point-of-care-1
7. Alexandraki I: "MKSAP for Students 4, writer of multiple choice questions for the "Urinary Tract Infection" and
"Community Acquired Pneumonia" chapters; ACP-Clerkship Directors in Internal Medicine, 2009
8. Alexandraki I, Department of Medicine, University of Florida College of Medicine-Jacksonville (2008). 48-year-old
woman with HIV- Ms. Hunt. In SIMPLE: Simulated Internal Medicine Patient Learning Experience [Internet], eds.
Berman and Fall, Institute for Innovative Technology In Medical Education, Lebanon,
NH. http://www.simplecases.orq.
9. Palacio, C Contributing author "COPD" chapter of the textbook "Internal Medicine Essentials for Clerkship
Students" 2nd edition, ACP- Clerkship Directors in Internal Medicine. October, 2008
10. Palacio, C Contributing author "Hepatitis" chapter of the textbook "Internal Medicine Essentials for Clerkship
Students" 2nd edition, ACP- Clerkship Directors in Internal Medicine. October, 2008
11. Palacio, C Multiple Choice Question Writer. CDIM MKSAP 4 for Students. October, 2008
12. Palacio C. Rickets. BMJ publishing group point-of-care Website. July 2008 (US product on pocrates.com)
13. Palacio C. Rickets. BMJ publishing group Best Practice Website. January 2009 (International product on
bestpractice.com)
14. Carlos Palacio, M.D. ( October 2008). 65-year old woman-Mrs Thompson. In SIMPLE: Simulated Internal
Medicine Patient Learning Experience Project eds. Berman and Fall. http://www.simplecases.orq.


Department Research


Department of Medicine


Annual Report AY 2009


Department Research








15. Palacio C, Fauzia R. Blast Crisis. BMJ publishing group point-of-care Website. January 2009 (US product on
epocrates.com)
16. Palacio C, Fauzia R. Blast Crisis. BMJ publishing group Best Practice Website. January 2009 (International
product on bestpractice.com)
17. Phillips, James, M.D., Masri, Ghania, M.D. Chapter: Hypernatremia. 2009 Under contract for chapter
publication in the British Medical Journal- Point of Care. (Currently under peer review)
18. Masri, Ghania, M.D., Phillips, James, M.D. Chapter: Hyponatremia. 2009 Under contract for chapter
publication in the British Medical Journal- Point of Care.
19. Meenrajan S. Elder Abuse. Monograph for BMJ. Point of Care. 2009.

National and regional presentations (2007-2008)
1. Palnitkar RM, Shea YR, Holland SM, Banacloche JG, Palmore TN. Nontuberculous mycobacterial bloodstream
infections in NIH patients with primary and acquired immunodeficiencies (1996-2007). Poster at IDSA/ICCAC
2008.
2. Mannepalli S, Lauer J. Many faces of Tuberculosis: Tuberculous meningitis in an immunocomprimised patient.
Poster presentation at Statewide TB and Refugee Health Meeting Tampa Florida, October 2008.
3. Mannepalli S, Sands M, Guzman N, Khan A. Sleep quality and presence of sleep disordered breathing in an inner
city African American HIV seropositive population 50 years and older. American Conference for the Treatment of
HIV, Denver, Colorado in May 2009.
4. Mannepalli S, Sands M, Guzman N, McCarter Y. Pulmonary Nocardiosis as the initial presenting infection in
HIV/AIDS. Oral presentation at Annual American College of Chest Physicians meeting, Philadelphia, Pa. October
2008.
5. Mannepalli S, Lauer J. Mycobacterium tuberculosis osteomyelitis in a patient with Human immunodeficiency
virus/ Acquired Immunodeficiency syndrome (HIV/AIDS) A Clinical Reminder. Poster presentation at Regional
ACP meeting Tampa, Florida September 2008
6. Wood, D, Lukens-Bull, KM, Yin, X, Edwards, L, Livingood, W, Sawicki G. Factors related to reported to
employment, school attendance and other outcomes following transition for a national cohort of young adults
with special health care needs 2009 Pediatric Academic Societies Annual Meeting File # 753679
7. Wood, DL, Sawicki, G,, Yin, X, Nathan Demars, N, Edwards, L, Lukens-Bull, K, Livingood, W. Transition support is
associated with increased reported self-determination by young adults with special health care needs. 2009
Pediatric Academic Societies Annual Meeting File#754298
8. Reddy,S, Ramsubeik, R, Federico,J, Goodwich, R, Palacio,C, Vega KJ. Do HbA1C levels correlate with delayed
gastric emptying in diabetic patients? Poster Session, Digestive Disease Week, McCormick Place in Chicago, IL,
June 3, 2009, Abstract # 582494
9. Vega, KJ, Carlos Palacio, C, Mooradian A Validation of a gastroesophageal reflux questionnaire for use in African
Americans. Digestive Disease Week, Chicago, IL, June 2, 2009, Abstract # 585119
10. Lavine SJ. Left ventricular filling pressure can be estimated from systolic arterial pressure and left ventricular
relaxation time. J Am Sco Echocardiogr 2009; 22; 586 (abstract). Presented at the Scientific Sessions of the
American Society Echocardiography, June 2009, Washington, DC.
11. McMullan L, Smalheiser S, Weisberg I, Percy R, Hsu S, Zenni M, Miller AB: Association of ventricular arrhythmia
therapy and extent of scarred myocardium measured be single photon emission computed tomography Imaging in
ischemic heart failure patients. J of Card Failure 2008; 14; no 6S, pg S58
12. O'Connor C, Anand I, Fiuzat M, Plehn J, Gottleib S, Silver M, Lindenfeld J, Miller AB, et al: Additive effects of b 1 389
Arg/Gly alpha 2 c322-325 wt/del genotype combinations on adjudicated hospitalizations and death in the beta
blocker evaluation of survival trial (BEST). J of Card Failure 2008; 14: no 6S, pg S69
13. Wang N, Konstam M, Maggioni A, Traver B, Burnett J, Grinfeld L, Swedberg K, Udelson J, Zannand F, Cook T,
Zimmer C, O'Connor C, Miller AB, Gheorgiade M: Correlation of ejection fraction to early post discharge sudden
death and all cause mortality in the EVEREST trial. J of Card Failure 2008; 14: no 6S, pg S71
14. Wang N, Konstam M, Maggioni A, Traver B, Burnett J, Grinfeld L, Swedberg K, Udelson J, Zannand F, Cook T,
Zimmer C, O'Connor C, Miller AB, Gheorgiade M: Post discharge adjudicated outcomes in patients with implantable
defibrillators in the EVEREST trial. J of Card Failure 2008; 14: no 6S, pg S72
15. Smalheiser S, McMillan L, Venkataraman R, Percy R, ChapmanD, Zenni M, Miller AB: Association of heart failure class
and left ventricular dyssynchronymeasured by SPECT imaging in ischemic systolic heart failure patients. J of Card
Failure 2008; 14: no 6S, pg S90
16. Carson P, Gottleib S, Anand I, Plehn J, Silver M, Lindenfeld J, O'Connor C, Miller AB et al: Determination of
hospitalization type by investigator case report form or adjudication committee in a large heart failure clinical trial
(BEST). J of Card Failure 2008; 14: no 6S, pg S 93
17. Miller AB, Reichek N, St. John Sutton M, et al: Comparable blood pressure control and LV mass reduction in patients
with hypertension and LVH with ACE inhibitor alone or combined with B blockade 2009; in press J Amer Soc
Hypert Presented Late Breaking Trials ASH 2009


Department Research


Department of Medicine


Annual Report AY 2009


Department Research








18. Jimenez Quevedo P, Sabate M, Corrros C, Ferrer M, Alfonso F, Hernandez-Antolin R, Escaned J, Banuelos C,
Angiolillo DJ, Macaya C. Insights on the effect of secondary prevention on plaque composition and cardiac
events in diabetic patients. European Society of Cardiology 2008. Munich, Germany.
19. Wiviott SD, Antman E, Angiolillo DJ, Meisel, Dalby, Verheugt, Goodman, Murphy, Mccabe, Braunwald Greater
effect of intensive antiplatelet therapy with prasugrel compared with clopidogrel in diabetics in TRITON TIMI
38. European Society of Cardiology 2008. Munich, Germany.
20. Rossini, Musumeci, Lettieri, Molfese, Mantovani Sirbu, Mihalcsik, Spirito, Gavazzi, Angiolillo. Outcomes of long-
term triple therapy with aspirin, clopidogrel, and warfarin in patients undergoing coronary stenting. European
Society of Cardiology 2008. Munich, Germany.
21. Tamburino, Angiolillo, Capranzano, Di Salvo, Caggeggi, Tomasello, Capodanno, Galassi, Ussia, Bass. Long-term
clinical outcomes after drug-eluting stent implantation in unprotected left main coronary artery disease.
European Society of Cardiology 2008. Munich, Germany.
22. Angiolillo, Bernardo, Trabetti, Zanoni, Cavallari, Capranzano, Macaya, Pignatti, Fernandez-Ortiz, Bass Role of
MDR-1 gene polymorphisms on clopidogrel responsiveness in patients with coronary artery disease. European
Society of Cardiology 2008. Munich, Germany.
23. Frelinger AL Michelson AD; Braunwald E; Downey WE; Angiolillo DJ; Xenopoulos NP; Jakubowski JA; Li Y;
Murphy SA; Qin J; McCabe CH; Antman EM; Wiviott SD, for the TRITON-TIMI 38 Investigators.
Pharmacodynamic assessment of platelet inhibition by prasugrel versus clopidogrel in the TRITON-TIMI 38 Trial.
American Heart Association 2008. Chicago, II.
24. Capranzano P, Ferreiro JL, Sumner S, Desai B, Charlton RK, Box L, Zenni MM, Guzman LA, Bass TA, Angiolillo
DJ, Evaluation of a modified light transmittance aggregometry protocol to assess P2y12 blockade induced by
clopidogrel. American College of Cardiology/i2 Summit 2009. Orlando, Fl.
25. Angiolillo DJ, Bernardo E, Capranzano P, Sabate M, Ferreiro JL, Alfonso F, Jimenez-Quevedo P, Hernandez R,
Guzman LA, Macaya C, Fernandez-Ortiz A, Bass TA. Platelet Disaggregation: a Novel Parameter of Clopidogrel
Responsiveness? American College of Cardiology/i2 Summit 2009. Orlando, Fl.
26. Capranzano P, Ferreiro JL, Sumner S, Desai B, Charlton RK, Zenni MM, Guzman LA, Bass TA, Angiolillo DJ.
Clopidogrel-induced antiplatelet effect assessment by flow cytometry and point-of-care based assays: correlation
between VASP and verify now P2Y12 testing. American College of Cardiology/i2 Summit 2009. Orlando, Fl.
27. Angiolillo DJ, Bernardo E, Capranzano P, Sabate M, Jimenez-Quevedo P, Ferreiro JL, Alfonso F, Hernandez R,
Macaya C, Fernandez-Ortiz A, Bass TA. Prognostic implications of high platelet reactivity as defined by multiple
agonists in diabetes mellitus patients on dual antiplatelet therapy. American College of Cardiology/i2 Summit
2009. Orlando, Fl.
28. Meenrajan S, Ketty A, Petrucelli O, S Nahman. evaluating the effect of an intense orientation session on
resident attitudes toward continuity clinic training. Southern American Federation for Medical Research.
Abstract. February 12-14, 2009.
29. Meenrajan S, Ketty A, Petrucelli O, S Nahman. Evaluating and impacting resident attitudes toward continuity
clinics, medical education week, University of Florida, College of Medicine Jacksonville. Apr 2009.
30. Mohsen A, Meenrajan S. Case report of a rare case of metastatic hepatocellular carcinoma. Florida ACP. 2009
31. Sottile, E. Improving your clinical teaching: from concepts to action, American College of Physicians Pre-Course
2009, Philadelphia, PA.
32. Munoz, JC, Pudhota ,S Smith AS, Vega K. Modified technique to extract malpositioned or migrated self-
expanding stents from the esophagus and stomach. American College of Gastroenterology meeting. 2009.
33. Munoz, JC, Smith AS. Unusual objects removed from unusual patients: a case series and literature review
American College of Gastroenterology meeting, 2009.
34. Smith, AS, Munoz, JC, Vega K, Nutritional differences at the time of colorectal cancer diagnosis: a potential
explanation for disparities in outcome between African Americans and non-Hispanic Whites. American College of
Gastroenterology (ACG) meeting. 2009.
35. Vega KJ, Langford-Legg TL, Jamal MM. Gender variation in lower esophageal sphincter pressure and length.
Am J Gastroenterol 2008; 103 (Sl): S2. (Poster presentation, ACG 2008.
36. Pudhota S, DiTeodoro LA, Vega KJ, Wludyka P, Bullock D, Lambiase LR. Ultrasound marking improved
percutaneous liver biopsy yield. Am J Gastroenterol 2008; 103 (S1):AS144. (Poster presentation, ACG 2008.
37. Smith AS, Cole M, Vega KJ, Munoz JC. Palliation of malignant rectosigmoid obstruction secondary to locally
invasive prostate cancer with multiple overlapping self-expanding metal stents. Am J Gastroenterol 2008; 103
(Sl): S348-9. (Poster presentation, ACG 2008.
38. Vega KJ, Palacio C, Jamal MM. Validation of a gastroesophageal reflux questionnaire for use in African
Americans. Accepted for presentation, DDW 2009.
39. Chisholm S, Khoury JE, Jamal MM, Vega KJ. The frequency of confirmed Barrett's esophagus varies by ethnicity
and gender. Accepted for presentation, DDW 2009.
40. Reddy S, Ramsubeik K, Federico J, Goodwich R, Palacio C, Vega KJ. Do HbA1C levels correlate with delayed
gastric emptying in diabetic patients? Accepted for presentation, DDW 2009.


Department Research


Department of Medicine


Annual Report AY 2009


Department Research









41. Luyu Yao Haizhen Zhu Yiling Xu Louis R. Lambiase David R. Nelson Chen Liu Xiaoyu Li M1808.
Inhibition of Hepatitis C Viral (HCV) Replication By In Vitro Dimerization of IFN Regulatory Factor-3 (IRF3)
Accepted poster DDW 2009.
42. Pudhota, S, Bullock, MD, Lambiase, LR, Kottoor R. Retrospective analysis of predicting factors for complications
of colonoscopy. Accepted Poster DDW 2009.
43. Zaiden R.; A retrospective review of demographics and stage of presentation in patients with ER/PR/Her2-Neu
receptor negative (triple negative) breast cancer. 31st Annual San Antonio Breast Cancer Symposium December
2008.
44. Rana F, Jasani N. Racial Discrepancies in Breast Cancer in Urban Hospital Retrospective Analysis. San Antonio
Breast Symposium, December 2008 .
45. Zaiden R, Latif N, Pham D, Hosenpud J. Dermatofibroma Protuberans: A case report and review of literature.
Accepted in Clinical Advances in Hematology and Oncology. Abstract 12.08.
46. Rana F. A retrospective review of demographics and stage of triple-negative breast cancer. Abstract #30042
IDe11553 www.asco.ora and www.ico.orq June 2009.
47. Rana F, Garg P, Guthrie TH. Toxicity of adjuvant chemotherapy in elderly breast cancer patients. Journal of
Investigative Medicine February 2008.
48. Rana F, Garg P. Factors influencing utilization of hospice care versus aggressive treatment options in pancreatic
cancer patients. Journal of Investigative Medicine February 2008, American Society of Clinical Oncology, Annual
GI Cancer Symposium Proceedings, January 2008.
49. Garg P, Rana F. Pancreatic cancer and diabetes. Journal of Investigative Medicine February 2008.


Annual Report AY 2009 Department Research


Department Research


Department of Medicine


Annual Report AY 2009


Department Research








DIVISION OF CARDIOLOGY
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Division of Cardiology should have a good financial bottom line for FY 09 both on the professional
side and technical side (Shands side). For FY 09, Cardiology should finish the year with a positive
bottom line on the professional side and will be over flex budget on the hospital bottom line for
contribution margin. At this time, financial are current only through April 09.

In FY 09, Cardiology added three new Cardiologists to the group. Two Electrophysiologist joined the
group; Dr. Robert Kim joined in September 2008 and Dr. Daniel Katz joined in April 2009. We now have
four Electrophysioliogist in the Cardiology practice. Also in May of FY 09, the hospital approved capital
to put in a new intracardiac recording system in both EP labs. This new technology will not only improve
patient care but will also improve procedure time and documentation. The Electrophysiology team will
be expanding their programs in the areas of Atrial Fibrillation ablations and sudden death. The
Electrophysiology program also has plans of expanding their services into the St. Augustine area in FY
10. In July 09, the Electrophysiology fellowship program will begin with two new fellows joining the
program for a yearlong fellowship.

The division continues to practice in Lake City and St. Mary's, Georgia, both being strong practices. The
Lake City practice ramped up in volume over the past year with our commitment of having a cardiologist
at this practice full time. Lake Shore opened a diagnostic Cath lab in November 07, in collaboration with
The CV Center. We continue to provide Medical Directorship for this Catheterization lab. The Division
also started seeing patients in Live Oak at Shands Live Oak hospital in November 08. In December 08,
our cardiologist started reading all the nuclear studies from Live Oak remotely at the Shands Jacksonville
campus. Plans are for Live Oak to obtain an ECHO machine and all ECHO's will be read remotely by our
cardiologist in FY 10. We are also exploring the option of placing a cardiologist in the Dowling Park
retirement community (just outside Live Oak) a half day a week.

The Peripheral Vascular Program continues to be strong under the leadership of Dr. Luis Guzman. Our
volume of peripheral cases has remained steady. We are currently working with the Department of
Surgery in regards to adding a Vascular Surgeon who would be shared between Cardiology and the
Department of Surgery.

