Title: CTSI newsletter
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Title: CTSI newsletter
Series Title: CTSI newsletter
Physical Description: Serial
Language: English
Creator: Clinical and Translational Science Institute, University of Florida
Publisher: Clinical and Translational Science Institute, University of Florida
Place of Publication: Gainesville, Fla.
Publication Date: October 2008
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Bibliographic ID: UF00090016
Volume ID: VID00004
Source Institution: University of Florida
Holding Location: University of Florida
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Tools for the Job:
The Translational
Technologies and
Resources Program

Meet the TTR
Director

RFA Announcement

Pilot Project Grants
Awarded!


Articles describing the
CTSI's Community En-
gagement and Research
Program (CERP) will be
featured in the November
Newsletter. Capitalizing
on Florida's unique size
and diversity, CERP will
build on community-based
initiatives already being
undertaken by a host of UF
faculty to further encour-
age, strengthen and support
collaborative partnerships
between UF clinical and
translational scientists and
communities statewide.


Volume 1, Issue 4 October 2008


INSIDE THIS ISSUE


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.8909


TECHOLOGIE-S AND R, JR.

uch of the attention given to CTSI programs has gone to issues
like training, mentoring, and facilitating the sharing of informa-
tion between scientists and healthcare professionals within the
broad CTSI community. CTSI participants will have access to training,
mentoring, and management programs to help broaden the scope of their
collaboration, and they will be able to take advantage of a wide variety of
analytical and information technology assets to help the translational aspects
of their work.

The CTSI has two broad goals in the areas of translational technologies and
resources: First, to establish a formal Translational Technologies and Re-
sources (TTR) Program that will coordinate the activities of an integrated
network of technology cores throughout the CTSI constituent organizations;
and second, to establish new technology-based cores to support those doing
cutting edge work in translational science. The new cores will provide both
the technology necessary for the work and advanced training in the use of
those technologies so researchers can make best use of the most appropriate
technology for their projects.

Where We Start

While the CTSI will be establishing a program to coordinate the translation-
al activities of several technology cores, many of the cores themselves are
already established and successful. Among the core programs that will make
up the TTR are:

Interdisciplinary Center of Biotechnology Research (ICBR)

This Center, established in 1987, is directed by Robert Ferl, PhD and occu-
pies 33,000 sq. ft. on the first floor of the Cancer Genetics Research Com-
plex on the UF campus near the Health Sciences Center. The ICBR features
12 core service laboratories divided among four divisions: Genomics, Pro-
teomics, Cellomics, and Bioinformatics. In addition to access to technology,
the ICBR offers a wide range of training and education programs for both
faculty and students.















Volume 1, Issue 4 October 2008


TOOLS ~1 FO TH JOB TH TRNSAIOA TEHOLGE AN REOUCSPRGA


Center for Pharmacogenomics

Established in 2001, the Center works to bring to-
gether staff from various colleges and disciplines for
projects in pharmacogenomics. The Center, which cur-
rently hosts several promising research projects, is part
of the national Pharmacogenetics Research Network.

DNA, Tissue, and Serum Banks

Did you know that there are multiple banks storing
DNA, tissue, and serum for prostate, breast, brain,
hematological, head and neck and liver tumors and
cord blood at the Health Science Center? If you didn't
know, don't feel alone. Whether due to accidents of
location or other reasons, many of the banks within the
organizations that make up the CTSI are well-hidden
secrets. There are long-standing rationales for restrict-
ing access to some of these resources, but the result is
a loss of opportunities for cross-discipline and transla-
tional research.

Biobehavioral Research

UF is home to a number of different centers of
biobehavioral research. Among the centers scattered
throughout the university's colleges and departments
are the College of Dentistry's Comprehensive Center
for Pain Research, the Addictive and Health Behaviors
Research Institute at UF's Jacksonville campus, the
Center for the Study of the Psychology of Emotion
and Attention, the Claude D. Pepper Center for Re-
search in Oral Health in Aging, the Cognitive Neuro-
science Laboratory in the Department of Psychiatry,
the Brain Rehabilitation Research Center, the Brooks
Center for Rehabilitation Studies, and the McKnight
Brain Institute. The depth of biobehavioral research at
the University of Florida is great.


