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|Labor of love|
|Ctrl, alt, anesthetize|
|The science of sharks|
|Dieting, smoking linked in teen...|
|Fatty acids and diabetes onset|
|Public health phenom|
|From the lab to the field|
|Librarians on film|
|UF surgeon helps soldiers|
|Center studies aging|
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Table of Contents
Labor of love
Ctrl, alt, anesthetize
The science of sharks
Dieting, smoking linked in teen girls
Fatty acids and diabetes onset
Public health phenom
From the lab to the field
Librarians on film
UF surgeon helps soldiers
Center studies aging
On the Cover
Table of Contents
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Last month, Florida Lt. Gov. Jeff Kottkamp visited the UF colleges of
Medicine, Business and Law to meet faculty and students and to
participate in a number of events. During his visit to the Health Science
Center, Kottkamp (above, right) met with College of Medicine Dean
Bruce Kone (left), medical student Rana Yehia, Dr. Hubert Fernandez,
Dr. Richard Bucciarelli and Dr. Marco Pahor. Kottkamp also got
hands-on experience using the UF-developed Human Patient Simulator.
Leading the demonstration was Dr. J.S. Gravenstein, a UF graduate
research professor emeritus of anesthesiology who helped pioneer the
simulator, which is in use worldwide to help teach students critical care
skills. (Photos by Sarah Kiewel)
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
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Labor of love
College celebrates 25 years of
r i S
By Tracy Brown Wright
When Betty Hilliard came to Florida
in 1960 to join the UF College of
Nursing's faculty, she was one of only
three nurse-midwives in the state. Now, almost
50 years later and 25 years after she founded
the first nurse-midwifery program in Florida,
there are more than 300 practicing nurse-
midwives in the state. Many are alumni of the
UF nurse-midwifery program.
Establishing the program was no easy feat, though. Hilliard faced
detractors who thought midwives might compete with physicians and
struggled to find qualified faculty and preceptors. It was a challenge, but
it's one that the students, leaders and alumni who gathered Sept. 7 to
celebrate the program's 25th anniversary are glad Hilliard tackled.
"Although encountering resistance to the nurse-midwifery profession in
much of her professional life, Betty persevered and continued to dedicate
herself to women's health," said Alice Poe, C.N.M., D.S.N., a UF associate
professor of nursing and coordinator of the nurse-midwifery program. "Betty
doggedly pursued the establishment of the nurse-midwifery program that we
celebrate today. She was such a wonderful mentor to me and so many others
- so kind and giving and willing to share her knowledge."
After the initial struggles, the UF nurse-midwifery program opened in
1982 in Gainesville. At the time it was one of two nurse-midwifery
programs in the state. The program, which seeks to prepare students to be
professional nurse-midwives who can meet the health needs of
childbearing women and their families, eventually moved to the college's
"The UF nurse-midwifery program was founded and continues today
with the core mission that nurse-midwifery care focuses on the care of both
the individual and the family," Poe said. "We are preparing nurse-
midwives to provide the highest level of care to childbearing women and
their families based on a sound curriculum of science and clinical care. UF
(Top) Elizabeth DiCarlo, left, a certified nurse midwife and one of the first faculty
of the nurse midwifery program, and Betty Hilliard, founding coordinator of the
program, advise Sonja Speed, of Citra, Fla., concerning her newborn daughter.
(Bottom) The College of Nursing recently celebrated the 25th anniversary of its
nurse-midwifery program. Shown here at the celebratory luncheon are, from left,
Alice Poe, the program's coordinator; Betty Hilliard, a UF professor emeritus of
nursing and founder of program; Charles Mahan, a former Florida state health
officer; and Kitty Ernst, the president of the American College of Nurse-Midwives.
nurse-midwives consider themselves partners with physicians in ensuring
that women and families have a safe and satisfying childbirth experience."
After Hilliard retired in 1990, Poe took the reins of the program and
remains the coordinator today. Since 1990, Poe has helped the program
secure significant state and federal funding and also has helped increase
the nurse-midwifery workforce by recruiting students from disadvantaged
backgrounds, medically underserved areas and underrepresented
"I think what strikes me most from my 17 years as coordinator of this
program and 22 years as a faculty member has been our graduates," Poe
said. "We have nurse-midwifery graduates across the state of Florida and
the country who have made an indelible mark on the health of women and
During the celebratory luncheon, Eunice "Kitty" Ernst, president of the
American College of Nurse-Midwives, presented Poe with a lifetime Gold
Commendation award for the program's 25 years of innovative and
compassionate midwifery care provided to families in Florida and the
education provided to midwifery students. 0
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
New computer simulation
allows users to practice
UF researchers developed the program shown above to help
medical residents and other anesthesia providers hone their
skills outside of the operating room.
By Ann Griswold
Welcome to the O.R. Your patient is Tom, a 35-
year-old man whose pre-op chart shows he's a
6-foot, 175-pound nonsmoker with mild asthma
and occasional heartburn relatively healthy except for
two painful gallstones.
Your mission, should you choose to accept it, is to anesthetize Tom during a routine
procedure to remove his gallbladder. You'll have 90 minutes to administer the correct
drugs at the correct doses, in the correct order, at the correct time and bring him
safely back to consciousness when the operation is complete. The surgeon, Dr. Stone,
picks up a scalpel. Tom's heart monitor beeps out a rhythmic beat. The timer is set ... Go!
All eyes are on you, waiting for your next move. Time in the operating room is
precious, so you'll need to be quick. You see a tray of syringes, but which to choose? How
much medication to administer and when? Dr.
Stone frowns, crossing his arms. Tension mounts
as you inspect various interactive monitors, note
Tom's vital signs and mull over the best course of
If this were real life, Dr. Stone would declare
you inept, the surgery would be rescheduled and
Tom would probably file an official complaint. But
relax! On a computer, medical residents and other
anesthesia providers can repeat the scenario as
many times as necessary without endangering
lives during the learning process.
UF anesthesiology researchers from the Center
for Simulation, Advanced Learning and
Technology have developed the virtual O.R.
program "Simulated Anesthesia Experience" to
give users a realistic way to hone their skills. To
create the background, the team used a panoramic
photograph of an empty operating room at Shands
Sem Lampotang, Ph.D., a UF professor of
anesthesiology in the College of Medicine, says
the simulation program is a safe and engaging way
for anesthesia residents and providers to
understand how body size affects a patient's
response to anesthesia and influences the potential
for complications during surgery.
"When we teach medical students and residents,
we usually assume (the patient is of average
weight)," he said. "But here, the inter-patient
variability is pretty dramatic and that makes the
program more unpredictable. With some things,
after you play three times you know exactly what
you need to do to get the desired result, so after
awhile it can get boring. This is more realistic."
Lampotang, also a co-inventor of the Human
Patient Simulator, collaborated with researchers David Lizdas, B.S., John Tumino,
Nikolaus Gravenstein, M.D., and Harshdeep Wilkhu, M.D., on the project. The team
received funding from the drug company Organon USA to develop the program, which is
now used by the company's sales staff to train and educate anesthesia personnel around
"If students are learning to be proficient and safe health-care providers while having
fun using the (simulation), we have succeeded as instructors and simulation designers,"
Lampotang said. O
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events. IIII 5
The science of sharks
Genetic origin for limbs found in creature known for biting them
When the first four-legged
animals sprouted fingers and
toes, they took an ancient
genetic recipe and simply extended the
cooking time, say UF scientists, writing in
the journal PLoS ONE.
Even sharks, which have existed for more than half a billion
years, have the recipe for fingers in their genetic cookbook -
not to eat them, but to grow them.
While studying the mechanisms of development in shark
embryos, UF scientists identified a spurt of genetic activity
required for digit development in limbed animals.
Previous work suggested the transition from fins to limbs
involved the addition of a late phase of gene activity during
embryonic development, something thought to be absent
during the development of fish fins.
The finding shows what was thought to be a relatively recent
evolutionary innovation existed eons earlier than previously
believed, shedding light on how life on Earth
developed and potentially providing insight
for scientists seeking ways to cure human
birth defects, which affect about 150,000
infants annually in the United States.
"We've uncovered a surprising degree of
genetic complexity in place at an early point '
in the evolution of appendages," said
developmental biologist Martin Cohn, Ph.D., an
associate professor with the UF departments of
zoology and anatomy and cell biology and a memb i
of the UF Genetics Institute. "Genetic processes .e i n..
simple in early aquatic vertebrates only to become m.rn
complex as the animals adapted to terrestrial livirn- Ih,\
were complex from the outset. Some major evoluti r.rn \
innovations, like digits at the end of limbs, may hj\ hb.n
achieved by prolonging the activity of a genetic pi I- m i h Ia
existed in a common ancestor of sharks and bony i.h, "-
Researchers say the same genes that produced a rn n ii nr,
likely enlarged their role about 365 million years ja-, in
amphibians struggling to adapt to swamps and te: i>I i iil
living, creating a distinct burst of development an J mrni
Using molecular markers to study the formation I .k ,li il
cartilage in embryos of the spotted catshark, UF sh l ni i
isolated and tracked the activity of Hox genes, a gi up I
genes that control how and where body parts deve Ilp r in all
animals, including people.
