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Title: CTSI newsletter
Physical Description: Serial
Language: English
Creator: Clinical and Translational Science Institute, University of Florida
Publisher: Clinical and Translational Science Institute
Place of Publication: Gainesville, Fla.
Publication Date: October 2009
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Volume ID: VID00012
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From the Director

Research Opportuni-
ties at the Malcom
Randall VAMC

VA Career Develop-
ment Opportunities
Overview of GRECC
Research
VA Rehabilitation
Outcomes Research
Center

Brain Rehabilitation
Research Center of
Excellence

Meta-Analysis Re-
search Opportunity


Volume 2, Issue 6 October 2009

Volume 2, Issue 6 October 2009


Last week the Principal Investigators of the CTSA Institutions had their annual
meeting with NIH staff in Rockville, MD. The two-day affair was informa-
tion-dense, particularly for me and the other representatives from the newly
funded CTSAs. Two inter-related themes dominated the meeting: 1) building a national
network of collaborating institutions across the entire spectrum of clinical and transla-
tional research; and 2) accelerating the process of protocol development and regulatory
review so that clinical trials can be implemented across institutions in a timely manner.

There are five strategic goals of the CTSA Consortium, as illustrated in Figure 1. Each
of these has a UF CTSA representative. Key Function Committees are also represented
by UF faculty members. The overall CTSA Steering Committee is composed of the
CTSA PIs and the Executive Committee is a rotating group from that membership.
The relationship of these investigator-led groups to the National Center for Research
Resources (the NIH Center that oversees the CTSAs) is illustrated in Figure 2.

Figure 1.


How is UF's CTSI doing in addressing these strategic goals and key functions of the
CTSA Consortium? Despite our youth, we have made progress in a number of areas,
including the recent $12.3M U24 grant award to Dr. Michael Conlon, Interim Director
of Biomedical Informatics, to enhance IT resources that will connect scientists across
the US and facilitate research collaborations. In addition, CTSI Investigators are
already participating in two CTSA-driven national clinical trials, one involving


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700


KFY FUNCTIONS


STRATEGIC GOALS


INSIDE THIS ISSUE I












II New slette


Volume 2, Issue 6 October 2009




a cardiac device for arrhythmias (local PI: Carl Pepine, MD), and a randomized clinical trial assessing the safety and
effectiveness of station administration in patients admitted with influenza to pediatric and medical intensive care units. For
this trial, UF participants include ICUs in Gainesville, Jacksonville and a hospital affiliated with A.G. Holley Tuberculosis
Hospital. Figure 2.

The CTSA Network has CTSA Conisoriiin and Governance
generated a number of regional
consortia, including one that has .a
just formed in the southeastern t
United States. The participant
institutions are UF, Arkansas,
Alabama, Emory/Morehouse,
UNC, Duke, Medical University
of South Carolina and Vanderbilt.
Several of the PIs from the
Southeastern CTSA Consortium
met last week to discuss the
possibility of organizing a
concerted effort in research
and training emphasizing CTSA
underrepresented minorities in CTSA Strategic Key Function
SGoals Committees Committees and
our region. Clearly, that impacts .a. Interest Groups.
a number of different Programs
within UF's CTSI, as well as a
multi- and interdisciplinary spectrum of UF investigators. I will keep you updated on the progress of these discussions.

Speaking of research and training opportunities, the remainder of this Newsletter is dedicated to alerting you to the many
opportunities offered through the Malcom Randall VA Medical Center, flagship of the North Florida/South Georgia VA
Heathcare System and a partner in the CTSI.

Happy Reading!