Unfortunately, there has never been a coordinated
effort to organize the groups or to disseminate infor-
mation regarding their methods or applications to the
wider community of faculty and students.

Mass Spectrometry

Mass spectrometry is a critical tool in the analysis
of small biomolecules in many CTS areas including
drug metabolism, analysis of stable isotopic meta-
bolic tracers, pharmacokinetics, and therapeutic drug
monitoring. It's no surprise, then, that UF has several
independent resources that utilize mass spectrometry
to gather data. The GCRC's Biomedical Mass Spec-
trometry Laboratory is well equipped with multiple
spectrometers and support equipment. The Analytical
Toxicology Laboratory of the College of Veterinary
Medicine includes a Class II biological safety cabinet
for handling biohazardous samples along with a vari-
ety of spectroscopic instruments. The High Resolution
Mass Spectrometry Laboratory provides mass spectral
identification and quantitative analysis to more than
50 research groups throughout the State University
System.

Imaging and NMR

Magnetic resonance has become a foundation technol-
ogy used in chemical and biological research. Magnet-
ic resonance's flexibility in application complements
its flexibility in technique and instrumentation to
make it a technology applicable to research as diverse
as drug discovery and anatomical imaging. The Ad-
vanced Magnetic Resonance Imaging and Spectrosco-
py (AMRIS) facility, a joint project of UF, the Depart-
ment of Defense, the McKnight Brain institute, and
the National High Magnetic Field Laboratory, houses


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.8909


Ctinica and Tanstatonat Scence Istitut















Volume 1, Issue 4 October 2008

TO L F RT E O : H RASATOA TEHOO IES AN REORE RGA


seven state of the art magnetic resonance spectrom-
eters. The applications supported by AMRIS include
molecular and cellular imaging, in vivo animal
imaging, high-resolution structural imaging, and high-
sensitivity small volume NMR.

Where We Want to Go

As good as UF's resources currently are, more support
and integration is needed before they can fully
function in multi- and interdisciplinary translational
research capacities. To enhance the quality, quantity,
and availability of advanced technologies, the TTR
Program will consist of a network of core facilities
- both currently existing and to be developed that
will form the foundation for biological, biobehavioral,
imaging, and analytical research resources within the
CTSI. Five cores will form the foundation of the TTR:
1) the Interdisciplinary Center for Biotechnology
Research (ICBR); 2) a new Genomics Core; 3) a new
Metabolomics Core; 4) a new DNA/Tissue Bank Core;
and 5) a new Biobehavioral Core.

General Core Training and Education

The resources within the technology cores will be
coordinated through the Administrative Core of the
CTSI, making it easier for interested researchers
to discover and coordinate applications of the
technology. Use of the technologies will be further
enhanced by the joint actions of the CTSI's Research
Portal system and its Biomedical Informatics Program
(BIMP). Its electronic Research Portal will be key in
letting researchers know about resources, including
technology, seminars, and workshops, through the
newsletter that you're reading now.


One of the basic commitments of the TTR is to
training. A key initial part of the training program
will be made up of a Translational Technology
Seminar Series, in which outside speakers and core
representatives will train potential technology users
and share information on the use of cutting edge
technology. For more in-depth training, potential
users, students, postdoc trainees, faculty, and staff will
be able to turn to seminars, short courses, and periodic
training sessions on the core technology components.

New Core: Genotyping

A new core, providing access to centralized state-of-
the-art, cost-effective genotyping technologies will be
established as the fusion of the genotyping services
offered by the Center for Pharmacogenomics and the
ICBR Genomics Core. The new core will enhance the
visibility of the services offered by the core and aid
in the coordination of the services as they are offered
to cross-disciplinary research teams throughout the
CTSI. For more information contact Dr. Julie Johnson
(johnson@cop.ufl.edu).