They discovered a phase of gene expression in sharks that
was thought until recently to occur only when digits began to
form in limbed animals.
Why, then, don't sharks have fingers?
Renata Freitas and GuangJun Zhang, co-authors of the paper
and graduate students in the zoology department of the College
of Liberal Arts and Sciences, speculate that sharks and many
other types offish do not form more dramatic appendages
during this late phase of Hox gene expression because it occurs
briefly and only in a narrow band of cells, compared with the
more extended time frame and larger anatomical area needed
to prefigure the hand and foot in limbed animals.
"We know when this particular Hox gene is mutated in
humans, it results in malformations of fingers and toes," Cohn
said. "Until now it was thought these mutations were affecting
a relatively recent innovation in the genetic process of limb
development. Our results show that this phase of Hox
expression is much more ancient and suggest that if the origin
of digits involved a prolonged activity of Hox genes, a
truncated period could result in defective digits."
In a parallel study, researchers at the University of Chicago
found this second phase of gene expression in paddlefish, a
primitive living descendant of early fish with the first bony
Finding the second phase in sharks, which have skeletons
By studying development in sharks, UF biologist Martin Cohn uncovered evidence that the genetic processes for digits in limbed
animals thought to be a relatively recent evolutionary innovation have an extremely ancient origin.
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
61 l 0 2O7 31
-- ~ II
consisting not of bone but of cartilage, means the genetic
processes necessary to muster fingers and toes existed
more than 500 million years ago in the common ancestor
of fish with cartilaginous skeletons and bony fish more
than 135 million years before digits debuted in the earliest
"The leap from aquatic life to terrestrial life is an
extremely dramatic, important point in evolution that has
captured the interest of many," said Marie Kmita, Ph.D.,
director of the Genetics and Development Research Unit at
the Institut de Recherches Cliniques de Montreal.
"Understanding how changes in gene regulation modify
the body architecture is of extreme interest to scientists
who are trying to find ways to improve human health by
learning from developmental processes. This work shows a
late phase of gene regulation seems fated to the emergence
of digits." 0
UF researchers studying how
pollutants affect bull sharks
By Meredith Woods
ending commonly prescribed medications down the drain may be taking a
bite out of the environment at least when it comes to shark habitat, UF
veterinary scientists say. In fact, the combination of flushing unused
medications and the natural excretion of drug residue from antidepressants,
cholesterol-regulating drugs and contraceptives into wastewater systems could be
having repercussions on aquatic animal life in general.
Researchers at the UF College of Veterinary Medicine's Analytical Toxicology
Core Laboratory, in collaboration with Mote Marine Laboratory in Sarasota, are
studying the bull shark's exposure to pharmaceutical drug residue found in the
waters of the Caloosahatchee River near Fort Myers. Bull sharks leave the ocean
to spend time in brackish rivers and estuaries, and the river serves as a nursery
for their young.
"Because bull sharks have the unique ability to survive in both saltwater and
freshwater environments, they are in close, frequent contact with people and,
as a result, are frequently exposed to wastewater pollutants found in freshwater
basins," said Jim Gelsleichter, senior scientist at Mote Marine Laboratory.
Scientists are trying to determine whether exposure to prescription residue
contaminants from water treatment plants and other sources affects the sharks'
ability to grow and reproduce.
"Treatment plants were designed to remove pathogens like viruses and
bacterial agents, and that they do very well," said Nancy Szabo, Gelsleichter's
co-investigator and director of UF's Analytical Toxicology Core Laboratory. But
these facilities simply aren't designed to deal with pharmaceuticals, she said.
Evidence suggests that low-level pharmaceutical pollution is widespread. In 1999
and 2000, the U.S. Geological Survey sampled 139 streams in 30 states for organic
wastewater contaminants, including common pharmaceuticals. Eighty percent of
the streams studied contained traces of chemical pollution. The consequences of
such contamination are not yet fully known, although some research has shown
even low levels of these contaminants affect several fish species.
Federal guidelines for proper disposal of prescription drugs recommend
flushing them down the toilet only if the accompanying patient information
specifically says it is safe to do so.
Gelsleichter is testing for the presence and levels of human drug contaminants
in bull shark blood by tagging bull sharks in the river basin with passive
sampling devices silicone rubber discs that collect chemical samples in the
water for later examination. When sharks are caught by local anglers or by the
Mote team on subsequent research expeditions, the tags are retrieved and sent to
UF's Analytical Toxicology Core Laboratory for analysis.
When the blood and silicone-rubber discs from the bull sharks arrive at the
laboratory, Szabo's team analyzes the samples to determine the variety and
concentration of chemicals present in the bull shark's environment.
The UF laboratory specializes in non-routine analysis. Szabo's team works
with researchers both at UF and elsewhere to develop appropriate methods for
measuring and analyzing whatever toxins are being examined. These techniques
are tailored specifically to each client.
For the bull shark study, the UF laboratory has been able to use distinctive
techniques to gauge chemical levels in bull shark blood. The laboratory worked
with Mote not only to design the experiment but also to adapt the analytical
methods used to ensure valid results are produced.
"The type of work we do requires a lot of effort, and one has to have the
expertise available to know where to even begin," Szabo said. O
Visit us online @ http://news.health.utl.edu/ for the latest news and HSC events. IIII 7
Where there's smoke, there's a diet?
Beginning a diet increases teen girls' risk of smoking
By April Frawley Birdwell
S tarting to diet seems to double the odds a
teenage girl will begin smoking, a UF study
UF researchers, who analyzed the dieting
and smoking practices of 8,000 adolescents,
did not find the same link in boys, who were
also less likely than girls to diet, according to
findings published in the American Journal of
"Dieting was a significant predictor of ..
initiation of regular smoking among females,"
said Mildred Maldonado-Molina, Ph.D., a UF
assistant professor of epidemiology and health
policy research and lead author of the study. MILDRED MALDONADO-MOLINA, Ph D
"We were expecting that this relationship was
going to be stronger among females. That has
been well-documented, especially because (nicotine) can suppress your appetite.
"In boys we found something we don't understand yet," she said. "We found
that those who were inactive dieters, those who first started dieting and then
stopped, were more likely to engage in smoking behaviors."
The researchers derived their findings from the answers of 7,795 adolescents
who were surveyed during the first two waves of the National Longitudinal
Study of Adolescent Health, completed in 1994 and 1996. The teens were in
seventh, eighth and ninth grade when surveyed.
UF researchers included the answers of adolescents who said they were trying
to lose weight and divided the group into four units: non-dieters, new dieters,
former dieters and consistent dieters, who said they were dieting both times they
were surveyed. They excluded teens who were already smokers and those who
admitted to taking diet pills, vomiting and using other unhealthy weight-loss
"That group (of teens who were beginning to diet) was the one we were most
interested in, seeing how the start of one behavior related to initiation of
smoking," Maldonado-Molina said.
Researchers also found that girls who consistently dieted were more likely to
Still, the number of children smoking in the United States has dropped in the
10 years since the first two waves of the survey were completed. In 1995, about 35
percent of high school students smoked regularly, according to the Centers for
Disease Control and Prevention. Now about 23 percent of high-school age
children reportedly smoke and 8 percent of middle school students do. The
percentage of girls who smoke is slightly higher in both age groups, according to
"In the last decade there has been a
decrease in smoking among adolescents,
in part because of all the campaigns and
policies against smoking."
- Mildred Maldonado-Molina, Ph.D.
a 2006 CDC report on tobacco use among youth.
"In the last decade there has been a decrease in smoking among adolescents,
in part because of all the campaigns and policies against smoking," Maldonado-
Molina said. "On the other hand, the practices of dieting are going up in both
females and males. We don't know if we did this study right now if that
relationship between smoking and dieting is going to be stronger (among
females) or different among males."
Smoking to suppress the appetite may be one reason why some dieting teens
pick up the habit, Maldonado-Molina said. But nicotine's ability to suppress the
appetite may not be the only reason teenagers are more likely to smoke after they
start dieting, said S. Bryn Austin, Sc.D., an assistant professor of pediatrics in
the division of adolescent medicine at Children's Hospital Boston and Harvard
"It's also possible that dieting itself is making people more vulnerable to
smoking," Austin said, noting that animal studies have shown a link between
food deprivation using substances such as tobacco. "If (animals) are extremely
food-deprived, they will use more drugs."
Despite the link, Maldonado-Molina said parents shouldn't go on red alert if
their child starts a diet. Some dieting practices, such as eating balanced meals,
can be a part of a healthy lifestyle, she said.
