Front Cover
 Table of Contents
 Post it
 Disaster relief: the HSC assis...
 Disaster relief: emergency...
 Craniofacial Center
 Muscular dystrophy
 Leeches in medicine
 The willed body program
 Building facility
 Feline/human AIDS links
 Genes and trauma
 Weight management
 Stuart Klein
 Back Cover


The Post
Full Citation
Permanent Link: http://ufdc.ufl.edu/UF00073869/00004
 Material Information
Title: The Post
Uniform Title: Post (Gainesville, Fla. 2001)
Physical Description: v. : ill. ; 28 cm.
Language: English
Creator: University of Florida -- Health Science Center
University of Florida -- Health Science Center. -- Office of Public Information
Publisher: HSC Office of Public Information
Place of Publication: Gainesville Fla
Creation Date: October 2005
Publication Date: 2001-
Frequency: biweekly
Subjects / Keywords: Health occupations schools -- Periodicals -- Florida   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
periodical   ( marcgt )
serial   ( sobekcm )
Statement of Responsibility: The University of Florida Health Science Center.
Dates or Sequential Designation: July 27, 2001-
General Note: Title from caption.
 Record Information
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 47826372
lccn - 2001229452
System ID: UF00073869:00004
 Related Items
Preceded by: Friday evening post (1989)


This item has the following downloads:

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Table of Contents
    Front Cover
        Page 1
    Table of Contents
        Page 2
    Post it
        Page 3
    Disaster relief: the HSC assists
        Page 4
    Disaster relief: emergency medicine
        Page 5
        Page 6
    Craniofacial Center
        Page 7
    Muscular dystrophy
        Page 8
    Leeches in medicine
        Page 9
    The willed body program
        Page 10
        Page 11
    Building facility
        Page 12
        Page 13
    Feline/human AIDS links
        Page 14
    Genes and trauma
        Page 15
    Weight management
        Page 16
    Stuart Klein
        Page 17
        Page 18
        Page 19
    Back Cover
        Page 20
Full Text



The Willed Q3
Body Program

/;` X ..


m p ~ ~

LJF Health Science
Celebrating 50 Years


Table of Contents
O DISASTER RELIEF Emergency medicine
O EDUCATION Craniofacial Center

@ PATIENT CARE Muscular dystrophy
( FIVE QUESTIONS Leeches in medicine
) COVER The willed body program
@ RESEARCH Feline/human AIDS links


O RESEARCH Genes and trauma
( RESEARCH- : management
@ PROFILE Stuart Klein

0 0 0 0 11 10 0

Bake sale for victims
of Hurricane Katrina

From a $20 muffin to a handful of cookies
for $.25, contributions of any size were
welcomed at a bake sale held by the
College of Dentistry for the victims of
Hurricane Katrina the week following
the disaster.
Selling sweet treats for donations,
the three-day bake sale raised more than
S. The money raised at the bake sale
will be matched by Henry Schein Inc., for
a donation of more than $1,500 to
hurricane relief efforts.
"It was neat to see how many people
wanted to give," said Harriet Hayes,
coordinator of the college's special events
planners that arranged the bake sale. "it
gave them an outlet when they didn't
know what to do."
Adrianna Rodriguez


Kathy Cannon (left) from orthodontics and Marta Miller (right), from Continuing Dental Education,
staff the bake sale table in the West Lobby entrance of the Dental Sciences Building. They offered a
whole gamut of sweets ranging from prepackaged honeybuns to homemade fudge brownies to
benefit Hurricane Katrina relief efforts.



Healthy Gators 2010, a campuswide initiative aimed at
producing a healthier University of Florida community, will
hold its formal kickoff 10 a.m. to 2 p.m. Oct. 26 at the
Reitz Union Colonnade.
Students, faculty and staff will have the chance to learn
more about the Healthy Gators initiative, explore the offerings
of student organizations and campus departments that have a
health-related mission, and receive free health screenings and
complimentary merchandise. Flu shots will be available at a
cost of $5 for students and $20 for faculty and staff.
At noon, UF first lady Chris Machen, chair of Healthy
Gators 2010, will deliver the kickoff speech. A former
practicing nurse, Machen said her leadership of this effort
was a natural for her because of her background in health
care. She especially likes Healthy Gators' emphasis on
prevention. Learn more about Healthy Gators 2010 at healthygators.hhp.ufl.edu.

The department of pediatrics will host the third annual
DeBusk Lectureship at 8 a.m. Nov. 4 in C 1-9.
Mary Allen Engle, M.D., a professor emeritus of
pediatric cardiology at Cornell University and the
author of more than 300 peer-reviewed journal
articles, will present a lecture titled "The Growth and
Development of Pediatric Cardiology."
Engle is the editor of six books focused on pediatric
cardiology. She worked with Helen B. Taussig, the
pediatric cardiologist who co-developed the Blalock-
Taussig operation.
Frank L. DeBusk, M.D., was the chief of the division
of general pediatrics and served on the UF faculty for
30 years, from 1966 to 1996. This lectureship was
established in his honor by faculty, residents and students
who were affected by his work and his teaching

Poster abstracts covering any aspects of genetics
research are encouraged for sessions at Florida
Genetics 2005, a symposium scheduled for Nov. 30
to Dec. 1 in the Reitz Union.
The event is sponsored by the UF Genetics Institute,
the Center for Mammalian Genetics, the Plant
Molecular and Cellular Biology Program and Health
Science Center Libraries.
UF faculty members, postdoctoral associates and
students have through Oct. 15 to submit abstracts.
Visit the seminars and events section of the UFGI
Web site at www.ufgi.ufl.edu for more information, or
call Michele Tennant, Ph.D., at (352) 846-0149.

The University of Florida Veterinary Medical Teaching
Hospital has been renamed the University of Florida
Veterinary Medical Center to more accurately reflect

the scope and sophistication of its inpatient and
outpatient services. The new name became effective
in July and was developed with input from clients,
clinicians in private practice and faculty.
"Our new name better represents the
comprehensive and sophisticated array of diagnostic
capabilities and innovative services we offer our
animal patients, including cardiology, animal behavior,
dentistry, acupuncture and integrative care," said
Dean Joseph A. DiPietro, D.V.M.
For more information, visit the college's Web site at

College of Nursing Graduate School
Opportunities Session
Thinking about taking the next step in your nursing
education? Whether you are considering graduate
school now or in the future, all students, alumni and
practicing nurses should plan to attend the College of
Nursing Graduate School Information Session at
2 p.m. Oct. 31 in the HPNP Complex Reception Area.
This session will provide valuable information on why,
how and when you can pursue your graduate degree in
nursing at UF. Call Tracy Brown Wright at (352) 273-
6421 and check the College of Nursing Web site, con.
ufl.edu, for more information.