Dr. Lyndon Box is the third Cardiologist who joined our group in FY 10. Dr. Box was an interventional
fellow in our program prior to joining on as faculty. Dr. Box has worked very aggressively this year with
the local EMS to develop protocols for STEMI patients, develop educational programs for EMT's
regarding STEMI's and work with EMS on state and national legislation issues regarding dedicated PCI
hospitals. He also has been instrumental in working with local EMS on standardizing the Electronic EKG
transmission systems for ambulances. We were able to purchase systems for local EMS program to
place in their ambulances so that EKG's could be transmitted directly to the physician/hospital from the
field. All devices have been installed and the in-house system in currently being installed in the
Emergency Department. This new system should have a great positive effect on door to balloon times.
In FY 09 we added a STEMI coordinator to our group to help facilitate the STEMI outreach /community
program.

The division has worked closely with the Director of Information Services/Medical Records/Coding in
regards to improving documentation and coding for the division. We have regular meetings with the
Director to go over outliers in documentation, new guidelines for documentation and coding. The plan is
for Cardiology to have dedicated coders in FY 10.


Cardioloav


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








In regards to customer service, we implemented a "customer service initiative" in FY 09. We looked
closely at our referral numbers from UF satellite offices. Offices with lower percentages for patients
referred to UF Cardiology were targeted initially. Dr. Bass made visits to each office and discussed how
we are doing, what we can do to improve our services, what it would take to have 100% referrals from
these offices. We also started our "physician of the day" program and "urgent appointment" line
program. We gave out laminated cards with one number to call if you need to talk immediately to a
Cardiologist or you need to get a patient in same day/next day to be seen by a Cardiologist.

Our Goals for FY 10 are as follows:

Hire a Cardiologist to develop /lead a Women's Cardiovascular Health Program
Place a Cardiologist in Callahan office two /2 days a week
Place a Cardiologist in the Dowling Park area, /2 day a month to start
Provide EP services in St. Augustine area
Continue to enhance the STEMI program with more outreach/education to EMS
services in all surrounding counties.
Look at possibility of taking ownership of a leading Cardiovascular journal
Continue to grow research in all areas of Cardiology
Enhance relationship with VA in regards to referrals for testing as well as collaboration
with their cardiologist
Develop relationship with department of surgery in regards to vascular support.
Develop strong relationship with new hospitalist service

Patient Care: As stated above, CV satellite offices continue to expand. Our Lake Shore office provides
cardiovascular care (physician visits as well as diagnostic testing) to Lake City and surrounding
communities. Physicians rotate to the Lake City office Monday through Friday. We have expanded
these services to Live Oak and hope to expand to the Dowling park area.

We continue with the practice in St. Mary's, Georgia. This office is equipped with diagnostic testing
equipment (ECHO machine/stress testing). UF cardiologists rotate to the practice Monday through
Friday. They cover office visits as well as hospital consults, at Camden Medical Center. We will start
performing Carotid ultrasounds in this office in FY 10.

We continue to see an increase in downstream revenue from both of these locations, especially the Lake
City office.

We have seen an improvement in our quality scores in AMI and CHF. We still have some improvement
to be made in AMI, but just as last year most of our fallouts were not on the Cardiology service. These
were patients seen on other services (non-cardiology). Solutions for these issues are being discussed.

Patient Satisfaction scores for both inpatient and outpatient services continue to be above the 85th
percentile. Great progress has been made in inpatient patient satisfaction scores in the CCU. Great
progress has also been made in wait times for patient undergoing invasive testing (heart cath or EP
procedure) in FY 10.

Education: We receive between 400-500 applications per year for five available spots in our Fellowship
Program. Applications are screened eighteen months prior to the start of the program. This past year
we received 510 applicants thru ERAS (Electronic Residency Application Service) of which 54 were
selected for interview. Individuals are invited based on medical school, quality of the medical residency,
USME scores, research performed, and letters of recommendations. Faculty evaluates candidates based
on interpersonal skills, academic potential, and clinical potential.


Cardioloav


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








Faculty conducts four sessions of Board review for medical residents. Significant changes were made in
the CCU service to shorten rounds, enhance teaching, and faculty-resident interaction.

Fellows passing their boards are at 94% and 100% in both the Cardiovascular Disease and
Interventional programs.

Research: With the dissolution of the Cardiovascular Imaging Core Laboratory, the division has been
actively involved in two main areas of research; clinical research and translational research.

Clinical Research: The division was involved in several multi-center sponsored research projects in the
fields of heart failure, arrhythmia electrophysiologyy), and coronary artery disease. We currently have 12
active sponsored research projects being conducted at the Division of Cardiology.

Translational Research: Our thrombosis research laboratory continues to grow and mature. In addition,
the state of the art assays for platelet function testing the research team has a medical director, a PhD,
4 post-doctoral research fellows, and a laboratory technician. The thrombosis research laboratory
currently performs numerous sponsored and investigator initiated studies. The thrombosis research
laboratory is among the most involved in the country for pharmacodynamic testing of antiplatelet agents
under clinical development. We have also been involved in testing assays for sponsors requiring FDA
approval of novel devices. The research group is among the most prolific academically with numerous
peer-reviewed publications in major scientific journals.


LISTING OF FACULTY MEMBERS


New Faculty


Robert Kim, M.D., Assistant Professor

iledical School Graduation date Tufts University School of medicine Boston, I1A
Internship.,residency and year St. Elizabeth s iledical Center Boston, i1A!
University of HIA Iledical Center-Worcester, Il1A
Subspecialty training and year Dartmouth-Hitchcock iledical Center Lebanon, rJH


Daniel Katz, M.D., Assistant Professor

iledical School Graduation date Ilew Jersey medicall School ilewark, [Jew Jersey
Internship. residency and year Brown University Rhode Island
Subspecialty training and year Albert Einstein College of Iledicine Bronx, [Jew York


1998
2001
2004
2008


1997
2000
2006


Lyndon Box, M.D., Assistant Professor


medical School ,/ Graduation date
Internship.,residency and year

Subspecialty training and year


University of l ississippi Birmingham, Alabama
Carraway methodist medical Center!Oregon Health Sciences
University
University of Florida Jacksonville, Florida


2001
2002
200-1
2008


Annual Report AY 2009 Cardiology


Cardioloov


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








Current Faculty

Dominick Angiolillo, M.D. Ph.D., Assistant Professor
Medical School Graduation date Tre Catno:iir : unr.est, o:f tne Sac:red Heart r.eal.:al S.:n:Il i, ital, 1997
Internship.,residency and year The Catno.:hc uni.ersit, :of the Sacred Heart i.leal:ai S:cno:,i, ital, 1997
Subspecialty training and year University Hospital of Salamanca, Spain./The Policlinico 1998
Agostino Gemelli University Hospital, ItalySan Carlos 2003
University Hospital


Theodore Bass, M.D., Professor and Division Chief
iledical School Graduation date Brown University 1976
Internship,,residency and year layo Clinic 1979
Subspecialty training and year Boston University 1981




Douglas Chapman, M.D., Assistant Professor
Medical School Graduation date Chicago Iledical School 198-1
Internship.iresidency and year University of lissouri 1987
Subspecialty training and year Iichael Reese Hospital 1990




Donald Conetta, M.D., Associate Professor
Fledical School / Graduation date Duke University 1970
Internship. residency and year Georgetown University 1975
Subspecialty training.year University of Florida 1977




Luis Guzman, M.D., Assistant Professor
medical School Graduation date University of Buenos Aires, Argentina 1982
Internship.,residency and year Churruca-Visca Hospital, Argentina 1986
Subspecialty training and year Instituto Cardiovascular Buenos Aires, Argentina 1989





Iledical School Graduation date Washington University 1990
Internship. residency and year Thomas Jefferson University 1993
Subspecialty training and year Thomas Jefferson University 1997




[ Steven Lavine, M.D., Associate Professor
mI medical School / Graduation date Temple University 1976
Internship.iresidency and year Temple University 1979
I Subspecialty training and year Temple University 1981


Annual Report AY 2009 cardiology


Cardioloov


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology


I -_i








Alan Miller, M.D., Professor
Fledical School / Graduation date University of Pittsburgh 1966
Internship/residency and year Ilount Sinai 1968
Internshipresidency and year George Washington University 1971
Subspecialty training and year Cleveland lMetropolitan Hospital 1973



David Nabert, M.D., Associate Professor
|Miedical School Graduation date UIlIDIJJ IJew Jersey lMedical School 1988
Internship,,residency and year Hackensack University iledical Center 1991
Subspecialty training and year Ochsner lMedical Foundation 1999




Joseph Pensabene, M.D., Assistant Professor
iledical School Graduation date The Chicago iledical School 198-1
Internship./residency and year Overlook Hospital 1987
Subspecialty training and year Cardiovascular Disease, IJorthwestern memorial Hospital 1990
Subspecialty training and year Interventional Cardiology, UCLA iledical Center 1991
Subspecialty training and year Cairia.: CT and Cardiac: I-1:i, uni.esii, ofr Flonda Jia.:.son.nIe 2006


Robert Percy, M.D., Associate Professor
iledical School / Graduation date University of ilississippi 1973
Internship.residency and year University of ilississippi 1977
Subspecialty training and year Joslin Clinic 1979
Subspecialty training and year lass General Hospital 1981



Martin Zenni, M.D., Associate Professor
I-ledical School / Graduation date University of Chicago 1986
Internshipresidency and year Tufts University 1989
S Subspecialty training and year Harvard iledical School 1992




PUBLICATIONS

Peer reviewed publications:
Ferreiro JL, Angiolillo DJ. Antiplatelet therapy: Clopidogrel plus PPIs-a dangerous combination? Nat Rev Cardiol. 2009
Jun;6(6):392-4. PubMed PMID: 19471283.

Suzuki N, Angiolillo DJ, Tannenbaum MA, Driesman MH, Smith C, Bikkina M, Meckel CR, Morales CE, Xenopoulos NP,
Coletta JE, Bezerra HG, Bass TA, Costa MA. Strategies for drug-eluting stent treatment of bifurcation coronary artery
disease in the United States: insights from the e-Cypher S.T.L.L.R.trial. Catheter Cardiovasc Interv. 2009 Jun
1;73(7):890-7. PubMed PMID: 19455662.

Cola C, Brugaletta S, Yuste VM, Campos B, Angiolillo DJ, Sabat6 M. Diabetes mellitus: a prothrombotic state implications
for outcomes after coronary revascularization. Vasc Health Risk Manag. 2009;5(1):101-19. Epub 2009 Apr 8. PubMed
PMID: 19436654; PubMed Central PMCID: PMC2672443.

Michelson AD, Frelinger AL 3rd, Braunwald E, Downey WE, Angiolillo DJ, Xenopoulos NP, Jakubowski JA, Li Y, Murphy SA,
Qin J, McCabe CH, Antman EM, Wiviott SD; for the TRITON-TIMI 38 Investigators. Pharmacodynamic assessment of
platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. Eur Heart J. 2009 May 12. [Epub ahead of
print] PubMed PMID: 19435740.


Cardioloov


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








Capranzano P, Ferreiro JL, Angiolillo DJ. Prasugrel in acute coronary syndrome patients undergoing percutaneous
coronary intervention. Expert Rev Cardiovasc Ther. 2009 Apr; 7(4):361-9. PubMed PMID: 19379060.

Price MJ, Berger PB, Angiolillo DJ, Teirstein PS, Tanguay JF, Kandzari DE, Cannon CP, Topol EJ. Evaluation of
individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity:
design and rationale of the GRAVITAS trial. Am Heart J. 2009 May; 157(5):818-24, 824.el. PubMed PMID: 19376306.

Angiolillo DJ. Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future
directions. Diabetes Care. 2009 Apr; 32(4):531-40. PubMed PMID: 19336638; PubMed Central PMCID: PMC2660456.

Capodanno D, Angiolillo DJ. Contemporary issues on clopidogrel therapy: a critical appraisal. Intern Emerg Med. 2009
Jun;4(3):195-8. Epub 2009 Mar 31. PubMed PMID: 19333714.

Angiolillo DJ. Platelet function testing in clinical practice: are we ready for prime time? Rev Esp Cardiol. 2009
Feb;62(2):113-6. English, Spanish. PubMed PMID: 19232182.

Tamburino C, Angiolillo DJ, Capranzano P, Di Salvo M, Ussia G, La Manna A,Guzman LA, Galassi AR, Bass TA. Long-term
clinical outcomes after drug-eluting stent implantation in unprotected left main coronary artery disease. Catheter
Cardiovasc Interv. 2009 Feb 15;73(3):291-8. PubMed PMID: 19214963.

Angiolillo DJ, Bhatt DL, Gurbel PA, Jennings LK. Advances in antiplatelet therapy: agents in clinical development. Am J
Cardiol. 2009 Feb 2; 103(3 Suppl):40A-51A. Review. PubMed PMID: 19166712.

Angiolillo DJ. Variability in responsiveness to oral antiplatelet therapy. Am J Cardiol. 2009 Feb 2; 103(3 Suppl):27A-34A.
Review. PubMed PMID: 19166710.

Angiolillo DJ. Emerging insights on antiplatelet therapy. Introduction. Am J Cardiol. 2009 Feb 2; 103(3 Suppl):1A-3A.
PubMed PMID: 19166706.

Biasucci LM, Liuzzo G, Della Bona R, Leo M, Biasillo G, Angiolillo DJ, Abbate A, Rizzello V, Niccoli G, Giubilato S, Crea F.
Different apparent prognostic value of hsCRP in type 2 diabetic and nondiabetic patients with acute coronary syndromes.
Clin Chem. 2009 Feb; 55(2):365-8. PubMed PMID: 19179271.

Rossini R, Musumeci G, Lettieri C, Molfese M, Mihalcsik L, Mantovani P, Sirbu V, Bass TA, Della Rovere F, Gavazzi A,
Angiolillo DJ. Long-term outcomes in patients undergoing coronary stenting on dual oral antiplatelet treatment requiring
oral anticoagulant therapy. Am J Cardiol. 2008 Dec 15; 102(12):1618-23. Epub 2008 Sep 24. PubMed PMID: 19064015.

Angiolillo DJ, Suryadevara S, Capranzano P, Zenni MZ, Guzman LA, Bass TA. Antiplatelet drug response variability and the
role of platelet function testing: a practical guide for interventional cardiologists. Catheter Cardiovasc Interv. 2009 Jan 1;
73(1):1-14. Review. PubMed PMID: 19089929.

Angiolillo DJ, Capranzano P, Desai B, Shoemaker SB, Charlton R, Zenni MM, Guzman LA, Bass TA. Impact of P2Y(12)
Inhibitory Effects Induced by Clopidogrel on Platelet Procoagulant Activity in Type 2 Diabetes Mellitus Patients. Thromb
Res. 2008 Nov 12. [Epub ahead of print] PubMed PMID: 19012950.

Angiolillo DJ, Suryadevara S, Capranzano P, Bass TA. Prasugrel: a novel platelet ADP P2Y12 receptor antagonist. A review
on its mechanism of action and clinical development. Expert Opin Pharmacother. 2008 Nov; 9(16):2893-900. Review.
PubMed PMID: 18937620.

Jim6nez-Quevedo P, Suzuki N, Corros C, Ferrer C, Angiolillo DJ, Alfonso F, Hernandez-Antolfn R, BaNuelos C, Escaned J,
Fernandez C, Costa M, Macaya C, Bass T, Sabat6 M. Vessel shrinkage as a sign of atherosclerosis progression in type 2
diabetes: a serial intravascular ultrasound analysis. Diabetes. 2009 Jan;58(1):209-14. Epub 2008 Oct 1. PubMed PMID:
18829988; PubMed Central PMCID: PMC2606874.

Antonios N, Angiolillo DJ, Silliman S. Hypertriglyceridemia and ischemic stroke. Eur Neurol. 2008;60(6):269-78. Epub
2008 Sep 27. Review. PubMed PMID: 18824854.

Tamburino C, Angiolillo DJ, Capranzano P, Dimopoulos K, La Manna A, Barbagallo R, Tagliareni F, Mangiafico S, Guzman
LA, Galassi AR, Bass TA. Complete versus incomplete revascularization in patients with multivessel disease undergoing


Cardioloav


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








percutaneous coronary intervention with drug-eluting stents. Catheter Cardiovasc Interv. 2008 Oct 1;72(4):448-56.
PubMed PMID: 18814218.

Carlson ER, Percy RF, Angiolillo DJ, Conetta DA. Prognostic significance of troponin T elevation in patients without chest
pain. Am J Cardiol. 2008 Sep 15;102(6):668-71. Epub 2008 Jun 26. PubMed PMID: 18773985.

Wiviott SD, Braunwald E, Angiolillo DJ, Meisel S, Dalby AJ, Verheugt FW, Goodman SG, Corbalan R, Purdy DA, Murphy
SA, McCabe CH, Antman EM; TRITON-TIMI 38 Investigators. Greater clinical benefit of more intensive oral antiplatelet
therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by
optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation. 2008 Oct
14;118(16):1626-36. Epub 2008 Aug 31. PubMed PMID: 18757948.

Angiolillo DJ, Guzman LA. Clinical overview of promising nonthienopyridine antiplatelet agents. Am Heart J. 2008
Aug;156(2 Suppl):S23-8. Review. PubMed PMID: 18657683.

Angiolillo DJ, Bates ER, Bass TA. Clinical profile of prasugrel, a novel thienopyridine. Am Heart J. 2008 Aug;156(2
Suppl):S16-22. Review. PubMed PMID:18657682.

Angiolillo DJ, Capranzano P. Pharmacology of emerging novel platelet inhibitors. Am Heart J. 2008 Aug;156(2 Suppl):S10-
5. Review. PubMed PMID: 18657681.

Angiolillo DJ, Guzman LA, Bass TA. Current antiplatelet therapies: benefits and limitations. Am Heart J. 2008 Aug;156(2
Suppl):S3-9. Review. PubMed PMID: 18657680.