"This doesn't mean if your child starts dieting they are going to start
smoking," she said. "I think (parents should) be vigilant and talk about it. It's
looking for those changes in behavior." 0
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
UF researchers to study 'designer' cells
University of Florida regenerative medicine researchers have received a
$1.6 million federal grant to study whether "designer" cells can be used to
rescue the brain from Parkinson's and other neurological diseases.
Using cell cultures and a rodent model of Parkinson's disease, scientists want
to study whether stemlike cells from mice and from adult human brains and bone
marrow can be adapted to deliver a potentially protective protein to the brain.
"Certain cells derived from brain or bone marrow may have the potential to be
engineered to release therapeutic factors in Parkinson's disease," said Dennis
Steindler, Ph.D., principal investigator of the five-year grant and executive
director of the Evelyn F. and William L. McKnight Brain Institute. "The
possibility of using a person's own cells to slow or perhaps even halt the course of
devastating neurological disorders offers a tremendous advantage, because there
is less chance the therapy will be rejected."
The new, five-year study is funded by the National Institute of Neurological
Disorders and Stroke. Scientists want to dose the brain with engineered cells
capable of producing growth factors that have shown promise for replacement
and preservation of neurons.
The idea is to nourish and protect brain cells that produce dopamine, a
substance essential for normal movement that is depleted in Parkinson's patients.
About 1.5 million Americans currently have Parkinson's disease, according to
the National Parkinson Foundation. The condition usually develops after the age
"It takes a great deal of dopamine-producing brain cells to die before
symptoms appear," said Ron Mandel, Ph.D., a professor of neuroscience in the
College of Medicine. "Our strategy is to protect these cells to slow or halt the
progression of the disease."
Scientists will first genetically engineer the ability to produce two particular
UF diabetes researcher Mark Atkinson
is overseeing a new research center at
UF geared toward studying the
human pancreas to learn more about
diabetes. The center will bank organs
from thousands of patients with or at
risk for type 1 diabetes.
growth factors into immature human cells that haven't quite finished developing,
and then introduce the modified cells into the models of Parkinson's disease.
"The idea is to obtain a few cells of the needed type from a patient, grow those
cells, modify them to produce growth factors that protect at-risk dopamine
neurons, and then put them back in the patient in a reasonable time," said
Kenneth Berns, M.D., Ph.D., a collaborator on the project and director of the UF
Genetics Institute. "It will be a challenge, but it will be a terrific application of
human gene therapy in adult human stem and progenitor cells as well as
differentiated cells." O
New UF pancreas bank could help
uncover clues about diabetes
By Melanie Fridl Ross
University of Florida will house a newly organized international research center for the study of the human
pancreas that will bank organs from thousands of patients with or at risk for type 1 diabetes in an effort to learn
more about the disease.
Known as nPOD, the Network for Pancreatic Organ Donors with Diabetes is supported by nearly $3 million per year
in grant funding from the Juvenile Diabetes Research Foundation, monies that also fuel research efforts at major
medical centers worldwide.
Type 1 or "insulin-dependent" diabetes occurs when white blood cells vital to the body's defenses against infectious
diseases launch a self-directed or "autoimmune" attack on cells in the pancreas that produce insulin, which helps
regulate how the body uses and stores sugar and other nutrients for energy.
But much remains to be learned about how type 1 diabetes develops, and the organ repository will help support a
massive research effort to answer key questions, said Mark Atkinson, Ph.D., the American Diabetes Association
Eminent Scholar for diabetes research at UF's College of Medicine and nPOD's director.
"Essentially, we need to learn a lot more about the human pancreas," said Atkinson, a pathologist. "Eight thousand
organ donors a year donate their pancreas. A large number go to pancreatic or islet cell transplantation. Some go to
research. But sad to say, many go unutilized. With nPOD, we hope to change that.
"Some of our theories on how diabetes develops date back to autopsy-based research studies that occurred during the
1960s. It is time to address old concepts with more modern tools," he added.
The bank will obtain organs in three ways. With the help of national organ procurement agencies, it will receive
organs from patients who exhibited risk factors associated with disease development. Through a collaboration with the
National Disease Research Interchange, the nation's largest placement unit for donated organs slated for research, the
bank will also receive organs from donors who had type 1 diabetes.
The third way nPOD will eventually obtain organs will be in cooperation with Dr. George King, M.D., from
Harvard's Joslin Diabetes Center. Under a proposal not yet finalized, pancreases obtained from deceased patients who
have had type 1 diabetes for more than 50 years will be sent to UF. O
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events. IIIII ), 9
Food for thought
Diet rich in fatty acids could thwart diabetes onset
By Melanie Fridl Ross
O mega-3 fatty acids have long been touted
for their heart-healthy and brain-boosting
benefits. Consider cod liver oil, fortified
infant formula and enriched eggs.
Now a study of nearly 1,800 children at risk for type 1 diabetes has found
that increased consumption of dietary omega-3 fatty acids appears to reduce the
risk of the body attacking its own insulin-producing cells, a precursor to this
form of the disease, report UF and University of Colorado researchers.
The findings appeared in the Sept. 26 issue of the Journal of the American
In the past few decades, there has been a dramatic rise in the incidence of
type 1 diabetes, both in the United States and in Europe a jump that
coincides with changes in food manufacturing that have led to a decline in
omega-3 fatty acids in the diet and an increase in the content of omega-6 fatty
acids, said Michael Clare-Salzler, M.D., a professor and the Stetson chair in
experimental pathology at the UF College of Medicine.
"The foods we are eating now are qualitatively much different than those
produced on a 1900s-era farm," Clare-Salzler said. "When animals are
commercially raised today, they are often fed grains rich in omega-6 fatty acids,
fatty acids that can promote inflammation. In the old days, animals received a
much more balanced intake of omega-3 and omega 6-fatty acids."
The amount of omega-3 fatty acids found in food today has dropped 28-fold
from 100 years ago, Clare-Salzler said. In contrast to the omega-6 variety,
omega-3 fatty acids have potent anti-inflammatory effects.
"Animal studies have shown inflammation in the insulin-producing cells of
the pancreas is an early event that leads to type 1 diabetes," said Clare-Salzler,
who also directs UF's Center for Immunology and Transplantation. "From
these studies in mice, it appears if you thwart inflammation you can prevent
the disease from occurring. The human parallel in this study indicates that
higher dietary intake of anti-inflammatory omega-3 fatty acids reduces the risk
of developing an immune response to the insulin-producing cells."
Scientists set out to study whether increased intake of omega-3 fatty acids
would be associated with prevention of or delay in the emergence of
autoantibodies in the blood that signal the immune system's attack on insulin-
producing cells. Children enrolled in the Denver-based Diabetes
Autoimmunity Study in the Young were all at increased risk for type 1 diabetes
and were evaluated until they were, on average, 6 years old.
Parents were asked annually to report what their
children ate, including how often they consumed certain
types of seafood and what kind of fat was used in cooking.
Blood samples also were taken to test study participants
for the presence of autoantibodies. Nancy J. Szabo, Ph.D.,
director of the Analytical Toxicology Core Laboratory at
UF's College of Veterinary Medicine, evaluated the fatty
acid composition of red blood cell membranes isolated
from blood samples taken from a subset of 244 children.
"Kids who had higher intakes of omega-3 fatty acids
had a significant reduction in the risk of development of
autoantibodies," Clare-Salzler said, adding that the risk of
developing the autoantibodies also went down as the
concentration of omega-3 fatty acids rose in the red blood
MICHAEL CLARE-SALZLER, M D
All fatty acids help bolster the structure and function
of cell membranes, but omega-3 fatty acids strongly
support the production of anti-inflammatory molecules
than can quell an immune attack on insulin-producing
cells, Clare-Salzler said.
The study's lead author was Jill M. Norris, Ph.D.,
M.P.H., a professor of preventive medicine and biometrics
at the University of Colorado at Denver's School of
Medicine. Funding came from the National Institutes of NANCY J S
Health and the University of Colorado's Diabetes
Endocrine Research Center.
UF and University of Colorado researchers are continuing to explore links
between diabetes and diet. Researchers are leading a National Institutes of
Health-funded multicenter pilot trial to examine whether babies who receive
dietary supplementation with the omega-3 fatty acid docosohexaenoic acid, or
DHA, show fewer signs of inflammation. An expanded version of the trial will
then determine whether DHA protects infants and children from the
development of autoantibodies that lead to diabetes in comparison with babies
who receive standard formula or diets with a much lower level of the omega-3
If the trial confirms the hypothesis that dietary supplementation with DHA
in infancy blocks early inflammatory events key to diabetes development, then,
the authors write inJAMA, "dietary supplementation with omega-3 fatty acids
could become a mainstay for early intervention to safely prevent the
development of type 1 diabetes." 0
101 IX Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
(EXTA)ODIAR A ESO
By Jill Pease
public health to
When Tara Anderson, D.V.M., graduated from the UF College
of Veterinary Medicine in 2003, she decided to work at a
small animal hospital first to hone her medical skills.