Michael Iseman, M.D., an expert on tuberculosis, will
discuss the future of tuberculosis from both global and
national perspectives at an Oct. 20 grand rounds.
Iseman is a professor of medicine at the University
of Colorado School of Medicine and the chair of
mycobacterial diseases at the National Jewish Medical
and Research Center in Denver. He has spent decades
working on the treatment, control and elimination of
tuberculosis. The talk will be held 11 a.m. to 12 p.m. in
the Health Science Center's Room C1-11.
After grand rounds there will be a welcome

reception and open house for UF's new Southeastern
National Tuberculosis Center.
Under the direction of Michael Lauzardo, M.D.,
the TB Center is founded on a five-year, $7 million
grant from the Centers for Disease Control through a
cooperative agreement with the Florida Department of
Health awarded to the division of pulmonary and critical
care medicine in the department of medicine. The TB
Center seeks to address the training, education, medical
consultation and technical assistance needs of health-
care providers and TB programs in 11 Southeastern
states, Puerto Rico and the U.S. Virgin Islands, with the
goal of eliminating tuberculosis.
Visit the open house noon to 2 p.m. at the 1329
Bldg., fifth floor, Suite 5180.

UF's Superior Accomplishment Awards Program,
now in its 16th year, recognizes Academic Personnel,
Technical Executive Administrative Managerial and
Support (TEAMS) employees and University Support
Personnel System (USPS) employees who have
contributed outstanding service in their fields during
the academic year of Aug. 1, 2004 through July 31,
2005. This program, coordinated by the division of
human resources, is calling for nominations.
Please don't miss this chance to recognize those
among us who make the extra effort. This year's
nomination period began Sept. 15 and runs through
Oct. 31.
Division-level winners each receive $200 along with
a certificate of appreciation, memento coffee mug
and celebration luncheon. Each division winner is also
eligible to be selected for one of six university-level
awards of $2,000 each or one of eight $500 awards.
In addition, each of the six category winners and
his or her guest will be invited to attend a UF football
game in the university president's box.
Nomination packets should be routed through your
respective college committee member. They are:
College of Dentistry Colette Cimino
College of PHHP Bonnie Pomeroy
College of Medicine M. Louise Brophy
College of Nursing Joan Hill
College of Pharmacy Terry Whisenant
College of Veterinary Medicine Ron McKeever
Student Health Care Center Joan Street
Office of the Senior Vice President, Health Affairs
Dennis Hines
For information, nomination criteria and nominations
forms, visit www.hr.ufl.edu/recognition/saa.

lne Ii3 a.m to 1I:30 pm Nov. 4, Chow
dow on habresadhtdosa h inco



Hurricane Katrina and the HSC

Duane Dede's colleagues and friends from department of clinical and
health psychology helped pack a 24-foot-long truck with furniture and
supplies that was destined for his family members evacuated from the
Gulf Coast.

By Denise Trunk

The Health Science Center and its staff, students and faculty responded
quickly to aid the victims of Hurricane Katrina. The stories and images of
loss and destruction moved many people to action in numerous ways, from
the colleges of Dentistry, Nursing, Medicine, Pharmacy, and Public Health and
Health Professions opening their doors to displaced students, to departments
organizing fund and food drives, to clinicians going to the area to provide disaster
medical assistance and to help with cleanup. The stories on the next few pages
present a glimpse of the group and individual efforts undertaken by those in the
HSC to help make a difference.
Mark Atkinson, Ph.D., a professor in the medical college's department of
pathology, immunology and laboratory medicine, is a well-known diabetes
researcher. While Hurricane Katrina was still a Category 1 storm, Atkinson was
already making initial preparations to assist in its aftermath, but not in a way
many people would expect.
Atkinson, who has organized medical mission trips to Haiti and other
developing countries, said he preferred to clear storm debris and help enable
people to reorder their lives, one fallen tree at a time. He and his wife, Carol, joined
a group of about two-dozen people from his Gainesville church to take a week off
work and travel to Gulfport, Miss., bringing food, supplies and manpower.
"The destruction was just block after block. Entire neighborhoods were in
rubble; people had their whole lives piled at the curb. While medical treatment is
obviously very important, I just wanted to go out there as someone who cares,"

Atkinson said.
The UF College of Public Health and Health Professions saw examples of
people joining forces to help displaced families.
For Duane Dede, Ph.D., a professor in the department of clinical and health
psychology, it was a tense time while 45 members of his family evacuated to a
hotel in Tuskegee, Alabama. He sent out an e-mail asking friends in the
department for "a little help." He was unprepared for the tremendous response.
The department and the college mounted a campaign to gather items for his
family, who were left with nothing. Five days after the storm hit, Dede,
accompanied by Sam Sears, an assistant professor of clinical psychology, had
loaded up a 24-foot truck filled with donated furniture, essential items and
$11,000 and drove it to Dede's family.
"Know that everyone was simply amazed that so many would give so much
and they are completely grateful," Dede said. "As we opened and unloaded the
truck, the initial [reactions] ranged from amazement to being on the verge of
tears, by them and us. Besides my wedding ceremony and birth of my children,
this is the most amazing experience I have been involved in. Although there is so
much more to do, I think we have given them hope, reminded them what is
possible and let them know that others do care."
Students from the Gulf Coast have come to UF to continue their studies.
PHHP has four of Tulane's Master of Public Health students taking courses this
semester. In addition, the college has accepted two Tulane students into the
master's in health administration program in the department of health services
research, management and policy. A psychology intern from a closed New
Orleans hospital will complete her training in the department of clinical and
health psychology's internship program.
Some members of the college have traveled to the Gulf Coast. The National
Rural Behavioral Health Center at the UF College of Public Health and Health
Professions is working with local leaders to help affected communities manage
the psychological effects of the hurricane.
Center psychologist Brenda Wiens, Ph.D., a research assistant professor in the
department of clinical and health psychology, conducted a workshop on the
psychological impact of disasters on Sept. 14 at Mississippi State University in
Starkville. Workshop attendees included Cooperative Extension Office faculty
and agents from Mississippi, Louisiana and Alabama. The training was also
broadcast live to Extension staff in Louisiana and Alabama who are unable to
attend the training in person.
Many pets were also made homeless by Hurricane Katrina. To help, the
College of Veterinary Medicine is participating in a disaster fund drive
organized by the Association of American Veterinary Medical Colleges.
Initially, the AAVMC provided $20,000 in start-up funding for the campaign,
and the organization will match all contributions provided by students, faculty,
staff and alumni of the 32 North American colleges of veterinary medicine and
16 affiliated departments of veterinary science and comparative medicine.
The money will help to support the coordinated effort that the profession of
veterinary medicine is making in providing disaster relief.
"The profession of veterinary medicine has an important role to play in this
unprecedented natural disaster, and it is doing so," said Dr. Joseph A. DiPietro,
dean of the College of Veterinary Medicine and president of the AAVMC. "I
think the human dimensions of this catastrophe are well understood. But
thousands and thousands of companion and agricultural animals have been
killed, injured and displaced. Veterinarians are also playing an important role in
dealing with the potential infectious disease and public health problems." Q



