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WE HEAR YOU
On the basis of the results of our spring reader survey, we took your suggestions
and revamped The POST with a new look that is easy on the eyes and content
that covers more of the exciting developments happening every day at the Health
Science Center. With its new design, profiles and editorial features we endeavored
to make The POST a more useful tool for readers who want to learn about the
latest research, patient care, education and administrative activities of the HSC
The POST staff and everyone in HSC News & Communications thank all those
who participated in our survey and to those community members who help make
the Health Science Center the top medical institution in the Southeast. We hope
you enjoy the publication and welcome any comments or suggestions you may
TABLE OF CONTENTS
) UP FRONT RESEARCH- Turtle Treasure Trove 6 EXTRAORDINARYY PEOPLE
POST IT News to use @ COVER FEATURE -Access Denied DISTINCTIONS HSC Achievers
LEADERSHIP Barrett's Vision PATIENT CARE Ortho's New Home JACKSONVILLE
( EDUCATION CSI: UF @ PROFILE William Mann FIVE QUESTIONS More Med Schools?
Responding to a request from the Governor's
Office, the College of Veterinary Medicine sent
a team to South Florida to assist in the animal
relief effort under way in the aftermath of
Ann Lindholm, a
pit bull puppy
whose paw was
Charley. The UF
bandaged it and
antibiotics to the
Veterinary student Marissa Curtis (from left), veterinary
technicians Brandee Thacker and Bronwyn Onze, Dr. Lori
Alvarez, a first-year anatomical pathology resident, and veterinary
student Ann Lindholm gather around a flea-infested puppy
brought to the disaster relief site in Wauchula by a good
Samaritan. The UF team cleaned the puppy and treated it with
semi.^ -- I
HSC INAUGURAL FARE: SO MANY CHOICES...
UNIVERSITY OF FLORIDA
As Health Science Center colleges put the finishing touches on their plans related to the inauguration of
UF President Bernie Machen, Sept. 9 is shaping up as a garden of intellectual delight. But you better bring a
tape recorder, because most of the key speakers' presentations overlap.
Each of the six Health Science Center colleges has something planned, from invited speakers to guided
tours. Here is the breakdown of the principal speakers:
Formal speaking activities begin at noon at the College of Public Health and Health Professions when
Edward Sheridan, Ph.D., a senior vice president and provost emeritus of the University of Houston, presents
"A Response to Chronic Crisis in Higher Education" in Room G101 of the HPNP complex.
At 12:05 p.m., a pair of prolific clinical research scientists from the College of Medicine will take
the podium in Communicore lecture hall C1-4: Mark Atkinson, Ph.D., a professor in the department of
pathology, immunology and laboratory medicine, and Daniel Okun, M.D., an assistant professor in the
department of neurology.
At 12:45 p.m., the College of Pharmacy will host a symposium to discuss the role of partnerships in the
drug discovery process in the HPNP Auditorium.
At 1 p.m., the College of Veterinary Medicine will host astronaut/veterinarian Richard M. Linnehan. The
NASA scientist will present "Veterinary Medicine in Low Orbit: New Discoveries, Perspectives and Possibilities
in our Profession" in Lecture Hall A of the Veterinary Academic Building.
The College of Dentistry will feature David Wong, professor and chairman of the UCLA School of
Dentistry's division of oral biology and medicine, at 1:30 p.m. in Room D3-3 of the dentistry building. Wong
will present "Dentistry in the Post-Genomic Era: Where are We and Prospects for the Future."
Also at 1:30p.m., College of Nursing faculty will highlight the college's current research and community
efforts and its lona M. Pettengill Nursing Resource Center.
CHECK OUT THE DETAILS AT HTTP://OPI.HEALTH.UFL.EDU
FLY SOUTH THIS WINTER
Local community, 1:.:: I :i- : i -h.:l i .: it II-,e Health Sciernlc
service between C-G.:n-: 1- :ii, 1 :.:l.I u ll r ,.: Il::
Beginning Sept. :'': : n ,-: ,,e.:h : ,i- : II tfl, thr .e round..
Tampa and Ft. Lau.:l.i.:l.:l-
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capital resources," :.:,,.:1 i l.: I,I T,,l:.1. -,.:-,.:I: I.:t IF i i:, i- nt for corner iJnBe
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in books of 12 and -1 Th.- t : I .::, In: I :.:iir :l' .:I :i.:l I:., .:I i l::t or group haij i j! n-ij
are completely tra .:ie.:l:.11- :1 1...:, I:. u:- : .:l .:l: t t : .:.:or:ling to Tubb. TheIyk e Io
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FOR MORE INFORMATION CONTACT TUBB AT TUBBML@SHANDS.UFL.EDU
A DRIVING CHECK-UP
While driving, do curbs and parked cars seem to jump out of nowhere and get in your car's path?
You might want to take a cue from Minette Hendler. She knows all too well how the aging process can
lead to a decline in driving abilities.
Hendler, 76, recently took the time to get an evaluation of her own driving skills by specialists with the
newly launched Independence Drive, an assessment and rehabilitation service offered by the National Older
Driver Research and Training Center at the College of Public Health and Health Professions.
A licensed occupational therapist gives older drivers two-hour assessments of their driving ability
-including physical, vision and cognitive testing, and evaluations of on-road driving skills -and then
offers additional services. To any drivers deemed unsafe, the center provides training and/or the use of
equipment to enable a person to drive safely, and will provide information and counseling on transportation
Independence Drive is located at 5000 N.W. 34th St., Suite 1, in Gainesville.
FOR MORE INFORMATION, CALL 392-8850
BARRETT'S BIG PICTURE
The senior VP sets a strategic direction
for the Health Science
By Tom Fortner
Douglas Barrett is an M.D. by training, but
for all his preoccupation with numbers, he
might as well have been a mathematician.
In particular, the number 10 seems branded on his
consciousness. As in Top 10.
And no, that's not Gator football. Breaking into
the elite group of public institutions of higher
education is an oft-stated goal of UF, and Barrett
has embraced it with missionary zeal since he
became vice president for health affairs two-and-a-
half years ago.
His appointment in July as one of three UF
senior vice presidents suggests how important the
Health Science Center will be in achieving the
aspirations of the university. For confirmation, one
only has to look at the competition.
"If you look at the characteristics of the
institutions that we are trying to knock out of the
top 10 public universities, each and every one of
them has extraordinarily strong, nationally ranked
health science center colleges," Barrett said
recently. "So to get where we want to go, we must
grow and strengthen research, education and
service components of the Health Science Center
Barrett thinks the VP model, in which his
position is separate from the dean of the College of
Medicine, is a good one to coordinate this
ambitious effort. Getting to the next level "requires
focus, it requires unique and specific attention," he
said. "And so this model says that there is an
individual within the university structure who gets
up each morning with a focus on making that
happen, and with undivided responsibilities
For the academic year just beginning, Barrett
has a lengthy "to do" list. It is studded with major
initiatives that might take years to accomplish,
though Barrett is eager to move ahead on all fronts.
Included on the list are strengthening core
relationships with clinical partner Shands
HealthCare and the HSC campus in Jacksonville,
and forging new alliances with the likes of Scripps
Florida and additional Veterans Affairs medical
units. The rest of the list can be roughly divided
among people, facilities and operations.
THE "B" TEAM
After beginning his job without a separate VP
staff, Barrett is now putting the finishing touches
on his team. The last major piece of the puzzle is
Russ Armistead, the new associate vice president
for finance and planning who began work Aug. 16.
Armistead, who comes from Wake Forest
University and its nationally prominent medical
center, will lead efforts to integrate financial
information and use that knowledge to guide
decision making for the HSC as a whole. Barrett
said Armistead, experienced in both academic and
clinical financial management and planning, has
"the administrative experience and professional
presence" to inspire confidence among those with
whom he works.
Armistead joins a group of senior staff members
who include veteran administrator Tom Harris,
associate vice president, and Richard Bucciarelli, a
member of the pediatrics faculty whose extensive
experience in government relations Barrett is
putting to use as a key member of the HSC
On the immediate horizon, Barrett will make
another critically important hire when he names
the new director of UF's McKnight Brain
Institute. He calls it "one of our first real
opportunities to align a decision on academic
program leadership with the new strategic plan of
He said the new director will not only be an
eminent scientist but a "true leader who sees this
job as creating the success of interdisciplinary
It's no secret that joining the top tier of public
universities will require a major investment in
research in the people and programs that can
attract funding to spur discovery. According to
Barrett, the main limitation to expanding the
research agenda is the lack of space devoted to
fundamental biomedical research.