She liked working with patients, too, save the occasional biter and scratcher. But Anderson realized she
wanted to focus her attention on helping animals and people in another way through infectious
disease research and public health.
She found an opportunity to do just that in the College of Veterinary Medicine's doctoral program and
the College of Public Health and Health Professions' Master of Public Health program. As a doctoral
student, Anderson has joined the UF team investigating the recently discovered canine influenza virus,
and as a public health student, she expanded her knowledge of epidemiological research methods.
Anderson, who graduated with a master's degree in public health in August and expects to complete
hcr d-.,ct-ratc in 2nno. hclicvcs veterinary medicine and public health are natural partners.
"I'uhlII hi Il h ii jJiii.. nl component of the veterinary profession and is an important focus of its
IuI u iL." ,\ nJe. i. n iJ ",\Iih..u4 h companion animal clinical practice and appreciation of the human-
jn r!m j h,,n j! \i \ irr p.. I ni. wve need to highlight the vital roles veterinarians also play in public
p! JLI IL-
IFrr:mi! i L !Li ll. .u J ..J.. iach as SARS and H5N1 avian influenza are just two examples of
/ ,r, IL J !.a J. J !. J. i hji can spread from animals to humans that have recently caused major
puhl IL h allh Fi !hL \\!ii h \pf.! I ise in wildlife and domestic animal health, veterinarians are
in I i u rrn ri al ir h i 'h il L h. pi mentionn and control of these and many other public health threats,
,\nJ i,.! rn ,jiJ
,\ nJr ,..n I ui i rlh !n\ i n I !i citing the canine influenza virus under the direction of veterinary
!cjiha! h I'ul (u Ii!hh,. II \ ",. PIh.D., and Cynda Crawford, D.V.M., Ph.D. The UF team, along with
L-. llh..i ajI ( I ..! nr Iini!\ iiy and the Centers for Disease Control and Prevention, announced the
J ... \\ ..I j innr in rlu nI/ I/ ih e years ago when they confirmed that a form of equine influenza had
lumprdJ ,p I. J. J i. ( aie..I i he respiratory infection have now been reported in dogs in 25 states
jnJ \\j him.i-n. ) ( ih preliminary data showing a 16 percent infection rate. At this point there is
no evidence that canine influenza is a zoonotic disease.
"Since canine influenza is so new, we look to the literature on
equine, avian, swine and human influenza viruses for clues
regarding potential mechanisms of transmission, viral
pathogenesis, diagnosis and control," Anderson said. "We are in
the process of studying the epidemiology of canine influenza
trying to determine if there are any particular age groups or
breeds of dogs that are more susceptible to the disease, and if
there are hot spots for outbreaks, such as boarding kennels,
shelters and dog day care centers. Hopefully as we learn more
about canine influenza, we can contribute to the study of
influenza viruses in other species as well."
Anderson has also been involved in the development of UF's
new joint D.V.M./M.P.H. program. The program was launched
this summer with 10 students currently enrolled.
Anderson is an excellent role model for students pursuing
veterinary and public health training, said Nabih Asal, Ph.D., a
professor of epidemiology and biostatistics in the College of
Public Health and Health Professions.
"Tara is one of the most outstanding graduate students I have
encountered in academia," Asal said. "She has all the qualities
needed for a successful career combining veterinary medicine
and public health: high intellect, knowledge, curiosity,
organizational and communication skills, training in veterinary
medicine and epidemiology, and motivation." 0
Dr. Tara Anderson is combining her knowledge of veterinary medicine with a degree in
public health to study infectious diseases in animals and humans.
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events. I 11
UF's Biomechanics and Motion Analysis Laboratory helps athletes improve their mechanics and avoid injuries. Freshman baseball
player Travis Lawler visited the lab in September to participate in a study on the mechanics of pitching.
A PLAY-BY-PLAY BREAKDOWN OF A LAB
BY ANN GRISWOLD
121 1 I Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
lhie rising star of the Gator baseball team, freshman pitcher
Travis Lawler, stands on the other side of an observation
window with quarter-sized reflective markers stuck to his
arms, legs and torso. As Lawler raises a baseball to his chest and *.
prepares to hurl an 80 mph fastball across the length of the room, :
red strobe lights fire at lightning speed, gleaming off the markers
on his body.
Lawler, like most elite athletes, lives his life at the brink of physical devastation. But if you asked him
about it, he'd beg to differ. ".*
What Lawler would agree on the thing he has in common with some of baseball's fastest pitchers ,
and hardest hitters, think New York Yankees stars Roger Clemens and Alex Rodriguez is his
uncanny ability to breach the corporal barriers that constrain most people. Each pitch generates
enough force to snap the tendons in an average person's shoulder like brittle twigs crunching under a
hiker's heavy foot.;
But however invincible these champions appear on the outside, their fates are, in fact, delicately
balanced above a pivotal point where one false move a single bad throw or a lapse in mechanics -
could send them careening down the scale toward irreparable injury.
"To perform at that level, they've always got to be right at the edge of damage," says Bryan Conrad,
M.S., a biomedical engineer who has worked with UF's Biomechanics and Motion Analysis Laboratory
since it was built three years ago. "So obviously they train for that and develop physically to _.A
accommodate those stresses, but over time the microdamage can accumulate." 'I*
That's why Gainesville is the place to be if you're an athlete. The College of Medicine's motion "
analysis laboratory at UF's Orthopeadics and Sports Medicine Institute is one of only two facilities in
the nation that can analyze the mechanics of your baseball pitch, golf swing, volleyball spike or football
pass in minute detail and send you away stronger, faster ... and smarter, with a new set of performance-
enhancing skills that evaluate and minimize your potential for serious injury. Even UF's own
"Superman" quarterback Tim Tebow visited the lab this summer to work on his passing technique. The
motion analysis lab got to the bottom of Tebow's mysterious shoulder soreness and sent him away with
a few pointers for improving his throw.
Sports-related injuries sideline more than just professional and collegiate athletes, though. Nearly 40
million kids and young adults play team sports and about a tenth of them suffer recreation-related
injuries each year, according to the Centers for Disease Control and Prevention. As Ame ic i .n h ,~ e -,
more active, data gathered in labs like UF's could help the backyard quarterback as much ja ii hp. l I
"This is state-of-the-art technology. It's what the best use and Gators are the best, so th i- 11." .a\
John Barrett, M.S., head athletic trainer for the UF baseball team and a clinical instructc ..I ai hkii
training in the College of Health and Human Performance. "There's so much they can d(., pr r n -
wise. The data is so helpful. You strive to have injury-free seasons, because that's what help, \ ,u \ in "
HOW DOES IT WORK?
The entire scene the pitch, the lights, the athlete in motion is captured by a netw. .1 k .M.I 2
high-speed cameras and transmitted back to a Dell computer, where Lawler appears as a 3-1) hi, ,n i
man, throwing a ball on a gridlike field.
"This is the same system people are using for animations, like Toy Story 2," says Nigel / h n. Ph 1)
adjusting various controls on his keyboard that bring the bionic man to life on his flat-panr m..rnrii.i
"We're using the same technology to analyze human motion."
continued on page 4 1
*# 2.m r ;E
%?; a: -.
* ..~ ~ -
-~~ ~*q 1-~ei3*
* r .,- I A
WHERE UF ATHLETES ARE ALWAYS NO. 1
h1i 1.1- ii I- 1 I1 1-ii .1 1u I.i- latest news and HSC events. IIII 13
were devised in 2002 by UF anesthesiologist
Nikolaus Gravenstein, M.D., and collaborators
with Williams Sports Group. The pads keep
players cool on the sidelines by circulating cold air
through ventilation channels running through
the inside lining. Air conditioning now comes
standard in top brands like Douglas Custom Pro
and Riddell Power shoulder pads.
Zheng, director of the motion analysis laboratory and an assistant professor of
orthopaedics and rehabilitation in the College of Medicine, isn't the first scientist to
measure the velocity of bones and joints under the skin using biomechanical analysis,
the technical term for his impressive array of strobe lights, cameras and reflective
But he is an innovator in the science of sports motion: Zheng was one of the first to
develop a series of computer programs that compares detailed analyses of the
mechanics of professional and novice athletes to reveal how a baseball pitch, for
example, could be tweaked to enhance performance.
Zheng's current work with Lawler and several other Gator baseball pitchers is part
of a collaboration with the Tampa Bay Devil Rays that was recently funded by Major
"Basically, these are the professionals this is what they are doing," he says,
paging through a report filled with algorithms, models and 3-D images of baseball
pitchers in various stages of motion. "We break down those biomechanical variables
into sections like the arm-cocking phase and the acceleration phase, based on where
your arms are positioned."