Angiolillo DJ, Bates ER. Platelet inhibitor therapy: current perspectives and emerging novel agents: introduction. Am
Heart J. 2008 Aug;156(2 Suppl):S1-2. PubMed PMID: 18657679.

Angiolillo DJ, Capranzano P, Goto S, Aslam M, Desai B, Charlton RK, Suzuki Y, Box LC, Shoemaker SB, Zenni MM, Guzman
LA, Bass TA. A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes
mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study. Eur Heart J. 2008
Sep;29(18):2202-11. Epub 2008 Jun 21. PubMed PMID: 18567918.

Valgimigli M, Campo G, de Cesare N, Vranckx P, Hamon M, Angiolillo DJ, Sabat6 M, Ferrari F, Furgieri A, Tumscitz C,
Repetto A, Colangelo S, Meliga E, Kubbajeh M, Parrinello G, Percoco G, Ferrari R. Tailoring treatment with tirofiban in
patients showing resistance to aspirin and/or resistance to clopidogrel (3T/2R). Rationale for the study and protocol
design. Cardiovasc Drugs Ther. 2008 Aug;22(4):313-20. Epub 2008 Jun 17. PubMed PMID: 18561010.

Giles T, Miller AB, Elkayam,U et al: Pioglitizone use in early heart failure, J of Card failure 2008; 14: 445-452.

Lavine SJ, Conetta DA. Comparison of the effect of pressure loading on left ventricular size, systolic and diastolic function
in canines with left ventricular dysfunction with preserved and reduced ejection fraction. Cardiovasc Ultrasound. 2008
Nov 18;6:57.


Abstracts:
Lavine SJ. Left ventricular filling pressure can be estimated from systolic arterial pressure and left ventricular relaxation
time. J Am Sco Echocardiogr 2009; 22; 586 (abstract). Presented at the Scientific Sessions of the American Society
Echocardiography, June 2009, Washington, DC.

McMullan L, Smalheiser S, Weisberg I, Percy R, Hsu S, Zenni M, Miller AB: Association of ventricular arrhythmia therapy and
extent of scarred myocardium measured be single photon emission computed tomography Imaging in ischemic heart failure
patients. J of Card Failure 2008; 14; no 6S, pg S58

O'Connor C, Anand I, Fiuzat M, Plehn J, Gottleib S, Silver M, Lindenfeld J, Miller AB, et al: Additive effects of b 1 389 Arg/Gly
alpha 2 c322-325 wt/del genotype combinations on adjudicated hospitalizations and death in the beta blocker evaluation of
survival trial (BEST). J of Card Failure 2008; 14: no 6S, pg S69
Wang N, Konstam M, Maggioni A, Traver B, Burnett J, Grinfeld L, Swedberg K, Udelson J, Zannand F, Cook T, Zimmer C,
O'Connor C, Miller AB, Gheorgiade M: Correlation of ejection fraction to early post discharge sudden death and all cause
mortality in the EVEREST trial. J of Card Failure 2008; 14: no 6S, pg S71


Cardioloav


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








Wang N, Konstam M, Maggioni A, Traver B, Burnett J, Grinfeld L, Swedberg K, Udelson J, Zannand F, Cook T, Zimmer C,
O'Connor C, Miller AB, Gheorgiade M: Post discharge adjudicated outcomes in patients with implantable defibrillators in the
EVEREST trial. J of Card Failure 2008; 14: no 6S, pg S72

Smalheiser S, McMillan L, Venkataraman R, Percy R, ChapmanD, Zenni M, Miller AB: Association of heart failure class and left
ventricular dyssynchronymeasured by SPECT imaging in ischemic systolic heart failure patients. J of Card Failure 2008; 14:
no 6S, pg S90

Carson P, Gottleib S, Anand I, Plehn J, Silver M, Lindenfeld J, O'Connor C, Miller AB et al: Determination of hospitalization
type by investigator case report form or adjudication committee in a large heart failure clinical trial (BEST). J of Card Failure
2008; 14: no 6S, pg S 93

Miller AB, Reichek N, St. John Sutton M, et al: Comparable blood pressure control and LV mass reduction in patients with
hypertension and LVH with ACE inhibitor alone or combined with B blockade 2009; in press J Amer Soc Hypert Presented
Late Breaking Trials ASH 2009

Jimenez Quevedo P, Sabate M, Corrros C, Ferrer M, Alfonso F, Hernandez-Antolin R, Escaned J, Banuelos C, Angiolillo DJ,
Macaya C. Insights on the effect of secondary prevention on plaque composition and cardiac events in diabetic patients.
European Society of Cardiology 2008. Munich, Germany.

Wiviott SD, Antman E, Angiolillo DJ, Meisel, Dalby, Verheugt, Goodman, Murphy, Mccabe, Braunwald Greater effect of
intensive antiplatelet therapy with prasugrel compared with clopidogrel in diabetics in TRITON TIMI 38. European
Society of Cardiology 2008. Munich, Germany.

Rossini Musumeci, Lettieri Molfese, Mantovani Sirbu, Mihalcsik, Spirito, Gavazzi, Angiolillo. Outcomes of long-term
triple therapy with aspirin, clopidogrel, and warfarin in patients undergoing coronary stenting. European Society of
Cardiology 2008. Munich, Germany.

Tamburino, Angiolillo, Capranzano, Di Salvo, Caggeggi, Tomasello, Capodanno, Galassi, Ussia, Bass. Long-term clinical
outcomes after drug-eluting stent implantation in unprotected left main coronary artery disease. European Society of
Cardiology 2008. Munich, Germany.

Angiolillo, Bernardo, Trabetti, Zanoni, Cavallari, Capranzano, Macaya, Pignatti, Fernandez-Ortiz, Bass. Role of MDR-1
gene polymorphisms on clopidogrel responsiveness in patients with coronary artery disease. European Society of
Cardiology 2008. Munich, Germany.

Frelinger AL, Michelson AD; Braunwald E; Downey WE; Angiolillo DJ; Xenopoulos NP; Jakubowski JA; Li Y; Murphy SA;
Qin J; McCabe CH; Antman EM; Wiviott SD, for the TRITON-TIMI 38 Investigators. Pharmacodynamic Assessment of
Platelet Inhibition by Prasugrel versus Clopidogrel in the TRITON-TIMI 38 Trial. American Heart Association 2008.
Chicago, II.

Capranzano P, Ferreiro JL, Sumner S, Desai B, Charlton RK, Box L, Zenni MM, Guzman LA, Bass TA, Angiolillo DJ,
Evaluation of a Modified Light Transmittance Aggregometry Protocol to Assess P2y12 Blockade Induced by Clopidogrel.
American College of Cardiology/i2 Summit 2009. Orlando, Fl.

Angiolillo DJ, Bernardo E, Capranzano P, Sabate M, Ferreiro JL, Alfonso F, Jimenez-Quevedo P, Hernandez R, Guzman LA,
Macaya C, Fernandez-Ortiz A, Bass TA. Platelet Disaggregation: a Novel Parameter of Clopidogrel Responsiveness?
American College of Cardiology/i2 Summit 2009. Orlando, Fl.

Capranzano P, Ferreiro JL, Sumner S, Desai B, Charlton RK, Zenni MM, Guzman LA, Bass TA, Angiolillo DJ. Clopidogrel-
Induced Antiplatelet Effect Assessment by Flow Cytometry and Point-of-Care Based Assays: Correlation between VASP
and VerifyNow P2Y12 Testing. American College of Cardiology/i2 Summit 2009. Orlando, Fl.

Angiolillo DJ, Bernardo E, Capranzano P, Sabate M, Jimenez-Quevedo P, Ferreiro JL, Alfonso F, Hernandez R, Macaya C,
Fernandez-Ortiz A, Bass TA. Prognostic Implications of High Platelet Reactivity as Defined by Multiple Agonists in
Diabetes Mellitus Patients on Dual Antiplatelet Therapy. American College of Cardiology/i2 Summit 2009. Orlando, Fl.


Annual Report AY 2009 Cardiology


Cardioloav


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology






aroo D


CLINICAL ACTIVITIES


CONTRACTS AND GRANTS

Sponsor Date Begun Study
Eli Lilly Jul-06 SWAP
Eli Lilly Apr-08 TACA
Atra Zeneca Mar-07 PLATO
Baxter Jan-08 TRAC-R
Baxter Jul-06 ACT34
Medtronic Dec-05 REVERSE
Medtronic Jan-05 ENDEAVOR IV
Molecular Insight Pharmaceuticals Sep-07 MIP
Cordis Mar-08 SAPPHIRE WW
Amgen Sep-07 RED-HF
Novacrdia/Merck Sep-07 PROTECT
The Medicines Company Mar-07 CHAMPION PCI
The Medicines Company Apr-09 CHAMPION Platform
Schering-Plough Sep-08 TRA2P TIMI 50
Accumetrics Oct-08 GRAVTTAS
Eisai Jun-08 LANCELOT 201
Portola Jan-09 INNOVATE-PCI
Cardiokine Oct-08 BALANCE
Synvista Jun-08 BREAK-DHF-1
Sanofi Aventis Jul-08 INTENSIVE
St Jude Medical May-08 DETERMINE
St Jude Medical Dec-08 QuickFlex
Momenta Jun-08 EMINENCE
Johnson & Johnson Jun-09 ATLAS II TIMI 51
Debiopharm May-09 IGNITE
Solvay Apr-09 RenoDefend 1
Biogen Idec Apr-09 POSEIDON


Annual Report AY 2009 Cardiology


Inpatient activity AY 08/09
CV In PT admissions 2016
Observations 346

Outpatient activity
Physician clinic visits *13,757
Cardiac ultrasounds 10,960
Cardiac nuclear studies 3,428
EKGs 55,332
Stress tests 4,430
Heart caths ** 2,488
EP procedures *** 504
Device placements 305
Cardiac rehab visits 3,074

*Attending and Fellows
Jax Clinic 9,156 ***Includes:
Lake Shore 1,454 Ablations, Cardioversions
Live oak 227 EP's, & Lead Extractions
St Marys 2,920

*Cath Only = 1638
Coronary = 656
Peripheral = 168


Cardioloov


Division Chief: Theodore Bass. MD


Annual Report AY 2009


Cardiology








DIVISION OF ENDOCRINOLOGY, DIABETES AND METABOLISM
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Division of Endocrinology, Diabetes, and Metabolism had a year of rapid growth and development in
all areas of the academic mission of the University of Florida. Clinically, major events included expansion
and centralization of clinical services, growth of the endocrinology fellowship and developing a clinical
research program. Academically, the division submitted multiple publications and contributed immensely
to the educational component of the University's mission in many training programs at the University of
Florida as well as non-university affiliated health care providers.

Patient care: The Division provides inpatient and outpatient consultation for the University of Florida
Jacksonville campus and satellite offices as well as for referring physicians in the Northeast Florida and
Southern Georgia region. Dr. Joe Chehade, Dr. Arshag D. Mooradian, Dr. Mae Sheikh-Ali, and Dr. Kent
R. Wehmeier are the core clinical faculty. The Division addresses clinical endocrinology problems related
to diabetes mellitus, metabolic syndrome, obesity, pituitary, thyroid, adrenal, and sex hormone gland
dysfunction. Patients with metabolic disorders including cholesterol, calcium, and metabolic diseases
such as osteoporosis and vitamin D deficiency are evaluated and treated. Thyroid needle biopsy
procedures under ultrasound guidance are offered and utilized by the division for the management of
thyroid disorders. The Division also coordinates outpatient and inpatient education services that includes
diabetic educators and implemented new devices that continuously monitor glucose levels for more
intensive metabolic control in patients with diabetes mellitus. A multidisciplinary approach with the
support of neurosurgery, ophthalmology, otolaryngology and radiation oncology is utilized in the
management of patients with pituitary disease.

Education: The most significant event this year was ACGME accreditation with commendation of the
Endocrinology fellowship in May 2008. The program received a two-year provisional accreditation, which
began in July 2008 with two fellows and under the direction of Dr. Wehmeier. Dr. Abdul Alamir and Dr.
Senan Sultan began their first year of fellowship in July of 2008. They have contributed immensely to
the clinical care, education, and research mission of the division. In residency education, Dr. Wehmeier
served the Internal Medicine Core Program as Director of Relevant Educational Programs in
Endocrinology. He is the primary liaison between the Core Residency Program and the division, and is a
member of the Resident Education Committee. Dr. Joe Chehade and Dr. Mae Sheikh-Ali made major
contributions to the training of the Internal Medicine Core program residents with didactic presentations,
Board review questions, and bedside teaching.

Dr. Chehade, Dr. Sheikh-Ali and Dr. Wehmeier participated in the Internal Medicine Update discussing
endocrinology topics of interest for the greater Jacksonville area.

Research: Under the direction of Dr. Michael Haas, the basic science programs in the area of hormone
action in oncology and atherosclerosis moved forward. Multiple grant applications have been submitted
to potential funding sources and in return several awards have been received. Multiple manuscripts
have been submitted as a result of the work conducted at the Endocrine labs. Both Dr. Alamir and Dr.
Sultan were recognized at the annual Research Day of the UF College of Medicine Jacksonville with a
cash award for their work in gene expression. The clinical program has been recruiting industry-
sponsored protocols in the area of diabetes and osteoporosis research. Marinella Lipiniski, Research
Coordinator, has been a great asset in creating these new venues for investigation.


Annual Report AY 2009 Endocrinology, Diabetes and Metabolism


Division of Endocrinoloov. Diabetes and Metabolism


Division Chief: Kent Wehmeier. MD


Annual Report AY 2009


Endocrinology, Diabetes and Metabolism






Dvi o


LISTING OF FACULTY MEMBERS

Joe Chehade, M.D., Associate Professor


medical School Graduation date
Internship residency and year
Subspecialty training and year


St. Joseph University School of iledicine, Beirut-Lebanon
Staten Island University Hospital
Saint Louis University School of iledicine


Michael Haas, Ph.D., Research Associate Professor


Graduate SchoolGraduation date
Post-Graduate Training and year


University of Nebraska Iledical Center
ilcArdle Laboratory for Cancer Research


Arshag D. Mooradian, M.D. Professor and Chairman, Department of Medicine


Sledical School Graduation date
Internship.,residency and year
Subspecialty training and year


American University of Beirut
American University of Beirut
University of ilinnesota


Mae Sheikh-Ali, M.D., Assistant Professor


iledical School Graduation date
Internship. residency and year
Subspecialty training and year


Damascus University School Iledicine
Drexel University College Of iledicine
ilayo Clinic, Jacksonville, Florida


Kent Wehmeier, M.D., Associate Professor and Division Chief


Sledical School / Graduation date
Internship/,residency and year
Subspecialty training and year


University of ilissouri-Columbia
Barnes-Jewish Hospital, Washington University
Saint Louis University School of lMedicine


W J


PUBLICATIONS

Sheikh-Ali M and Chehade J. A rational approach to initiation of insulin therapy in older adults. Geriatrics & Aging 2009
(in press)

Chehade J. Sheikh-Ali M, Alexandraki I, House J, Mooradian A, The Effect of Health Care Provider Education on
Diabetes Management of Hospitalized Patients. International Journal of Clinical Practice 2009 (in press)

Sheikh-Ali M. Chehade J and Mooradian A. The Antioxidant Paradox in Diabetes Mellitus. American Journal of
Therapeutics 2009 (in press).

Sheikh-Ali M, Sultan S, Alamir A, Haas M, Mooradian A. Hyperglycemia-Induced Endoplasmic Reticulum Stress in
Endothelial Cells. Nutrition 2009 (in press).

Le T, Bhushan V, Sheikh-Ali M, Abushahin F. First Aid for the USMLE STEP 2 CS, third edition, McGraw-Hill 2009 (in
press)


1992
1997
1997


1991
199-1


1980
1982
1985


1999
2005
2007


1988
1991
1993


Division of Endocrinoloov. Diabetes and Metabolism


Division Chief: Kent Wehmeier. MD


Annual Report AY 2009


Endocrinology, Diabetes and Metabolism








Alcalde R, Sheikh-Ali M. Growth Hormone Deficiency BMJ Best Practice (in press)

Alamir A, Sheikh-Ali M. Thyroid Function Testing Epocrates-BMJ publishing. July 09

Chehade JM, Wood DL, Fox LA Palacio C. Management of Diabetes in the Adolescent and Young Adult During
Transition. Northeast Florida Medicine. Volume 59, Number 4,Winter 2008.

Chehade JM, Sheikh-Ali M, Mooradian AD. Antioxidant Vitamins Micronutrients and Their Role in Diabetes. Diabetes
Forecast (in press)

Chehade JM, Sultan S. Evaluation of pituitary tumors. Epocrates-BMJ publishing. July 09

Wehmeier KR. Disorders of Calcium Metabolism. Schmitz P, Martin K and Miller D (eds) In Internal Medicine:Just The
Facts McGraw-Hill, New York. 2008.

Wehmeier KR. Metabolic Bone Diseases. Schmitz P and Miller D (eds) In Internal Medicine:Just The Facts McGraw-Hill,
New York. 2008.

Wehmeier KR, Mazza A, Hachem S, Ligaray K, Mooradian AD, Wong NCW, Haas MJ. Differential regulation of
apolipoprotein A-I gene expression by vitamin D receptor modulators. Biochim Biophys Acta. 1780: 264-273. 2008.

Wehmeier KR. The Thrifty Economy: Energy Storage and the Obesity Epidemic. Northeast Florida Medicine 59: 10-17.
2008.

Wehmeier KR and Wood D. Evaluation and Treatment of Bone Diseases in Youth with Chronic Health Conditions.
Northeast Florida Medicine 59: 35-42. 2008.

Mooradian AD, Haas MJ, Wong, NCW., and Wehmeier, KR. Obesity-related changes in high-density lipoprotein
metabolism. Obesity 16:1152-1160, 2008.