Peter W. Stacpoole, PhD, MD
Director, Clinical and Translational Science Institute
Associate Dean for Clinical Research and Training


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700















Volume 2, Issue 6 October 2009


The Department of Veterans Affairs (VA) was elevat-
ed to Cabinet-level status on March 15, 1989, and
is the second-largest of the 15 Cabinet departments.
As Secretary of Veterans Affairs, Eric K. Shinseki oversees
the Veterans Health Administration (VHA) system that pro-
vides benefits and services to nearly 24.5 million veterans
and their families. About a quarter of the nation's popula-
tion is potentially eligible for VA benefits and services
because they are veterans themselves, or are family mem-
bers or survivors of veterans. The VA's fiscal 2009 spend-
ing is approximately $93.4 billion, including $40 billion
for health care, $46.9 billion for benefits, and $230 million
for the memorial benefits. This amounts to a more than 7%
increase compared to fiscal 2008.

The North Florida/South Georgia Health
System

The Veterans Health Administration System is organized
into 21 regions called Veterans Integrated Services Net-
works, or VISN. Each VISN coordinates clinical and
research activities within its specified region of the country.
Our local VISN 8 is the VA Sunshine Healthcare Network.
Geographically, our network spans approximately 63,400
square miles that includes more than 1.8 million veterans
throughout Florida, Southern Georgia, Puerto Rico, and the
U.S. Virgin Islands with medical centers in Gainesville and
Lake City. Three satellite outpatient clinics and six com-
munity-based outpatient clinics are distributed across North
Florida and South Georgia.

Research in the VHA system

The Department of Veterans Affairs is one of the 10 largest
research and development (R&D) funding agencies in the
federal government. VA research has been responsible for
several key advances in health care. For example, VA re-
searchers invented the implantable cardiac pacemaker, per-
formed the first successful liver transplant, were responsi-
ble for the development of the nicotine patch, and provided


the groundwork for the first oral vaccine for smallpox. The
VA continues to encourage and facilitate research, recog-
nizing that participation in novel investigation may lead to
developments that improve quality of care, increases access
to the new treatments and more closely supervised medical
care for veterans, and ensures that the veteran population
is well-represented in studies that eventually lead to new
approved therapies.

By congressional mandate, research programs within the
VHA are conducted in order to enhance the quality of
medical care. While VA research emphasizes topics rel-
evant to military service-connected disabilities and illness,
this mandate historically has been interpreted quite broadly
so as to include basic science. Funding for VHA research is
separated into four main divisions: Biomedical Laboratory,
Clinical Science, Health Services, and Rehabilitation.

The Biomedical Laboratory division supports basic science
and preclinical research. The Clinical Science division is
oriented toward therapeutics and clinical trials for medical
conditions relevant to veterans. The Health Services divi-
sion is dedicated to issues in quality and improvement of
health care, again focusing on issues relevant to veterans.
The Rehabilitation division is responsible for develop-
ing research strategies for coping with serious illness and
injury. As a result of the emphasis on clinical relevance,
two-thirds of VA scientists are clinician-researchers.

The fiscal year 2009 budget for VHA research totals ap-
proximately $952 million, which represents a 6.8% in-
crease over 2008. Of this, more than half, or $530 million,
is committed to direct costs, with the remainder used to
provide research support. The VA maintains its own peer
review system to ensure that research grants are awarded
based on merit. Most research funding is distributed to
investigator-initiated research projects, with the remainder
used to support centers of excellence, career development,
and military service-directed research. VA investigators are
eligible to apply for other federal and pharmaceutical-spon-


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Volume 2, Issue 6 October 2009


OVRIWO EERHOPRUIISA H ACMRNALVM


scored sources of support, more than doubling the overall
VA research budget.

Collaborating with the VA

All scientists who apply for and receive Veterans Af-
fairs funding must be employees of the agency, although
many investigators hold joint appointments with academic
institutions, and much VA research is collaborative with
other institutions. VA investigators have several options for
collaboration with non-VA supported investigators. For VA
sponsored research, a number of contracting options are
possible that can provide either salary support to individu-
als or can specify services or products to be provided. Spe-
cific guidelines and oversight ensures that the contracting
mechanism complies with all VA requirements. Generally,
any use of VA facilities by a collaborator requires that the
individual go through a federal screening process leading
to a non-compensated (without compensation or WOC) VA
appointment.