It's simple: Professional athletes provide the baseline for near-perfect technique,
while everyone else tries to measure up. Things like the motion and angle of an
athlete's spine, the exact degree of each shoulder and hip rotation and the velocity of
each bone are analyzed in minute detail to identify areas for improvement.
For example, Tebow's analysis revealed he relies too much on his shoulder to throw
the ball and not enough on his hips. The solution? Rotate his hips earlier, which
Conrad says will generate more power and give Tebow's shoulder a much-needed rest.
Because performance enhancement and injury prevention go hand in hand, UF's
motion analysis lab provides Gator athletes with an advantage over most other college
teams by identifying the potential for serious injuries before they occur.
"We do research to understand injury mechanisms," Zheng says. "We would like to
be able to prehab before an injury so we can say, 'OK. You're about to break your
tendon. Let's do something to make this stronger.'"
In many cases, the news comes as little surprise. Athletes occasionally feel warning
signs of a serious injury before throwing the final ball that breaks the camel's back.
Lawler, who's still pitching on the other side of the observation window, seems
skeptical about the tightrope Conrad claims he's walking between fame and early
"If you know what you're doing, then it's not necessarily one pitch," Lawler says,
... ...... -
....... ... ......
. .. ......
grappling with the idea of being a fastball away from disaster. "Sometimes it's a constant
pain, but it feels like you can deal with it. And then all of a sudden there's just one big
But how can a computer algorithm predict what an athlete only suspects?
"Obviously we can't rotate a patient's knee until something breaks, just to measure the
strength of his knee joint flexibility," explains Conrad.
That's where the cadavers come in.
Zheng and Conrad study the anatomy of cadavers to develop 3-D models of human
bones and determine how contact between bones and joints influences recovery after sports
injuries, such as a torn anterior cruciate ligament.
"We actually put the ligaments on a machine and apply the forces to see what the
ultimate strength is," Conrad says "Then we can say, 'Okay, the actual patient is well under
COPING WITH CURVE BALLS
Despite the warning signs, most athletes aren't lucky enough to catch a potential injury
before it's too late. Virtually all athletes will experience a physical setback at some point in
"The most common serious injury we see is a ligament injury to the knee, an ACL
injury," says Peter Indelicato, M.D., head team physician for the UF Athletic Association
and division chief of sports medicine in the College of Medicine.
"How somebody moves in space where their head is in relationship to their shoulders,
their shoulders in relation to their hips, their hips in relation to their knees, their feet in
relation to their hips may be a factor in why one person tears their ACL doing an
activity and somebody else doesn't," Indelicato says.
Football players suffer more ACL injuries than other athletes, but these setbacks are
nowhere near as frightening as the prospect of a spinal injury that could cause life-long
On Sept. 9, during the first NFL game of the season, Buffalo Bills player Kevin Everett
suffered what doctors deemed a life-threatening spinal injury. Doctors thought his chances
of walking again would be slim, but because they used an experimental cooling technique,
he is making what experts consider a miraculous recovery. But other players haven't been
so lucky. Since 1978, five other NFL players have suffered similar injuries, some faring
better than others.
As it turns out, spinal injuries aren't over after the initial collision between two players.
continued on page
In the lab, researchers (above) use tape to
keep the reflective marker on Travis Lawler's
pitching hand secure when he throws the
ball. (Opposite page) Researchers in the lab
also work with people who have been
injured, such as Trevor Fleming, who tore his
anterior cruciate ligament playing football.
High-speed cameras track the markers on
Fleming's legs as he walks and transmit that
information back to computers, where
researchers can analyze his gait. UF
biomechanical engineer Nigel Zheng, right,
also measures the internal and external
rotation of Fleming's knee joint.
As UF's team physician, Dr. Peter Indelicato,
below, is on the field anytime a UF athlete is
injured. Here, he talks with a UF football
player during the Florida-Tennessee game in
One of the most popular sports drinks on
the market was formulated in 1965 In the
lab ofJ. Robert Cade, M.D.. a UF professor
of medicine. The blend of water. sodium.
potassium. phosphate and glucose was
designed to keep Gator football players
hydrated in the sweltering Florida sun.
Cade also invented hydraulic football
helmets that protect players from
concussions 3and a milk protein shake that
enhances muscle recovery after exercise.
An injured player is still at risk for more damage afterward, and the most dangerous
part is often simply moving the athlete to a spine board to the ambulance and finally to
the operating table.
An ongoing project at the motion lab mimics the entire process in cadavers, injury
and all, to identify potentially risky maneuvers.
"We have a team of athletic trainers, EMTs and orthopedic surgeons the types of
people who would be on the football field when they transport an injured player onto the
spine board, into the ambulance and into the hospital," Conrad says.
After inducing a spinal cord injury in a corpse, the team attaches GPS-like sensors to
various bones and tries to pinpoint unnecessary movement that could exacerbate an
already life-threatening injury. The data will help experts develop new guidelines for
moving injured athletes off the field.
Most of the time, Zheng and Conrad focus on routine health maintenance and minor
injury prevention, working with athletes such as Lawler and Tebow.
"We've taken athletes like our quarterbacks and analyzed their throwing motion to
see if they're heading toward a problem we can prevent," says Indelicato.
MIND OVER MATTER?
Improvements to technique don't always translate to more strikeouts and touchdowns,
though. At least not right away. While it might seem like working with the motion lab
could enhance an athlete's performance simply by boosting confidence, sport
psychologist Christopher Janelle, Ph.D., says that's probably not the case.
"You're changing something that is a well-learned habitual behavior," Janelle says.
"The whole process of thinking about what you're doing interferes with the ability to do
it. You're adding a cognitive element to performance that is typically not there,
particularly for elite-level athletes."
Janelle says those psychological barriers eventually can be overcome through
repetition, practice and focus, but the time it takes varies among athletes. In most cases,
athletes have been performing the same motion since they were only a few years old.
The prospect of changing that overnight is daunting and highly successful athletes are
not used to failure.
"The hope the reason that elite-level athletes are willing to take that risk is
because they know there's something that could be better with what they're doing,"
Janelle says. "There's the recognition that whatever this glitch may be, it has to change
for them to maximize their potential. It's hugely courageous for people to do this."
FOUNTAIN OF YOUTH
The secret to making the big leagues? Start young, Zheng says.
The reason Lawler can hurl a fastball with no problem while the average
person might require immediate transport to the emergency room is
because athletes who compete at an early age are built for success. Literally.
Lawler, who says he started playing ball as soon as he could walk, is a
perfect example. Repeated motion during early development can coax
muscles to attach at different locations, expanding the young athletes'
ranges of motion.
Baseball pitchers can reach surprisingly far back behind their necks to
gain enough momentum to throw a fastball. But the rest of us are better at
doing the mirror opposite pointing our fingers down toward the ground
and extending our hands back behind our body.
That just means we're not built for pitching, Zheng says. And no
amount of weightlifting or practice can change the attachment locations of
muscles after the body has stopped growing.
"You have to realize what you can and cannot do. Some things improve
with strength and conditioning, but for some things it's too late," Zheng
says. "You never hear of someone going to the U.S. Open without playing
tennis before age 10. They all start early. You can't catch up with them."
That doesn't mean elite athletes are immune to physical injury. As
Lawler, Tebow and dozens of other Gator athletes have learned at the
motion analysis lab, it just means they have to stay vigilant. One careless
move could land them on the sidelines for a day. Or for good.
But Lawler says that won't stop him from playing the game.
"I'll play forever, as long as I can," he says. "If I get hurt, I'll go to rehab.
Then if I can still play, I'll play."
And if he has to hang it up?
"Then I'll coach, probably."
A muscle-boosting powder, was developed by Bruce
Stevens, Ph.D., a UF professor of physiology and
functional genomics. Officially called glycine-L-
arginine-alpha-ketoisocaproic acid calcium, the
concoction boosts muscle recovery and enhances
athletic performance if taken before strenuous
exercise. And it doesn't just work in humans GAKIC
is patented for use in racehorses, too.
161 J U Visit us online @ http://news.health.ufl.edu/ for the latest news and HS
m -- E
A negative exercise machine that
emphasizes lowering a heavier weight
and then lifting a standard weight. was
designed in the early 199os by UF
orthopedic surgeon Michael MacMillan,
M.D., and a team of researchers. The
computerized machine was used to help
rehabilitate the injured hamstrings of
former UF and Dallas Cowboys star
F running back Enmitt Smith.
Study of online research skills
aimed at helping scientists
Health Science Center bioinformatics librarian Michele Tennant is assessing
how well faculty, postdoctoral associates and graduate students use online
resources to evaluate their training needs.
ow good are scientists at using bioinformatics databases to answer biological
Health Science Center bioinformatics librarian Michele Tennant, Ph.D.,
M.L.I.S., intends to find out.