Wehmeier. KR, Mazza A, Hachem S, Ligaray K, Mooradian AD. Wong, NCW, and Haas. MJ. Differential regulation of
apolipoprotein A-I gene expression by vitamin D receptor modulators. Biochemica et Biophysica Acta, 1780:264-273,
2008.
Lowman E, Mooradian AD. Macromelia masquerading as an acromegaloid syndrome in an adult with Klippel-Trenaunay
syndrome. Endocrine Practice. 14:109-111, 2008.

Mooradian AD. Asymptomatic hyperthyroidism in older adults? Is it a distinct clinical and laboratory entity? Drugs &
Aging 25(5):371-80, 2008.

American Diabetes Association, Bantle JP, Wylie-Rosett J, Albright AL, Apovian CM, Clark NG, Franz MJ, Hoogwerf BJ,
Lichtenstein AH, Mayer-Davis E, Mooradian AD, Wheeler ML. Nutrition recommendations and interventions for
diabetes: a position statement of the American Diabetes Association. Diabetes Care. Jan;31 Suppl 1:S61-78, 2008.

Palacio C, Masri G, Mooradian AD. Black cohosh for the management of menopausal symptoms: a systematic review of
clinical trials. Drugs Aging. 26:23-36, 2009.

Mooradian A and the Bypass Angioplasty Revascularization Investigation 2 Diabetes Study
Group. Baseline characteristics of patients with diabetes and coronary artery disease enrolled
in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. Am. Heart J. 156:528-536, 2008.

Alexandraki A, Palacio CC, House J, Catalano C, Mooradian AD. Resource-based relative value scale analysis between
teaching and non-teaching hospitalist services. Health Care Manag (Frederick). 28::81-5, 2009 .

Palacio CC, Alexandraki I, House J, Mooradian AD. A comparative study of unscheduled hospital readmissions in a
resident staffed teaching service and a hospitalist based service. Southern Medical Journal 102:145-149, 2009.

Mooradian AD. Dyslipidemia of type 2 diabetes mellitus. Nature Clinical Practice Endocrinology & Metabolism. 5:150-9
2009.


Division of Endocrinoloov. Diabetes and Metabolism


Division Chief: Kent Wehmeier. MD


Annual Report AY 2009


Endocrinology, Diabetes and Metabolism






Division of Endocrinology, Diabetes and Metabolism


Pambianco G, Lombardero M, Bittner V, Forker A, Kennedy F, Krishnaswami A, Mooradian AD, Pop-Busui R, Rana JS,
Rodriguez A, Steffes M, Orchard TJ and the BARI 2D Investigators. Control of lipids at baseline in the bypass angioplasty
revascularization investigation 2 diabetes (BARI 2D) trial. Preventive Cardiology 12: 9-18, 2009.

Pop-Busui R, Lu J, Lopes N, Jones TL, BARI 2D Investigators (Mooradian A). Prevalence of diabetic peripheral
neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort. J Peripher Nerv Syst. 14:1-13,
2009.

Schwartz L, Kip KE, Alderman E, Lu J, Bates ER, Srinivas V, Bach RG, Mighton LD, Feit F, King S 3rd, Frye RL; BARI 2D
Study Group (Mooradian A). Baseline coronary angiographic findings in the Bypass Angioplasty Revascularization
Investigation 2 Diabetes trial (BARI 2D). Am J Cardiol. 103:632-638, 2009.

BARI 2D Study Group (Mooradian A), Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM, Orchard
TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TL, Molitch ME, Nesto RW, Sako EY, Sobel BE. A
randomized trial of therapies for type 2 diabetes and coronary artery disease. N. Engl J Med. 360 :2503- 15, 2009


Book chapters:
Chehade J, Mooradian AD. Drug Therapy: Current and emerging agents in hyperglycemia. In: Diabetes in Old Age. 3nd
edition, A.J, Sinclair (ed), John Wiley & Sons Ltd., 2009.

National/ International presentations:
Sheikh-Ali, M., Sultan, S., Alamir, A.-R., Haas, M.J., and Mooradian, A.D. Hyperglycemia-induced endoplasmic reticulum
stress in endothelial cells: evidence for mitochondrial origin of the stress signal. Endocrine Society 91st Annual Meeting,
Washington DC, 2009.

Alamir, A.-R., Wehmeier, K.R., Sultan, S., Haas, M.J., Wong, N.C.W., and Mooradian, A.D. Regulation of apolipoprotein
A-I gene expression by the vitamin D metabolite 24, 25-dihydroxycholecalciferol. Endocrine Society 91st Annual Meeting,
Washington DC, 2009.

Sultan, S., Sheikh-Ali, M, Alamir, A.-R., Haas, M.J., and Mooradian, A.D. Uncoupling of hyperglycemia-induced oxidative
stress and endoplasmic reticulum stress in endothelial cells. Endocrine Society 91st Annual Meeting, Washington DC,
2009.

Mooradian AD. Obesity in the elderly. 9th Annual Conference in obesity, University of Southern Florida, Clearwater FL,
2008.

Mooradian AD. Dietary guidelines for diabetes. 9th Annual Conference in obesity, University of Southern Florida,
Clearwater FL, 2008.

Mooradian AD. ADA nutrition guidelines for people with diabetes. 10th symposium of Diabetes and Endocrinology, Saint
Louis University, Saint Louis, MO. 2008

Vega, KJ, Carlos Palacio, C, Mooradian A. Validation of a gastroesophageal reflux questionnaire for use in African
Americans. Digestive Disease Week, Chicago, IL, June 2, 2009.




CLINICAL ACTIVITIES


Inpatient Activity FY 08/09
Number of IP Consults 485

Outpatient Activity
Clinic Visits 4703
Thyroid Biopsies 165


Annual Report AY 2009 Endocrinology, Diabetes and Metabolism


Division Chief: Kent Wehmeier, MD


Annual Report AY 2009


Endocrinology, Diabetes and Metabolism






Division of Endocrinology, Diabetes and Metabolism


GRANTS AND CONTRACTS


Principal Sponsor/Title Project period Total direct
Investigator costs
Abdul Alamir, MD Endocrine Fellows Foundation 08/09 20,000.00
Abdul Alamir, MD Deans Fund Research Award for Residents and Fellows 08/09 5,000.00
Joe M Chehade, MD Amylin Pharmaceuticals,Inc. 01/09 21,000.00
Mae Sheikh-Ali, MD Novo Nordisk Protocol
Kent R. Wehmeier, MD Novo Nordisk Protocol


Annual Report AY 2009 Endocrinology, Diabetes and Metabolism


Division Chief: Kent Wehmeier, MD


Annual Report AY 2009


Endocrinology, Diabetes and Metabolism







DIVISION OF GASTROENTEROLOGY
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Division of Gastroenterology had an outstanding 2008-2009 fiscal year. Clinically, the Division saw
outpatients at the on-campus Ambulatory Care Center (ACC), Emerson Gastroenterology Clinic
(Emerson), Northside Multi-specialty Clinic (Northside Clinic Closure 5/09), Shands Jail Clinic, UF
Jacksonville Faculty Clinic, Beaches Digestive Clinic, and the Southside Digestive Clinic. Ambulatory
motility studies, capsule endoscopy, and diagnostic breath tests were performed at Emerson. Endoscopy
procedures were performed at Shands Jacksonville Medical Center and the Medical Partners Surgery
Center at Emerson. The research operation saw us acquiring several industry sponsored grants. We
presented abstracts at the American College of Gastroenterology meeting, as well as Digestive Disease
Week. Dr. Louis Lambiase, who was the chief of the division for the last ten years, accepted a position
as Vice Dean at the University of Tennessee, Chattanooga, TN.

Patient Care: The patient care aspect of the academic mission is pursued by the Division through
three University of Florida clinics, the provision of inpatient consult services at Shands Jacksonville,
inpatient and outpatient GI services at Baptist Medical Center Beaches and St. Luke's Hospital. The
Division continues to be the leader in Northern Florida in the treatment of viral hepatitis and staffs a
gastrointestinal motility laboratory that is among the most active in the state. We provide two special
clinics per week caring for patients with inflammatory bowel disease.

Education: The division is involved in the teaching for the residency program. Coordinated by Dr. Ravi
Kottoor, the division conducted resident rotations for inpatient gastroenterology consults and ambulatory
gastroenterology. Our faculty taught residents in morning report, noon resident conference, and internal
medicine grand rounds.

The division conducts a Gastroenterology Fellowship Program which consists of two fellows a year for
three years. The program continues its 100% board passing rate by previous year's graduates. After a
site visit conducted by the ACGME, the program was granted accreditation for the next three and a half
years.

Research: Divisional research activities include clinical trials and giving presentations at regional and
national meetings. A breakthrough work in Hepatitis C, done by Dr. Xiaoyu Li, has been accepted to be
published in the Journal of Viral Research and is available on-line as of August 29, 2009.

LISTING OF FACULTY MEMBERS

Robert Bass, M.D., Assistant Professor
iledical School Graduation date .lec.:ai C:iilee ,f Ge:i a 938
Internship/residency and year uni.eri.i, ,f So':utn .laarama 1991
Subspecialty training and year uni.es c., :,f Fl:iicla .jac.:son.ille 193




SSamir Habashi, M.D., Assistant Professor
l medical School Graduation date Ain-Shams University, Cairo, Egypt 1985
Internship/iresidency and year University of Florida Jacksonville 2003
Subspecialty training and year University of Florida Jacksonville 2007


Annual Report AY 2009 Gastroenterology


Gastroenteroloov


Division Chief: Louis Lambiase. MD


Annual Report AY 2009


Gastroenterology


I









Ravi Kottoor, M.D., Associate Professor
i-ledical School / Graduation date Kasturba -ledical College, India 1970
Internship.,residency and year Ottawa Civic Hospital 197-1
Subspecialty training and year Dalhousie University, Canada 1975




Louis Lambiase, M.D., M.H.A., Associate Professor and Division Chief
Iledical School i Graduation date University of iliami 1987
Internship.,residency and year University of Pittsburgh 1990
Subspecialty training and year University of Florida 1992
Graduate degree and year University of Nlorth Florida 2006



Xiaoyu Li, M.D., Ph.D., Assistant Professor
lHedical School Graduation date Harbin iledical University, China 1983
Internship. residency and year ilt Sinai School of iledicine 200-1
Subspecialty training and year University of Florida 2007
Graduate degree and year State University of ilevw York 2001



Juan Munoz, M.D., Assistant Professor
i-ledical School / Graduation date Universidada Complutense, Spain 1991
Internship. residency and year University of Florida Jacksonville 2001
Subspecialty training and year University of Florida Jacksonville 200-1




Paul Sievert, M.D., Assistant Professor
i-ledical School i Graduation date University of iliami 1996
Internship, residency and year lMedical College of Virginia 1999
Subspecialty training and year University of Florida Jacksonville 2003




Kenneth Vega, M.D., Associate Professor
iledical School / Graduation date Cornell University iledical College 1988
Internship/.residency and year Boston University School of medicine 1991
Subspecialty training and year Temple University Hospital 1995





PUBLICATIONS

Peer Reviewed Manuscripts:
Modified technique to extract malpositioned or migrated self-expanding stents from the esophagus and stomach. Munoz
JC, Khoury JE, Alizadeh M, Pudhota S, Smith-McCutchen A, Corregidor AM, Lambiase LR, Vega KJ.J Gastroenterol
Hepatol. 2009 Apr;24(4):547-51. Epub 2009 Feb 9.

Safety and antiviral activity of albinterferon alfa-2b in prior interferon nonresponders with chronic hepatitis C. Nelson DR,
Rustgi V, Balan V, Sulkowski MS, Davis GL, Muir A], Lambiase LR, Dickson RC, Weisner RH, Fiscella M, Cronin PW,
Pulkstenis E, McHutchison JG, Subramanian GM.Clin Gastroenterol Hepatol. 2009 Feb; 7(2):212-8. Epub 2008 Nov 7.


Gastroenteroloov


Division Chief: Louis Lambiase. MD


Annual Report AY 2009


Gastroenterology








Jamal MM, Samarasena J, Hashemzadeh MS, Vega K3. Declining hospitalization rate of esophageal variceal bleeding in
the United States. Clin Gastroenterol Hepatol 2008; 6:689-695.

Vega K3, Langford-Legg T, Jamal MM. Ethnic variation in lower esophageal sphincterpressure and length. Aliment
Pharmacol Ther 2008; 28: 655-659.

Vega K3, Jamal MM. Hispanic Americans and esophageal manometry. J Clin Gastroenterol 2009; 43: 197-198.

Munoz JC, Vega K3. Endoscopic removal of hollow colorectal foreign bodies with the use of a balloon catheter:
response. Gastrointest Endosc 2009; 69: 605.

Reddy S, Sullivan R, Zaiden R, Lopez de Mendoza V, Naik N, Vega K3, Nahman Jr NS, Alexandraki I. Hepatitis C
infection and the risk of bacteremia in hemodialysis patients with tunneled vascular access catheters. South Med J 2009;
102: 374-377.

Chisholm S. Gummadi B, Vega K3, House J. Sandostatin causing reversible thrombocytopenia. Eur J Gastroen Hepat
2009; 21: 474-5.
Habashi S, Draganov PV Pancreatic Pseudocyst World J Gastroenterol. 2009 Jan 7; 15(1):38-47

Vega K3, Chisholm S, Jamal MM. The spectrum of reflux esophagitis is equivalent between African Americans and non-
Hispanic whites. In press, World J Gastroenterol, 2009

Munoz J.C, Cole M Recurrent Gastrointestinal Bleeding in a 64-Year-Old Woman. Clinical Case. eMedicine, March 2009.

Munoz J.C and Pudhota S Large Inverted Diverticulum Simulating a Large Polyps Clinical challenge and image in GI
Gastroenterology Ms No GASTRO-D-09-00290R1


Abstracts:
Juan C. Munoz, Sunitha Pudhota, Aja S. Smith and Kenneth Vega. Modified technique to extract malpositioned or
migrated self-expanding stents from the esophagus and stomach. American College of Gastroenterology meeting.

Juan C. Munoz, Aja S. Smith Division Unusual Objects Removed from Unusual Patients: A Case Series and Literature
Review American College of Gastroenterology meeting.

Aja S. Smith, Juan C. Munoz, and Kenneth Vega. Nutritional differences at the time of colorectal cancer diagnosis: a
potential explanation for disparities in outcome between African Americans and non-Hispanic Whites. American College of
Gastroenterology (ACG) meeting.

Vega K3, Langford-Legg TL, Jamal MM. Gender variation in lower esophageal sphincter pressure and length. Am J
Gastroenterol 2008; 103 (Sl): S2. (Poster presentation, ACG 2008)

Pudhota S, DiTeodoro LA, Vega K3, Wludyka P, Bullock D, Lambiase LR. Ultrasound marking improved percutaneous
liver biopsy yield. Am J Gastroenterol 2008; 103 (S1):AS144. (Poster presentation, ACG 2008)

Smith AS, Cole M, Vega K3, Munoz JC. Palliation of malignant rectosigmoid obstruction secondary to locally invasive
prostate cancer with multiple overlapping self-expanding metal stents. Am J Gastroenterol 2008; 103 (Sl): S348-9.
(Poster presentation, ACG 2008)

Vega K3, Palacio C, Jamal MM. Validation of a gastroesophageal reflux questionnaire for use in African Americans.
Accepted for presentation, DDW 2009.

Chisholm S, Khoury JE, Jamal MM, Vega K3. The frequency of confirmed Barrett's esophagus varies by ethnicity and
gender. Accepted for presentation, DDW 2009.

Reddy S, Ramsubeik K, Federico J, Goodwich R, Palacio C, Vega K3. Do HbA1C levels correlate with delayed gastric
emptying in diabetic patients? Accepted for presentation, DDW 2009.


Annual Report AY 2009 Gastroenterology


Gastroenteroloov


Division Chief: Louis Lambiase. MD


Annual Report AY 2009


Gastroenterology









Luyu Yao, Haizhen Zhu,Yiling, Xu, Louis R. Lambiase, David R. Nelson, Chen Liu, Xiaoyu Li M1808. Inhibition of
Hepatitis C Viral (HCV) Replication By In Vitro Dimerization of IFN Regulatory Factor-3 (IRF3) Accepted poster DDW 2009

Sunitha Pudhota, Melvin D. Bullock, Louis R. Lambiase, Ravi Kottoor Retrospective Analysis of Predicting Factors for
Complications of Colonoscopy Accepted Poster DDW 2009.



HONORS AND AWARDS


Dr. Aja Smith-McCutchen was the recipient of the "System Based Improvement" award given by the
Division of Internal Medicine.