For collaborations in which a VA investigator participates
in university-sponsored research, it is expected that the VA
will be compensated for any use of its resources. To facili-
tate this process, subcontracts to the VA can be managed by
a nonprofit research corporation and education foundations
affiliated with VHA facilities. Our local nonprofit corpo-
ration is the North Florida Foundation for Research and
Education (NFFRE). Joy Mitchell serves as its executive
director.

Key points for any research using VA resources are the re-
quirements that the research must include the participation
of a VA-supported investigator and must be recommended
for approval by the local VA facility at the level of the VA
R&D committee. For an investigator who is interested
in access to VA resources, including our veteran patient
population, there are several ways to screen for opportuni-
ties and identify potential collaborations. The nonprofit
corporation has a staff that serve as a excellent source of


information as well as providing help with VA-specific IRB
issues. Other individuals to contact for information include
members of the R&D subcommittee for Research Support
or the R&D committee itself. Please see http://www.north-
florida.va.gov/research/rdcomm.asp for additional details;
see http://www.northflorida.va.gov/research/current.asp for
a list of current research investigators.

VA facilities

The availability of funding earmarked for research support
has lead to the development of state-of-the-art facilities at
the Malcom Randall VAMC. Shared resources that are ex-
pertly maintained are the norm. A newly renovated animal
facility includes remote monitoring capabilities for rodents.
Microscopy facilities include a Zeiss two-photon system
and a second Zeiss laser scanning confocal system, as well
as independent stations for microinjection, ratiometric fluo-
rescence imaging analysis and laser dissection microscopy.
The most recent acquisitions in 2009 include a Vevo 2100
Imaging System from VisualSonics that does non-invasive,
real-time, high resolution in vivo imaging. A Noldus video
and optical behavioral tracking system with EthoVision
and Catwalk is used for Morris water maze (memory and
learning), anxiety like behavior, activity motoring, social
behavior, pain, and gait analyses. From the standpoint of
clinical research, it should be noted that the VA utilizes the
award-winning Veterans Health Information Systems and
Technology Architecture (VistA) for computerized patient
records. Moreover, this is a no-cost, open-architecture
system available to hospitals. If it could be adopted by
UF/Shands, archived data could be accessed with identical
parameters at both of institutions, thus enhancing collabora-
tive research.

An initiative in genomics

In 2006, the Department of Veterans Affairs launched the
Genomic Medicine Program to examine the potential of
emerging genomic technologies, to optimize medical care


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700













Volume 2, Issue 6 October 2009

Volume 2, Issue 6 October 2009


OVRIWO EERHOPRUIISA H ACMRNALVM


for veterans, and to enhance the development of tests and
treatments for relevant diseases. VA funds 142 investigator-
initiated Merit Review projects related to genetics/genom-
ics for a wide spectrum of conditions prevalent in veterans
such as schizophrenia, Post Traumatic Stress Disorder
or PTSD, bipolar disorder, Alzheimer's, cardiovascular
disease, diabetes, cancer (prostate, breast, colon, bladder,
and lung), substance abuse, stroke, chronic viral infections,
autoimmune disorders, and Gulf War Illness. These studies
cover the spectrum of genetic-association, pharmacoge-
nomics, candidate gene analysis, single-nucleotide poly-
morphism (SNP) analysis, linkage studies, and proteomics/
metabolomics. Blood and tissue storage facilities include
a DNA bank/biorepository at the Boston VA with about
30,000 blood samples and 6,000 DNA samples collected
during multi-site VA clinical trials, a DNA coordinating
center at the Palo Alto (Calif.) VA linking clinical informa-
tion with data analysis and a tissue repository at the Tucson
VA.


tiered career development grant opportunities have pro-
vided protected time for medical researchers in the early
stages of their careers. This system has served to train
investigators and create a supply of clinician-scientists for
both VA and non-VA positions. These grants continue to be
funded at a favorable level and typically provide extensive
salary support. Awareness of these opportunities, however,
remains low among our affiliated educational institutions.
Increased involvement of the VA in academic recruitment
efforts, as well as better dissemination of information to
individuals leading academic departments and divisions
would be expected to improve our exploitation of these op-
portunities.