For all its strategic importance, the opening of
UF's Cancer and Genetics Research Building in 18
months will increase the amount of space devoted
to basic research by only 11 percent. And yet the
amount of HSC research activity has doubled in
the past five years.
"So we're doing twice as much research in the
same amount of space but we're adding only 11
Dr. Doug Barrett has his eye on the Top 10.
percent in research space," said Barrett.
Among his top priorities is to advocate fast-track
status for two construction projects an
interdisciplinary research building that includes a
biodefense research capability, and an expansion of
the Brain Institute that would include space for
advanced biomedical imaging programs. Each
project carries a price tag of $70 million to $100
"That's how far we need to get in order to have
the kind of facilities needed to maintain our
research momentum and recruit the kind of highly
productive new faculty that will get us into the Top
10," he said.
Down the road, Barrett sees the need for a
freestanding children's hospital as well as the
expansion of current clinical facilities. He notes
that in Florida, half of all pediatric hospital
admissions go to only seven institutions, including
Shands at UF. But Shands is the only one without a
distinct children's hospital, one that can best meet
the special needs of pediatric patients and their
In education, Barrett wants to start work on a
new training facility built around the technology
of simulation. UF has already blazed this trail with
the human patient simulator and other
innovations. He sees it as a field that will only grow
in importance, fueled by an emphasis on
strategy continued on 18
LA ~ibaJ rn, "
Forensic science students
are on the case
By Jessica Orr & Linda Homewood
Y you've seen the television shows Crime Scene Investigators -
you name the city. A team picks up samples with tweezers at the
scene of a crime. Scientists in lab coats peer at drug samples and
DNA through microscopes. Experts give testimony in courtrooms.
So who are these people, and how did they get their credentials Recer
anyway? They aren't doctors, nurses or EMTs. They are forensic
scientists, and they go to colleges like UF to get advanced education in the
field of forensic science.
Students like Terry Gallegos, a crime lab coordinator for the Tucson Police
Department Crime Lab, and Mike Byrnes, a special agent with the FBI, convened
this summer in Gainesville to take final exams as their last step toward earning a
master's degree from UF's distance learning forensics degree program.
More than 20 students of forensic toxicology completed their coursework online
so they could work full time while updating their credentials at home.
"This program allowed the most flexibility," said Gallegos, who received her
master's degree and a certificate in forensic toxicology. "The degree will augment
my credentials in court, and it will also help with new methods and programs that
may be brought into the lab."
The UF distance learning program offers master's degrees or certificates in
three areas. Forensic DNA and serology, and drug chemistry degrees are awarded
through the College of Pharmacy. A forensic toxicology degree is awarded through
the College of Veterinary Medicine.
A program that is available in all areas of the country may be especially
important for rural area law enforcement agencies that struggle to keep staff versed
in the latest technology and crime scene techniques.
Byrnes, who lives in Pennsylvania and participates on the bureau's crime scene/
forensic Evidence Response Team, is currently pursuing a master's in drug
chemistry as well as a certificate in DNA and serology.
"I find that this scientific training helps me maintain an analytical mindset,
both toward daily case work and crime scene analysis," Byrnes said. "I also help
teach techniques to other law enforcement agencies and am always interested in
nt graduates of UF's forensic program are ready to use their crime-solving skills.
presenting the most up-to-date information available."
Interest in UF's distance education forensic science program increased in the
past four years, said Ian Tebbett, Ph.D., a college of pharmacy professor and
program director. The program started with a first-year enrollment of 112, and this
year course enrollments are expected to exceed 1,000.
"We expect to see continued growth for the foreseeable time," said Tebbett.
Given the international nature of crime and terrorism, Tebbett has been working
with universities and agencies outside the United States, capitalizing on the
portability of distance learning.
"The goal is to make quality educational materials in forensic science available
internationally and in multiple languages in an effort to develop an international
network of organizations involved in training and education in crime detection
and prevention," he said.
UF has joined forces with the University of Edinburgh in Scotland, the
University of Canberra, Canberra Institute of Technology, the Australian Federal
Police, Silpakorn University in Bangkok and Feevale University in Brazil to
develop and deliver their programs.
Students around the world are finding their way to the program's Web site,
where they can ask questions about registration, courses and credit transfers or
even sample a free case study tutorial.
Elena Ceresa, a student from Ireland currently registered for the online
certificate in forensic toxicology, said her goal is to work in a forensic lab in
"I chose UF because the program seemed well-structured and because of the
professionalism shown in dealing with my queries," she said. 0
HUMAN SIMULATOR MAY HELP FUTURE
VETERINARIANS SAVE ANIMAL LIVES
Professional training through the use of
simulators that imitate real-life situations has
become a way of life in everything from space
flight to emergency medicine. Now, thanks
to a new anesthesia training program at the
College of Veterinary Medicine, this year's
veterinary graduates are the first in the country
to have studied anesthesia using the Human
Patient Simulator, developed as a teaching tool
by UF physicians in the 1980s. Educators say
the experience will make a huge difference in
enhancing students' confidence in handling
emergency situations, as well as their overall skill
sets in administering anesthesia to animals.
Veterinary students take part in an anesthesia
training course involving the Human Patient
PHYSICAL THERAPY TEAM TEACHES UPDATED
TECHNIQUES IN NICARAGUA
Members of the College of Public Health and Health
Professions' physical therapy department recently provided
instruction to the entire faculty of the only physical therapy
education program in Nicaragua.
Gloria Miller, M.A., M.H.S., a program director and
lecturer, Jennifer Stevens, Ph.D., M.P.T., a postdoctoral fellow,
and master's degree students Santiago Villamil and Lisa
Madariaga presented an intensive four-day course to physical
therapy professors at the Universidad Nacional Autonoma de
Nicaragua in Managua.
Nicaragua's physical therapy education and clinical practices
had not been updated in 12 to 15 years, said Miller.
"I'm all about empowering people," Miller said. "When you
teach the teachers and clinicians, you know you'll have an
impact on patient care."
By Sarah Carey
U F scientists have stumbled on a sea turtle
treasure trove that will help them better assess
the endangered animals' health.
Researchers are creating a database of
unprecedented size that will chart blood profiles of
turtles entering the intake canal of a nuclear power
plant in Port St. Lucie.
"This project is significant because the biochemical
components of blood plasma the liquid portion of
blood can help us determine the health status of
both populations of free-ranging sea turtles and those
ill sea turtles brought into rehabilitation facilities,"
said Elliott Jacobson, D.V.M., Ph.D., a professor of
zoological medicine at the College of Veterinary
Medicine and the project's lead researcher.
More than 1,000 turtles are trapped each year in the
Port St. Lucie power plant's intake canal, making it
one of the best sites in the world for access to a huge number of sea turtles. All the
turtles trapped in the plant's canal are removed, weighed, measured and tagged.
When the project began in late July, scientists added a step: They take a small
sample of blood from each turtle before releasing it or sending it to a rehabilitation
"A reliable and sizable database consisting of what essentially are 'blood
blueprints' for turtles appearing normal, as well as for those appearing sick, could
give veterinarians and rehabilitation specialists additional tools for deciding how
to treat these turtles and when to return them to the wild," Jacobson said.
Researchers aim to collect data from 415 turtles the first year and hope to
continue the project for five years.
Today, all sea turtles found in United States waters are federally listed as
endangered, except for the loggerhead, which is listed as threatened. Blood
parameters are commonly used to assess the condition of all sorts of animals,
In the past century, habitat destruction, incidental and intentional harvesting,
amd temperature change have accelerated decline of sea turtle populations
worldwide, according to the Smithsonian National Zoological Park Web site
(http://nationalzoo.si.edu). An increasing incidence of diseases and health-related
problems in the wild pose an additional threat to sea turtle survival.
A group of South Florida biologists and rehabilitation specialists help unload a loggerhead sea turtle from a
Clearwater Marine Aquarium van to a work area within the Port St. Lucie power plant. Aquarium staff took a
blood sample from the turtle, which had been found injured in the power plant canal. They sent the animal to
CMA for rehabilitation, before releasing it back into the ocean.
Collaborators in the project, which is funded by the Florida sea turtle license
plate grant program and managed by the Caribbean Conservation Corporation,
include UF's Archie Carr Center for Sea Turtle Research, Marinelife Center of
Juno Beach and the Clearwater Marine Aquarium. The Archie Carr Center will
create a database based on species, size, sex and water temperature at time of
sampling and will link this data to a Web page where the findings will be available
to those working with sea turtles around the world.