Aided by a $25,000 Donald A. B. Lindberg Research Fellowship from the Medical
Library Association, Tennant is assessing how well faculty, postdoctoral associates
and graduate students use online resources in an effort to evaluate their training
Her research, which took her to health and science libraries at the University of
Arizona, the University of Southern California-Norris and the University of
Colorado-Denver this summer, will help support scientists studying subjects that
range from human cancer treatments to plant evolution.
Anecdotal evidence suggests researchers may not be as proficient as they think at
using online resources, such as those from the National Center for Biotechnology
Information. Tennant wants to find out how accurate that idea is.
In addition, she wants to determine the extent to which multiple paths can be taken
to arrive at a correct answer which is how NCBI resources are intended to work.
Also of interest is why users take particular paths and what they do when they
reach roadblocks. This portion of Tennant's project aims to shed light on the design
of the online resource.
In a separate research endeavor, she was awarded a $2,000 David A. Kronick
Traveling Fellowship to help her study bioinformatics support services at various
medical libraries. A bioinformatics research specialist affiliated with the UF Genetics
Institute, Tennant was one of the first librarians in the United States to provide such
services through the library.
Other institutions have since copied and enhanced the UF model, so Tennant is
traveling to four libraries to research new methods, aiming to identify how these
contemporary systems provide their services and how they could be applied to UF.
"I am interviewing librarians, library directors, and clients," she said, "to explore
areas such as how duties and responsibilities are divided among the bioinformatics
support specialists, how funding was secured for these positions, what added value
comes from such services and multiple individuals providing them, and what
attributes an individual must have to perform well as a library-based bioinformatics
In addition to USC-Norris, she recently visited Harvard's Countway Medical
Library as part of the Kronick project. O
to study depression
in Latina women
By Tracy Brown Wright
Depression is fairly common among Latina women
but is often left untreated, says a UF nursing
researcher who has received a National Institutes
of Health grant to study the problem.
Jeanne Marie Stacciarini,
Ph.D., R.N., a UF assistant
professor in the College of
Nursing, has received a $202,113
grant from the NIH to study
depression in Latina women and
promote diversity in health-
related research. The
supplementary grant is part of a
larger project looking at ways to
S reduce women's health disparities
JNE MARIE STACCIARINI, Ph D through an approach called
research. UF nursing researcher Shawn Kneipp, Ph.D.,
A.R.N.P., is leading that study.
Stacciarini's preliminary findings revealed that unique
health beliefs, strong community values, language barriers
and dependency on men make it difficult for Latina women
who are depressed to be properly identified. These factors
also impair their ability to receive treatment, leaving many
women incapable of taking care of themselves and their
Stacciarini's goal is to develop an effective community-
based, culturally appropriate intervention to treat
depression in Latinas and to help more Latina women
access treatment. She plans to collaborate with researchers
and community representatives from Central and North
In the first year of the two-year grant, Stacciarini will
work with Kneipp and her research team to learn more
about community-based research and make research
connections in the community.
In the second year, Stacciarini will conduct a pilot study
to learn more about mental health services for Latina
women in Alachua County, determine cultural barriers to
treatment and examine possible community-based
approaches to intervention. 0
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events. III 17
And now for our
UF video 'Librarians to the Rescue'
wins award at international film festival
HSC library staff members, from left, Dwight Bennett, Nita
Ferree, Ned Davis and Ellie Bushhousen were key members of
the cast and crew of "Librarians to the Rescue." Bushhousen,
above, played the part of Dr. Stern. UF videographer Don
Loftus, above, spearheaded the project and filmed the video.
By April Frawley Birdwell
Anyone who's ever been in school will recognize this scene: Tough-
talking professor enters classroom, issues stern reminder about
research assignment. Students groan, conk heads on desks, look
confused befuddled, even.
And then she delivers the clincher. Cue the ominous
"It requires materials that can only be found in our
libraries," the professor says. "You can't just 'Google' or
'Yahoo' your way through this, people."
The library? Isn't that just a place where bespectacled
librarians dust books, bark "Shhh!" and mumble about
the Dewey Decimal System?
That's the misconception librarians have been
battling for years and one of the reasons staff members
from the Health Science Center Libraries produced
"Librarians to the Rescue," an educational video about
the UF Libraries system and its services.
There's no word yet whether the video, which airs on
the closed-circuit televisions in dorm rooms and on
cable channel 96, has yielded more library visitors. But
"Librarians to the Rescue" is already making a mark ...
at film festivals. The video, written and directed by
HSC Libraries webmaster Dwight Bennett, received
honorable mention honors from the Columbus
International Film and Video Festival as part of its 55th
annual Chris Awards. The awards ceremony, which
Bennett plans to attend, will be held Nov. 10.
"It's not merely a library award. This is a 55-year
running film festival for educational videos and there
were 600 submissions, so we were pleasantly surprised
to win," said Ned Davis, a marketing and public
relations coordinator for the HSC Libraries who served
as assistant director for the project.
The idea for the video started with Don Loftus, a
video production coordinator in the UF Office of
Academic Technology, Bennett said. Loftus suggested
the university produce several videos to teach students
about UF's nine libraries and the different ways
librarians can help students gather information. Bennett
offered to write the first one and lead the project.
The 22-minute piece chronicles four students and
their quest to complete an assignment from the aptly
named Dr. Stern. With a background in theater, HSC
librarian Ellie Bushhousen, M.S.L.I.S., plays Dr. Stern
to professorial perfection, barking, "This assignment
was designed to be hard," amid a classroom of wide-
She was convincing. She confused "real" students by
barging into a lecture hall proclaiming their
assignment was due in a week. The announcement was
just for a quick classroom shot the crew needed for the
movie, but the students there didn't realize it until
"You could have heard a pin drop," Bushhousen said,
with a laugh. "Those kids were freaked."
In all, 19 people worked on the video, including
students from UF and Santa Fe Community College
and staff members from several UF libraries. The crew
spent several months shooting and then editing the
video, which premiered in the dorms about a year ago,
"There were a lot of people working on this for no
other reason than just because they thought something
positive needed to be done," Bennett said. "They were
Bushhousen and Nita Ferree, M.L.I.S., also an HSC
librarian, hope the video teaches those who watch it
that the library is more than just a place where books
are kept on shelves. Librarians actually spend most of
their time helping people scour through databases for
information, finding facts and teaching others how to
search journals and other sources.
"We're here to be the guides," said Ferree, who
played a librarian that helps the students in the movie.
"Information is power and we want to give that power
to the people."
"This isn't the 18th or 19th century," Bushhousen
added. "Libraries are dynamic places. There's
something for everyone."
Ferree nodded and said, "And, the price is right." 0
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
For the American warrior
UF professor spent two weeks overseas in hospital for wounded troops
By Patricia Bates McGhee
"Give a thumbs up."
That's the first order wounded soldiers receive at the Landstuhl Regional Medical Center in Germany. As the largest
U.S. military hospital outside the country, Landstuhl is the chief caretaker of injured troops evacuated from Iraq and
Afghanistan. Often, because soldiers' injuries from roadside explosives and bombs are so severe, a thumbs up is the only
way doctor and patient can communicate, says Eric Frykberg, M.D., a UF professor of surgery at the College of Medicine-
"It was incredibly touching to see these patients intubated so they couldn't talk, with devastating injuries and
covered with burn dressings somehow muster the strength to give us that universal 'I'm OK' sign," said Frykberg, who
spent two weeks at the hospital in August as part of an American College of Surgeons visiting surgeon program.
Even with years of experience as a former U.S. Navy surgeon deployed to Saudi Arabia during the first Gulf War and as
a busy trauma surgeon in Jacksonville, Frykberg said he was surprised by the level of devastating injuries among soldiers
taken directly from combat-zone field hospitals to Landstuhl.
"I was in the military, but what I saw at Landstuhl was something you rarely see it was mass casualty and managing
mass casualty is very different from anything we've learned and requires a whole new approach to medical care," he said.
"I've been here in the trauma center for 22 years and published a lot about trauma. (They wanted) someone experienced
in trauma to go over there and have a give-and-take approach to educating surgeons about trauma care while also learning
from them new techniques being applied to wounded soldiers."
Frykberg conducted two grand rounds lectures and was involved in the care of about 36 patients at Landstuhl.
"The most common reason, by far, for injuries are bomb blasts the IEDs (improvised explosive devices), suicide
bombers and roadside bombs," he said." I saw only two typical war injuries from gunshot wounds."
Bombs cause devastating blast injuries rarely seen in a typical trauma center stateside, Frykberg added.
"You hear about the deaths on the news, but there's very little you hear about a whole generation having really devastating
injuries like mangled bodies and lost limbs," he said. "We have a huge level of amputees among these young soldiers now
looking toward a life of significant disability."