The VA has an outstanding patient population, both in
terms of patient numbers and access to care, a state-of-the-
art electronic medical record system, and an administra-
tive structure supportive of the research enterprise. These
factors create an attractive environment for translational
research.


Career development in the VA system

The VA offers robust support for career development in
clinical and translational research. Over several decades,





Veterans L Health Administration

Research Development

Improving Veterans' Lives -o- www.research.va.gov


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700















Volume 2, Issue 6 October 2009


VA CAEE DEEOMN OPPORTUNITIES


Background/overview
The Veterans Affairs career development and mentor-
ing programs were established to provide mentor-
ing for junior researchers so they can learn from
renowned, experienced VA researchers. Graduates of this
program have become national and international leaders in
their research fields. Mentoring awards include pre-doc-
toral, disability supplements, nursing research initiatives,
post-doctoral awards, and the Career Development Program
(CDP).

Scope of research/mission

Awards are provided in the VA's four research areas: bio-
medical laboratory, clinical science, health services, and
rehabilitation research. The majority of the awards are open
to VA and non-VA applicants, especially those working in
research areas of high priority to the VA.

Mentoring and career development pro-
grams

Pre-doctoral awards are available to graduate students who
have completed doctoral course work in a rehabilitation
health care profession such as rehabilitation engineering,
OT/PT, audiology, speech-language pathology, nursing
and psychology. Research Disability Supplements provide
additional funds to existing rehabilitation centers and merit
review investigators to support the development of re-
searchers with disabilities.

The Nursing Research Initiative accepts applicants from all
four research areas for those who have completed their doc-
toral degrees. The Initiative also funds pilot studies, as well
as mentored awards for junior and senior nurse researchers.

Post-doctoral awards are available for clinicians (MD and
PhDs) who have completed a geriatrics fellowship, other
sub-specialty training, or clinical doctorate residency in-
terested in improving the health outcomes of older Ameri-
cans via the Geriatrics Advanced Research Fellowship. It


provides full salary support for two years with a minimum
of 75% protected research time.

The CDP program has four levels of career development
awards. Career Development Award 1 (CDA-1) provides
research experience to applicants who work closely with
mentors on funded research. This award provides up to two
years of salary support.

The Career Development Award 2 (CDA-2) provides
mentored research experience to applicants to support their
development into independently funded VA researchers.
Applicants propose their own research projects and work
closely with mentors to complete and publish project find-
ings. This award ranges from three to five years in duration,
including salary support and project funds.

The Career Development Transition Award (CDTA) is
open only to clinician researchers, and supports applicants
no more than 10 years beyond training in the transition to
become independently funded VA research scientists. It
provides salary support for up to three years.

The Career Development Enhancement Award (CDEA) is
open to all senior VA clinicians and non-clinician scientists
providing up to six months of full salary support for educa-
tional leave to learn new research skills.

Administrative

Program guidelines, relevant resources, instructions, and
application forms are available at http://www.research.
va.gov/funding.

Existing relationship with CTSI and/or UF

Recent trainees have come from a variety of disciplines
from the UF College of Medicine, Public Health and Health
Professions, Nursing, Health and Human Performance,
Pharmacy, and Engineering. Candidates can work with their
advisors and mentors to develop training programs that
incorporate the resources of the UF newly funded CTSI.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700
















Volume 2, Issue 6 October 2009

OVRVEWO G C RSARCH
BYSTV BORST P. C ATNG ASOCIAT DIRETO FOR REEAC


he Veteran's Affair Medical Center (VAMC) Geriat-
ric Research Education and Clinical (GRECC) is a
center of excellence under the leadership of Director
Dr. Ronald Shorr, M.D. The center's overall mission is to
support and increase geriatrics in response to the needs of
our growing population of older veterans.