CLINICAL ACTIVITIES


Inpatient Activity AY 08/09
Number of IP Consults 1446
Shands Jacksonville Inpatient Procedures 1356
Baptist Beaches Inpatient Procedures 84
St. Lukes Inpatient Procedures 5
Outpatient Activity
Clinic Visits 13793
Shands Jacksonville Outpatient Procedures 4547
Jacksonville Beach Surgery Center Outpatient Procedures 729
Jacksonville Surgery Center 648
Medical Partners Surgery Center 704


GRANTS AND CONTRACTS


BUDGET BUDGET AWARD
PI TITLE BEGIN END SPONSOR AMT
ALBA
A Phase lib, Randomized, Double-Blind, Placebo Controlled Study THERAPEUTICS
KOTTOOR for the Treatment of Active Celiac Disease with AT-1001 7/31/08 5/2/09 CORP $4,500.00
A Phase 3 Multicenter, Randomized, Placebo-controlled, Double-
blind Study to Evaluate the Safety and Efficacy of Golimumab
Maintenance Therapy, Administered Subcutaneously, in Subjects
KOTTOOR with Moderately to Severely Active Ulcerative Colitis 8/28/08 8/31/09 CENTOCOR $4,938
A Phase 2/3 Multicenter, Randomized, Placebo-controlled, Double-
blind Study to Evaluate the Safety and Efficacy of Golimumab
Induction Therapy, Administered Intravenously, in Subjects with
KOTTOOR Moderately to Severely Active Ulcerative Colitis 8/28/08 4/17/10 CENTOCOR $10,778
A randomized, double-blind, placebo-controlled, parallel group, multi-
center study to investigate the safety and efficacy of CP-690,550 in
KOTTOOR subjects with moderate to severe Crohn's Disease 5/16/08 3/10/10 PFIZER INC $11,966.25
A Multi-center, Investigator-blinded, Randomized, 12-month, Parallel-
group, Non-inferiority Study to Compare the Efficacy of 1.6 to 2.4g
Asacol Therapy QD Versus Divided Dose (BID) in the Maintenance of PROCTER AND
KOTTOOR Remission of Ulcerative Colitis 3/12/08 11/14/08 GAMBLE $10,906.25
A Prospective Study Quantitating Fecal TNF-ALPHA In Active IBD UCB PHARMA
KOTTOOR Compared To Other Forms OfAcuteE Enterocolitis 1/15/08 3/6/09 INC $15,625.00
Protocol 0000810: An Open-Label Clinical Study Evaluating the Long
Term Safety of ALTU-135 in the Treatment of Patients with Exocrine ALTUS
Pancreatic Insufficiency ue to Chronic Pancreatitis or PHARMACEUTIC
LAMBIASE Pancreatectomy 10/16/07 8/23/09 ALS $12,967.00
A Phase 3, Randomized, Multi-Center Study to Evaluate the Efficacy
and Safety of Albumin Interferon Alfa-2b in Combination with
Ribavirin Compared with Peginterferon Alfa-2a in Combination with
Ribavirin in Interferon Alfa Naive Subjects with Chronic Hepatitis C
LAMBIASE Genotype 1. ACHIEVE-1 2/19/07 12/12/09 DUKE UNIV $32,146.83


Gastroenteroloov


Division Chief: Louis Lambiase. MD


Annual Report AY 2009


Gastroenterology







G e D


LAMBIASE


A Phase 3, Randomized, Multi-Center Study to Evaluate the Efficacy
and Safety of Albumin Interferon Alfa-2b (alb-IFN) in Combination
with Ribavirin Compared with Peginterferon Alfa-2a (PEGASYS or
PEG-IFNa2a) in Combination with Ribavirin in Interferon Alfa Naive
Subjects with Chronic Hepatitis C Genotvpe 2 or 3. ACHIEVE-2/3


2/19/07


1/24/09


DUKE UNIV


$22.795.95


An extension protocol to evaluate the long-term effects of treatment
with peginterferon alfa-2a (PEG-IFN)- or interferon (IFN)- based HOFFMANN LA
LAMBIASE therapies for patients with chronic hepatitis C 10/4/05 7/15/09 ROCHE INC $5,075.00
A Randomized, Multicenter, Double Blinded, Phase IV Study
Comparing the Safety and Efficacy of Pegasys 180pg plus
Copegus 1000 or 1200 mg to the Currently Approved Combination
of Pegasys 180pg plus Copegus 800 mg in Interferon-nafve
Patients with Chronic Hepatitis C Genotype 1 virus infection HOFFMANN LA
LAMBIASE coinfected with human immunodeficiency virus (HIV-1) 5/16/06 4/30/09 ROCHE INC $2,311.63
Randomized, Multicenter, Double-Blinded, Phase IV Study Evaluating
the Efficacy (as Measured by Sustained Virological Response) and
Safety of 360 mcg Induction Dosing of Pegasys in Combination
with Higher Copegus Doses in Treatment-nafve Patients with
Chronic Hepatitis C Genotype 1 Virus Infection of High Viral Titer and HOFFMANN LA
LAMBIASE Baseline Body Weight Greater than or Equal to 85 kg 12/19/06 8/17/09 ROCHE INC $1,732.00
An Open-label, Roll-over Safety Study of AGI-003 (Arverapamil) in PPD
LAMBIASE the Treatment of Irritable Bowel Syndrome with Diarrhea (IBS D) 12/17/07 11/21/08 DEVELOPMENT $2,066.25
A Randomized, Double-blind, Placebo-controlled Study of
AGI-003 (Arverapamil) in the Treatment of Irritable Bowel Syndrome PPD
LAMBIASE with Diarrhea (IBS-D) 12/17/07 11/21/08 DEVELOPMENT $625.00
A Phase III, Multicenter, Open Label, Extension Study to Evaluate the
Long-term Safety of Renzapride 4 mg Once Daily in Women with ALIZYME
LAMBIASE Constipation-Predominant Irritable Bowel Syndrome (c-IBS) 1/6/06 11/30/08 THERAPEUTICS $3,470.00
A Phase III, Multicenter, Randomized, Double-Blind, Placebo-
Controlled, Parallel Group Study of Renzapride in Women with ALIZYME
LAMBIASE Constipation-Predominant Irritable Bowel Syndrome (c-IBS) 9/15/05 11/30/08 THERAPEUTICS $3,737.00

A PHASE 3, SAFETY & EFFICACY STUDY OF BOCEPREVIR IN SCHERING
PREVIOUSUNTREATED SUBJECTS WITH CHRONIC HEPATITIS PLOUGH RES
LAMBIASE C GENOTYPE 1 8/1/08 9/10/09 INST $21,957.30
A double-blind, randomized, placebo-controlled, parallel group study
of rimonabant 20 mg daily for the treatment of Type 2 diabetic SANOFI
LI patients with nonalcoholic steatohepatitis (NASH) 9/26/08 7/9/09 AVENTIS $3,000.00
A double-blind, randomized, placebo-controlled, parallel group study
of rimonabant 20 mg daily for the treatment of non-diabetic patients SANOFI
LI with nonalcoholic steatohepatitis (NASH) 9/26/08 7/10/09 AVENTIS $3,000.00

VEGA Validation of The GERQ for Use in African Americans 1/1/05 10/31/09 ASTRAZENECA $16,666.67

TOTAL $190,263.88


Annual Report AY 2009 Gastroenterology


Gastroenteroloov


Division Chief: Louis Lambiase. MD


Annual Report AY 2009


Gastroenterology







DIVISION OF GENERAL INTERNAL MEDICINE
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Division continues a robust inpatient and outpatient practice and is an integral part of the
educational experience for the Internal Medicine residency.

Patient Care: The Division of General Internal Medicine is comprised of 12 members who are board
certified in Internal Medicine. Their clinical care includes: the provision of inpatient care as the
attending for the four inpatient teaching services, outpatient care at three locations: the ACC, Faculty
Clinic and the UF Multispecialty Clinic on Emerson, an inpatient Internal Medicine consultation service
and medical evaluation of patients admitted to the Psychiatry service. The division has experienced
significant growth in its outpatient practice as the newer physicians in the group have established
themselves as excellent clinicians. JaxHATS (Jacksonville Health and Transition Services) clinic held on
Tuesday and Thursday mornings continues as a model program for the transition of adolescents and
youth with special healthcare needs from their pediatricians to adult providers. Dr. Edwards works with
Dr. Wood, a general pediatrician, to staff this clinic. JaxHATS serves as a medical home for these young
people.

Education: The Division provides faculty supervision of residents on the four general internal medicine
inpatient teaching services, inpatient medicine consultation service and geriatrics. The division also
provides faculty supervision and mentoring of all categorical medicine residents in their outpatient
continuity practice and urgent care clinics.

Dr. Sottile continues to serve as a facilitator for the "Teaching Residents to Teach" seminar -a 6-8 hour
intradepartmental seminar offered each year at the University of Florida Health Science
Center/Jacksonville. Dr. Sottile also served as a facilitator at a one day seminar "Clinical Teaching" in
conjunction with the national ACP meeting.

Drs. Jeff House and Senthil Meenrajan are Associate Program Directors for the Internal Medicine
Residency Program. Drs. Alexandraki and Palacio serve as Associate Clerkship Director and Clerkship
Director for medical students from Gainesville who rotate on the Internal Medicine service (inpatient and
outpatient). Dr. Jeff House also coordinates monthly M&M/QA for the training program. Drs.
Alexandraki, Edwards, House and Meenrajan also serve as key clinical faculty for the Core Training
Program in Internal Medicine.

Drs. Edwards, House and Sottile serve on the House Staff Evaluation Committee. Drs. Alexandraki,
Edwards, House and Meenrajan serve on the Resident Education Committee. All members of the division
have participated in and/or presented at the noon conference core curriculum series held daily as well as
the Friday afternoon ambulatory didactic sessions and Board review.

Most of the members of the division participated in the 2009 Update in Internal Medicine, held at Amelia
Island Plantation. Drs. Edwards and Halperin were co-directors for the program. It was an excellent
program. A dinner honoring Malcolm Foster, MD for his contributions to Internal Medicine was held in
conjunction with the meeting. A number of Dr. Foster's previous chief residents were able to attend and
shared their experiences with Dr. Foster and how meaningful his mentorship has been to them.

Research: Research in the division continues to focus on continuing medical education, clinical
research, and faculty facilitation of resident research projects. Drs. House and Meenrajan worked with
resident recipients of the Dean's Fund Research Awards. Drs. House, Alexandraki and Palacio have a
number of projects underway.


General Internal Medicine


Division Chief: Linda Edwards. MD


Annual Report AY 2009


General Internal Medicine






General Internal Medicine Division Chief: Linda Edwards. MD


LISTING OF FACULTY MEMBERS

Irene Alexandraki, M.D., Assistant Professor
iledical School Graduation date University of Athens, Greece
Internship, residency and year Hahnemann University Hospital
Subspecialty training and year Baylor College of Iledicine (Infectious Disease)




Linda Edwards, M.D., Associate Professor, Associate Chairman and Division Chief
Medical School Graduation date East Carolina University
Internship, residency and year Jacksonville Health Education Programs


Malcolm Foster, M.D., Professor
Sledical School i Graduation date
Internship, residency and year
Subspecialty training and year




Alan Halperin, M.D., Professor
Medical School. Graduation date
Internship, residency and year


Bowman Gray School of medicine
University of Florida, Gainesville
University of Florida, Gainesville (Infectious Disease)





University of Kansas
University of Wisconsin


Jeffrey House, D.O., Assistant Professor
iledical School / Graduation date lJova Southeastern College of Osteopathic iledicine
Internship, residency and year University of Florida Jacksonville





Ghania Masri, M.D., Assistant Professor
iledical School i Graduation date Damascus University, Syria
Internship and year Cleveland Clinic Foundation
Residency and year Case Western Reserve University




Senthil Meenrajan, M.D. M.B.A, Assistant Professor
iledical School Graduation date iladras iledical College, India
Internship, residency and year Robert Packer Hospital
Subspecialty training and year Oregon Health Sciences University (Geriatric -ledicine)
Post-graduate training and year Canyon College (IlBA: Healthcare Administration)


[ W I


Annual Report AY 2009 General Internal Medicine


1989
1998
2001





1981
1985


1963
1966
1967





1971
197-






1997
2001






1989
1992
199-1





1997
200-1
2005
200-1


Sl I


General Internal Medicine


Division Chief: Linda Edwards. MD


Annual Report AY 2009


General Internal Medicine






General Internal Medicine Division Chief: Linda Edwards. MD


Carlos Palacio, M.D., M.P.H., Assistant Professor
iledical School Graduation date University of iliami
Internship, residency and year University of Florida, Jacksonville
Post-graduate training and year University of IJorth Florida (IIPH, laster of Public Health)




James Phillips, M.D., Assistant Professor
iledical School Graduation date St. Georges University, West Indies
Internship. residency and year University of Florida, Jacksonville





Pramod Reddy, M.D., Assistant Professor
Medical School/ Graduation date Sri Dev Raj Urs iledical College, India
Internship/residency and year Stony Brook University Hospital





Manish Relan, M.D., Assistant Professor
iledical School Graduation date Armed Forces iledical College, India
Internship and year Brookdale University Hospital
Residency and year Scranton Temple Residency Program




Elisa Sottile, M.D., Assistant Professor
iledical School / Graduation date Temple University School of -ledicine
Internship. residency and year University of Pennsylvania


1993
1997
2007





2001
2005






1992
2000






1995
2000
2002





1993
1997


PUBLICATIONS

SC Reddy, R. Sullivan, R. Zaiden, V. Lopez De Mendoza, KJ Vega, NS Nahman, Jr, I. Alexandraki. Hepatitis C and the
risk of bacteremia in hemodialysis patients with tunneled vascular access catheters. South MedJ2009 Apr; 102(4):374-7
PMID: 19279528

Alexandraki, C. Palacio, J. House, A.D. Mooradian, C Catalano. A Resource-Based Relative Value Scale Analysis
Between Teaching and Nonteaching Hospitalist Services. Health Care Manag (Frederick). 2009 Jan-Mar:28(1):81-5.
PMID: 19225341

I. Alexandraki, R. Sullivan, R. Zaiden, C. Bailey, Y. McCarter, A. Khan, JK. Offutt, UY. Bhatt, D. Plott, NS. Nahman Jr.
Blood culture isolates in hemodialysis vascular catheter-related bacteremia: Am J Med Sci, 2008 Oct;336(4):297-302.
PMID 18854670

Edwards L, Gauger C, Rana F "Sickle Cell Disease: The Transition from Pediatric to Adult
Providers" Northeast Florida Medicine, Vol 59, No 4 2008.

Reiss J, Wood D, Edwards L, Daniel P "Healthcare Transition for Youth with Special Healthcare Needs" Northeast
Florida Medicine, Vol 59, No 4 2008.


General Internal Medicine


Division Chief: Linda Edwards. MD


Annual Report AY 2009


General Internal Medicine









Chisholm S, Gummadi B, Vega KJ, House J. "Sandostatin Causing Reversible Thrombocytopenia", Eur J Gastroenterol
Hepatol. 2009 Feb 24

Masri G, Cuffe S, Edwards L "Mental Health Issues in Adolescents and Young Adults" Northeast
Florida Medicine, Vol 59, No 4 2008.

Senthil Meenraian. MD. MBA. S. Subbiah, "Considerations in the Management of Colorectal Cancer in the Elderly".
Northeast Florida Medicine. Vol 60, Nol 2009

Palacio C, House J, Mooradian A, Alexandraki A. "A comparative study of unscheduled hospital readmissions in a
resident staffed teaching service and a hospitalist based service". South MedJ. 2009 Feb;102(2):145-9.

F. Arnaldo, N. Anatoliotakis, C. Palacio, D. Nabert, S. Hsu. "Increased N-Terminal-Pro-B-Type Natriuretic Peptide Levels
in Patients With Appropriate Implantable Defibrillator Therapies". Heart Lung. 2009 Jan-Feb;38(1):10-6. Epub 2008 Sep
11. PMID: 19150526

Palacio, C. Editorial "Psychological Effects of Poor Outcome on Physicians" Southern Medical J 2008 Oct;101(10):985..
PMID: 18791535

Carlos Palacio, Ghania Masri, Arshag Mooradian "A Systematic Review of the Clinical Trials of Black Cohosh in the
Management of Menopausal Symptoms"_DrugsandAging. 2009; 26(1):23-36. PMID: 19102512

Carlos Palacio, Jeffrey P. Harrison and Dave Garets "A Conceptual Model for Benchmarking Electronic Medical
Records Initiatives "Journal of Medical Systems, January 2009

Chehade, J, Palacio, C, Wood, D, Fox, L "Management of Diabetes in the Adolescent and Young Adult during Transition"
Northeast Florida Medicine, Vol 59, No 4 2008

Reddy P, Mooradian AD. "Diuretics: An Update on the Pharmacology and Clinical Uses". AmJ Ther.2009 Jan 8.


Book Chapters and Monographs:
Alexandraki I, Contributing author "Community Acquired Pneumonia' chapter of the textbook "Internal Medicine
Essentials for Clerkship Students ', ACP- Clerkship Directors in Internal Medicine, pages 197-199, 2009

Alexandraki I, Contributing author "Urinary Tract Infection" chapter of the textbook "Internal Medicine Essentials for
Clerkship Students ', ACP- Clerkship Directors in Internal Medicine, pages 180-182, 2009

Alexandraki I, Department of Medicine, University of Florida College of Medicine-Jacksonville. HIV-Related
Opportunistic Infections (2009) [Internet], eds. BMJ Point of Care. http://aroup.bmi.com/products/evidence-centre/bmi-
point-of-care-1

Alexandraki I: "MKSAP for Students 4" writer of multiple choice questions for the "Urinary Tract Infection" and
"Community Acquired Pneumonia" chapters; ACP-Clerkship Directors in Internal Medicine, 2009

Alexandraki I, Department of Medicine, University of Florida College of Medicine-Jacksonville (2008). 48-year-old
woman with HIV- Ms. Hunt. In SIMPLE: Simulated Internal Medicine Patient Learning Experience [Internet], eds. Berman
and Fall, Institute for Innovative Technology In Medical Education, Lebanon, NH. http://www.simplecases.orq.

Palacio, C Contributing author "COPD" chapter of the textbook "Internal Medicine Essentials for Clerkship Students" 2nd
edition, ACP- Clerkship Directors in Internal Medicine. October, 2008

Palacio, C Contributing author "Hepatitis" chapter of the textbook "Internal Medicine Essentials for Clerkship Students"
2nd edition, ACP- Clerkship Directors in Internal Medicine. October, 2008

Palacio, C Multiple Choice Question Writer. CDIM MKSAP 4 for Students. October, 2008

Palacio C. Rickets. BMJ publishing group point-of-care Website. July 2008 (US product on pocrates.com)


General Internal Medicine


Division Chief: Linda Edwards. MD


Annual Report AY 2009


General Internal Medicine








Palacio C. Rickets. BMJ publishing group Best Practice Website. January 2009 (International product on
bestpractice.com)

Carlos Palacio, M.D. ( October 2008). 65-year old woman-Mrs Thompson. In SIMPLE: Simulated Internal Medicine
Patient Learning Experience Project eds. Berman and Fall. http://www.simplecases.orq.