Marinelife Center and Clearwater Marine Aquarium are the primary recipients
of ill or injured turtles found in the canal. Power plant-based personnel from a
federally contracted organization known as Quantum Inc., fish the turtles out of
the canal. Then, Quantum staff members determine if the turtles are sick and if so,
arrange for transport. Staff members release the large, air-breathing reptiles back
into the sea when they seem healthy.
Officials will collect blood from turtles at the power plant and sick ones will be
retested again at the rehabilitation centers where they are sent.
"While people have been collecting data on turtle blood for years, I believe this
may be the largest project of its type in terms of numbers to be sampled," said
Sandy Fournies, M.A., a rehabilitation specialist at Marinelife Center. "Also, this
project will be unique in that the results will be available on the Web."
"Any information that advances our understanding of sea turtles helps us
become better at rehabilitation," Fournies said. 0
FINDING A CLUE
TO A MYSTERIOUS
Doctors have no way of knowing which lupus patients are likely to develop
one of the autoimmune disorder's most dangerous and life-threatening
aspects: kidney disease, which afflicts as many as half of the 1.5 million
Americans who have lupus.
In an article published in Arthritis and Rheumatism, study co-author Hanno
B. Richards, M.D., co-director of UF's Lupus Clinic, and doctors with the
Center for Autoimmune Diseases at the UF Health Science Center describe a
protein they identified that shows up in markedly increased levels in the urine
of lupus patients with kidney disease. They also have located the variant of
the gene that overproduces the protein. The researchers say this may enable
doctors to use a simple urine test to look for the presence of the protein as an
early indicator of kidney disease and could open a door to the development
of preventive treatments.
Richards, an assistant professor in the College of Medicine, said the study
results showed kidney disease was about two to three times more likely to
develop in lupus patients with certain genetic variants that produce a protein
called monocyte chemoattractant protein 1, or MCP1, which acts as a traffic
cop that directs immune system cells toward sites of inflammation.
"All we can do now is quote newly diagnosed lupus patients the statistics
for the chance of kidney disease," Richards said. "We can offer detailed
genetic testing and assess what the likelihood of the disease might be. But
with MCP1, we can screen for the levels in the urine and base our need for
treatment on that."
Dr. Hanno Richards prepares samples to screen for kidney
DEFECT CORRECTED IN UTERO
UF scientists have delivered gene therapy
to the womb and reversed respiratory muscle
weakness in fetal mice carrying a form of
muscular dystrophy. The researchers, writing in
Development, were able to dramatically improve
respiratory muscle function.
Barry Byrne, M.D., Ph.D., who directs the
Powell Gene Therapy Center, said delivering
gene therapy before birth -as the immune
system is still forming could correct lethal
hereditary diseases while evading an immune
system attack against the virus used to transport
the corrective genes and the proteins they
produce. Metabolic diseases could be among
the first targeted with the method, which works to
replace missing or defective enzymes.
GENE THERAPY TARGETS WEIGHT GAIN
Obesity researchers at UF believe pets and
even people may someday benefit from gene
therapy research aimed at breaking through the
biochemical bottleneck that makes middle-aged
mammals gain weight.
A study of obese, diabetic rats presented by
Philip Scarpace, Ph.D., at the Endocrine Society
annual meeting showed gene therapy helped
the animals shed excess weight and eat less by
stimulating production of a brain protein called
pro-opiomelanocortin. The treatment apparently
side-stepped leptin resistance, which occurs
when obese mammals overproduce a hormone
that regulates energy use and appetite and
ceases to be an effective dietary control.
ADDICTED TO FOOD
Four UF studies published in the current issue
of the Journal of Addictive Diseases present new
evidence suggesting chronic overeating can be a
form of substance abuse. The enjoyment of food
and appetite engages the same brain pathways
that snare illicit drugs users, said Mark Gold,
M.D., UF chief of addiction medicine and co-
author of three of the papers.
"What's the difference between someone
who's lost control over alcohol and someone
who's lost control over good food?" Gold
asked. "When you look at their brains and
brain responses, the differences are not very
Study finds racial disparities in
oral cancer treatment, survival
By Lindy Brounley
Black men battling oral and throat cancer in Florida don't live as long as their
white counterparts and are less likely to undergo surgery to treat the disease,
a UF study reveals.
"We found that African-American males in Florida died 44 percent earlier than
did white males, and were also more likely to receive only radiation therapy and
not surgery than were whites," said Scott Tomar, D.M.D., Dr. P.H., an associate
professor in the division of public health services and research at UF's College of
The study, published in Cancer Causes and Control, is one of the nation's first
state-specific reports of racial disparities in treatment and survival of the deadly
disease. On average, black men in the study died a year sooner after diagnosis than
white men a finding consistent with national data showing that white men are
twice as likely as black men to survive five years after diagnosis, Tomar said.
"Our study is unique in that it looks at state-specific data," Tomar said. "This
eliminates a great amount of regional variation in the data. Previous studies that
have attempted to look at issues of racial disparities have used samples of people
from around the country, and they mixed geographic differences with racial
differences, making it difficult to understand what might be happening differently
for blacks than for whites."
Nearly 30,000 people are diagnosed with oral cancer in the United States every
year, according to the National Cancer Institute. Although the number of cancer
cases in general has steadily declined during the past 10 years, black men
historically have been disproportionately represented in the number of new cases,
and their survival rates are dismal compared with those of white men and of
Florida has one of the highest oral and
throat cancer incidence rates in the country
and the fifth highest mortality rate double
the number of deaths than the top four
women of both races.
Florida was of particular interest to Tomar because it has one of the highest oral
and throat cancer incidence rates in the country and the fifth highest mortality
rate double the number of deaths than the top four states combined, Tomar said.
UF researchers examined data gathered by the Florida Cancer Data System on
oral and throat cancer diagnosis, treatment and mortality for more than 27,000
Floridians between 1988 and 1998.
The researchers compared data only on black and white patients; individuals of
Dr. Scott Tomar compared survival rates of blacks and whites who had oral and
other races were excluded from the study sample. The study's final sample size of
21,481 people included 19,331 white men and women and 2,150 black men and
Analysis of the data revealed twice as many cases of the cancers diagnosed in
men as in women. Most occurred in people 51 to 74 years of age, with a median age
of 65 although blacks were significantly younger and poorer than whites at the
time of diagnosis.
The study's most compelling evidence: The cancers of blacks were twice as likely
to have spread by the time of diagnosis. However, regardless of tumor location or
whether the cancer had metastasized, blacks consistently were less likely to
undergo surgery than were whites.
Differences in survival rates were even more striking, with blacks having a
median survival time of 360 days compared with 649 days for whites. Although the
incidence rate for black and white men became nearly equal over the study's 10-
year period, the disparity in survival time did not significantly change.
"There is this difference in how people are treated, and that contributes to the
huge racial disparity in survival. Unfortunately, we just don't know why there are
those differences," Tomar said. "Our next line of investigation is to begin to tease
out some of the answers." 0
FOR MORE ON THIS STORY, VISIT: HTTP://NEWS.HEALTH.UFL.EDU/STORIES/2004/AUG/080304 LINDY.SHTML
NOT FOR EVERYONE
Triage tool assesses Parkinson's patients for surgery
The allure of a new brain surgery technique to relieve the stiffness and
shaking caused by Parkinson's disease may lead to unnecessary operations,
UF researchers say, but a new screening tool they developed could prevent
Researchers and clinicians affiliated with UF's McKnight Brain Institute
described in a recent issue of Neurology the first standardized method to help
doctors triage patients who have the best chance to be helped by a promising
treatment called deep brain stimulation.
"We all know this can be a dramatic therapy for patients, but we want the
right type of patients to get the surgery because they are the only ones who
are going to do well with it," said Michael Okun, M.D., co-director of the UF
Movement Disorders Center and a neurologist with the College of Medicine.
Okun, in collaboration with UF Movement Disorder Center co-directors Kelly
Foote, M.D., a neurosurgeon, and Hubert Fernandez, M.D., a neurologist,
developed the Florida Surgical Questionnaire for Parkinson's Disease, a five-
section triage tool to help general neurologists and health-care professionals
who see the vast majority of patients with Parkinson-like symptoms better
determine which may benefit from the surgery.
"Patients have come into our practice who have already received implants
who would have never received this therapy if they had been screened
properly," Okun said. "We realized all the doctors sending patients our way
were trying to get the best possible care for their patients, but they didn't have
the information to evaluate candidates."
With the operating room lights turned low and the audio speakers
turned up, Dr. Michael Okun watches a monitor and listens to what
an electrode moving through his patient's brain tells him about its
whereabouts during a deep brain stimulation procedure.