The center's research focuses on frailty,
and its investigators have active pro-
grams in basic, translational clinical
and health service research. The a r
mission also includes develop-
ing Clinical Demonstration
Projects, which are health
services-related studies con-
ducted at the VA Geriatric
Evaluation Module, a sub-
acute geriatrics ward. GR

The GRECC offers several opportunities for those who
would like to embark on a career in academic Geriatrics,
including the following:

Special fellowship in Advanced Geriatrics

Each year, the center has one new position for this one- to
two-year program that is designed for physicians and other
clinicians who have completed a clinical fellowship and
would like to begin a career in research. The program offers
protected time for research, education in research meth-
ods, and a wide choice of potential mentors. For informa-
tion, contact Program Director Dr. Rebecca Beyth, MD at
Rebecca.Beyth@va.gov, or Co-director Dr. Connie Uphold
Ph.D. at Connie.Uphold@med.va.gov.

Career development award

This is a two- to five-year mentored VA award that provides
salary only (CDA I) or salary plus research funds (CDA
II) and is designed to provide research and other resources


needed for establishing an academic career.

Clinical demonstration projects

The GRECC runs the Geriatric Evaluation and Man-
agement (GEM) program at the VAMC and conducts
clinical demonstration projects at this sub-acute
care ward.

S* "Gait and Balance Assess-
m..ent with Live Video from
computerized Patient Re-
\ cord System (CPRS) Inter-
\ face with Vista Imaging"
will videotape the gate
of patients in the GEM
and the Gait and Balance
Clinic.

* "Intervention to improve care at life's end in VA Medi-
cal Centers," Gainesville, is part of a multi-center Health
Sciences Research and Development (HSR&D) study
using the BEACON order set. BEACON stands for Best
practices for End of life care And Comfort care Order
sets for our Nation's veterans.

* "Web-based information materials for caregivers of
veterans post stroke" develops materials for stroke
caregivers and places them on MyHealthyVet, which is
a personal electronic medical record accessible to each
veteran.

* "Home safety assessment utilizing a video camera" is
a project to perform home assessment remotely.

* "Implementing evidence in the detection and treatment
of post-stroke decision making" is a project employ-
ing targeted screening to identify depression in stroke
patients.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700


i












II New slette


Volume 2, Issue 6 October 2009




* "Intervention development for shared decision making in stroke prevention" This HSR&D project funded by the Qual-
ity Enhancement Research Initiative (QUERI) involves development of a video with script to aid patients with atrial
fibrillation to better interact with their health provider regarding the decision to use anti-coagulation medication.

Individual research programs of GRECC investigators

* Dr. Steve Borst, Ph.D., Stephen.Borst@va.gov, is conducting basic and clinical studies to investigate mechanisms of
sarcopenia and bone loss during aging and to test strategies for combating these conditions.
* Dr. Connie Uphold, Ph.D., Connie.Uphold@med.va.gov, is conducting educational and health services caregiver sup-
port for stroke and other conditions.
* Dr. Rebecca Beyth, M.D., MSc., Rebecca.Beyth@va.gov, is conducting health services and educational research in the
use of anticoagulants in the elderly.
* Dr. Nihal Tumer, Ph.D., Nihal.Scarpace@va.gov, is conducting basic research in the control of blood pressure and
obesity.
* Dr. Ronald Shorr, M.D., Ronald.Shorr@va.gov, is conducting clinical and health services research in the area of fall
prevention.
* Dr. Kenneth Heilman, M.D., heilman@neurology.ufl.edu, is conducting clinical research in Alzheimer's disease, ne-
glect, and a variety of neurological conditions associated with aging.
* Dr. Miho Bautista, M.D., Miho.Bautista@med.va.gov, is conducting educational research in geriatrics.
* Dr. Lewis Randonovich, M.D., Lewis.Radonovich@va.gov, is conducting clinical research in infection control.