Palacio C, Fauzia R. Blast Crisis. BMJ publishing group point-of-care Website. January 2009 (US product on
epocrates.com)

Palacio C, Fauzia R. Blast Crisis. BMJ publishing group Best Practice Website. January 2009 (International product on
bestpractice.com)


HONORS AND AWARDS


Irene Alexandraki, M.D.




Linda Edwards, M.D.




Malcolm Foster, M.D.





Alan Halperin, M.D.

Jeff House, D.O.




Senthil Meenrajan, M.D.









Carlos Palacio, M.D.


Elisa Sottile, M.D.


University of Florida Exemplary Teacher Award 2009
Peer Reviewer Journal of General Internal Medicine
Peer Reviewer Journal of Medical Education
Judge National Poster Finals, ACP Annual Meeting 2009

Elected Member and President-Elect, Faculty Council HSC/Jacksonville
Member, Executive Committee, UF Self-Insurance Program
University of Florida Exemplary Teacher Award 2009
Louis S. Russo Outstanding Professionalism in Medicine Award 2009

Governor, Florida Chapter of the American College of Physicians
Treasurer, Board of Directors, Duval County Medical Society
Board of Directors, ACP Foundation
Board of Directors, Florida Georgia Blood Alliance
University of Florida Exemplary Teacher Award 2009

Chair, Institutional Review Board, UF & SJMC

University of Florida Exemplary Teacher Award 2009
Chair, Medical Performance Improvement Committee
UF and Shands Jacksonville Medical Center


University of Florida Exemplary Teacher Award 2009
DCMS representative- FMA's Health, Education and
Public Policy Committee
Duval County Medical Society
Journals and Communication Committee
Homeland Security, Bioterrorism and
Emergency Preparedness Committee
Legislative Committee

Vice-Chair, Institutional Review Board


University of Florida Exemplary Teacher Award 2009


Annual Report AY 2009 General Internal Medicine


General Internal Medicine


Division Chief: Linda Edwards. MD


Annual Report AY 2009


General Internal Medicine






Geneal Iteral Mdicie Dvisin Chef:Lind Edwrds M


CLINICAL ACTIVITIES


Inpatient Activity AY 08/09
Numbers of Inpatient Admissions 4196
Inpatient Days 20068
Average length of stay 4.78
Number of OBU Admissions 967
Number of SNU Admissions 301
Number of IP Consults 1455

Outpatient Activity
Clinic Visits 15097


Annual Report AY 2009 General Internal Medicine


General Internal Medicine


Division Chief: Linda Edwards. MD


Annual Report AY 2009


General Internal Medicine








DIVISION OF HEMATOLOGY & MEDICAL ONCOLOGY
ACADEMIC YEAR 2009 (7/08 6/09)


Highlights

The Division of Hematology & Medical Oncology continued outstanding accomplishments in its clinical
and academic missions. The division maintains an ACGME accredited Oncology fellowship training
program and actively participates in training internal medicine residents and medical students in
inpatient and outpatient settings. Dr. Fauzia Rana, with the help of Tumor Registry, initiated and
conducted the first Breast Cancer Symposium and conducted a Breast Cancer Screening program at the
Proton Therapy Institute.

Each member of the division has a strong role in division activities. Dr. Rana is Division Chief of
Hematology/Oncology. Dr. Pham continues his efforts in the Thoracic Oncology Program and he is on
the Quality Improvement Committee. He also works with the Proton Therapy Institute in collaboration of
patient care. Dr. Janet Hosenpud is Director of the Medical Oncology Fellowship and continues to work
closely with the education of the fellows. We have been successful in hiring Dr. Robert Zaiden as
Assistant Professor of Medicine. Dr. Zaiden will join us July 1, 2009.

Patient care: The division continues to work closely with hematology-oncology leadership, and central
administration of the UF College of Medicine Gainesville, to coordinate the divisional mission with
growth and development of the Jacksonville Hematology/Oncology Program. Due to the new Proton
Beam Facility, it is anticipated that when at full capacity, the facility will result in a 30-50% increase in
inpatient and outpatient activity. This year we have already seen a 25% increase in Analytic cases data
received from Tumor Registry. In July of 2009, Dr. Rana will be expanding her outpatient clinic to the
Emerson location. This will be a multidisciplinary clinic in conjunction with the Breast Surgeon, Radiation
Oncologist and Pathologist. With the hiring of additional faculty, the division will increase its ability to
serve patients, demands and to set a foundation for increasing patient volume.

Education: The division continues to support the Internal Medicine Residency Program through
facilitation of morning report and noon conference core curriculum. The division offers a consult
experience in medical oncology to residents at all training levels. We have a weekly didactic lecture
series that gives fellows the opportunity to present cases to the faculty. Continuing support of education
to division fellows, we have a monthly Journal Club that generates discussion on various oncology
related topics throughout the year. There is a quarterly city wide joint conference between University of
Florida and Mayo Clinic of Jacksonville. This opportunity allows the fellows to present unusual cases. The
fellowship in medical oncology continues to prosper with all positions filled for July 2009 and 2010. Our
fellowship program has been granted accreditation for five years.

Research: The Division of Hematology/Oncology is currently conducting 9 clinical trials. We are
planning to start approximately 5 new trials in near future. We have started collaboration with Mayo
Clinic-Jacksonville and will be conducting cooperative group clinical trials, in addition to the ongoing
retrospective and prospective studies.


Annual Report AY 2009 Hematology/Oncology


Hematoloav/Oncoloov


Division Chief: Fauzia Rana. MD


Annual Report AY 2009


Hematology/Oncology






e t l D o e u a


LISTING OF FACULTY MEMBERS

Janet Hosenpud, MD, Assistant Professor


Medical School / Graduation date
Internshipresidency and year
Subspecialty training and year


Dat Pham, MD Assistant Professor

iledical School,, Graduation date
Internship, residency and year
Subspecialty training and year


University of Washington
iledical College of Wisconsin
Oregon Health Sciences University


University of Florida Jacksonville
University of Florida Jacksonville
University of Florida Jacksonville


Fauzia Rana, MD, Chief and Assistant Professor


iledical School i Graduation date
Internship/residency and year
Subspecialty training and year


Fatima Jinnah iledical College
University of Rochester IJewv York
Dana Farber Deaconess Hospital, Harvard


PUBLICATIONS

Pham D. Multidisciplinary Approach to Colorectal Cancer Treatment. Northeast Florida Medicine Vol. 60, Nol; 9: 2009

Nguyen T, Pham D. Adjuvant Chemotherapy for Colon Cancer. Northeast Florida Medicine Vol. 60, No.l; 20-21; 2009

Zaiden R, Pham D. Chemotherapy for Metastatic Colorectal Cancer. Northeast Florida Medicine Vol. 60, No 1: 22-23;
2009.

Meenrajan S, Subbiah S, Pham D. Consideration in the Management of Colorectal Cancer in the Elderly. Northeast
Florida Medicine Vo. 60, Nol; 24-28; 2009

Reddy S, Sullivan R, Zaiden R, De Mendoza V, Naik N, Vega K, Nahman S, Alexandraki I. Hepatitis C Infection and the
Risk of Bacteremia in Hemodialysis Patients with Tunneled Vascular Access Catheters. Southern Medical Journal Volume
102, Number 4, April 2009

Nguyen T, Pham D. Adjuvant Chemotherapy for Colon Cancer. Northeast Florida Medicine Vol. 60, No 1; 20 21;
3.2009.

Edwards L; Gauger C, Rana F. Sickle Cell Disease: Transition from Pediatric to Adult Providers; NEFM, vol. 59, No. 4
December 2008

Rana F, Garg P, Buzaianu E, Guthrie T. Predictors of Toxicity and Toxicity Profile of Adjuvant Chemotherapy in Elderly
Breast Cancer Patients (The Breast Journal)

Zaiden R, Rana F. Sinunasal Lymphoma presenting as recurrent Sinusitis (pending publication Consultants Live)

Palacio C, Rana F. Blast Crisis; British Medical Journal: December 2008; online epocrates.com/u29111026

Nguyen T, Pham D. Adjuvant Chemotherapy for Colon Cancer. Northeast Florida Medicine Vol. 60, No 1; 20 21;
3.2009


1979
1980
1982


1997
2000
2002


1982
1990
1993


Hematoloav/Oncoloov


Division Chief: Fauzia Rana. MD


Annual Report AY 2009


Hematology/Oncology









Zaiden R, Nguyen T.Large B Cell Lymphoma presenting as recurrent sinusitis. Accepted for publication in Consultant

Cortas J, Seither K, Maziaz R, Pham D et al. Superiority of Rasburicase Versus Allopurinol on Plasma Uric Acid Control in
Adult Patients with Hematologic Malignancies at Risk of Developing Tumor Lysis Syndrome: Results of a Randomized
Comparative Phase III Study; 12:2008


Abstracts:
Zaiden R. 31st Annual San Antonio Breast Cancer Symposium; A Retrospective Review of Demographics and Stage of
Presentation in Patients with ER/PR/Her2-Neu Receptor Negative (Triple Negative) Breast Cancer. December 2008
Rana F, Jasani N. Racial Discrepancies in Breast Cancer in Urban Hospital Retrospective Analysis. San Antonio Breast
Symposium, December 2008, San Antonio TX; presenter.

Zaiden R, Latif N, Pham D, Hosenpud J. Dermatofibroma Protuberans: A case report and review of literature. Accepted
in Clinical Advances in Hematology and Oncology. Abstract 12.08

Rana F. A retrospective review of demographics and stage of triple-negative breast cancer. Abstract #30042 IDe11553
www.asco.ora and www.ico.orq June 2009.


CLINICAL ACTIVITIES


Inpatient Activity AY 08/09
Numbers of Inpatient Admissions 173
Inpatient Days 1079
Average length of stay 6.24
Number of OBU Admissions 8
Number of IP Consults 421
Outpatient Activity AY 08/09
Clinic Visits 4970


CONTRACTS AND GRANTS


Principal Sponsor Title Project Total
Investigator Period Direct Cost

Pham, Dat 13 Research Phase III Trial, Breakthrough Cancer Pain in Subjects taking 03/22/2007- $16,967.32
(Ingenix opoids (043 Pain study) 02/26/2009
Pharmaceutical
Service)

Pham, Dat Favrille (Favid- Phase II Study of Continued Immunotherapy with Favid (Id- 07/01/2004- $1,299.50
08) KLH) and GM-CSF in Patients with Stable or Responding Grade 03/11/2009
1 or 2 Follicular B-Cell Lymphomas.

Pham, Dat Medarex (MDX- Phase III Trial, Melanoma Stage III or IV 05/17/2005- $2,807.00
010-20) 03/23/2009

Pham, Dat Merck & Co, Inc Phase I/II, Lung NCSLC Relapses or Refractory Merck 05/01/2007- $2,300
NSCLC 0863-056 12/31/2010

Pham, Dat GSK Glaxo SABRE NSCLC Study 04/23/2007- $3,080.00
11/18/2012

Pham, Dat UF Research PHASE III,...IRINOTECAN AND CETUXIMAB VS. 09/03/2003- $15,123.65
Foundation IRINOTECAN AS 05/27/2008


Hematoloav/Oncoloov


Division Chief: Fauzia Rana. MD


Annual Report AY 2009


Hematology/Oncology









Principal Sponsor Title Project Total
Investigator Period Direct Cost
Pham, Dat Eli Lilly Observational Study Description H3EOUS-B001 Nonsmall Cell Pending Pending
Lung Cancer. The Impact of Ethnic Origin on Patients Being
Treated Second Line With Pemetrexed.

Pham, Dat Amgen Prospective Multi-national Observational Study to Assess Pending Pending
20060392 Health Resource Utilization Associated with Skeletal Related
Prospective -- Events in Patients with Bone Metastases Secondary to Breast,
Observational Prostate, or Lung Cancer, or Multiple Myeloma.

Rana, Fauzia University of A Phase II Trial of Preoperative Capecitabine Plus Cisplatinum 09/30/2008- $10000.00
Florida in Early Stage ER Negative, PR Negative, HER-2 Negative 09/30/2009
Breast Cancer

Rana, Fauzia Amgen, Inc Phase II, MDS Indication Thrombocytopenia associated 12/04/2006- $8047.30
AMGEN MDS with lenalidomide therapy in MDS 11/06/2009
20060102

Rana, Fauzia Amgen, Inc Phase II, MDS Indication Thrombocytopenia associated 12/04/2006- $29,497.30
AMGEN MDS with hypomethylating agent therapy in MDS 11/06/2008
20050232

Rana, Fauzia Alexion P06-001 Examination of PNH, by Level of CD 59 pm RBC and WBC in 03/09/2007- $1,120.00
Exam of PNH bone marrow failure syndrome 12/21/2008
(EXPLORE)

Rana, Fauzia Millenium Multiple Myeloma Study-C05009 05/14/2008- $9,609.50
04/08/2009

Johnson & A Randomized, Double-Blind, Placebo Controlled, Multicenter Pending Pending
Rana, Fauzia Johnson Study Evaluating Epoetin Alfa Initiated at 40,000 IU Every
Pharmaceuticals Week or 80,000 IU Every Week Versus Placebo in Subjects
,Inc. EPO With IPSS Low- or Intermediate-1 Risk Myelodysplastic
Syndromes at Risk For Transfusion.

Rana, Fauzia Wyeth-Breast -- A Phase 3 Randomized, Open Label Study of Neratinib Versus Pending Pending
Protocol 3144A- Lapatinib Plus Capecitabine for the Treatment on ErbB 2
2-3003-WW Positive Locally Advanced or Metastatic Breast Cancer.

Rana, Fauzia Celator Phase IIB, Multicenter, Randomized, Open Label, Trial of CPX- Pending Pending
Pharmaceuticals 351 (Cytarabine:Daunorubicin) Lipsome Injection versus
Inc Cutarabine and Daunorubicin in patients with untreated AML
60-75 years of age.

Rana, Fauzia Celator PHASE IIb, Multicenter, Randomized, Open-label Trial of CPX- Pending Pending
Pharmaceuticals 351 (Cytarabine:Daunorubicin) Liposome Injection Versus
Inc Intensive Salvage Therapy in Adult Patients 560 Years Old
with AML in First Relapse Following an Initial CR >1 Month
Duration

Rana, Fauzia PPD A Randomized, Double Blind, Placebo-Controlled Study of the Pending Pending
JAK2 Inhibitor INCB018424 Administered Orally to Patients
with Primary Myelofibrosis (PMF) and Post Polycythemia
Vera/Essential Thrombocythemia Myelofibrosis (Post-PV/ET
MF).


Annual Report AY 2009 Hematology/Oncology


Hematoloav/Oncoloov


Division Chief: Fauzia Rana. MD


Annual Report AY 2009


Hematology/Oncology







DIVISION OF INFECTIOUS DISEASES
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Division of Infectious Diseases has continued its clinical and academic missions during this past
year. The division is comprised of 6 infectious diseases consultants, all of whom are dually boarded in
internal medicine and infectious diseases; 1 Nurse research coordinator and 1 travel medicine nurse. The
division provides clinical consultation in infectious diseases at the Shands Hospital/Jacksonville, Hospital
Infection Control direction of Shands Hospital, transplantation infectious diseases consultation at Shands,
outpatient travel and tropical medicine services, outpatient infectious diseases consultation, and clinical
infectious diseases research. The division maintains an ACGME accredited Infectious Diseases fellowship
training program and actively participates in the training of internal medicine residents and medical
studies in inpatient and outpatient infectious diseases. The division has a contract with the Duval County
Health Department (DCHD) to provide professional consultation and programmatic direction for their
HIV/AIDS, TB and STD programs and clinical care to the counties' HIV/AIDS, TB and STD patients in
DCHD specialty clinics. This contract funds 1.7 FTE of the division's ID physician time.

Each member of the division has a strong administrative role in division activities. Dr. Sands is currently
the university ID Division Chief, Medical Director of Communicable Diseases for Duval County Health
Department and ID Division Fellowship Program Director. Dr. Vandevelde directs the Travel Medicine
section. Dr. Guzman is the Chair of Hospital Infection Control for Shands Hospital, the Division Research
Director and coordinates resident and student subspecialty education. Dr. Mitchell-Samon is the Director
of the DCHD HIV section. Dr. Bailey is the Director of the DCHD STD section and oversees the DCHD
Refugee Health section. She is the university Assistant ID Fellowship Program Director and the
consultative liaison for infections in solid organ transplantation at Shands Hospital. Dr. Lauer is the Chief
of the DCHD TB section.

Patient care:
University ID Division inpatient and hospital based activity: The division provides full time infectious
consultation throughout the Shands/Jacksonville Hospital system. During the 2008-2009 academic year,
the division performed over 610 inpatient infectious diseases consultations with subsequent follow-up at
Shands Hospital.

Outpatient services: Travel medicine services are provided daily for overseas travelers. 773 travel
patients were seen between July 1, 2008 June 30, 2009.

The division offers outpatient ID consultation by referral provided by Drs. Guzman and Vandevelde at
the ACC clinic and more recently also at the Emerson Clinic. During the 08-09 academic year there were
253 outpatient ID consultative visits.

Under contract with the DCHD, the division provides professional and administrative oversight and care
for the HIV/AIDS, TB, STD and refugee screening clinical services for the DCHD specialty clinics. During
the 08-09 academic year, ID division physicians delivered or over-sighted the care for over 2,600
HIV/AIDS patients, 5410 STD visits, 1013 refugee visits and over 7559 TB visits at DCHD specialty
clinics.