Like the injuries, the type of care provided at Landstuhl differs from hospitals here. The focus at Landstuhl is stabilizing
patients so they can be sent back to the U.S. The hospital is just a way station between the battlefield and hospitals where
they will recover, such as Walter Reed Hospital in Bethesda, Md., or the San Antonio Burn Center in Texas.
"We helped stabilize the patients, assisted surgeons in the O.R. and got the medical records up to date so we could
provide the continuity of care needed to get the patients back to the states for their definitive care," Frykberg said. "Then
we turned around and prepared for more incoming patients."
But each patient leaves with one thing from Landstuhl, a quilt with the words "For an American warrior" embroidered
on it. Each patch is signed with personal messages from the volunteers who make them.
"Even now, when I look at my photos from my Landstuhl experience and see the quilts being loaded with each patient
for the flight home, I recognize the dedicated and caring medical personnel who helped that patient make it that far,"
Frykberg said. "The handwritten signatures, comments and drawings say it all." 0
Visit us online @ http://news.health.ufl.edu/ for the latest news ar
couln~t al, wit
th aten t to aiv
Eric Frykbe M.D.19
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PUBLIC HEALTH AND HEALTH PROFESSIONS
M.D., M.Sc. C.T.M., a clinical
associate professor in the
department of behavior
science and community health,
traveled to La Paz, Bolivia, in
August as a technical adviser
for the Americas Antimicrobial
Resistance Initiative sponsored Amaya-Burns
by the Pan American Health
Organization/World Health Organization and the
U.S. Agency for International Development. She
worked with medical school deans from the private
and national universities of El Salvador, Paraguay,
Peru and Bolivia to update their curricula by
adding guidelines for the prevention and control of
hospital-acquired infection and the rational use of
antibiotics. Amaya-Burns has served as a technical
adviser for the initiative since 2001.
MICHAEL DANIELS, Sc.D.,
a professor and chief of the
division of biostatistics in the
department of epidemiology
and biostatistics, was
elected to be a fellow of
the American Statistical
Association in recognition of
his professional contributions
and leadership in the field Daniels
of statistical science. He was
honored at the association's annual meeting in
July in Salt Lake City.
AMY YARBROUGH, Ph.D.,
an assistant professor in the
department of health services
research, management and
policy, received the American
College of Healthcare
Executives' 2007 Health
Award. The $25,000 award
will support Yarbrough's Yarbrough
research on the challenges and benefits of
employing health-care managers who have no
formal education in health administration. She will
conduct a multilevel study of 10 U.S. hospitals and
a follow-up survey of 2,000 health-care executives.
COLLEGE OF PHARMACY
JULIE A. JOHNSON,
Pharm.D., received the
American Association of
Colleges of Pharmacy's
prestigious Paul R. Dawson
Biotechnology Award at
its annual meeting in July.
Johnson's research focuses
on disease-gene associations Johnson
and the influence of race and
ethnicity on drug response. The National Institutes
of Health and the American Heart Association
have continuously funded her work since 1990.
"Julie has found an area of research that promises
to change the way patients are treated with drug
therapy," said William H. Riffee, Ph.D., dean of the
College of Pharmacy.
COLLEGE OF MEDICINE
WAYNE GOODMAN, M.D.,
chairman of the department of
psychiatry, has begun a three-
year term on the state's Suicide
Council. "The Suicide
Council will develop and
implement a statewide strategy Goodman
to reduce Florida's suicide rate,"
said Gov. Charlie Crist in a written statement. "I
am hopeful that through their work, fewer families
and communities will be affected by suicide."
STEPHEN I. HSU, M.D.,
Ph.D., the R. Glenn Davis
associate professor of clinical
and translational medicine
in the division of nephrology,
hypertension and renal
transplantation, has been
named director of the M.D./
Ph.D. program. Hsu came to UF
in July from Harvard Medical
School, where he was an assistant professor of
medicine at Brigham and Women's Hospital. Hsu
is an expert in the fields of cell cycle regulation,
nephrogenomics and nephroproteomics.
Ph.D., a professor of
the Society for Education in
Anesthesia's annual $5,000
award for excellence and
innovation in anesthesia
education at the association's
2007 meeting. Lampotang, a
member of UF's Center for Lampotang
Simulation, Advanced Learning and Technology,
was instrumental in designing the Human Patient
Simulator, as well as numerous other teaching
tools, including the "Simulated Anesthesia
Experience" featured on page 5.
COLLEGE OF VETERINARY MEDICINE
PABLO PINEDO, a graduate
student in the college, has
received the Richard Merkal
Memorial Fellowship to attend
the International Colloquium
on Paratuberculosis this month
in Tsukuba, Japan. Pinedo
will give a presentation on
his research, which focuses Pinedo
on genetic resistance to
paratuberculosis also known as Johne's disease
in beef and dairy cattle.
MIKE WALSH, D.V.M., has
been named the associate
director of UF's Aquatic Animal
Health program. Walsh was
formerly a head veterinarian
at Sea World of Florida. His 21
years in aquatic health have
been marked by innovation
and improvement in the care of Walsh
manatees, seals and sea lions,
penguins, dolphins, whales, sea turtles and sharks
as well as beached whales and dolphins.
Crystal Apple Award
The UF College of Pharmacy was one
of eight pharmacy schools to receive
the first-ever Academic-Practice
Partnerships for Learning Excellence
Award -also called the Crystal Apple
Award from the The American
Association of Colleges of Pharmacy
this summer. UF was chosen for having
an exemplary partnership with Shands
that helps produce quality educational
experiences and patient-care teaching
environments for pharmacy students.
The award was presented to pharmacy
educators David M. Angaran, M.S.,
a clinical professor of pharmacy,
Thanh Hogan, Pharm.D., the director
of pharmacy at Shands Jacksonville,
and Sharon A. Basile, Pharm.D., a
pharmacist and preceptor at Shands
Jacksonville. The award was created
to improve pharmacy education
and practice by encouraging quality
professional experience programs.
Each of the 2007 awardees will be
featured in US Pharmacist and in the
Advanced Practice Experience Site
Profiling System, a tool kit designed for
pharmacy schools to identify, document
and profile models of exemplary
education practice sites. Shown with
the award in the photo above are,
clockwise from top right, Dean William
Riffee, Basile, Hogan and Angaran.
201 01 i O
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events.
UF researchers se
By Ann Griswold
ew people had
heard of AIDS 26
years ago. That has
handedd. Today more than 1
million people have HIV or AIDS in the
U.S. and more than a tenth of them are Floridians.
To combat the epidemic, College of Medicine
researchers are spearheading a multi-institutional
effort to establish Florida's first Center for AIDS
A "HIV/AIDS is a significant public health
problem in Florida," said Maureen Goodenow,
Ph.D., a UF AIDS researcher who's leading the
group. "As a state, we're third in the country with
the numbers of HIV/AIDS cases. There are at
least 100,000 infected individuals that we know
The National Institutes of Health initiated the
Centers for AIDS Research program in 1988 to
support collaborations between basic scientists
and clinicians, bringing AIDS research from the
MAUREEN GOODENOW, Ph.D.
lab to patients. The NIH currently supports 19
other centers at top-ranked institutions across the
nation, including Harvard University, Duke University and Case Western
Florida researchers, who recently met for a planning session, hope to obtain seed
money from the state's Centers of Excellence program first to help them generate
preliminary data for the group's formal application to the NIH next spring.
If awarded, the Florida Center for AIDS Research will be the first center on
ek to establish Florida's first AIDS research center
the list to harness the collective
strength of more than three
research institutions. Goodenow is
currently collaborating on the
nine Florida institutions. Aside from
principal investigators from four UF colleges,
Goodenow's team includes experts from the
University of South Florida, the University of Central
Florida, Florida State University, the H. Lee Moffitt Cancer Center
& Research Institute in Tampa, Tampa General Hospital, Wolfson Children's
Hospital in Jacksonville, Merck & Co. Inc. and the Ponce School of Medicine in
The group aims to study the disease across the lifespan, with the goal of
improving quality of life for adolescents and older individuals affected by HIV/
AIDS, Goodenow said.
About 19 percent of Americans infected with HIV/AIDS are over 50,
according to the Centers for Disease Control and Prevention. Sexually
transmitted diseases in the elderly population have become increasingly
problematic in recent years, thanks in part to performance-enhancing drugs
such as Viagra.
"Body changes that occur with AIDS are comparable to accelerated aging,"
said Marco Pahor, M.D., director of UF's Institute on Aging and chair of the
College of Medicine's department of aging and geriatrics.
Much of the current knowledge about the aging process, including the factors
that influence loss of skeletal muscle mass and strength, originated from AIDS
research, Pahor added.