SPOTTING EARLY SIGNS OF A RARE BRAIN DISORDER
A rare swelling of the brain that is nonetheless the most common diabetes-
related cause of death for children with the disease could be caught earlier
potentially saving lives if practitioners learn to recognize key signs.
Doctors, long familiar with major symptoms associated with the deadly
complication, may be missing subtler clues that could tip them off to a
problem much sooner, when treatment is most likely to work, says UF pediatric
endocrinologist Dr. Arlan Rosenbloom. And now, after poring over dozens of
medical records on a hunt for crucial patterns, the researchers have devised a
standardized way to screen for these signals at a child's bedside.
Statistical methods were used to identify the combinations of symptoms most
likely to accurately identify the earliest onset of cerebral edema, a swelling of
the brain that can rapidly cause severe brain damage or death. These signs
were incorporated into a bedside protocol researchers then used to evaluate
patients. They included a slowing of heart rate, altered level of consciousness
and age-inappropriate incontinence, along with vomiting, headache or
The screening method was 96 percent accurate in detecting cerebral edema.
In addition, the approach identified four cases of cerebral edema among 69
patients not recognized to have a problem. All had recovered spontaneously.
The study, described in Diabetes Care, also confirmed that many youngsters
with cerebral edema at first have no apparent changes on computed
tomography scans of the brain. Therefore, the diagnosis of cerebral edema
needs to be made at the bedside, and CT scans should be postponed until after
treatment begins, Rosenbloom said.
PUTTING A FINGER ON LIMB DEVELOPMENT
Fingers are key to the art of communication, whether it's a politician
flashing a "thumbs up" to a cheering crowd or a bride displaying a
diamond-bedecked ring finger.
Now scientists at UF and Harvard University have described how the art
of cellular communication -how cells "talk" and what happens when they
stop -plays a crucial role in normal limb development and the formation
of digits in mice, a discovery that sheds light on the same process in
people. The researchers detail their discovery in the journal Cell.
Why the five fingers on a hand form into the sizes and shapes they do
and the fundamental mechanisms that cause some people to be born
without fully formed fingers or extra fingers has been a mystery until now.
Understanding the development process could someday help doctors
correct defects before birth or help regenerate limbs lost to accident or
amputation, researchers say.
The findings also could shed light on the development of the body's
more-critical organs, said Brian Harfe, Ph.D., a developmental biologist at
the College of Medicine and the paper's lead author.
"This is the first time anyone has figured out how the body regulates
the size of not just of the limb, but possibly of other organs during
development," he said.
Libraries battle to unlock online access
E.,' E--!!!: T i i ll.
1 IiILLiInl Ini, rinls ma\ he convenient, but the
\ .! \ am..]-lhl ll\ ''I I h Ii! mji has put information
-"ul ''I iuLJh 1.ri man\ LJcdmrLc medical libraries
anJ IhLii pr i rn..
[uLli ak I1i hLjlih p..lI \ jan lvst Jeffrey Scott,
Ih 1) h.. \'.j -. nJu lI !ni ia i rature review for a
!IL.aJich PI-!ILI ,~ jI m.nJ ih ago when he was
JLrn J rn ilirn .JI. i.. Thl J.:i,i ral oftheAmerican
.1 Ji d, .-1 at .?. t.?,,
"I '.a. Jurrmhl.unrJJ." hLe !J "Not having
ja ,,n mjakL, !i \!l\ Jdillul I i. achieve a certain
Ii\ l I ..I p!..Juil i'\ !LLquiiJ I..! the work I do."
,.. II hjJ i.. J ..p ,'.h i hl h '. as working on, leave
h! .. Il r! in ihe I jlih I'!..l ions/Nursing/
I'haj mJL\ ( ..mrr p\ jnJ hujJ io the library to pull
I h Iiu!i rin l II I hie hIll
I'he ri%'. nrilirin m.Jium changing the way
pu!hilh.l!, parkaJci anJ pl ib heir product-and
L alji i ncriL I' uL alji i n, I. i researchers like Scott
t h.. nriJ ih !ii lih!i i a Lin'l always afford to pay.
I'uhiheL hi\.L i aiJ Ihei i jtes for online access
hLLjuM mrrI.! i!nJ! Jduaji aJ!e anceling their
uhl.L! pi !..nr, nJ jaid ,,!ir: i he information
Ih!,,ui h i he Inlir n l uinL-. institutional
,uh, !pl !i.n, Il!ih p! !Ls, !usirict access, leaving
iu! !ril pulsh!,hi h'IJdirni he keys to the
LIl li.nir Jdjijhja ..I ..,11'Il !\e knowledge. Many
l 1,- .. I ih h lunimi puhlihirng model say only
u n !i u I l .. ". rpLn" ~JLLLa i.. academic research
ILfI.p aI n jr~a i lcu ihe public and other
scientists unfettered admission to federally funded
The issue hit home this spring and summer at
I h, I Icalth Science Center Libraries, which was
un hki to pay for online subscriptions toJAMA
anJ another leading scientific journal, The New
E; %lan Journal of Medicine. Both journals are
available online today, but for the price of a year's
ubh .L ipi i. n to both journals, librarians could have
bought a shiny new car. That the largest teaching
mldiL jl center in the Southeast did not have timely
a.LLc. o1 medical research findings may seem
shocking, but universities nationwide are facing
ih saim. chalklnges.
FROM PRINT TO PIXELS
WhInI hU! I! lil!ii aj ur review, general research
or for acquiring a copy of a particular scientific
article, online access is an increasingly necessary
service to maintain, according to HSC librarians.
Online peer-reviewed journals have become the
primary medium for medical research publishing
because they are fast, timely and efficient.
William Riffee, Ph.D, the associate provost for
distance, continuing and executive education and
dean of pharmacy, said his 800 off-campus,
distance-learning students have a particular need
for electronic access to library journals, but that it
is necessary for all faculty and students.
"If we don't have electronic access we have got to
walk over to the library, or send someone over, find
a journal, photocopy it, bring it over here to our
office to make use of it for our students. In this day
and age of electronic connectivity it is absolutely
asinine to have to do that," Riffee said. "And for us,
for our faculty and students, electronic access to
the medical and scientific literature is absolutely
essential for our research."
Medical health libraries, including those at UF,
are under pressure to subscribe to a burgeoning
number of electronic journals, databases and
publications. At the same time, institutional
subscription costs have skyrocketed from 10
percent to nearly 2,000 percent, depending on the
journal, as publishers consolidate and bundle their
journals. The transition to the online revolution is
straining library budgets, publishers' profit
margins and the public's ability to access medical
information old and new.
Faith Meakin, director of the Health Science
Center Libraries, said few research professors and
even fewer students still want to use the hard copy
of a journal.
"Right now we are moving more and more to
only getting an electronic format," Meakin said.
"We are a very on-demand society. We want things
when we want them, and we want them now. So
this format appeals. In some cases there isn't a hard
copy at the library. Some major publishers, Elsevier
for example, require that somewhere in the state
library system someone must subscribe to the print
version. But most of the faculty, to be honest,
would be perfectly happy if they never had to come
into the library again."
r convenience comes at a price, I
and academic institutions are
bearing the burden.
Lenny Rhine, Assistant Director for
Collection Management, said the HSC library
has seen rates jump in the past year for e-journals.
For example, he said the library paid $345.80 in
2003 for a print edition of JAMA and that price
included online access for the institution. In 2004,
the price for a print subscription was $379.05, but it
did not include online access. Instead, the 2004
price for online access toJAMA was $6,690 a
roughly 1,800 percent increase for the same
information. If access to the AMA's online archives
is thrown in it raises cost to $9,690.
"WhatJAMA deduced is that they were losing a
significant number of print subscriptions because
the institutions had the online access with their
single print subscriptions," Rhine said. "Therefore,
they changed the pricing model to maintain the
Meakin added that many students and faculty
who subscribed to journals dropped their personal
subscriptions and use their UF IP address to access
the e-journals with the HSC subscription licenses.
Smaller publishers have been purchased by
conglomerates, such as the British-Dutch Reed
Elsevier, which supplies more than 20,000
scientific, technical and medical products,
including journals, books, databases and portals.
The conglomerate has the ability to bundle
thousands of journals and price them much like a
cable company bundles and prices cable channels,
putting the more desirable journals or channels
into the higher-priced bundled packages.