Education:
Grand Rounds: The division actively participates both presenting at Medical Grand Rounds and are
regular attendees. This academic year faculty gave presentations at 4 UF Grand Rounds, 1 Baptist
Medical Center Grand Rounds and 2 topical lectures at the Internal Medicine Annual Update, Amelia
Island


Infectious Diseases


Division Chief: Michael Sands, MD


Annual Report AY 2009


Infectious Diseases





Division Chief: Michael Sands, MD


Fellowship Training: The division maintains an ACGME accredited fellowship in infectious diseases with
one fellow for each of the 2 clinical fellowship years. The fellowship program had an accreditation
inspection during this academic year and has been re-accredited on a 6 year cycle.

Resident Training: Faculty provide ID noon core curriculum conferences for the residents; ID
consultation teaching rounds; outpatient HIV/AIDS continuity clinics; and resident ID board review
sessions.

Medical Student Education: Dr. Guzman presents the HIV/AIDS core content conference for UF medical
students by teleconference with UF Gainesville. Medical student rotate on the infectious consultative
service.

ID Division Conference Schedule: The division maintains a full conferencing schedule with ongoing
meetings Monday and Thursday noon. Conference topics include: regularly scheduled cases conferences;
ID board reviews; monthly journal club; HIV topical reviews; monthly TB cases and topical reviews;
monthly research conferences; travel and tropical medicine conferences; transplantation ID conferences;
and monthly Med/Peds ID joint conference.

Cooperative extramural resident and fellows' training: As part of their curricula, Mayo Clinic ID fellows,
UF Intensivist fellows, UF Pediatric ID fellows and UF Podiatric-Orthopedic residents rotate on the UF ID
consultative service.

Research: Drs. Guzman and Bailey serve as members of the University of Florida/Jacksonville
Institutional Review Board.

The division is responsible for performance of components of federal and state categorical grants
awarded to the DCHD for TB, HIV, refugee and STD care and epidemiologic services. These grants are in
excess of $6.5 million. Additionally the division has been instrumental in acquiring and directing a federal
Ryan White Title 3 grant of $300,000 annually for improved community based access to care, that
provides HIV/AIDS care to 250 indigent patients not otherwise brought into care or previously lost from
case.

UF research and scholarly writing included: 10 abstracts presented at UF Research Day, 5 abstracts
presented at national and statewide meetings, 7 book chapters and 10 journal articles accepted for
publication, 7 externally funded research protocols and 4 internally developed research protocols.


LISTING OF FACULTY MEMBERS

E Christina Bailey, MD, Assistant Professor
i-ledical School 1 Graduation date University of Texas Health Science Center, Houston, TX 1995
Internship.residency and year University of Florida Department of iledicine, Jacksonville, FL 1998
Subspecialty training and year University of Florida Department of iledicine, Jacksonville, FL 2000

Nilmarie Guzman, MD, Assistant Professor

i medical School Graduation date Ponce School of medicine, Ponce, PR 1996
Internship. residency and year Damas Hospital, Ponce, PR 1999
Subspecialty training and year University of Florida Health Science Center, Jacksonville, FL 2006


Infectious Diseases


Annual Report AY 2009


Infectious Diseases






Division Chief: Michael Sands, MD


Jeffrey Lauer, MD, Assistant Professor

iledical School Graduation date University of i[ew ilexico School of Iledicine, Albuquerque, 11il 199-1
Internship,,residency and year University i*ledical Center, Jacksonville, FL 1997
Subspecialty training and year University iledical Center, Jacksonville, FL 1999



I Levonne Mitchell-Samon, MD, Assistant Professor

i medical School / Graduation date University of South Florida College of iledicine, Tampa, FL 1997
Internship, residency and year University of Florida Shands Jacksonville, Jacksonville, FL 2000
Subspecialty training and year University of Florida Shands Jacksonville, FL 2002



Michael Sands, MD, MPH&TM, FIDSA, Associate Professor and Division Chief

iledical School Graduation date Georgetown University, Washington, DC 1972
Internshipresidency and year St. lary's Hospital, San Francisco, CA 197-4
Subspecialty training and year Tulane University School of Public Health& Tropical iledicine, 1975
[Jew Orleans, LA II1IPH&TI)I
Louisiana State University School of iledicine, ilew Orleans, LA 1977
(Infectious Diseases)
northwestern Mlemorial Hospital, Dept. of Pathology, Clinical 1981
microbiology Section (Clinical l1icrobiology)

Alexander Vandevelde, M.D., Associate Professor

iledical School Graduation date University of Louvain iledical School, Belgium 1963
Internship. residency and year St. Vincent s iledical Center, Jacksonville, FL 196-1
University i*ledical Center, Jacksonville, FL 1969
Subspecialty training and year University of Florida iledical School, Gainesville, FL 1971



PUBLICATIONS

Book Chapters:
Mucormycosis; Palnitkar RM, Sands M. Epocrates, BMJ online monograph

Chancroid. Bailey, CL Epocrates, BMJ online monograph

Urethritis Bailey, CL Epocrates, BMJ online monograph

Leptospirosis. Guzman, N. Epocrates BMJ online monograph

Coxiella. Guzman N. Epocrates BMJ online monograph

Vibrios other than V. cholera. Sands M. Epocrates BMJ online monograph

Hantaviruses in the United States. Sands M. Epocrates BMJ online monograph


Journal Publications:
Blood Culture Isolates in Hemodialysis Vascular Catheter-related Bacteremia Alexandraki I, Sullivan R, Zaiden R, Bailey C,
McCarter Y, et al. Am J Med Sci 2008;336(4)

The strategies for management of antiretroviral therapy (SMART) study group, including Sands M. Major clinical
outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART
study. JID 2008;197:1133-44.

Annual Report AY 2009 52 Infectious Diseases


Infectious Diseases






Division Chief: Michael Sands, MD


The strategies for management of antiretroviral therapy (SMART) study group, including Sands M. Inferior clinical
outcomes of the CD4 cell count-guided antiretroviral treatment interruption strategy in the SMART study: Role of CD4
cell counts and HIV RNA levels during follow-up. JID 2008;197:1145-55.

Bailey C, Smith V, Sands M. Hepatitis B vaccine: A seven year study of adherence to the immunization guidelines and
efficacy in HIV- 1 positive adults. IJID 2008; 12:e77 e83.

The SMART/INSIGHT and D:A:D Study Groups, including Sands M. Use of nucleoside reverse transcriptase inhibitors and
risk of myocardial infarction in HIV infected patients. AIDS 2008, 22:F17-F24.

Mannepalli S. Sands M. Guzman N. McCarter Y. Pulmonary nocardiosis as the initial presenting infection in HIV/AIDS.
Chest (meeting abstracts) 2008, 134: C54001

Fox Z, Phillips A, Cohen C et al and the SMART study group including Sands M. Viral resuppression and detection of drug
resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor based regimen. AIDS
2008;22:2279-2289.

Vindas-Cordero J, Sands M, Sanchez W. Austrian's triad complicated by suppurative pericarditis and cardiac tamponade:
A case report and review of the literature. DID 2009;13:e23-e25.

Mocroft A, Wyatt C, Szczedh L, et al and the SMART study group including Sands M. Interruption of antiretroviral
therapy is associated with increased plasma cystatin C. AIDS 2009;23:71-82.

Mitchell-Samon L. Non-infectious cause of Pneumonia in an immune compromised patient.. Manuscript accepted for
publication in Hospitalist Physician


Abstracts presented at meetings:
Nontuberculous mycobacterial bloodstream infections in NIH patients with primary and acquired immunodeficiencies
(1996-2007); Palnitkar RM, Shea YR, Holland SM, Banacloche JG, Palmore TN Poster at IDSA/ICCAC 2008:

Many faces of Tuberculosis: Tuberculous meningitis in an immunocomprimised patient. Mannepalli S, Lauer J. Poster
presentation at Statewide TB and Refugee Health Meeting Tampa Florida, October 2008

Sleep Quality and Presence of Sleep Disordered Breathing In an Inner City African American HIV Seropositive Population
50 years and older. Mannepalli S, Sands M. American Conference for the Treatment of HIV, Denver, Colorado in May
2009.

Pulmonary Nocardiosis as the initial presenting infection in HIV/AIDS. Mannepalli S, Sands M. Oral presentation at
Annual American College of Chest Physicians meeting, Philadelphia, Pa. October 2008

Mycobacterium tuberculosis osteomyelitis in a patient with Human immunodeficiency virus/ Acquired Immunodeficiency
syndrome (HIV/AIDS) A Clinical Reminder. Mannepalli S. Lauer J. Poster presentation at Regional ACP meeting ,
Tampa, Florida September 2008


HONORS AND AWARDS


Michael Sands., M.D. Exemplary Teacher 2008
Nilmarie Guzman, MD Exemplary Teacher 2009


Annual Report AY 2009 Infectious Diseases


Infectious Diseases


Annual Report AY 2009


Infectious Diseases






Infetiou Diease Diisio Chef: ichel Snds M


CLINICAL ACTIVITIES


Inpatient activity AY 08/09
Consults 611

Outpatient activity
UF Travel Medicine 773
ID Consultation Clinic 253
DCHD HIV/AIDS patients 2600
STD visits 5410
Refugee visits 1013
TB visits 7559


GRANTS AND CONTRACTS


Principal Sponsor/Title
Investigator

Guzman CEFTO-SSK-4001 A prospective, multi-center, observational registry involving patients hospitalized with
complicated skin and soft tissue infections (cSSTI) for IV antibiotic therapy

Sands NCI-NIH/ Identification and functional analysis of metastasis proteins NV 17751: Observational Cohort
Study of Pneumonia in Fuzeon-Exposed and Non-Exposed Patients.

Guzman NXL104/2001 A prospective, multicenter, investigator-blinded, randomized, comparative study to
estimate the safety, tolerability and efficacy of NXL104/ceftazidime vs. imipenem cilastatin followed by
appropriate oral therapy in the treatment of complicated urinary tract Infections in hospitalized adults
(open)

Sands Ceftibuten Study: Evaluation of Single-Dose Ceftibuten for Treatment of Uncomplicated Gonocaccal
Urethritis in Men.

Bailey A prospective study of the effect of Compath use on renal transplant outcomes.

Mitchell-Samon An accelerated schedule for Hepatitis B vaccination of HIV patients Pilot study assessing completion
rates and seroconversion

Mannepalli, Sands Sleep disorders in elderly HIV infected Afro-American patients seen in a large inner city clinic.

Guzman A4001067 An International, Multicenter, Prospective Observational Study of the Safety of Maraviroc used
with Optimized Background Therapy in Treatment-Experienced HIV-1 Infected Patients (open)

Bailey Antimicrobial susceptibility of GC isolates to an alternative panel of antimicrobial agents.

Guzman NP303-101 (ADVENT): Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Two-Stage Study
to Assess the Efficacy and Safety of Crofelemer 125 mg, 250 mg, and 500 mg Orally Twice Daily for the
Treatment of HIV-Associated Diarrhea (ADVENT Trial)

Guzman GS-US-183-0145 A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the
Safety and Efficacy of Ritonavir- Boosted Elvitegravir (EVG/r) Versus Raltegravir (RAL)
Each Administered With a Background Regimen in HIV-1 Infected, Antiretroviral Treatment-Experienced
Adults

Guzman GS-US-164-0216 The SWIFT Study: A Prospective, Randomized, Open Label Phase IV Study to Evaluate
the Rationale of Switching from Fixed Dose Abacavir (ABC)/Lamivudine (3TC) to Fixed-Dose Tenofovir
DF (TDF)/Emtricitabine (FTC) in Virologically-Suppressed, HIV-1 Infected Patients Maintained on a
Ritonavir-Boosted Protease Inhibitor Containing Antiretroviral Regimen


Infectious Diseases


Division Chief: Michael Sands. MD


Annual Report AY 2009


Infectious Diseases





Division Director: N. Stanley Nahman, Jr, MD


DIVISION OF NEPHROLOGY AND HYPERTENSION
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

In the 2009 academic year, the division of Nephrology and Hypertension continued to make headway in
meeting the goals of the academic mission. In patient care, our first off site chronic dialysis venture
with our dialysis provider (DCI) opened and began enrolling patients in August. In education, the
Nephrology fellowship continued to thrive under the leadership of Dr Heilig, including the establishment
of a joint renal pathology conference with Mayo Clinic Jacksonville. In addition, our annual "Update in
Nephrology" CME course was a success for the second year in a row. In research, Dr. Heilig successfully
moved his basic laboratory program from the University of Chicago to the UF Jacksonville campus and
he has continued with a high level of productivity. Additionally, the group continues its collaborative data
mining study of the USRDS with the University of North Florida. Academically, Dr. Heilig was an invited
speaker at an international symposium on protein transporters in Turin, Italy, and the Division presented
abstracts at the ASN, the AFMR and the National Dialysis Conference.

Patient care: The most important advance this year was the opening of the new outpatient dialysis
unit at the Gateway center in Jacksonville. The division of Nephrology serves as the medical director of
the 24 station facility. The rapid growth of our outpatient dialysis population necessitated the
expansion, and the unit is already at 30% capacity. The inpatient consult service continued to grow and
for logistical reasons, the inpatient Nephrology service (Neph A) was eliminated and merged with the
consult service. This has greatly enhanced the provision of Nephrology consultative services and
significantly improved the educational platform for the fellows. In the outpatient arena, the Nephrology
referral practice continues to grow. The strong presence of faculty in the outpatient clinic has stimulated
a large influx of new referrals and fostered the continued growth of the outpatient practice. Finally, the
outpatient vascular access clinic, and a surgical service for the provision of vascular access has continued
to aid in the goal of establishing permanent access in all of our dialysis patients.

Education: The most significant event this year was the recruitment of Dr. Charles Heilig as the
program director of the Nephrology fellowship program. Dr. Heilig is a seasoned academic nephrologist
with extensive experience in research, teaching and mentoring, and has proven to be a valuable addition
to the program. In addition, both senior fellows attended the ASN, the first year fellows attended the
National Kidney Foundation spring meetings and one senior fellow presented at the AFMR Nephrology
Fellows Research platform at the Southern AFMR in February. This year the division successfully
established a quarterly joint renal pathology conference with Mayo Clinic Jacksonville, and facilitated the
establishment of an elective rotation on Nephrology consults with the Naval Air Station Jacksonville
family practice program. In teaching, Dr. Nahman was selected as an exemplary teacher by the College
of Medicine for 2009. Finally, the Division conducted its second annual Update in Nephrology CME
conference in February, and the sessions were very well received. The group plans another course in
2010.

Research: The major accomplishment this year was the moving and establishment of Dr. Heilig's basic
science laboratory from the University of Chicago to the UF Jacksonville campus. In addition, Dr. Heilig
was an invited speaker at the Gordon Research Conference on Membrane Transport Proteins in Lucca
(Barga), Italy in July. He was among 40 international speakers and discussed the role of transporter
proteins and apoptosis. He has also obtained funding from DCI for continued support of his laboratory.
In clinical research, the division continues the UNF data mining studies of the USRDS with Dr.'s
Elfayoumy and Wludyka with submission of our first collaborative research grant in spring 2009. Dr.'s
Urquidi and Nahman also submitted NIH and DOD grants assessing the effect of circadian rhythm
disturbances on development of metabolic syndrome. Although unfunded, the work has generated


Nephroloqv and Hypertension


Annual Report AY 2009


Nephrology






Division Director: N. Stanley Nahman, Jr, MD


interest from the Office of Naval Research, and the collaboration continues. Finally, Dr. Cu published a
book chapter on the immunology of renal transplantation in Essential Clinical Immunology.

In the past year, the Division successfully recruited Dr. Hartiha Sakhamuri (senior Nephrolgy fellow from
our program). She is expected to join the group in fall 2009. Dr. Maddirala departed in November. At
this time, recruitment of additional faculty continues. We anticipate that the Division maintain its
positive trajectory during the coming year, and expect the above in-progress activities to attain fruition
during that time.

LISTING OF FACULTY MEMBERS

Gil Cu, MD, Assistant Professor


iledical School Graduation date
Internship/ residency and year
Subspecialty training and year



Charles Heilig, MD, Professor

iledical School Graduation date
Internship, residency and year
Subspecialty training and year


University of the Philippines
Lutheran -ledical Center, IJY
Beth Israel Iledical Center, INY


University of ilinnesota
i layo Clinic Rochester
Brigham and Women's Hospital, Harvard University


Ronald Mars, MD, Associate Professor


i medical School / Graduation date
Internship, residency and year
Subspecialty training and year


St Louis University
Emory University
Emory University


N. Stanley Nahman, Jr, MD, Professor and Division Director


i medical School 1 Graduation date
Internship, residency and year
Subspecialty training and year


-ledical College of Ohio
Presbyterian Hospital Denver, HIt Carmel Health, Columbus
The Ohio State University


IL I


Virginia Urquidi, PhD, Research Associate Professor


Graduate School and year
PhD
Post-doctoral training


University of Bilbao, Spain
Oxford University, UK
Oxford University, UK


PUBLICATIONS

Alexandraki I, Sullivan R, Zaiden R, Bailey C, McCarter Y, Khan A, Offutt, JK, Bhatt U, Plott D, Nahman Jr NS: Blood
culture isolates in hemodialysis vascular catheter-related bacteremia. Amer J Med Sci, 336:297-302, 2008.

Goodison S, Urquidi V: Breast tumor metastasis: analysis via proteomic profiling. Expert Rev Proteomics. 5:457-67, 2008


1983
1991
1995


198-1
1987
1990


1972
1976
1978


1979
198-1
1987


1978
1992
199-1


Nephrology and Hypertension


Annual Report AY 2009


Nephrology






Division Director: N. Stanley Nahman, Jr, MD


Reddy S, Sullivan R, Zaiden R, Lopez V, Naik N, Vega K, Nahman Jr NS, Alexandraki I: Hepatitis C infection and the risk
of bacteremia in hemodialysis patients with tunneled vascular access catheters. SMedJ, 102:374-377, 2009.