A helping hand:

UF faculty help in Hurricane

Katrina disaster

By April Frawley Birdwell

hey had been through hurricanes before.
Members of the Northeast Florida Disaster
Medical Assistance Team, DMAT FL-4, knew
what to bring tents, generators, medical supplies,
whatever it took to set up a medical clinic on the fly.
And the team, who waited in Alabama while Hurricane
Katrina's winds whipped the Gulf Coast in August,
knew what to expect in a storm-ravaged area.
But when the team moved to a devastated area of
Mississippi after the storm, Jay Schauben, Pharm.D.,
deputy commander of the team and a UF professor of
emergency medicine and pharmacy in Jacksonville,
realized this was not an ordinary mission.
"The loss, we could see it in people's faces," said
Schauben, who spent eight days in Mississippi after the
storm. "They were in such need."
Disaster medical teams from across the country
flocked to the Gulf Coast to treat patients in need and
provide support to hurricane-battered hospitals in the
wake of Category 4 Katrina, which cut a swath of
destruction over 90,000 square miles.
UF faculty members like Schauben and dozens of
Shands employees, most of whom belong to DMAT
FL-4, have been part of that relief effort since before
the storm made landfall. Most have responded to
natural disasters before, including the spate of
hurricanes that struck the state last year, but it didn't
compare to Katrina, they say.
"Along the ocean it is totally devastated," said David
Seaberg, M.D., an associate chair for the UF emergency
medicine department who returned Sept. 11 from an
eight-day deployment to Mississippi. "You would see

Dr. David Seaberg (second from left, above) was one of several UF faculty members who traveled
to Mississippi after Hurricane Katrina to help with relief efforts there. Seaberg, who was deployed
to the area with his disaster medical assistance team, spent eight days helping people in towns
like Biloxi (left), Long Beach (above) and Pass Christian, Miss.

concrete slabs and that would be it."
When DMAT units are deployed during a disaster,
the group sends teams of 35 typically a mix of
doctors, nurses, paramedics and mental health
counselors to the area. In hurricanes past, Schauben
said teams have spent most of their time helping
damaged hospitals, setting up makeshift clinics in the
parking lot and relieving fatigued workers.
But with so much damage and need after Katrina,
Schauben said his team was told "to find what needed to
be done and just do it." The team, which was based in
coastal Jackson County, also sent out small "strike
teams" of doctors, nurses and counselors to assess health
needs in areas where people could not get to clinics.
"People didn't have transportation," Schauben said.
"They didn't have gas. We had to do it differently."
Seaberg spent most of his time working with a strike
team, traveling to decimated towns like Pass Christian,
Miss., where people sifted through the rubble hunting
for mementos of their lives before Katrina.
"There's nothing left," Seaberg said of the town,
which according to reports is 70 percent gone.
Doug Scott, M.D., a UF assistant clinical professor
of emergency medicine, was sent to an area just north
of Biloxi, Miss., a couple days after the storm with his

Orlando-based DMAT to set up a small clinic at an
American Red Cross shelter there.
Nearly 30 miles away from a partially functioning
hospital, Scott's team saw 80 to 90 patients the first day.
That number increased as more people found out where
they were. Most who came suffered from chronic
illnesses like diabetes and needed medication. Others
were dehydrated after days in the heat without water.
"I think there is going to be a need for medical
support there for a long time," Scott said.
But in the first days after the storm, what people
needed most, doctors often could not provide: food and
water, Schauben said. DMAT members usually only
carry enough food to feed themselves for three days.
They were brought there for medical relief, but
Schauben said his team did whatever it could to help
people, whether it was giving tetanus shots or
distributing ice.
The pleas for help, coupled with the tales trickling in
from patients who lost everything, weighed heavy on
many team members. Luckily, Schauben said, mental
health workers were there to keep workers focused.
"In some cases we felt helpless," Schauben said. "We
found ourselves giving them our own food, our own
water." 0



Support for

first responders

By Patricia Bates McGhee

When Deborah Provost, secretary for Research Affairs and IRB at UF HSC
Jacksonville, was driving to work Aug. 31, she heard on the radio that the
federal government had dispatched DMAT FL-4, Jacksonville's firefighter
search-and-rescue team, to Mississippi to help Hurricane Katrina victims.
She also heard that DMAT FL-4 found the hurricane survivors not only distraught
but hungry with many having not eaten since Aug. 29. But when she heard that
the firefighters gave their own food rations to the hurricane survivors, that's when
Provost got involved.
The radio station asked listeners to deliver food donations to any Jacksonville fire
station by 6 p.m. to be loaded on a truck scheduled to leave Jacksonville at 8 p.m. "As
soon as I got to work, I spoke to my supervisor, Teresa Dillinger, who agreed that we
should try to do something," Provost said. "She suggested that I contact Michelle
Cothran in Shands Human Resources so she could get the word out and help get the
project going.
"As soon as we sent out the word, the money began to come in and the response
was overwhelming!" Provost said. "I even received e-mails from employees who
were parents of the DMAT FL-4 firefighters, and they made requests for certain
items and thanked me for letting the employees help."
Then she contacted the Winn-Dixie warehouse to see if they were interested in
donating to the cause. "The warehouse manager, Scott Preston, worked with me to
make it happen," Provost said. He asked her to go to a local store, get the warehouse
code from the items on the shelf and then e-mail him the list. "I went during lunch
to the local Winn-Dixie on State Street and ran around the store with the manager
to get the warehouse codes and then e-mailed the list to Scott, who then started
pulling cases of food from the shelves in the warehouse.
"The next thing I knew, I had money and cases of food to be picked up at the
warehouse but needed a larger vehicle to do this," she said. "Debbie Snipes, secretary
in Internal Medicine, jumped in and donated her time and van to go with me to pick

Deborah Provost (left) and Winn-Dixie grocery warehouse manager Scott
Preston (center) and his assistant load up the donated supplies for delivery
to the fire station. Employees of UF HSC Jacksonville and UF & Shands
Jacksonville donated nearly $2,000 in the one-day fundraising campaign.

up the food."
By the end of the workday they collected $1,924.38 to purchase food and supplies
for DMAT FL-4. But the UF Shands Jacksonville team spirit didn't end there. With
just 30 minutes to spare to deliver the donations, Provost and Snipes were rerouted
to another fire station at the last minute.
"As we arrived at the first station, we found their fire truck station had had a
minor accident," Provost said. "They had flat tires and blocked lanes, and hurt
firemen were being rushed to of course Shands Jacksonville!"
Happily, no one was seriously hurt. The firefighters made it to Shands, and Provost
and Snipes made it to the second station just in time to load up the truck before it
headed to DMAT FL-4 in Mississippi. 0

S-A2 -s' ,,

Some of the students who helped man a donations table were (from left) Tony
Amelio, Matt Tucker, Alan White, Jia Liu, Jen Bongorno, Roslyn Frank, Ann
Griswold and Lourdes Andino.