The University of California at San Francisco
and Cornell University are among those that
boycotted Elsevier rather than accept a bundle
agreement. Earlier this year, UCSF was able to
negotiate a systemwide agreement with Elsevier to
keep inflation down. Journal subscription costs,
a% h.ih>i in electronic or print f..i mn. i\ pijIllI
in!iLJL \ percent to 10 percent \ji!lI\
In [ul\. authors Joan B. Schl:mrngn anJ \I !\hajl
k. Kionenfeld published an ji I le in the Journal of
the Medical Library Association that followed the
total cost and average cost of the 111 journals on
the Brandon/Hill list of journals for medical
schools and analyzed those figures with regard to
the Cost Price Index (which measures inflation)
from 1967 to 2002.
The authors found the cost for the period
increased more than 2,300 percent. Information
that would have cost $1,643 to purchase in 1967
today costs $40,406. In 2002, a hospital library
with a budget that had increased at a rate
corresponding to the CPI could purchase 20
percent of the journals it had purchased in 1967,
the study said.
Meanwhile, the UF library funding, which
primarily comes from the State of Florida's
dedicated libraries acquisition budget, is not
increasing nor is the HSC Libraries' share of the
"The Health Science Center library receives less
than $2 million in acquisitions money,
and $35 million goes to the other state
university libraries including others at "Ri
UF," Rhine said.
Additional funding comes from the to
department of sponsored research, which
is responsible for divvying up the
research grant monies that flow into UF pe
Rhine and Meakin said the Health int
Science Center brings in about 55
percent of UF's total grant money and
receives only about 16 percent of the
indirect cost assigned to UF library
Meakin said the funds that come from the state
are devoted to securing the libraries' educational
materials for students and teachers, and the grant
funds disbursed by the department of sponsored
research are dedicated to supporting the HSC's
researchers. At this time, she said, there is no
funding source dedicated to the libraries' support
of the clinical function.
Once the repository for information, academic
libraries are fast becoming an information gateway.
With the shift to e-publishing, journal publishers
now hold and maintain the research databases and
are becoming the keepers of collective knowledge.
And when the library can't afford an online
subscription, faculty, staff and students lose access
to the journal archives as well as to the current
I jJ! i ..n !Ill\. l!h! !!i t I hi pi !\ l, ..I I he
Lh..1lj I\ IL ..diJ 11 'L l..p j Iuhb L ipi ..n I..%
a--., I. I hI .rInlin> Il.uinil volumes we had
pi!c i..ulI\ paJJ I .." ,\.l jkin said. "It is like
renting a car. We have no ownership of what we
paid for in the past. The publishers control the
rights to the scholarly research. We are concerned
about the university's right to have access to the
intellectual property produced by its faculty, staff
and students. What will happen if, say, the journal
goes out of business? All that information goes
While academicians provide content for these
journals, and edit and peer-review the articles, it is
the publisher who owns the copyright and makes
Moreover, as users' institutions cannot afford
access, the potential influence of many articles is
lost. The impact of an article is the extent to which
it is read, built upon and cited. Researchers vote on
the relevance and use of an article by using and
citing it. Before researchers can cite an article, they
must be able to access it.
How can the public regain control of public
knowledge, especially that which is federally
ght now we are moving more and mo
only getting an electronic format. Most
the faculty, to be honest, would be
rfectly happy if they never had to cor
o the library again."
Faith Meakin, Director, HSC Librari
There is an international movement attempting
to break the publishers' stranglehold over the flow
of information it's called open access. The term
refers to a model where researchers pay to cover
publishing fees and users can access research
findings online free.
There are many initiatives that are attempting to
address the issues of open access, copyright and
scholarly information. The nonprofit organization
of scientists and physicians, the Public Library of
Science, has started a free and open access biology
journal and plans to launch a medical journal this
fall. Researchers pay about $1,500 for publication
and printing costs with funds written into their
grants and readers access the information for free.
Although providing a free online peer-reviewed
forum is gaining some support in the academic
community, it is still a gamble for individual
scientists who base their reputations on publishing.
Many scientists are hesitant to move to the open
,, i\ Ltrem because researchers are bound to
puhi ih in ,i .ihhl!,hJ journals. In acjdcmij.
Le !i nl !ii .pJIi .n J! buil ..n heir publishing
!.i-.J W\\hhIh Ih.\ i ILn.nu!i.. a promotion or
win grant i u n J i n ..I J n d. pL n J on which refereed
journals accept inJ pubhlih Iheii work. Some
journals, st~ih j.-1~..-1, I hI .\::, England Journal
of Medicine, Science, Cell and Nature, are considered
to be the most competitive, hence the most
"I like the theory, and everyone likes the th.. \
of open access," said Brian Harfe, an assistant
professor of developmental biology at UF. "Bui
until these journals have the reputation, it is iall\
hard for us to publish in them, particularly a,
someone who is just establishing a repul i !.. n "
In February, Elsevier said open acc ,,. j, j
publishing model, was not financially !jhe ..I!
"Publishers are unlikely to cover puh Ii hi nri
costs with revenues of just $1,500 per ai I Ak."
company officials said in a written corrir nL "1 .I
universal access to be a reality, published muiI
continue to make articles available in mull lpk
media formats. To rely on the Internet jI..ne I..
distribution, as most Open Access joui n r, J...
risks reducing levels of access, m ..rn
these beneficiaries: only 11 pri! Lnl ..I I he
re world's population uses the Inrii nei "
Recently the open access m..' r~ mni
t gained official sanction.
A British House of Comm.. n
committee and the appropril ..n,
S committee of the U.S. Houst ..I
Representatives have both m..rr J i.
support the open access forum I, I
publicly funded research. The
es appropriations committee recommended
that the National Institutes of Health
provide the public with free, online
access to federally funded research in PubMed
Central, a popular digital archive maintained by
the National Library of Medicine, by 2005.
As a response, a handful of publishers are
accepting various aspects of a new open-access
business model. For one, Elsevier is now allowing
institutions or authors to republish their own
research on their institutions' Web sites after it
appears in one of its journals.
Riffee said it is necessary for researchers to take
charge to ensure access to their work and the work
of other faculty.
"There has got to be some national
organization," Riffee said, "in which we gather
those who contribute and subscribe to these
journals who can then talk with publishers such as
Elsevier and others and say, 'This is our
intellectual property so why don't we negotiate
subscription rates. Let's talk about what kind of
revenue streams you publishers need, but keep
those subscription rates within reason so that we
can access the information.'" 0
E., T. !!!
Dr. Thomas Wright and Dr. MaryBeth Horodyski are among two dozen faculty who will call the orthopaedics building their new home.
UF orthopaedists will have more elbow room rehabilitation. "We'll have accommodations for many
beginning with the September opening of a $25 outpatient procedures, research labs, radiology
million facility. Here patients with a variety of bone, services and academic offices for all the faculty in the
joint and musculoskeletal problems can be seen, same building."
diagnosed and, in many cases, treated under a single Shands HealthCare will provide occupational and
roof. The building ranks as one of the nation's largest physical therapy services, Gearen said. A division of
and most comprehensive orthopaedics and sports UF's radiology department will operate a diagnostic
medicine facilities. imaging center featuring X-ray, magnetic resonance
imaging and computed
"Clinics now located miles apart will be The orthopaedics
under one roof accommodating outpatient surgical practice will remain
at Shands at UF.
procedures, research labs, "By bringing our
radiology services and outpatient programs
together we'll have
academic offices for all the additional operational
efficiencies," Gearen said.
faculty in the same building." "A central location will also
be a more convenient for the
Peter Gearen patients and the physicians.
We've worked hard to create
a welcoming environment
for our current patients and
for new patients who are
UF's new Orthopaedics and Sports Medicine referred to us."
Institute is located at the intersection of southwest The building contains several features new to the
34th Street and Hull Road. The four-story, 120,000- orthopaedics department, including a sophisticated
square-foot building also will serve as headquarters human motion laboratory equipped with high-speed
for the College of Medicine's department of cameras that can record movement from every
orthopaedics and rehabilitation, viewpoint, Gearen said.
"Clinics now located miles apart will be under one "The motion analysis laboratory will enable
roof," said Peter Gearen, M.D., a UF associate physicians to analyze problems ranging from
professor and chairman of orthopaedics and neuromuscular disease to poor athletic form," he
said. "We'll serve patients ranging from disabled
children to professional athletes to grandparents
rehabilitating after joint-replacement surgery.
"Once all orthopaedic faculty are housed under
one roof, they are likely to interact more," Gearen
added. "Being together will strengthen collaboration
efforts and make translation of research from 'bench
to bedside' easier."
The building's site was chosen in part because it
offered easy access to a major traffic artery, said A.