"The proposal illustrates how the university can effectively draw on its
comprehensive set of resources to target an important issue such as AIDS," said
Win Phillips, D. Sc., UF's vice president for research. "By inviting so many
other institutions in the state to collaborate, Dr. Goodenow and her colleagues
have further strengthened the case for why Florida should have a Center for
In an opening speech at a recent planning session, Douglas J. Barrett, M.D.,
UF's senior vice president for health affairs, said the center will provide an
unprecedented opportunity for "Gators and Seminoles and Knights and Bulls to
work together to do what's right, in terms of the best investment of Florida's
dollars and Florida's people." O
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events. I 21
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Learn how diseases could
Oct. 11, 7p.m.
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College of Nursing p
clinic gets new digs
Archer Family Health Care new clinic dedication
16939 SW 134th Ave, Archer. For more information,
Raise money for breast cancer
Oct. 20, 9 a.m.
Making Strides Against Breast Cancer of
Gainesville Walk. p
Northeast Park, 400 N.E. 16th Ave., Gainesville
To join the Shands Team for the walk, e-mail
Kara White at firstname.lastname@example.org or call
352-265-0680, ext. 72222.
Celebrate UF Homecoming
A lunch with history
Oct. 11, 12p.m.
TIl Hi: :iry of Medicine Lecture Series presents
H,: r:i improve medical care: An 18th-century
.il:1:11:: II, "with Antoinette Emch-Deriaz, Ph.D., a
UF I:i11:lre :.sor of history.
I ,:iiii.i, ,core Building, Room C1-15
For the future pharmacist
Oct. 14, 1 p.m.
C 1:11C-1i- ,:t Pharmacy Open House
PFuI)c Health and Health Professions/Nursing/
Fr .armacy Complex. For more information, call
_'_-273-6217 or e-mail email@example.com.
Carve a jack-o-lantern
Reminisce about nursing school
Nov. 2, 2p.m.
I Iillc-qg ( 1 1I j m '. F:I -1.Ii'in)i I i|ii-i I H iiii : -
H ', li hll c- (l111 1 h, .11 i ll '. ,'IIII.j iI-
Medical school memories
I i:,ll 1-- i 1,1, I i-, I ,:1Il- l l.l l F;h-lI.llIIll
-,.,l m,,f/,:i' lf ,.,H, ,, ifli ,,,i ::' [ ,::'ir f:: I l ;.lt I I I ,.h./( ./ i fl
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Learn about genetics research
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-,I ,,,1:' rhi I,hiiIiI F,h hill I_- ii ii ,"I ii
For additional information and more HSC events, visit the HSC News calendar of events: www.news.health.ufl.edu/calendar.asp. To contribute to the calendar, e-mail Anney Doucette at firstname.lastname@example.org, or call 352-273-5772.
UF researcher studies therapies
for muscular dystrophy
By Stephanie Fraiman
It all started with a game of handball and a
Krista Vandenborne, Ph.D., P.T., ended up in a cast after tearing
a ligament playing handball in her native Belgium. Months later, when
the cast was removed, Vandenborne couldn't believe how her leg looked
without it. Deteriorated. Weak, even.
"I wanted to learn more about how and why that happened," said
Vandenborne, a professor and chair of the department of physical
therapy in the College of Public Health and Health Professions. "I
think it's pretty typical. People don't really think about a profession
until they need it."
Now an internationally known leader in human muscle physiology
and rehabilitation, Vandenborne has focused her attention on helping
children with a far more serious form of muscular degeneration -
muscular dystrophy. There are nine types of muscular dystrophy, a
neuromuscular disease that affects about 250,000 Americans, according
to the Muscular Dystrophy Association. The most common form in
children Duchenne muscular dystrophy only affects boys and by
age 12, many need a wheelchair. Vandenborne is developing imaging
strategies to help determine the effectiveness of different muscular
dystrophy therapies in young children using the McKnight Brain
Institute's powerful magnet, the 3-Tesla whole-body scanner.
Magnetic resonance imaging provides precise, noninvasive
assessments of muscle tissue quality that allow researchers to
determine the natural progression of muscular dystrophy throughout
the body, the muscles that should be targeted for therapy and the
efficacy of therapeutic interventions.
"Muscular dystrophy is a disease that has a huge impact on patients
and currently there is no cure," Vandenborne said. "It's a devastating
disease that deserves a lot of attention."
A mother of two, Vandenborne empathizes with the parents whose
children are the focus of her research.
"It's hard as a parent. You want to help as much as you can," she said.
Vandenborne's commitment to the children and families involved in
her research is remarkable, said Roxanne Moseley, whose son Kenneth,
15, is a study participant. When Roxanne's younger son, Thomas,
decided to focus on muscular dystrophy research for his middle school
science fair, Vandenborne met him at the library on a Sunday afternoon
to advise him on his project.
"She ended up giving us two hours of her Sunday," Moseley said.
"When people are giving up their Sundays to help with a school
project, that's dedication. No doubt about it."
Krista Vandenborne, right, and her husband, Glenn Walter, second from right, lead the
Muscle Physiology Laboratory, where researchers conduct basic science and clinical
studies on muscle degeneration and regeneration. Research team members also include,
from left, Nathan Bryant, Sean Germain, Wendy Han, Donovan Lott, RavneetVohra,
Sunita Mathur and Claudia Senesac.
Working to cure muscular dystrophy is a family affair for Vandenborne. Her children run
lemonade stands and donate the money they earn to muscular dystrophy research. Her husband,
Glenn Walter, Ph.D., an assistant professor of physiology and functional genomics in the College of
Medicine, also studies muscular dystrophy. The couple, who met in a lab during graduate school at
the University of Pennsylvania, sometimes collaborate on research projects.
Vandenborne and the researchers in her lab are also studying muscle adaptation after spinal cord
injuries and during cast immobilization the problem that got her interested in muscle
degeneration in the first place
Graduate students say Vandenborne not only involves them in her research but also encourages
them to think independently and design their own projects.
"When we are thinking of new topics for research, Dr. Vandenborne has us explore the options
and think about everything by ourselves," said Prithvi Shah, a graduate student who conducts
spinal cord injury research in Vandenborne's lab. "In the long run, you feel good that you created
the entire research yourself."
As chair of the physical therapy department since 2002, Vandenborne has also led her
department to new heights with increased research funding, the development of a Doctor of
Physical Therapy degree, clinical fellowships, NIH-funded predoctoral training programs and a
highly successful research and clinical seminar series.
"She has a vision and it's easy to get motivated by her because she's so motivated by what she sees
for the future," said Claudia Senesac, Ph.D., P.T., a UF clinical assistant professor of physical
therapy who collaborates with Vandenborne. 0
Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events. III I 23
The founder of UF's neuropsychology
program, Paul Satz, right, spoke about
the early years of the program at the
College of Public Health and Health
Professions' advisory board meeting
Sept. 14. Satz, who directed the UF
program from 1964 to 1979, went on to
establish similar programs at the
University of Victoria and the University
of California, Los Angeles. He is now
retired and living in Hawaii. In his talk
Satz praised his former UF students,
several of whom are internationally
recognized in the field, including Russell
Bauer, chair of PHHP's department of
clinical and health psychology, left, and
Charles Schauer, vice president of
clinical research and external affairs for
the Brooks Health System in
Jacksonville. "What happened in those
early years pushed the field of
neuropsychology to the boundaries, and
it happened here at the University of
Florida," Satz said.
Dr. Mobeen Rathore, a professor of pediatric infectious
diseases and immunology at the College of Medicine-
Jacksonville, founded the Rainbow Center, the only
comprehensive pediatric and family-focused AIDS program
in Northeast Florida.
Dr. Sarosh Batlivala (center left), a senior resident in pediatrics,
stood in the rain with about 25 of his colleagues Oct. 2 in front of
Shands AGH. They joined doctors at hospitals around the country in
the 15-minute stand to protest a possible presidential veto of
extended funding for the State Children's Health Insurance Program.
UF Health Science Center
Office of News & Communications
Senior Vice President,
Douglas J. Barrett, M.D.
Director, News &
April Frawley Birdwell
Melanie Fridl Ross, John Pastor
April Frawley Birdwell, Tracy Brown,
Sarah Carey, Anney Doucette, Linda
Homewood, Lindy McCollum-
Brounley, Patricia Bates McGhee, John
Pastor, Jill Pease, Melanie Fridl Ross
Stephanie Fraiman, Meredith Woods
Cassandra Jackson, Beth Powers,
The POST is the monthly internal
newsletter for the University of
Florida Health Science Center, the
most comprehensive academic
health center in the Southeast,
with campuses in Gainesville
and Jacksonville and affiliations
throughout Florida. Articles feature
news of interest for and about HSC
faculty, staff and students. Content
may be reprinted with appropriate
credit. Ideas for stories are welcome.
The deadline for submitting items to
be considered for each month's issue
is the 15th of the previous month.
Submit to the editor at afrawley@ufl.
edu or deliver to the Office of News &
Communications in the Communicore
Building, Room C3-025.
UF Health Science Center
UNIVERSITY of FLORIDA