New Core: Metabolomics

The Metabolomics Core will provide researchers
with research tools applicable to every aspect of
laboratory and clinical research conducted through
the CTSI. Working closely with patient-oriented
investigators, the Metabolomics Core will be able to
advance knowledge of normal physiology and disease
mechanisms and conduct early-phase testing of new
therapeutics in human subjects. Metabolomics will
provide a tool for researchers at UF to understand the
effects of interventions to move clinical and


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.8909














Volume 1, Issue 4 October 2008


T O O L O R T H J O B TH TR NS A IO A TE H O O I S A D R S U CS PR G A


translational medicine into a phase in which
discoveries are rapidly accessed and developed for
application to patients with the greatest chance of
benefit.

The Metabolomics Core will represent a network
of five UF laboratories and the Stedman Center or
Nutrition and Metabolism at Duke University. The
Core will be divided into two basic functions: the
Molecular Identification and Metabolomics Group,
and the Quantitative Metabolomics Group. Both
groups focus primarily on the measurement of drugs,
chemicals and their metabolites in biological tissues
and fluids. Both have experience in developing
new analytical methods and working with difficult
biological sample matrices, so they will do most of the
work setting up new analytical and sample handling
methods for CTSI clients and projects. The newest
facility, the Nutrition Metabolomics Laboratory
(NML) is currently being formed to address the
specific needs of nutritionally-related research and will
be incorporated into the Quantitative Metabolomics
Group. A significant overall focus of these groups
is the development and application of methods, new
or modified, specific to a clinical and translational
researcher's project. For more information contact Dr.
David Powell (powell@chem.ufl.edu).

New Core: DNA and Tissue Bank

The DNA and Tissue Bank Core will bring together
a collection of independent silos of genetic and
tissue repositories under a common administrative
and operational framework. In addition, the Core
will provide a centralized workflow to ensure the
integrated function of the components. Enhanced
collaboration among investigators and comprehensive
inventory management should make each of the


constituent banks, and the collection of the banks
in total, far more valuable to individual research
projects and the university community as a whole. The
following component tissue banks on the Gainesville
campus currently exist: Pancreas; Brain (McKnight
Brain Institute); Stem Cell/Cord Blood (UF-Shands
Cancer Center); Prostate (Department of Urology);
Breast (Department of Surgery); Liver (Department
of Pathology); TrialNet/Diabetes Prevention Trial-
1 (DPT-1); serum bank (Department of Pathology);
the DNA repository in the GCRC; the Saliva Bank
(College of Dentistry) and the DNA Bank for
cardiovascular diseases (College of Pharmacy). For
more information contact Dr. Michael Clare-Salzler
(salzler@ufl.edu).

New Core: Biobehavior

The Biobehavioral Core will coordinate access
to biobehavioral research resources across the 12
colleges of the CTSI, provide research personnel
trained to administer a repertoire of validated
behavioral assessments, provide consultation on the
use of potential assessment tools, and offer training
in the use of validated assessment tools. The Core
will maintain a library of validated CTS assessment
instruments, providing a valuable resource to a wide
variety of clinical and translational researchers. The
Biobehavioral Core will also provide skilled graduate
students and postdoctoral fellows to collaborate
with investigators in the application of neurological
and neuromuscular assessments in both laboratory
and clinical research settings. For more information
contact Dr. Sara Jo Nixon (sjnixon@ufl.edu).


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.8909


CTS1 Newsletter I















Volume 1, Issue 4 October 2008

MEET~~~ THmT IETO YCRI


he TTR Program.
will be directed by -. ,:'
Dr. Jesse Gregory,:
Professor of Food Science ; .
and Human Nutrition in
the College of Agricul-
tural and Life Sciences.
Dr. Gregory is also that .,
College's representative
on the CTSI's governing
Steering and Planning
Committee. Dr. Gregory
has been involved in
teaching and research on
the faculty of UF since 1977. He has a highly produc-
tive research career primarily in the chemistry, nutri-
tional properties and metabolic function of B vitamins,
especially folate and vitamin B6. He has a strong lev-
el of extramural research funding primarily from the
NIH and USDA and is recognized internationally as a
leader in the fields of vitamin nutritional biochemistry
and the application of stable isotopic tracer techniques
to the study of human metabolism. Dr. Gregory has
been a GCRC investigator since the early 1990s and
has been a member of the GCRC Scientific Advisory
Committee since 2001.