Miles Albertson, associate director of facilities
planning and construction for the Health Science
"The idea of having a clinical building just
dictates that it has to be somewhere patients can get
in and out without a lot of hassle," said Albertson,
who has served as the project manager for the site for
about two years.
Patient considerations also require a fast, precisely
orchestrated start-up, Gearen said. Although
furnishings and equipment have been installed
throughout the summer, relocation of more than 150
employees must be accomplished during the Labor
Day weekend. Patients will be seen at the old
locations through Sept. 3 and at the new building
beginning Sept. 7. No break in patient care is
"It's been a huge undertaking," Gearen said.
Albertson and Gearen praised the administrative
staffs of the UF orthopaedics and radiology
departments and Shands at UF for their efforts
preparing for the move. Gearen said Albertson and
Doug Cruce, a project manager for builder Turner
Construction Co., have been indispensable during
the transition. Q
PATIENT, AUDIOLOGIST SOUND
ALARM FOR AWARENESS OF
Sam Haddad heard a faint hissing
sound in his ears for as long as he can
remember. But that changed suddenly
one day in 2002, when the soft noise
became a roar.
"The noise in my ears was so loud,
I could barely hear voices," Haddad,
manager of the industry relations
office at John F. Kennedy Space
Center and a Titusville resident, said.
Haddad's physicians said he had an
untreatable condition called tinnitus,
the perception of sound in one or
both ears when no external sound is
present, often referred to as "ringing in
When his doctors told him it would
worsen over time, Haddad turned
to an internationally recognized
expert on tinnitus treatment, James
Hall III, Ph.D., chief of audiology at
the UF Speech and Hearing Center
and chairman of the department
of communicative disorders at the
College of Public Health and Health
Hall used a component of tinnitus
retraining therapy, a technique that
helps a person gradually ignore the
sound of tinnitus. The method involves
extensive counseling on tinnitus'
causes, and a custom-fit device placed
in or behind the ear that creates
distracting soft, pleasant sounds.
"At my first meeting with Dr. Hall he
predicted that within six months, the
hissing noise in my ears would be back
to the low level I had before," Haddad
said. "I thought that was unbelievable,
but when the noise was gone after a
month, I called Dr. Hall and told him
he was a miracle worker!"
Sam Haddad of Titusville, who suffered from tinnitus, has his hearing
checked in the UF Speech and Hearing Center at Shands at UF. After
James Hall, Ph.D., custom fit a device behind Haddad's ear to create
distracting soft sounds, his tinnitus diminished. Haddad said, "I thought
that was unbelievable, but when the noise was gone after a month, I
called Dr. Hall and told him he was a miracle worker!"
NEW HELP FOR STROKE PATIENTS
Two decades is too long for stroke victims to wait for science to assist
With that in mind, UF and the Department of Veterans Affairs have
joined forces in a $2.7 million mission to accelerate research with the
greatest potential to help people with strokes and other brain injuries.
Called the Translational Research in Rehabilitation Initiative, the effort
will recruit three new faculty members to the College of Medicine's
Department of Neuroscience and marshal the talents of UF scientists and
physicians to drastically shorten the time between scientific discovery and
the development of therapies to improve the lives of stroke patients. On
average, it takes 17 years before discoveries in clinical trials are routinely
incorporated into medical treatment.
"We want to shorten the period of time to something far more
immediate," said Leslie Gonzalez-Rothi, Ph.D., a neurology professor.
"Our goal is to do a much better job translating discoveries in animals in a
timely fashion to reconstruct the damaged nervous system."
TEAM PERFORMS RARE LIVER SURGERY
UF surgeons at Shands at UF medical center recently performed a
rare ex-vivo liver resection procedure on a patient suffering from liver
cancer. The eight-hour surgery was performed in April, and the patient is
reported to be doing well. According to Alan Hemming, M.D., director of
hepatobiliary surgery and an associate professor of surgery in the College
of Medicine, the ex-vivo (out of body) procedure is appropriate only for
patients with liver tumors that are not capable of being removed by surgery
with standard operative techniques.
"This procedure is a radical one that is only used in the most dire
circumstances...so it's not something that has been used very often,"
said Hemming, one of only a handful of surgeons worldwide who have
performed this surgery.
FOR MORE INFORMATION ON THIS STORY, VISIT
WWWNAPA UFL.EDU/200NNFWS/VA-STROKF HTM
Occupational therapy chairman explores
technologies to aid seniors
By Jill Pease
As America's population ages, seniors and their families are searching for ways to extend
independence and quality of life. The work of William Mann, O.T.R., Ph.D., is leading the way
in technologies that will enable seniors to live in their homes and drive safely for longer.
Mann, chairman of the department of occupational therapy at the College of Public Health
and Health Professions, guides the development of new assistive technologies devices
designed to make everyday tasks easier for seniors and people with disabilities as the
director of the Rehabilitation Engineering Research Center on Technology for Successful
Aging. In his other major research role as director of the National Older Driver Research and
Training Center, Mann and his colleagues offer interventions to help older people drive safely
longer and provide counseling, education and training on alternatives to driving.
"Bill Mann has been a strong voice within the profession of occupational therapy for
attention to the issues of aging and disability," said Frederick P. Somers, the associate
executive director of public policy of the American Occupational Therapy Association. "His
leadership in promoting independence and quality of life for older people with disabilities
through technology is unsurpassed."
And Mann has the distinction of leading a department that has the largest research
enterprise of any occupational therapy academic program in the United States, with faculty
research that is widely recognized for advances in aging and technology and rehabilitation
Boasting one of the first and the largest distance master's degree programs for practicing
occupational therapists in the country and the addition of a new clinical service in older driver
assessment, the department is a leader is fulfilling its education and service missions as well.
Mann champions a climate of shared goals within the department.
"The department works hard to recruit the very best faculty, staff and graduate students,
who can take responsibility for given areas," he said. "I give them the responsibility and
appropriate resources, and good outcomes happen I don't have to hover or micro-manage.
My role is to be available to help with developing ideas and to deal with difficult problems. I
believe in hard work, but it should be fun.
"A very important goal of mine is to see junior faculty and doctoral students grow and
develop strong research careers," Mann said. "Mentoring at the faculty, postdoctoral and
doctoral levels is something I consider critical, and given my long career as a researcher, it's
something I take very seriously."
The chairman of the occupational therapy department at State University of New York at
Buffalo and a faculty member there from 1974 to 2000, Mann was drawn to the chairmanship
at UF because of the opportunity to lead a department while devoting a significant amount of
time to his own research, which has been funded by more than $23 million in research awards
over the years.
At the Rehabilitation Engineering Research Center on Technology for Successful Aging,
Mann is partnering with Sumi Helal, Ph.D., a UF professor of computer and information
science and engineering, and private industry to develop a fully equipped "smart house" with
a centralized computer network voice commands voice to turn on appliances and open and
close window curtains for its aging occupants. Construction of a smart house is under way at
the Oak Hammock at UF retirement community and researchers will soon be able to conduct
research on "smart technology" in a real home environment.
As the director of the National Older Driver Research and Training Center, Mann addresses
another aspect of elderly independence, the ability to drive safely for as long as possible. 0
14 1.1.1i U.
HIGH-VOLTAGE LAB MANAGER HAS IMAGES TO UPHOLD
By John Pastor
An extraordinary mouse had died.
It was unusual, for one thing, because it received a bone-marrow transplant.
Furthermore, it was a transgenic mouse, meaning DNA had been artificially
introduced into the animal's genes. More important, it was the last surviving
mouse in a vital experiment.
When it unexpectedly died late on a Friday afternoon, the researcher was
confronted by a dilemma. Who do you call when your genetically modified
mouse the sum of years of work inadvertently expires on the weekend? And
don't say "Ghostbusters."
Enter Tim Vaught, the manager of the Optical Microscopy Facility at the Evelyn
F. and William L. McKnight Brain Institute
"We called this one the 'million-dollar mouse' because all of its siblings had
died, but this one went the complete term of the research," said Vaught, who
interrupted his weekend for the anxious scientist.
Emergency sessions are part of the routine for Vaught, who has imaged
everything from alligator eggs to human DNA. He dashes off the features of the
optical microscopes like a BMW dealer talking about the 7 Series: "We got the
Decon first, the Confocal a couple of months later and a couple of months later, the
Zeisses. I can teach anyone the basics in an hour. The first couple of times people
use them, I want them to do it while I'm here so I can jump in and say, 'wait a
second. I can make that picture better and I can show you how."'