What could I do to help?
In the wake of Hurricane Katrina, one graduate student asked
herself, "What could I do to help?" So Lourdes Andino and
other graduate students from Dr. Al Lewin's lab in the
department of molecular genetics and microbiology got together
and called the Center for Leadership and Service at UF and were
told the American Red Cross was in dire need of new blankets
and bottled water.
The labmates decided they would see what they could do to
gather donations at the Health Science Center. The students
made up flyers, sent out e-mails to the entire Health Science
Center. They set up a table at the Academic Research
Building's courtyard and the students took turns manning the
table from 8 a.m. to 5 p.m. from Sept. 7 to 9, and accepted
donations of water, new blankets, food and money.
By the end of three days, these students had collected over 60
large cases of bottled water, at least 30 new blankets, and many
bags and boxes of canned food. Also, to everyone's surprise,
they raised over $3,000 in cash for the Red Cross.
Wayne McCormack


-- -------------- ------- n i f

R L-.,;


UF Craniofacial Center Director William Williams, Ph.D., (pictured second from left)
hosted the group of 22 Brazilians from the University of Sao Paulo at Bauru.
Program co-organizers and USP faculty are Maria Ines Pegoraro-Krook, Ph.D., (far
left) and Jeniffer Dutka-Souza, Ph.D., (third from left).

Craniofacial Center hosts

international program

The UF Craniofacial Center hosted its 12th Annual
International Program on "Speech, Language,
Hearing and Swallowing Disorders: Advances in
Diagnosis and Treatment" in partnership with the
University of Sao Paulo at Bauru College of Dentistry
and Department of Fonoaudiology. The weeklong
summer program attracted 22 Brazilian private
practitioners, University of Sao Paulo faculty and
graduate students in the field of speech-language
pathology. The UF Craniofacial Center and University
of Sao Paulo will host a dual program in 2006 with a
speech pathology course and a workshop for dental
specialists interested in temporomandibular joint
dysfunction and facial pain, directed by Facial Pain
Center Director Henry Gremillion. For additional
information on this UF/Brazil program, please call
(352) 846-0801 or visit www.cleft.ufl.edu.
-Lindy McCollum-Brounley

A $1.3 million donation builds Food Animal

Reproduction & Medicine Service a home

When Deriso Hall is completed in late 2006, the faculty and staff of the Food Animal
Reproduction & Medicine Service in the College of Veterinary Medicine will finally
have all of their base operations under one roof.
"As long as we've existed, we've never had everything together," said Owen Rae,
FARMS service chief and a longtime CVM faculty member. "What this building will
do is give us a home base that will provide us with everything we need to function: a
reception area, office space, a large seminar room with video projection capabilities, a
large teaching area and two full-sized laboratories."
Deriso Hall is the direct result of a public-private partnership that began with an estate
gift to the college from Bob and Evelyn Deriso, a Tampa couple who once had interests in
cattle. The Derisos asked their attorney, Dan Brown, a friend of UF's professor emeritus
Paul Nicoletti, how they could contribute in a meaningful way to help the cattle industry.
Brown told them about Nicoletti's contributions in the area of brucellosis, a deadly disease
that affects livestock and that was a major concern to cattle owners.
The rest, as they say, is history.
The Derisos' $1.3 million gift was made in honor of Nicoletti's professional contributions
toward brucellosis control, and was subsequently matched and supplemented with
additional state dollars.
Groundbreaking ceremonies for the 10,000-square-foot building to be known as
Deriso Hall took place June 6, with approximately 60 people in attendance, including
representatives from the university's facilities planning division, Perry Construction
and many former and current faculty and staff members from the department of large
animal clinical sciences.
Presentations began in the large animal hospital auditorium, with brief remarks by
college Dean Joseph DiPietro, LACS chair Eleanor Green, Nicoletti, attorney Robert
Clark, Vice President of the Institute of Food and Agricultural Sciences Jimmy Cheek
and UF President Bernie Machen. Sarah Carey

Earline Nicoletti, Dr. Paul Nicoletti and Dean Joseph DiPietro (from
left) gather at the groundbreaking for Deriso Hall, the future home
of the Food Animal Reproduction & Medicine Service in the College
of Veterinary Medicine. Construction of the 10,000-square-foot
building began with a $1.3 million gift from Bob and Evelyn Deriso,
given in honor of Nicoletti's professional contributions toward
brucellosis control.



UF doctors cast net

to help muscular

dystrophy patients

By John Pastor


Where a sha red axnPf n a.m" sEfR ,t e a hSl Ol r e ., hr

Ahmula DylifOph

Learn More

Mission Statement
UFanawu. wij ProvIfe parents. Plitents. researchers end
Physicians with important new Jnformaton about Muscular
Dystphy With te hope 01fanefetve thrapy or aur on
me horizon Ihem can be nob hmls Smd on identiyng
factors thal may Do 80111valng and should be avoided or
factors as"X'soc with slOwed Progression etu can be
Implemented The UF~naw.,u database oriecl voluntary
submissions of personal expes. lifis.ylee and
disease coursea I Wiil allow as rapidly as pasaioIe me
identicatci oaffelpful and harmrftl factors This proactw wil
Share all confrmed reault wim regisrtred users.

Cantisus E i p~
UI A P p I v @II o nl ro N a IIo nr 5 ru iV b F W 9b." I Ien d 1` O81)(1 1 a nd S .rv i

"No single institution that provides

care collects enough experiences

or data, but we've built a

mechanism to create a large

database at a single source to

catalog a geographically

broader experience."