Mailing Address:



Office:


Phone:
Fax:
E-mail:


University of Florida
FSHN Department
P. O. Box 110370
Gainesville, FL 32611-0370
208B FSHN Bldg
Newell Drive
UF Campus
352-392-1991x225
352-392-9467
JFGregory@mail.ifas.ufl.edu


RFA Announcement

New Funding Opportunity!!!

The Research Partnership in Cognitive Aging, a
newly launched public-private effort to support cur-
rent and emerging research on age-related changes
in the brain and cognition, announced Oct. 15 it will
accept online applications for two new funding op-
portunities to be awarded by the National Institute on
Aging (NIA).
The partnership, jointly funded by the NIA and the
Orlando-based McKnight Brain Research Foundation,
through the Foundation for the National Institutes of
Health, is expected to award $20 million in research
grants over the next five years. The partnership aims
to expand understanding of how we think, learn and
remember with age and develop interventions that
maintain cognitive health as we grow older.
NIA is accepting online applications until Nov. 3
for RFA-AG-09-009, Interventions to Remediate
Age-Related Cognitive Decline, at http://grants.nih.
gov/grants/guide/rfa-files/RFA-AG-09-009.html; and
RFA-AG-09-010, Neural and Behavioral Profiles of
Cognitive Aging, at http://grantsl.nih.gov/grants/
guide/rfa-files/RFA-AG-09-010.html.

The NIA anticipates awarding the grants in mid-2009.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.8909















Volume 1, Issue 4 October 2008


The second (August) edition of the Newsletter essentially was an RFA for seed money support through our new
Pilot and Collaborative Projects Program. We received 20 proposals by the September 26 deadline for receipt
of applications. The Programs' Executive Committee made the following awards on September 30 with funding
available by November 1, 2008.

CTSI Pilot and Collaborative Project Program Awards (October, 2008).
Category Awardee Academic Title of Project Award
Affiliation
Graduate Student Adam Mecca College of Medicine Cerebroprotection via Viral-Mediated Gene $ 7,500
Delivery ofAngiotensinAT2 receptors
Rachel College of Medicine Elucidating the Role of CTGF and TGFP-1 in $ 7,488
Watson Joint Fibrosis
Junior Faculty Rhonda Coo- College of Medicine PPARy Expression in Key Metabolic Organ $ 17,500
per-DeHoff, Systems is Modulated by Treatment with
PharmD Thiazide Diuretics and ACE Inhibition
Margaret Ri- College of Dentistry Determinants of Pain Response in Tem- $ 17,500
beiro-Daslilva, poromandibular Muscle and Joint Disorder
DDS, PhD (TMJD)
Novel Methods* Timothy J. College of Medicine Development of a MALDI hybrid linear ion $ 24,800
and Technology Garrett, PhD trap/time-of-flight imaging mass spectrom-
eter
Sara Jo Nixon, College of Medicine Applying Nanotechnology to Addiction $ 22,600
PhD Recovery
Major Lakshmyya College of Dentistry Association Between Periodontal Disease and $ 50,000
Initiatives* Kesavalu, Cardiovascular Disease
B.V.Sc
David H. College of Liberal A Global Metabolomic Approach to Pediatric $ 70,708
Powell, PhD Arts & Sciences Neuro-Metabolomic Disorders
Total $218,096
* Multiple co-investigators and/or colleges were represented by these proposals, but only the PIs and their colleges are listed.

Congratulations to the awardees! Competition was stiff and many meritorious proposals could not be funded.
For those who did not apply or who were unsuccessful this round, we plan to announce the next RFA in the
March, 2009 Newsletter.


Clinical and Translational Science Institute University of Florida Gainesville, FL 352.265.8909


CTS1 Newsletter I




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