Ironically, Vaught's background is not in optical microscopes, but in electron
microscopy and engineering. In fact, Vaught, who lives in Gainesville with his
wife, Kim, the director of community improvement for the Gainesville Area
Chamber of Commerce, and their two children, can make lightning strike. That's
"The man who taught me was the first one to ever engineer a lightning strike
over land, and the one who taught him was the first one to ever do it over water,"
Why would anyone want to do that?
"In our case, several companies from France, Germany and Canada were
confident that electrical equipment in houses wouldn't be damaged if lightning
struck the power lines," Vaught said. "So we set up power lines and built three
mock houses in Starke to test the claims. We worked through the summer. At the
end of two months, the biggest thunderstorm I've ever seen rolled in. We shot one
"The stuff in the houses got fried," Vaught said, "but making lightning strike on
cue helped get the property and all equipment donated to UF." 0
LEARN MORE AT: WWW.MBI.UFL.EDU/FACILITIES/OM/
HEALTH SCIENCE CENTER
RUSSELL E. ARMISTEAD,
has been named Health
Science Center associate
vice president for finance
and planning following
a national search. He
began his duties Aug. 16.
Armistead spent 24 years
at Wake Forest University,
where he served as vice
president for health services administration for
10 years and managed all business operations
for the university's nationally prominent medical
school. He holds a bachelor's of science degree
in business and accounting and an M.B.A. He is
a certified public accountant.
FAITH MEAKIN, director
of the HSC Libraries, was
elected to a three-year term
on the board of directors
for the Medical Library
Association and named
as an MLA fellow for
"sustained and outstanding
contributions to health
Meakin has also been chosen for the 2004
edition of Who's Who in America.
BETH LAYTON, HSC
Libraries' deputy director,
won an Association of
Academic Health Science
Scholarship to attend the
Association of College &
Leadership Institute for
Academic Librarians in
At the MLA 2004
conference LENNY RHINE,
librarian, received the
award in recognition
of his "dedication and
outstanding service and
leadership in international
cooperation and outreach."
The HSC Libraries received First Place in MLA's
2004 Creative Promotions contest for the
'RxEAD: Prescription for Knowledge' campaign.
Kicked off during National Medical Librarians
Month in October, the campaign, which displayed
large posters and bookmarks of HSC deans and
administrators posing with their favorite books,
aim to raise the visibility of the libraries, creating
and reinforcing connections with patrons.
CHARLES G. WIDMER,
D.D.S., M.S., an associate
professor of orthodontics, has
been appointed director of
clinical research at the Parker
E. Mahan Facial Pain Center.
Widmer has been a member
of the center since 1993 and
conducts an active research
program in jaw muscle
biology and orofacial pain. As director, Widmer
will provide leadership to the center's plan to
emphasize on clinical research in orofacial pain.
NICHOLAS BODOR, Ph.D., D.Sc., a
College of Pharmacy graduate research
professor emeritus, was awarded the Gold
Cross of Merit of the Hungarian Republic
by Hungarian President Ferenc Madl.
Madl lauded Bodor's contributions to the
international field of drug development and his
leadership at the IVAX Drug Research Institute in
BOSE, Ph.D., an assistant
professor of physiology and
functional genomics, received
a three-year grant for almost
$180,000 from the March
of Dimes and a three-year
grant for $240,000 from the
American Heart Association
to study a protein that fosters
cholesterol transport in mitochondria, to make
Gov. Jeb Bush has tapped
MARTIN LAZORITZ, M.D.,
to help the state come up with
drug options for doctors
who treat Medicaid patients.
Lazoritz, associate chairman
for clinical operations in the
psychiatry department at the
College of Medicine, was
recently the first psychiatrist named to Bush's
Medicaid Pharmaceutical and Therapeutics
Committee. The committee oversees a voluntary
preferred drug program that produces a list of
cost-effective drugs physicians may prescribe for
Three medical students received American
Cancer Society R.G. Thompson Memorial
Summer Research Fellowships. Each student
received a $2,500 research stipend. The
projects' principal investigator was James Zucali,
Ph.D., a professor of medicine.
HILLARY ZALAZNICK, a fourth-year medical
student, is studying thyroid nodules in an effort to
identify risk factors that would help practitioners
distinguish which are symptomatic of benign
thyroid disease and which are actually cancerous.
Her faculty mentor is UF pathologist Nicole
KARLY KAPLAN, a fourth-year medical student,
studies combining breast reconstruction with
mastectomy. Her mentor is Jason Rosenberg,
M.D., an assistant professor of plastic and
COLIN E. MOORE, a second-year medical
student, conducted a population-based study
of bone disorders, Maffuci's syndrome and
Ollier's disease, and evaluated the incidence of
malignant degeneration. His mentor is Mark T.
Scarborough, M.D., an associate professor and
chief of the division of orthopaedic oncology.
The National Institutes of
Health awarded a five-year
grant totaling $1.25 million
to W. CLAY SMITH, Ph.D.,
a UF assistant professor
of ophthalmology, to
investigate how a crucial
eye protein moves back
and forth in retinal cells.
The protein, arrestin,
stops a chemical reaction that converts light into
nerve impulses so the reaction can begin again.
Arrestin's movement probably plays a role in
controlling the sensitivity of our eyes.
PATRICK J. ANTONELLI, M.D., has been named
chair of the College of Medicine's Department of
Otolaryngology following a national search. He
succeeds Kevin Robbins, M.D.
Antonelli has been at UF 10 years, serving as vice
chairman of the department since 2001. He is
also assistant dean for clinical informatics of the
college and chief medical information officer at
College of Nursing doctoral students DEBORAH
CANTERO, ANNETTE KELLY and CHARLES
ZEILMAN are recipients of a $5,000 scholarship
given by the American Association of Retired
Persons (AARP). The scholarship, given in honor
of Betty Severyn, a recently retired AARP national
board member and College of Nursing alumna,
was awarded to support nursing students whose
research explores aging related issues.
A SALUTE TO SERVICE
Investigators affiliated with the Brooks Center
for Rehabilitation Studies and the College of
Public Health and Health Professions have
recently secured a host of grants to fund
stroke rehabilitation research.
Supported by a $1.5 million grant from the
National Center for Medical Rehabilitation
Research of the National Institutes of Health,
STEVEN KAUTZ, Ph.D., an investigator at
the Department of Veterans Affairs Brain
Rehabilitation Research Center and the
director of the Brooks Center's Human Motor
Performance Laboratories, will lead a group
of researchers investigating the mechanisms
responsible for walking impairment in
patients diagnosed with stroke.
Director PAMELA W.
DUNCAN, Ph.D., leads
a program to reduce the
risk of a second stroke
and maximize quality
of life for veterans
with stroke that was
recently funded with
a $1.1 million grant
from the VA Health Services Research and
Additional Brooks Center researchers have
recently received grants:
HUANGUANG "CHARLIE" JIA, Ph.D., a
research health scientist at the RORC and an
ad unct professor in the department of health
services and administration, will research
Florida veterans' use of health-care services
and outcomes after stroke with $376,052 in
funding from the VA Health Services Research
and Development Service.
CHRISTOPHER JOHNSON, Ph.D.,
an assistant professor of health services
administration and a research health scientist
at the RORC, has received a $398,000 VA
Health Services Research and Development
Service grant to research the utilization and
quality of care for veterans diagnosed with
stroke receiving community nursing home
care paid for by the VA.
CRAIG VELOZO, Ph.D., an associate
professor and associate chairman in the
department of occupational therapy, in
collaboration with Shelley Heaton, Ph.D.,
an assistant professor in the department of
clinical and health psychology, is funded by
a three-year, $346,135 grant from the NIH.
They are working to develop a computer-
based model for assessing cognitive
functional status of patients with a traumatic
brain injury that is accurate, efficient and
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James Keedwell III
Melanie Fridl Ross
JACKSONVILLE ORTHOPAEDICS DEPARTMENT
LAUNCHES PODIATRY RESIDENCY PROGRAM
Good news for aching Florida feet: UF's Health Science Center Jacksonville recently
launched the university's first podiatry residency program, one of a small number
nationwide based at an academic institution.
The three-year program, offered by the department of orthopaedic surgery at UF's
College of Medicine Jacksonville, gives budding doctors of podiatric medicine a broader
medical and surgical education than many residencies, said Stephen Meritt, D.P.M., a UF
instructor of orthopaedic surgery and director of the program.
"It's the future of our profession," said Meritt, a board-certified podiatrist in private
practice for almost 30 years and a staff member at Shands Jacksonville.
Launched in July, the program currently has two first-year and two second-year students, he said. Beginning
next year, a total of six students will be enrolled.