patients and families affected by muscular dystrophy urgently need to
take practical steps to help slow the destructive course of the disease,
say UF researchers who recently launched a Web-based effort to
collect information from people coping with the illness.
"The reason that it is so important to identify things that may offer a
margin of benefit is that the realistic time horizon for a real treatment or cure
is within decades, maybe sooner," said Dietrich Gravenstein, M.D., an
associate professor of anesthesiology associated with UF's College of
Medicine. "I have experience with individuals that suffer from rare diseases. I
see how stoic the parents and patients are who face these challenges and I
have been frustrated by how little scientifically validated advice there is to
simply help them confidently make the many choices they face."
Muscular dystrophies, genetic diseases characterized by progressive
weakness of the muscles that control movement, affect between 50,000 to
250,000 people at any one time, according to the Muscular Dystrophy
Family Foundation. In Duchenne muscular dystrophy, which affects 1 out
of every 3,500 to 5,000 boys, the disease starts to tear down muscles at birth
and is typically diagnosed before age 6. Most patients are wheelchair-
dependent by 12. By their late teens, most require a respirator to breathe.
Victims of the disease do not live past their 20s.
The Web site www.UFanswers.org will collect voluntary
submissions about personal experiences, lifestyles and the progression of
the disease. Even families who have lost loved ones can contribute their
experiences and help others living with muscular dystrophy. Names will be
kept strictly confidential.
Questions about diet and medication even the moment a wheelchair is
brought into a household will be asked through the site. The Web site differs
from blogs or traditional sites in that it is a data warehouse that researchers
with approved protocols can mine for strategies to impact the disease.
"Anecdotal information is unscientific, but by gathering it in great
numbers, we hope to pinpoint factors that are causally related to an
improved disease course," said Gravenstein, who has a son with muscular
dystrophy. "Right now, we are forced to speculate. It's terribly
disheartening. For example, conventional wisdom is to let children regulate
their own play, that when they tire they will rest. Yet strenuous exercise and
contact activities are discouraged because this accelerates muscle loss. So,
we are left to ask: are other activities such as stair climbing harmful or
harmless? And with the respiratory or cardiac failure all patients eventually
develop, are these accelerated if someone in your home smokes? What are
the effects of surgery and how are the anesthetics managed? Parents
anguish over such questions for which there are currently no answers -
and we hope to shed light on them."
Funding to build the database is through support from the Florida-based
I. Heermann Anesthesiology Foundation. Anesthesiologists are particularly
interested because they participate in tendon release and spine stabilization
procedures, common in muscular dystrophy patients, Gravenstein said.
"Children with muscular dystrophy and their parents don't have a rosy
future since there is still no cure for this disease," said Hans van Oostrom,
Ph.D., an associate professor of anesthesiology and biomedical engineering
who designed the www.UFanswers.org Web site. "No single institution that
provides care collects enough experiences or data, but we've built a
mechanism to create a large database at a single source to catalog a
geographically broader experience. Our objective is to do statistical analysis
on these data and report our validated results back to participants.
Ultimately, we would like to make these data available to anyone who has a
legitimate interest, but only in a way that guarantees the absolute
confidentiality of the people who contributed their experiences." 0

Q8 11 ,- .



Vampire worms doing

what they do best

For centuries, doctors used leeches to
drain blood from patients, a practice they
thought could cure everything from
pneumonia to headaches. As medicine
advanced, physicians realized
bloodletting did more harm than good
and the bloodsucking annelid worms
disappeared from medicine. Or did they?
Leeches are used so widely in medicine
today that the Food and Drug
Administration regulates them and an FDA
advisory committee recently suggested
doctors issue prescriptions if they want to
use them. Hollis Caffee, M.D., a UF
professor of surgery who has used leeches
for 20 years, explains how leeches benefit
modern medicine.

is use of leeches in
Mostly they're used to deal with congestion, when there's
too much blood in a part of the body. Sometimes it's an
area of skin that has been moved from one part of the
body to another, sometimes it's a finger. It's a very simple
way to drain excess blood out of tissue when it cannot get
out by itself through normal routes. When the veins are
partially blocked, blood builds up and that creates a lot
of pressure. These guys drink blood, that's what they do,
and that removes the excess.

is the most common I
.. a leech is used to t
It varies a little from one practice to another. I do a lot of
hand surgery, and sometimes when there is a crush injury
of the hand, it blocks some of the veins and stops blood
from getting back out of the finger. Or when a finger
has been reattached and we can only reattach one vein
and that proves to be insufficient (to drain the blood), we
might attach a leech to that finger. Those are the most
common reasons why I use leeches.

how leeches are used on patients at
We use leeches fairly rarely, about two or three times a
year. When the occasion comes up, we order a small
number from a supplier, usually six, and attach them one
at a time. Usually it's a short-term treatment over a matter
of days. Either the problem has resolved by then or it's
not going to resolve. Usually two to three (leeches) are
applied a day, sometimes four or five.

How do you attach them to a ,
We block off all the other areas, usually with plastic
bandages, so the leech attaches where we want it. We
pick it up with a gloved hand and just set it down. It will
start sucking blood out until it's full and then it will just
fall off. They'll stay on usually an hour or two. But even
after they come off, the (human tissue where they were
attached) will usually bleed because a leech bite has an
anticoagulant in it, and that keeps the blood from clotting
where the bite was.

Is form of that
has same effect as leech?
There is nothing that is as effective. When we have an
area of skin where blood is backed up, this is by far the
simplest and only effective way of correcting it. It is a
benign form of treatment and it is very safe. Leeches
aren't anything horrible. They won't give you any
diseases. Most people are very tolerant of the idea. There
is occasionally a person who can't stand to look at them.
But they seem to get past that.

1 :I.9


.**..... :T he
......l.. ..............

Donated bodies help educate future

health professionals


By April Frawley Birdwell

he woman's fingernails still gleamed pink with
polish. Nina Mayer couldn't help but notice as she
peered at the body on the table.
Like most first-year medical students, Mayer felt a little
nervous about her first gross anatomy lab. One of the first
classes new medical students take in the UF College of
Medicine, gross anatomy is often considered a gateway
into the world of medicine, the key building block to a
doctor's career.
It's also the first time students dissect a human being.
Mayer worried as she walked into her first lab. Would
she have to make the first cut, she wondered? Would she
see the cadaver's face? Worse yet, would she faint? But as
Mayer looked down at the hands of the 82-year-old artist
who donated her body so medical students like her could
become doctors, she realized the overwhelming
responsibility before her. She had to learn as much as she
could. She had to make this woman's gift count.
"It hit home what a wonderful thing these people did
for us," said Mayer, now a second-year student in the
college. "I felt this huge obligation and responsibility. I
thought, 'I need to respect this body as much as I can and
learn as much as I can to honor this gift they gave us."'
Donating one's body is a choice few people make. About
400 to 500 people donate their bodies to medical education
in Florida each year. That equals about two-tenths of 1
percent of all the people who die in the state each year,
said Lynn J. Romrell, Ph.D., associate dean for medical
education at UF and executive director of the State
Anatomical Board, which oversees the use of human
specimens for education in the state.
But it's a gift medical, dental and other health educators
rely upon. Without cadavers, anatomists could not train
budding surgeons to understand the complexities of

human anatomy or show potential oncologists what
cancer really looks like.
"In order to understand the body in total, its physics,
its texture, there's no way, right now, other than
dissection," said Stephen Sugrue, Ph.D., chairman of the
UF anatomy and cell biology department and chairman
of the State Anatomical Board. "It has been tried. It's
been that way for a couple hundred years."