Sun Y, Urquidi V, Goodison S: Derivation of molecular signatures for breast cancer recurrence prediction using a two-way
validation approach. Breast Cancer Res Treat, in press

Sakai Y, Goodison S, Cao W, Urquidi V, Namiki K, Porvasnik S, Urbanek C, Rosser CJ. VEGF induces expression of Bcl-2
and multiple signaling factors in microvascular endothelial cells in a prostate cancer model. World J Urol, 2009 Jun 4.
[Epub ahead of print]

Cu G and Zabriskie JB. Immunological aspects of transplantation, in Essential Clinical Immunology, John B. Zabriskie,
Editor, Cambridge University Press, New York, pg 331-349, 2009

Vesely E, Heilig C, Brosius III F. GLUT1 induced cFLIP expression promotes proliferation and prevents apoptosis in
vascular smooth muscle sells. Am J Physiol Cell Physiol, July 8, 2009 (E-Pub. ahead of print)

Wang Y, Heilig Y, Minto Y, Chen S, Xiang M, Dean D, Geiger R, Chang A, Pravtcheva D, Schlimme M, Deb D, Wang Y,
Heilig C. Nephron-deficient FVB mice develop rapidly progressive renal failure & heavy albuminuria involving excess
glomerular GLUT1 & VEGF. Lab Invest, in press


HONORS AND AWARDS


R Sullivan


C Heilig


NS Nahman, Jr


3rd place Fellows' Research competition American
Society for Clinical Investigation, Southern section

Invited Speaker, Gordon Conferance, Lucca, Italy

Exemplary teacher, UF College of Medicine


CLINICAL ACTIVITIES


Inpatient activity AY 08/09
Inpatient Nephrology admissions 2971
Consults 1029
Acute dialysis runs 4265
Outpatient activity
UF Jax Nephrology clinic visits 4024
Outpatient dialysis visits 5353

1 Closed February 28, 2009


GRANTS AND CONTRACTS


Principal Sponsor/Title Project period Total direct
Investigator costs

Heilig C Dialysis Clinic Inc / Mechansims of GLUT 1-induced glomerulosclerosis 10/08 8/12 $436,733
(projects C-2957 and C-3000)
Florida Breast Cancer CoalitionResearch Foundation
Urqui V The PRAME gene in Tumor Progression2009-2010 $75,000

Urquidi V NCI-NIH/ Identification and functional analysis of metastasis proteins 9/04-8/09 $1,250,000

Urquidi V NCI-NIH/Towards a non-invasive molecular test for bladder cancer 9/07 8/12 $1,450,000


2008


2008

2009


Nephrology and Hypertension


Annual Report AY 2009


Nephrology






Division Director: N. Stanley Nahman, Jr, MD


Annual Report AY 2009 Nephrology


Urquidi V Susan G Komen breast cancer Research Fdn/Isolation of monclonal 7/06 6/09 $200,000
metastasis-inhibiting antibodies

Urquidi V University of Florida Dean's Fund Faculty Research Grant/ The role of MMP8 8/07 9/10 $30,000
protein isoforms in migration and invasion capabilities of breast cancer cells

Nahman J, NS Dialysis Clinic Inc/Update in Nephrology 2009 2/09 $20,000

Sommer B, Fistula first program/Dialysis Clinic Inc 3/07 2/10 $225,000
Nahman Jr NS
(Co-PI)

Darlington A, University of Florida Dean's Fund for Residents and Fellows Research 2/07 -1/08 $5,000
Nahman Jr NS Grant/The use of thromboelastography as a tool to predict tunneled catheter
(mentor) loss

Nguyen T, University of Florida Dean's Fund for Residents and Fellows Research 11/07 10/08 $5,000
Nahman Jr NS Grant/Steps Toward Prevention: A Retrospective Analysis of Risk Factors in
(mentor) ESRD Patients Who Are Exposed to Gadolinum and the Associated
Development of Nephrogenic Systemic Fibrosis "


Nephrology and Hypertension


Annual Report AY 2009


Nephrology








DIVISION OF PULMONARY, CRITICAL CARE AND SLEEP MEDICINE
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

The Division of Pulmonary, Critical Care and Sleep Medicine has had a productive year. The fellowship
training program in Pulmonary and Critical Care Medicine began this year. The fellowship has been an
excellent experience for all of us. We hope to add two new faculty this coming year. We will add two
fellows per year for a total of 6 fellows by 7/2010.

Patient care: The Asthma Clinic, Sleep Clinics, Thoracic Oncology Clinics, Pulmonary Hypertension and
Interstitial Lung Disease Clinics are all busy and have waiting lists of patients who wish to be seen. All
faculty members and fellows have become proficient in ultrasound guided procedures and in
endobronchial ultrasound. We have begun to use general anesthesia to enable us to place endobronchial
stents in the outpatient surgical center.

Education: For the third consecutive year a member of our faculty (Luis Laos, M.D.) was selected as
teacher of the year by the Internal Medicine housestaff. The fellows are being given the dominant role in
providing the MICU monthly lecture series.

Research: The Pulmonary Hypertension and Interstitial Lung Disease program under Dr. Bajwa has
attracted an international study (Compass II) and a grant is being submitted for consideration of NIH
funding. Dr. Usman had an oral presentation at the American Thoracic Society meeting concerning
echocardiographic findings in critically ill HIV patients. Each member of the faculty has had at least one
manuscript published in a peer reviewed journal.


LISTING OF FACULTY MEMBERS

Abubakr Bajwa, M.D., Assistant Professor


i medical School i Graduation date
Internshiplresidency and year
Subspecialty training and year


King Edward medical College
University of South Dakota
ilayo Graduate School of iledicine


James D. Cury, M.D., Associate Professor and Division Chief


iledical School Graduation date
Internship!residency and year
Subspecialty training and year


University of iliami
Barnes Hospital!Washington
Washington University


I 1W


Kathryn Koch, M.D, Associate Professor


Medical School / Graduation date
Internship,/residency and year
Subspecialty training and year


John Hopkins
i-ledical University of South Carolina
Case Western


Annual Report AY 2009 Pulmonary, Critical Care & Sleep Medicine


1999
2003
2007


1981
198-1
1987


1975
1977
1979


Pu monary, CrtLca Car anDepM eDvsonCe:JmsMCrM .


l i i l d l di i


iii hi f


Annual Report AY 2009


Pulmonary, Critical Care & Sleep Medicine









Luis Laos, M.D., Associate Professor

Fledical School Graduation date University Peruana Cayetano Heredia iledical School of Peru 1986
Internshipresidency and year SUIIY, Brooklyn 1995
Subspecialty training and year University of Florida, Gainesville 1998




PUBLICATIONS

Daniels J, Cury J, Diaz J. An Unusual Cause of Post-Obstructive Pneumonia. Chest. 2007; 13:930-3.

Rascon-Aguilar I, Pamer M, Wludyka P, Cury J, Coultas D, Lambiase L, Nahman S, Vegas K. Role of Gastroesophageal
Reflux Symptoms in Exacerbations of COPD. Chest. 2006; 130:1096-1101.

Anatoliotakis N, Chisholm S, Moncur L, Ketty A, Cury J. A hypotensive 22 year old man with chest pain, cough and an
abnormal chest radiograph. Chest 2009;135:228-32.

Afessa B, Bajwa AA, Salman SS, Paroxysmal atrial fibrillation in critically ill patients with sepsis. Journal of Intensive Care
Medicine 2008 May-June; 23(3):178-83. Epub 2008 Apr 28.

Bajwa AA. A clinical experience with Bosentan in a heterogenous pulmonary hypertension population. Chest 2006
October; Supp 130(4):2558.

Kramer D, Arasi L, Cancbal J, Bajwa AA. Automated prone positioning and axial rotation in critically ill non-trauma
patients with ARDS. (Accepted pending publication) Journal Intensive Care Medicine.

Usman F, Pulido J, Bajwa AA. A 19 year old boy with exertional dyspnea. (Accepted, pending publication).

Griffin JP, Koch KA, Nelson JE, Cooley ME. Palliative care consultation, quality-of-life measurements, and bereavement
for end-of-life care in patients with lung cancer. ACCP evidence-based clinical practice guidelines (2nd edition). Chest
2007;132(3 Suppl);404S-422s.

Koch KA. Allow Natural Death: Do Not Resuscitate Orders. Northeast Florida Medicine. 2007 (Suppl);9-13.

Mazidi P, Bajestani S, Khan M, Khair T, Laos L. Goodpasture's Syndrome: A Case Report and Review of Literature. The
Internet Journal of Internal Medicine. 2008:Volume 7, Number 2.



HONORS AND AWARDS

Luis Laos, M.D. University of Florida Exemplary Teacher 2008



CLINICAL ACTIVITIES


Inpatient activity AY 08/09
Inpatient Pulmonary admissions 449
Inpatient Days 3023
Average length of stay 6.73
Number of IP Consults 962
Outpatient activity
Clinical Visits 2956
Procedures
Bronchoscopies 539
Sleep Studies 666


Annual Report AY 2009 Pulmonary, Critical Care & Sleep Medicine


Pulmonary, Critical Care & Sleep Medicine


Pulmonary, Critic D.


I..l 1 f' ^*_ 1.- lf' .. l_- l Ui .jIJ ,


r^:..:*:__ ^*L:-C. i-.-.-_ r *..-.. RJI r


Annual Report AY 2009





Division of Rheumatology and Clinical Immunology


DIVISION OF RHEUMATOLOGY AND CLINICAL IMMUNOLOGY
ACADEMIC YEAR 2009 (7/08 6/09)

Highlights

Although we are still a small division, we have achieved milestone steps in our steady march towards a
successful and interdependent division for patient care, research and education at University of Florida
College of Medicine, Jacksonville. Dr. Gurjit Kaeley, as an Assistant Professor of Medicine and Director of
Musculoskeletal Ultrasound, and Marinella Lipinski, as a research coordinator, joined us in December
2008. We have also successfully recruited Dr. Chrysoula Pappa as an Assistant Professor of Medicine and
she will be joining our division in July 2009. Dr. Ghaith Mitri joined UF Jacksonville as the Division
Chief in September 2007 as the first full-time rheumatologist in over ten years. There is a major
shortage of rheumatologists in Jacksonville and we hope with our diverse backgrounds, supportive
leadership, hard work and compassion to excel in patient care, research and education will allow us to
establish the first fellowship training program in Rheumatology at this institution by July 2010. Currently,
we have full-time coverage of outpatient and inpatient consults and rheumatological services especially
musculoskeletal ultrasound and IV infusion therapies. We are also working on providing allergy testing
and expertise as part of our clinical immunology practice. Education was emphasized with more student
and resident rotations, lectures, guest speakers, and round table discussions covering multiple
rheumatological and healthcare related issues. Academically, the division published multiple publications
in peer-reviewed journals, was awarded a grant and is working on multiple clinical trials, both
pharmaceutically sponsored and investigator initiated.

Patient care: The most important achievement was improving access to rheumatological services in
the outpatient and inpatient settings. In previous years, the next available appointment for a new patient
exceeded 6 months, but it has been minimized to couple of weeks. Inpatient rheumatology consultations
are now covered by board certified rheumatologists 24/7 throughout the year. More specialized and
patient oriented services are constantly being added to the outpatient setting, such as various infusion
services and musculoskeletal ultrasound. The goal is to provide the highest quality of care in response to
our patient's needs and to take leadership position in patient satisfaction.

Education: Education is one of the division's top priorities. It is the key element in advancing
healthcare and recruiting the rheumatologists of the future. Numerous medical students and residents
rotated in the outpatient and inpatient consultative services. Numerous lectures have been given to the
internal medicine residents and other training programs within the UF College of Medicine, Jacksonville
and our grand rounds included invited guest speakers. Several round table discussions involving
residents and faculty from UF and Mayo Clinic in Jacksonville were facilitated in order to strengthen the
collegial and collaborative efforts between our educational institutions, residents, and faculty members.
For the first year we accommodated rheumatology fellow from outside institutions, such as George
Washington University and UF Gainesville, for musculoskeletal ultrasound training. Ultimately, we hope
to offer training courses in musculoskeletal ultrasound and a rheumatology review course for the local
and national medical community. We are working in collaboration with UF College of Medicine,
Gainesville and the Mayo Clinic in Jacksonville, FL to establish a fellowship training program for the next
academic year.

PUBLICATIONS

K. Ramsubeik, R. Maharaj, G Mitri. When diagnosis of rheumatologic disease does not "follow the book. J Musculoskel
Med. January 2009; 26(1): 11-14.

K. Ramsubeik, H. Griffiths, G Mitri. Arthritis in a patient with severe psoriasis: Narrowing the differential. J Musculoskel
Med. Accepted for publications in September 2009.


Division Chief: Ghaith Mitri, MD, MMM


Annual Report AY 2009


Rheumatology/Clinical Immunology






Division of Rheumatoloav and Clinical Immunoloav


G. Mitri. Familial Mediterranean Fever. BMJ Point-of-Care 2009; www.pointofcare.bmj.com. (September 2009)
Bruyn GA, Naredo E, Moller I, Moragues C, Garrido J, de Bock GH, D'Agostino MA, Filippucci E, Iagnocco A, Backhaus M,
Swen N, Balint PV, Pineda C, Milutinovic S, Kane DJ, Kaeley G, Narvaez JA, de Agustin J, Wakefield RJ, Narvaez J,
Schmidt WA. Reliability of ultrasonography in detecting shoulder disease in patients with rheumatoid arthritis. Ann Rheum
Dis. 2009 Mar;68(3):357-61. Epub 2008 Apr 4.


LISTING OF FACULTY MEMBERS

Gurjit S Kaeley, M.B.B.S., Assistant Professor and Director of Musculoskeletal Ultrasound


medical School.Graduation date
Internshiplresidency and year
Subspecialty training and year


The London Hospital Iledical College, London, UK
University of Tennessee College of iledicine
University of Tennessee College of iledicine


Ghaith Mitri, M.D. M.M.M., Assistant Professor and Division Chief


Sledical School./Graduation date
Internshipresidency and year
Subspecialty training and year
Post-Graduate Training and year


Damascus University School of medicine
Scranton Temple University
University of Pittsburg School of lMedicine
ilarshall School of Business, USC


CLINICAL ACTIVITIES


Outpatient activity
Clinical Visits 1,734


CONTRACTS AND GRANTS


Principal Sponsor/Title Budget/
Investigator Value

Mitri G A randomised, double-blind, placebo-controlled, multi-centre prospective dose-finding Phase $110,512
II/III study with atacicept given subcutaneously to subjects having recently experienced a
flare of systemic lupus erythematosus (SLE). Sponsored by SERONO.
Mitri G An open-label, randomized study to evaluate the safety, tolerability and efficacy of tocilizumab $39,496
(TCZ) monotherapy or TCZ in combination with non-biologic DMARDs in patients with active
rheumatoid arthritis who have an inadequate response to current non-biologic or biologic
DMARDs. Sponsored by Roche.

Bajwa A (PI) Pulmonary Arterial Hypertension (PAH): COMPASS 2: Effects of combination of bosentan and $60,000
Mitri G (Sub-PI) sildenafil versus sildenafil monotherapy on morbidity and mortality in symptomatic patients
Kaeley G (Sub-PI) with pulmonary arterial hypertension A multicenter, double blind, randomized, placebo -
controlled, parallel group, prospective, event driven Phase IV study. Sponsored by Actelion.

Mitri G Psoriatic Arthritis: GRAPPA: The development of a composite measure of disease activity in
Kaeley G psoriatic arthritis: GRAPPA collaborative exercise Status: Open IRB03 Approved.

Mitri G CORRONA: Consortium of Rheumatology Researchers of North America, Inc. Data Collection
Kaeley G Program, Protocol 02-021.

Mitri G Psoriatic Arthritis: A phase 3 multi-centre, randomized, double Blind, placebo controlled trial of Pending
Ustekinumab, a fully human anti-IL 12/23p40 monoclonal antibody, administered
subcutaneously in subjects with active psoriatic arthritis. Sponsored by Centocor. Site
selected.


1990
1996
1998


1995
1999
2001
2007


Division Chief: Ghaith Mitri. MD. MMM


Annual Report AY 2009


Rheumatology/Clinical Immunology






Division of Rheumatology and Clinical Immunoloqv


Mitri G RA: WA 19926 A multi-center, randomized, double blind, parallel group study of the safety, Pending
remission and prevention of structural joint damage during treatment with tocilizumab (TCZ),
as a monotherapy and in combination with methotrexate (MTX), versus methotrexate in
patients with early, moderate to severe rheumatoid arthritis. Sponsored by Roche.


Kaeley G RA: A Randomized, Double-blind, Placebo-controlled, Multiple-dose Study to Evaluate the Pending
Safety, Tolerability, and Efficacy of AMG 827 in Subjects with Rheumatoid Arthritis and an
Inadequate Response to Methotrexate. Sponsored by Amgen.

GRANT: 2009 -2010: Unrestricted grant from Wyeth to develop validated Web Atlas of $46,500
Sonographic Scoring of Rheumatoid Arthritis Activity.

GRANT: 2008-2009: Unrestricted equipment loan from Sonosite. Equipment Value: $70,000 $70,000


Annual Report AY 2009 Rheumatology/Clinical Immunology


Division Chief: Ghaith Mitri, MD, MMM


Annual Report AY 2009


Rheumatology/Clinical Immunology















































Department of Medicine
University of Florida
College of Medicine Jacksonville
653-1 West 8th Street, L20
Jacksonville FL 32209
904-244-8846
www.hscj.ufl.edu/im/




University of Florida Home Page
© 2004 - 2010 University of Florida George A. Smathers Libraries.
All rights reserved.

Acceptable Use, Copyright, and Disclaimer Statement
Last updated October 10, 2010 - - mvs