Northeast Florida patients can benefit from the new source of podiatric care, and the program gives the
orthopaedic surgery department a chance to forge new professional relationships, said B. Hudson Berrey, M.D.,
a UF professor of orthopaedics and rehabilitation and head of orthopaedic surgery on the Jacksonville campus.
"We have a lot of interest from the podiatric community here," said Berrey, who helped organize the
program. "It will help us with our interactions with the community providers and be a source of future patient
The program also is one of a handful nationwide that bases podiatrists at the same institution throughout
their residency, following a model developed by the national accrediting agency, the Council on Podiatric
THE LEGACY OF HEROES
Traveling multimedia exhibit honoring orthopaedic surgeons who served in World War II will visit Shands
Jacksonville in September. Titled "The Legacy of Heroes," the exhibit, including photos, written accounts
and a film, honors orthopedists' service to their country and the medical advances they made possible.
Health Science Building Atrium
653 W. 8th St.
Sept. 16-17, Sept. 20-24
9 a.m. 5 p.m.
A reception will be held at 6:30 p.m. Sept. 21
at the same location.
H. MARTIN NORTHUP,
M.D., brought home the gold,
but he didn't have to go to
Athens for it. A professor of
radiology at UF's College
of Medicine Jacksonville,
Northup was the 2004
recipient of the Florida
Radiological Society's Gold
Medal Award, presented to a
member of the society for outstanding achievement
in diagnostic and therapeutic radiology. The award
was presented July 10 at the society's annual
meeting in Fort Lauderdale.
Kidney transplant expert
THOMAS G. PETERS, M.D.,
director of the Jacksonville
Transplant Center at Shands
Jacksonville, has been elected
to a three-year term on the
American Society of Transplant
Surgeons' executive council,
its governing body. Peters will
serve as a councilor-at-large,
working with 11 other physicians, including current
society President Richard J. Howard, M.D., Ph.D.,
a professor of surgery at UF's College of Medicine
in Gainesville. The society is the world's largest
organization for transplant surgeons.
The executive committee of the Society of Thoracic
Surgeons has named FRED H. EDWARDS, M.D.,
professor of surgery and chief of cardiothoracic
surgery at UF's College of Medicine Jacksonville,
as the chairman of the Society of Thoracic
Surgeons National Database. Edwards will oversee
management and use of the database, which
tracks patients in three categories adult cardiac
surgery, general thoracic surgery and congenital
heart surgery and is an important resource
for physicians analyzing surgical outcomes, risk
assessment and other issues. With more than 2.5
million patients enrolled since its inception in 1986,
it is the world's largest thoracic surgery clinical
strategy continued from 4
interdisciplinary learning and the opportunity
provided by simulation to "really attack the problem
of error reduction."
Operationally, Barrett has two areas of focus. The
first is an ongoing effort to bring greater clarity to
the organizational role of UF's major health-related
centers and institutes, especially in how they relate
to colleges and departments. That activity will be
coupled with an effort to flesh out plans for the
university's less mature strategic initiatives in aging,
children and families, and the environment.
At the same time, he will work with Armistead
and the HSC college deans to begin to formally
implement "responsibility-centered management
principles" essentially the decentralization of
management responsibility such that "decision
making and financial accountability reside as close as
possible to where the real work of a university
occurs. That is in the colleges and departments."
As much as this approach will require a "culture
change," the HSC colleges have already been
working in this direction for several years. Said
Barrett: "We will be leaders of responsibility-
centered management within the university."
Even though he is eager to get there, Barrett
recognizes that breaking into the top echelon of
public institutions is something that can't happen
tomorrow, next week or even next year. It is
something that has to be achieved, step-by-step, good
decision by good decision, over a number of years.
"I'm a marathoner, not a sprinter," he said. "At UF
we have an opportunity to be among the best. But big
goals, like finishing marathons, are ultimately
reached by steady focus and persistence. Our Health
Science Center is made up of remarkably talented
people. With teamwork and dedication, we can help
make UF a truly great university." 0
at the College of Medicine, spoke to POST staff about his views
on the need for additional medical schools in Florida.
Does Florida have a physician shortage?
Based on numbers of physicians per 100,000 people, the answer would be no. Florida is the
fourth-largest state and has the fourth-largest number of physicians. However, there are several flaws
in looking at such a raw number. First, the data is flawed, and Florida does not have a database to let
The procs us know how many registered physicians are practicing or how much they are practicing. Second, the
real issues are where physicians are practicing, which specialties they are practicing and the scope of
their practices within their specialties. Lack of this information inevitably leads to making an assessment
based on how long it takes to get an appointment with a physician, which is not very comforting.
Regardless, as the population ages, Florida grows, that population increasingly ages, the malpractice
climate in Florida remains unchanged and the gender of physicians increasingly changes, I believe there
we gradual is no doubt that Florida will have a shortage of physicians in the future, regardless of how a shortage is
PHOTO BY LISA BALTOZER defined.
Which public universities are looking at establishing medical schools,
and what process is in place to influence this activity?
Florida International University, the University of Central Florida and Florida Atlantic are interested in starting
medical schools. The latter is developing a program with the University of Miami, but I have little doubt that this is their
strategy for having a medical school in the future, just as Florida State's program with UF served that purpose.
The process is supposed to be that the Board of Governors decides if a new school should be established. If history
is any guide to the future, then the decisions will ultimately be political, one way or another. Of course, private medical
schools can be created without approval by the BOG, or the Legislature. The Lake Erie Pennsylvania College of
Osteopathic Medicine is opening a campus this fall in Bradenton and will be admitting its first 150 students.
Would a new public medical school help alleviate the physician shortage?
A new medical school will provide new physicians, but it will take seven or more years from the time they begin
before they are ready to practice, and that is after the school is built. Nationwide data have shown that graduates are
more likely to practice near where they do their residency than in the state where they went to medical school. Florida
is ranked 45th or 46th in the number of residency positions. Every position of every kind in Florida fills every year. If
we graduate more medical students, they will have to go elsewhere to do residencies and will therefore likely practice
National policy thinkers, like the Institute of Medicine, advise that if more medical students are part of the answer to
a physician shortage t tn the shortage should be overcome by increasing the class size of existing schools, a far more
What would be better ways to increase physician supply?
The most direct answer is to increase the number of available residency positions. Recruit the best graduates of this
nation's medical schools to residency programs in Florida. Let others bear the costs of educating students, attract them
to our residencies and therefore increase the chances they will practice in Florida.
An even better strategy is to develop programs to attract fully trained physicians to Florida. Provide student debt
forgiveness, for example. Provide some sort of malpractice protection. And since the graduating classes are increasingly
women, provide programs that are a better fit for them, things like flexible hours and child care.
How optimistic are you that a rational solution will be crafted for this issue?
Building new medical schools is the least effective and most expensive way to increase Florida's future physician
supply. I would personally feel more confident of a rational solution if the universities seeking new medical schools were
more candid about the reasons they want them. They want medical schools because this will increase the prestige of
their universities and allow them to compete for research funding, and some may believe that clinical revenues will be
available to help their universities. Some of these reasons are perfectly rational, defensible and even laudatory, which
leads me to believe they could be effectively argued.
LOOKING' AT YOU
Garth Dixon, a lab technician in the Tom Berryman (from left), AC mechanic, Danny Buckland, AC
Academic Research Building, tidies technician, and Lonnie Akins, AC technician, are keeping it cool.
Lee Kaplan (left), graduate
assistant in the department of
molecular genetics and
microbiology, and Hazel Levy,
graduate assistant in biochemistry,
grab some joe at the new
Starbuck's coffee cart.
UF Health Science Center
Office of News & Communications
Senior Vice President for Health Affairs
Douglas J. Barrett, M.D.
Director, News and Communications
Melanie Fridl Ross, John Pastor
UF Health Science
Tracy Brown, Sarah Carey, Tom Fortner, Linda
Homewood, Lindy McCollum-Brounley, Tom Nordlie,
John Pastor, Jill Pease, Melanie Fridl Ross, Denise
Kim Smith, Beth Powers, Cassandra Jackson
The POST is the monthly internal newsletter for the
University of Florida Health Science Center, the
most comprehensive academic health center in
the Southeast, with campuses in Gainesville and
Jacksonville and affiliations throughout Florida.
Articles feature news of interest for and about HSC
faculty, staff and students. Content may be reprinted
with appropriate credit. Ideas for stories are welcome.
The deadline for submitting items to be considered
for each month's issue is the 15th of the previous
month. Submit to the editor at email@example.com or
deliver to the Office of News & Communications in
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