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Volume 2, Issue 6 October 2009


VA REAIITTO OUCOE REEAC CE n nNTER


he Rehabilitation Outcomes Research Center
(RORC) at the North Florida/South Georgia Veter-
ans Health System in Gainesville conducts inter-
disciplinary research to improve the health, function, and
community integration of veterans challenged by disability
and limited access to health related services. It is the only
Research Enhancement Award Program jointly supported
by core-funding from both VA Health Services Research
and Development and Rehabilitation Research and Devel-
opment services.

Rehabilitation and the management of disability and illness
are emerging as dominate themes in the VA strategic vision,
and the RORC mission directly addresses these evolving
priorities through a multifaceted strategy. This includes ex-
amining how to improve the access, design, administration,
management, and cost of care; by using state of the science
methodologies to develop new and more precise measures
across the continuum of care; and by evaluating innova-
tive systems and processes of care through the continuum,
including the psychosocial aspests of recovery, informal
care-giving, and community reintegration.

The primary research focus of RORC is to evaluate reha-
bilitation programs and interventions that result in optimal


patient outcomes. Research in the Center is organized the-
matically by outcomes of interest, including health, func-
tion, independence, quality of life, community integration,
access, quality, and cost.

At RORC, research programming is supported by Adminis-
trative, Methodological, Dissemination, and Career Devel-
opment/Training cores. A Steering Committee of national
content area experts and an advisory panel of local VA and
UF leaders provide guidance and support.

The coalescence of expertise and talent among neurosci-
entists, interdisciplinary rehabilitation researchers, health
service researchers, clinicians, and social scientists at the
RORC, the Brain Rehabilitation Research Center, the Ge-
riatric Research Education and Clinical Center, the Stroke
and Polytrauma Quality Enhancement Research Initiatives,
and UF provide access to unusually strong and innovative
research programs aimed at improving VA rehabilitation
care.

Using the depth and breadth of expertise available in the
community, the RORC is uniquely positioned to strengthen
existing outcomes evaluation methods and measures in
rehabilitation outcomes research.


Rehabilitation Outcomes Research Center

P ~~W~~R~~ 3 PPno~nR~I* p


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700
















Volume 2, Issue 6 October 2009


BRI REAIITTO REEAC CETE OFg EXCELLEn n *NCE


The Brain Rehabilitation Research Center of Excel-
lence (BRRC) in Gainesville is one of 15 Veteran
Affairs centers of excellence nationwide exclusively
focused on rehabilitation research. Its mission is to enhance
the quality of life of veterans with central nervous system
injury or disease through research focused on maximizing
recovery of motor or cognitive function through rehabilita-
tion

Brain or spinal cord disease or injury produces the most
handicapping of all chronic conditions in adulthood.
Funded in 1999 by the Department of Veteran Affairs Re-
habilitation Research and Development Service, the BRRC
is located at the Malcom Randall VAMC and headed by
Program Director Dr. Leslie Gonzalez Rothi, Ph.D., and
Medical Director Dr. Stephen Nadeau, M.D.

The Center's research targets innovating and refining effec-
tive treatments which focus on potentiating neural plasticity
and neural network reorganization via theoretically moti-
vated behavioral and/or physiological treatment protocols
and translational research projects. The program empha-
sizes three main goals:

* Developing and refining effective behavioral treatments
of disease that maximize experience-dependent learning
and specifically target motor or cognitive deficits resulting
from central nervous system injury.
* Translating existing knowledge of the basic science of
neural plasticity to delivery in humans.
* Developing technologic applications for measurement
and prediction using functional neuroimaging and sophisti-
cated quantitative human performance measurement.

The BRRC encourages, advises, and supports research-
ers and clinicians by providing educational and research
infrastructure opportunities to those who are interested in
initiating clinically relevant research in rehabilitation of
neurocognitive and neuromotor impairments. These include
infrastructure support such as access to research clinic


rooms, research therapists, subject recruitment and screen-
ing services, IRB management, and doctoral-level biostatis-
tical consultation. Research training opportunities include
mentored awards, an expert speaker series, and annual
rehabilitation research methods training courses.