- Bedrock of health education

Most students come to medical school with some
knowledge about anatomy. They have seen diagrams of
what the human body looks like on the inside. They have
seen models. And with the proliferation of health shows
on TV, most have probably watched real surgeries or other
procedures at home.
But working with real bodies is something that cannot
be duplicated, particularly because most students attend
medical school to learn how to help real people, not
models, anatomy professors say.
"It's gaining an appreciation for how complex (the
body) really is," said Thomas Hollinger, Ph.D., an
associate professor of anatomy. "There's nothing you can
do in medicine without knowing anatomy."
Cadavers are not used just to train doctors. Dental
students take a gross anatomy class, as do physician's
assistant students, physical therapy students and even
biomedical engineering students.
"This donation provides the bedrock of (education) in
so many fields," Hollinger said.
Physical therapy students will never have to perform
open-heart surgery or extract a brain tumor, but they do
need an intimate understanding of how the body works
and moves so they can help their patients recover from

debilitating injuries.
"It's a hands-on profession that deals with the way
people move," said Claudia Senesac, P.T., M.H.S., a
lecturer in the physical therapy department of the College
of Public Health and Health Professions. "It's one thing
to learn on each other. But to see it, feel it, pick it up and
manipulate it. You can't do that on a model."

Computer models and even newer virtual reality
programs do help, Sugrue said. Medical students actually
walk through the dissection on a computer before lab, but
the programs aren't advanced enough yet to replace the
experience, he said.
The images from Ron Butendieck's gross anatomy class
last year are seared into his head. But that's a good thing,
the second-year medical student says.
"It's not a normal experience to dissect another human
being," Butendieck said. "As you go through it, you don't
forget those images. That's why we get more out of dissection.
If you do it in person, you learn so much more."
But it's more than just learning thousands of facts and
mapping body parts; there's a subtle transition medical
and dental students make when they enter a gross anatomy
lab and work with a cadaver, Sugrue said.
"It turns it up a notch," he said.

S-Changes in dissection

Before 1543, most doctors rarely dissected a human
cadaver during their medical training. Most students
witnessed a dissection but rarely performed one
themselves, according to an article published in the
journal Academic Medicine in 2000.
But a young doctor named Andreas Vesalius changed that.
In 1543, Vesalius authored an anatomical atlas that
shed a startling light on what was known about anatomy



*jMpniCHut.-fn oA

at the time. In his book "On the Fabric of the Human
Body," Vesalius detailed how Galen, the anatomist
scientists and physicians had been studying for more
than 1,000 years, had based much of his work on animal
Vesalius' book highlighted the importance of seeing
the body for oneself in order to understand anatomy. And
to this day, anatomists know no better way to teach
students about the complex structures inside human
beings, Sugrue said.
The importance of human dissection to medical
education may not have changed much through the years,
but the culture of dissection has.
Dissection may have been necessary for doctors to learn
anatomy, but in some states it was illegal until the early
19th century. But the need to study cadavers not only for
education but also for scientific research was still great,
with advances in surgical techniques redefining medical
practice. According to the Academic Medicine article, this
led many young doctors and students to obtain cadavers
the only way they could: grave robbing.
Recognizing the importance of anatomy, many states
passed laws in the mid-19th century that allowed medical
schools to use unclaimed bodies in medical education.
Most medical schools used unclaimed bodies for gross
anatomy until 1968, when a law was passed in the United
States ensuring a person's right to donate their body to
science, according to an article that appeared in the
Journal of the American Medical Association in 2002.
Now, nearly all bodies used in gross anatomy courses at
medical schools across the country are donated.
And just as the way medical schools obtain cadavers
has changed through the years, the culture around the
dissection has slowly changed along with it.

Researchers have found that although students in the
1970s often did not discuss their feelings about dissecting
another human, students today expect to talk about it.
Romrell, who has taught anatomy at Harvard as well as
at UF, said he explained the importance of respecting the
body at both schools but now also holds a session for
students before class begins to talk about dissection.
Although most medical students know they will have
to dissect a human body, it doesn't make it any less surreal
or emotional for some students, particularly those who
have lost family members, Sugrue said.
That's why professors help students understand the
meaning behind the gift in addition to helping them
focus on what they are there to learn.
"One does not want to dwell too much on it," he said.
"There's a balance."
Senesac actually prepares her students for the dissection
by bringing them into the lab while the cadavers are still
zipped inside bags to let them stand in the room and get
used to the idea. She, too, stresses the importance of
"I tell them, 'You want to treat this person like a
member of your family,'" she said. "These people have
donated their bodies so we can learn how to treat the

I Respecting the gift

Romrell keeps a stack of letters in his top desk drawer.
He's read them all before, but his voice still cracks a little
when he reads from them and his eyes glisten at the
"These are tough (to get through)," he says as he flips
through the pages, past the letter from the daughter about
why her father wanted to donate his body to medicine to

the tale of the school teacher who decided to use her body
to keep teaching, even after death.
Romrell often shares these letters with his students,
who are also told the person's age, occupation and cause
of death. Most students have tears in their eyes when he
finishes. He usually does too.
It's part of making sure students understand the
meaning of the gift in front of them, but that's something
that rarely seems to escape students today.
"That's the biggest message (professors) try to send, to
just be happy that these (donors) thought about you," said
second-year student Nina Mayer.
It's a gift students pay tribute to at the end of the school
year. Each class holds its own special ceremony to honor
the donors who helped teach them about anatomy.
Students at most institutions with gross anatomy courses
hold ceremonies like this these days, Romrell said.
Medical students usually hold a candlelit ceremony and
reflect on each of the 25 cadavers their class used during
the year. Emotions often run high, Romrell said.
Mayer spoke at her class' ceremony earlier this year.
She talked about the 82-year-old painter with the pink
polished nails, the first donor her group used.
Like the painter, most of those who do donate their
bodies in Florida are older. The average age is 72. But the
Anatomical Board receives the bodies of younger people
too, particularly when they have cancer and cannot donate
their organs to help save a living person.
Their occupations run the gamut from doctor to
housewife to mechanic, Romrell said. But they have one
thing in common: They wanted to help other people.
"The reason almost any person gives is they or a family
member have had a significant illness," he said. "They want
other people to be spared that suffering."