The Center provides a participant recruitment infrastruc-
ture consisting of a database of individuals with stroke and
spinal cord injury who are interested in referral for research
participation. It also provides personnel support, includ-
ing therapists, engineering, IRB, statistical, and secretarial.
Currently more than 800 subjects who have been screened
by a neurologist, physical therapist, neuropsychologist, and
speech pathologist are included in the database. Typically
two to three subjects are screened weekly and added to the
database. All of these participants have given their consent
to be contacted for referral to ongoing or future research
studies. The BRRC also has available multiple assessments
of upper extremity (UE) and lower extremity (LE) function,
as well as materials for various massed-practice UE/LE
rehabilitation interventions. These assessments also include
numerous neurophysiological and speech-related testing.

The BRRC encompasses a 7,700-square-foot facility,
which houses research laboratories, and investigator and
administrative offices. Each investigator has a dedicated
telephone, computer (containing a full array of Microsoft
software) and connections to secured networks at both the
VA and UF. Intranet connections within the VA and Internet
connections to UF allow full access to library facilities and
shared software (e.g., MatLab, SPSS, and SAS). The Cen-
ter also has research laboratories for treatment and therapy
interventions, a conference room, and data storage facili-
ties. In addition, it houses the VA/UF Brooks Center for
Rehabilitation Sciences Human Motor Performance Labo-
ratory directed by Dr. Steven Kautz, Ph.D, and a Transcra-
nial Magnetic Stimulation (TMS) laboratory directed by Dr.
Jeffrey Kleim, Ph.D.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700














Volume 2, Issue 6October2009
Volume 2, Issue 6 October 2009


BRRC Transcranial Magnetic Stimulation
Laboratory

The laboratory is a 300-square-foot suite containing state-
of -the-art transcranial magnetic stimulation equipment to
study the neurophysiological substrates of rehabilitation-
dependent recovery from stroke.


The suite includes a computerized stereotaxic neuronaviga-
tion system (Brain Sight) that integrates volumetric mag-
netic resonance imaging (MRI) scans with the TMS sys-
tem. This allows for the precise localization of stimulation
location on the cortex and ensures the reliability of repeated
stimulation. The stimulation system itself also includes a
70 mm Magstim coil and Grass EMG recording apparatus.
Two G5 Macintosh computers are also dedicated to the
collection and analysis of EMG responses and motor map
topography. The lab also provides a full time technician to
run the laboratory and oversee all experimental procedures.
Investigators have unlimited access to these facilities and to
the expertise of the Kleim's team.

BRRC Neuroimaging Research Core
The BRRC has a Neuroimaging Core lead by Dr. Bruce
Crosson, Ph.D., ABPP/cn, to support functional and struc-
tural neuroimaging for cognitive and motor studies. This
core focuses on data acquisition and technology develop-
ment for functional and structural neuroimaging, with an


emphasis on MRI. It consists of 15-20 people who have the
knowledge and technical skills to support functional MRI,
diffusion tensor imaging (DTI), mapping of white matter
tracks with DTI, and lesion analysis. This core resource is
available to BRRC investigators with funded projects or
approved pilot studies.












VA/University of Florida Human Motor
Performance Laboratory

The primary focus of the 1,800-square-foot Human Motor
Performance Laboratory is to assess motor performance in
individuals with injury, disease, or age-related changes in
motor function. It is a joint VA/UF laboratory that is housed
in the BRRC under the direction of Kautz. The laboratory
is equipped with a VICON Motion Systems motion capture
camera system, consisting of the VICON 612 data station
with eight active video channels and a 64- channel A/D
board for analog signals. There are 10, 1,000-Hz M2 cam-
eras (digital CMOS M2 series cameras that have a resolu-
tion of 1280 x 1024) with visible infrared variable intensity
DST strobes. Software includes a VICON workstation,
VICON polygon, VICON Body Builder, Plug-in Gait,
Plug-in Modeler, VICON Real Time II, and a VICON Plug-
in to export C3D data to Motion, Muscle, Joint, and Bone
file (ASCII) to use with SIMM.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700














Volume 2, Issue 6October2009
Volume 2, Issue 6 October 2009


The lab is also equipped with the materials necessary to
complete UE or LE force measures and analyses. The
laboratory houses a programmable Adept-six robotic arm,
load cells to measure arm and finger/thumb forces, plat-
form for UE/LE stabilization, the Strength-Dexterity Test
System, and a split-belt treadmill. It is equipped with a
Konigsberg Instruments T42, 16-channel telemetry EMG
system designed to transmit on a discreet carrier frequency
set between 176 and 216 MHz, and a Biodex for isokinetic
strength testing. Three full-time biomedical engineers are
employed to assist investigators in data collection and
analysis.

BRRC Locomotor Training Laboratory

The Locomotor Training Laboratory, lead by Dr. Andrea
Behrman, Ph.D, PT is a 700-square-foot facility dedicated
to providing two kinds of locomotor training: using a body
weight support system and treadmill with manual assis-
tance, and also using an overhead body weight support sys-
tem over ground with a 40-foot straight path and 90 degree
turn with 10-foot straight path for persons with locomotor
dysfunction. The lab also has a low mat for donning the
body weight support harness and digital recording and edit-
ing capabilities.


For the past decade, the BRRC has focused research and
capacity-building programs on discovery and develop-
ment of treatments for cognitive or motor consequences
of neurologic disease or injury. We hope to continue to
develop the BRRC in ways that increase the potential for
treatments that will alleviate the suffering experienced by
those who live with these conditions and their caregivers.
We are never far from the realization that our work must be
measured by the impact it has on the daily lives of veterans
living with these conditions.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.273.8700












II New slette


Volume 2, Issue 6 October 2009






This upcoming Spring Semester, Drs. Jonathan Shuster and Caprice Knapp will be co-teaching (Course # GMS
6846), Meta-Analysis. We will be conducting two to three meta-analyses, one or two for randomized clinical trials
and one or two for epidemiologic/observational studies. These will be done from scratch, namely this will not be a
reenactment of any meta-analysis conducted to date. The instructors and students can help you bring your question
to fruition. Eligibility: Topic must be health related, but any person at UF is invited to submit a proposal.

Once topics are selected, the process will be as follows:
(1) Determine the research question the meta-analysis will address.
(2) To the best extent possible, find the totality of studies that address the topic.
(3) To the best extent possible, obtain the individual study effect sizes and precision. Summary data
would be fine, but individual data elements would be preferred.
(4) Conduct the analysis
(5) Present the results in class
(6) Publish the findings in a peer reviewed medical journal. Proposer would be first author.

Meta-Analysis plays a significant role in Comparative Effectiveness Research, an important area of interest at the
NIH. If you go to PUBMED (Google), and search on Meta-Analysis you will get over 37,000 (44,000,000) hits
respectively. See http://en.wikipedia.org/wiki/Meta-analysis for additional information about the subject.

If you are interested in a particular topic, please contact one of us. Please provide a one paragraph summary of
the proposed topic by Monday, November 23, 2009.

Dr. Jonathan Shuster (jshuster@biostat.ufl.edu) [265-0111 ext 86503] or Dr. Caprice Knapp cak@ichp.ufl.edu [265-
0111 ext 86087]



Employment
Did you know that there are multiple venues through which both internal and external jobs are posted?

For Job Seekers
https://jobs.ufl.edu University of Florida jobs postings.
http://www.union.ufl.edu/jobs/ Reitz Union student job listings.
http://www.sfa.ufl.edu/programs/workstudy Federal Work-Study Program.
http://www.sfa.ufl.edu/programs/ops.html Other Personnel Services jobs.
http://www.sfa.ufl.edu/programs/oce.html Off-Campus jobs.
http://www.sfa.ufl.edu/programs/vaworkstudy.html Veteran's Affairs Work-Study.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.273.8700




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