~I 11

. .,:11 F,
, .!L:' ,IT, 4,

.. I -l




from the

ground up

By April Frawley Birdwell






Dr. Richard Smith, shown here with a baby in a photo that originally
appeared on the cover of a football program in 1964, was the first
chairman of pediatrics at UF. Now retired, Smith is still proud of the
College of Medicine's early years.



vision U Innovation U continuity

he teaching hospital was a hole in the ground filled with water when
Richard Smith, M.D., first visited the new University of Florida College
of Medicine. It didn't look promising.
Joachim S. Gravenstein, M.D., had never heard of Gainesville when he was
recruited to lead the college's anesthesiology department in 1958. He had to
look up the town in an encyclopedia. It didn't say much.
There were few restaurants in Gainesville and little to do on a Friday night.
The country town didn't have much to offer those recruited to be the Health
Science Center's first faculty members in the late 1950s and early 1960s.
Just a little sunshine and the opportunity of a lifetime.
The new medical school offered something to young faculty they never
would be able to do at schools like Harvard: the rare chance to build entire
departments the way they wanted them to be.
"The excitement about the new medical school was palpable," said
Gravenstein, now a graduate research professor emeritus in the anesthesiology
department. "Everybody was young and enthusiastic and idealistic and you
could feel this by talking to people."
That's what enticed Arthur Otis, Ph.D., to leave his "good job" as an
associate professor at Johns Hopkins University to be UF's head physiology
professor in 1956.
"This I thought was a chance to build something more on my own," he said.
"I didn't find another place that was better. It gave me personal freedom."
There were only two people in Otis' department that first year and a lot of
work to do. But to many faculty members who came in those first years, the
adventure outweighed the workload.
There was also an air of idealism in the College of Medicine that early faculty
members say trickled down from the top. Founding Dean George T. Harrell
held high standards for the college. His ideas ranged from the simple -
demanding student lab coats have big pockets for the books they were apt to
carry to the lofty insisting all specialists staff the general medical clinic.
"He said, 'First and foremost you are physicians and you will take care of
patients,'" Gravenstein said. "Whatever came, we were supposed to handle it."
The medical clinic policy didn't last long but the commitment to patients
did. Smith, the first pediatrics department chairman, said the hospital filled a
niche in Florida, providing a level of specialized care patients previously had
to leave the state to receive. Because of this, the hospital attracted interesting
and complicated cases from across the Southeast, which Smith believes
attracted faculty and students and made the health center what it is today.
"We started finding people who had a spirit of adventure," Smith said. "We
grew as a medical school based on great people."
The spirit of adventure was alive in the College of Nursing too, where founding
Dean Dorothy Smith, M.Ed., and her faculty turned a college started in a humble
Quonset hut into one of the most respected nursing schools in the world.
"Basically everybody who started here wanted this place to succeed," said
Jennet Wilson, M.S.N., who joined the nursing faculty in 1957, in an interview
for the Samuel Proctor Oral History program. "Not everybody gets a chance to
start a new program."
Nursing and medical faculty collaborated in and out of the hospital. Nursing
professors gave "their two cents' worth" when administrators were interviewing
new medical faculty, Wilson said. Students were trained to have mutual respect
for each other and faculty members worked closely in the new hospital.
"The first open heart surgery that was done here [was] incredible," said
Lucille Mercandante, M.A., who joined the nursing faculty in 1958, in her oral
history. "We thought open heart [surgery] was something. Now you have got
heart transplants, kidney transplants, liver transplants. I mean, open heart,
that was the thing."
There was a heightened camaraderie among faculty too. Smith said he and other
faculty played poker together and when they had a problem, they hashed it out.
"We were all very close," he said. "I'm very proud of those early days." Q



College of Medicine faculty members (from
left) Melvin Fried, Thomas Maren, Melvin J.
Fregly, Kenneth C. Leibman, lan Hood,
George Gifford, Henry Hinkley and Arthur B.
Otis gathered for the college's 20th
anniversary celebration in 1976.

Golden glimpses

Joachim S. Gravenstein

Most doctors can't say they went to medical
school twice. But that's what Joachim S.
Gravenstein, M.D., decided to do after finishing
his research fellowship in anesthesiology at
Harvard University in 1956.
After coming to Harvard as a resident, the
Berlin native felt his German medical training
was not up to par, so he enrolled in the Harvard
Medical School to catch up. The decision earned
him the distinction of being the only medical
student recruited to be a department chief in
UF's College of Medicine in 1958.
Gravenstein, 80, was the anesthesiology
department's first chief, a position he held until
1967. He left UF in 1969 for Case Western
Reserve University in Ohio, where he also
directed the anesthesiology department. Ten
years later, he came back to UF, where two of his
sons have followed in his footsteps.
He's won awards and written papers and
books, but Gravenstein, now a graduate research
professor emeritus, is perhaps most noted for his
work on the Human Patient Simulator, which he
and a team of anesthesiology faculty developed
in the 1980s. Most of his work now is with the
simulator, using it to teach medical students and
even local science teachers who want to show
their students the effects of drug use.

Robert Cade

Everyone knows about Gatorade. It's only the
best-selling sports drink in history. But what
about the other inventions spawned in the lab of
Robert "Bob" Cade, M.D., who developed
Gatorade with his research fellows in 1965?
Perhaps "Hop 'N Gator," a beverage that
combined the intoxicating ingredients of beer
with electrolytes to get it in and out of the
system quickly, could have been a hit too?
Talking about the lab-brewed beer still elicits a
chuckle from Cade, a professor emeritus.
Cade, 78, came to the UF College of Medicine
in 1961 as an assistant professor in the renal
division. During his 38 years as a full-time
faculty member and researcher, Cade also
developed a cholesterol-reducing drink and a
hydraulic football helmet. He also is known for
his research on rheumatoid arthritis and lupus.
Although Gatorade was originally developed
solely to aid the football team, Cade is most
proud of the medical uses of the drink, in
particular that it has helped sick children stay
hydrated. Gatorade, which includes a perfect
combination of glucose and sodium to increase
the rate of absorption, is used as much now for
medical reasons as athletic ones, he says.
Even Cade still drinks a glass most mornings.
He likes orange.

Jodi Irving

As one of the senior faculty members of the
College of Nursing, Jodi Irving, M.S.N.,
A.R.N.P., has strong ties to the college's
heritage. She currently serves as co-chair of the
50th anniversary committee and is spearheading
the creation of a history room, which will be an
in-house museum displaying the college's
historical information, photos and memorabilia.
Irving, an assistant professor of psychiatric-
mental health nursing in the department of
health care environments and systems, was first
attracted to UF in 1965 by the opportunity to
teach at a health center and by the reputation
and innovative style of the founding dean,
Dorothy M. Smith. Through her 30 years at the
college, she has taught public health, family
health, fundamentals of nursing, community
nursing and now psychiatric-mental health
nursing. She currently serves as advisor to the R.
N. to B.S.N. students.
"In the early years, there was an ambience of
high energy and excitement within the college
and the health center," Irving said. "The
collegiality within the health center and the
mutual respect that was between the college of
nursing and nursing services was very apparent.
Dean Smith's vision attracted many visitors and
notables in nursing education in those days and as
a young nurse I felt I was in rarified air getting to
interact with these well known individuals."



UF scientist finds

unexpected link

between cat and

human AIDS viruses

By Sarah Carey

UF researcher has discovered an unexpected link between the viruses that
cause feline and human AIDS: Cats vaccinated with an experimental
strain of the human AIDS virus appear to be at least as well-protected
against the feline version of the disease as those immunized with the vaccine
currently used by veterinarians.
The surprise finding may mean cats with feline immunodeficiency virus, also
known as FIV or feline AIDS, could eventually be treated even more effectively
using some form of the experimental human vaccine. Researcher Janet Yamamoto,
a professor at UF's College of Veterinary Medicine, also theorizes that these
emerging relationships between the two viruses could one day lead to a vaccine for
human AIDS.
Results from Yamamoto's research were published in the September issue of
FIV is a natural infection of domestic cats that results in an immunodeficiency
syndrome resembling HIV infection in humans. Since its discovery in 1987, FIV
infection of cats has been used in vaccine studies as a small-animal model of
human AIDS.
"We were the first to demonstrate that you can make an effective vaccine against a
virus in the AIDS family of viruses," said Yamamoto, a co-discoverer of FIV.
Yamamoto holds the patent on the only approved vaccine available through
veterinarians to protect cats against FIV. Her most recent studies have attempted to
improve the efficacy of that vaccine by using strains of FIV found in cats in which
the disease had not progressed for some reason over a period of several years.
To determine the extent to which the human and feline AIDS viruses react to
each other, and any implications that might exist for vaccine efficacy, Yamamoto
began experimenting with long-term, nonprogressive strains of FIV that led to
the current commercial vaccine. Now she is working on an HIV vaccine
consisting of HIV virus from long-term, nonprogressing individuals.
"We purposely made vaccines with strains that weren't virile," Yamamoto said.
"We found that whenever we tried using less virulent strains of virus, we were able
to make a better vaccine."
Yamamoto's team was also surprised to discover that a core protein found in
HIV also effectively protects cats against FIV.
"So what does this mean to human AIDS research? The viruses HIV and FIV
are from the same viral family," Yamamoto said. "For that reason, the amino acids
that make up the proteins in both viruses share some common regions. There
appear to be regions of HIV, or variations of the core protein we used in our
studies, that may provide protection in vaccine form against HIV."
Some compounds made from separate virus strains have been successfully used
in vaccines against viruses from the same subfamily, such as smallpox in humans,

Dr. Janet Yamamoto with a cat in her laboratory

which is made from cowpox virus, and human measles vaccines for canine
distemper in puppies.
"Therefore, protective vaccines based on cross-reactive regions of AIDS viruses
can provide broad immunity, and may be useful against viruses that are currently
evolving in a new host, such as HIV infection of humans," Yamamoto said.
Alan L. Landay, a professor of immunology and microbiology and associate
department chair at Rush University Medical Center in Chicago, called
Yamamoto's findings "very exciting."
"This raises a potential whole new area for research in the field of vaccines that
with the current approaches haven't yielded any success to date," said Landay,
whose research team is working to develop novel immune strategies to treat HIV
infection. "We need to explore all the potential options available to us for
developing an HIV vaccine." Q



Scientists get

look at genes'



By John Pastor

U sing a new method to identify networks of
infection-fighting genes, scientists writing in a
recent online edition of Nature say more than
15 percent of our genes are mobilized to defend against
microbial attacks.
The body's overwhelming genetic defense, which
has implications for the survival of patients who are
severely burned or injured, was revealed in a sweeping
analysis of gene activity in volunteers who were
injected with a bacterial product that temporarily
created flulike symptoms.
"During a 24-hour period, the expression of more
than 3,700 genes changed in blood leukocytes," said
Lyle Moldawer, Ph.D., a surgery professor in the
University of Florida College of Medicine, part of the
national consortium that published the findings. "It
was a dramatic reprioritization of genes. But beyond
individual genes, we were able to look at networks, or
functional modules of different gene clusters, that
change in concordance with one another. We have now
identified previously unknown relationships among
different genes that tell us in greater detail how blood
cells respond to an infectious challenge."
Inflammation is part of normal healing when people
are severely burned or injured, but in some patients, it
can be fatal, causing bloodstream infections and
multiple organ failure. Learning how and why
inflammation becomes harmful will help doctors more
accurately predict how each injured patient will fare.
UF Genetics Institute researchers are part of a
national group of scientists united by a five-year, $37
million "glue grant" from the National Institute of
General Medical Sciences.
Scientists injected healthy volunteers with a
microbial product that temporarily causes nausea and
fever, triggering natural immune responses.
The condition is similar to sepsis, which can happen
when the body's infection-fighting white blood cells
spring into action, causing potentially harmful
inflammation in the process.
"Basically we made the volunteers appear septic for
a couple of hours and examined changes in the gene
expression from their white blood cells," Moldawer
said. "Such genomic analyses give us the ability to

Dr. Henry Baker (left) and Dr. Lyle Moldawer are working with a national consortium of
researchers to learn how and why inflammation an immune response that affects the entire
body becomes dangerous for some patients and not for others. In a report in the journal
Nature, the researchers described how inflammation alters the expression of genes within white
blood cells. By looking at how people respond to injury on a genomic level, researchers hope
someday to be able to tailor treatments to patients' individual needs.

simultaneously survey the activity of every gene in the
cell, giving us vast lists of genes that change in
response to stimulation. It provides us with an
unprecedented amount of data."
To make sense of the enormous amount of
information, researchers plugged their list of nearly
4,000 gene changes into a database of interactions of
known human and mouse genes developed by Ingenuity
Systems Inc. of Mountain View, Calif. The results
identified the networks of genes that helped the body
respond to the challenge.
"The apparent repression of genes that occurs has
never been fully appreciated," said Henry Baker,
Ph.D., associate director of the UF Genetics Institute
and director of the UF lab that performs genomic
analyses for the consortium. "Initially, more than half
of the genes became less active, but over the long haul,
they were more focused on the inflammatory response.
By drawing samples for analysis over six time points
in 24 hours, we were able to infer the sequence of

events and how some changes in gene expression cause
other changes."
The research is particularly valuable because it plots
inflammatory response over time, according to Scott
D. Somers, Ph.D., NIGMS program director of this
glue grant.

"In the case of injury, time is critical," Somers said.
"To provide the best treatment, doctors need to know
how the human body responds in the moments and
days after an injury. No other study of injury or
inflammation has tracked changes to the entire human
genome over time."
The glue grant team includes scientists from the UF
College of Medicine; Stanford University; Washington
University; the University of Medicine and Dentistry
of New Jersey-Robert Wood Johnson Medical School
in New Brunswick, N.J.; Ingenuity Systems Inc.; the
University of Rochester School of Medicine in
Rochester, N.Y.; and Massachusetts General Hospital,
Harvard Medical School in Boston. Q

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11 1h 1. 111 ,

UF researchers to study weight

management programs for children

By Jill Pease

This fall, researchers from UF, in conjunction with UF Cooperative Extension
offices in participating counties, will conduct a no-cost weight management
program targeting children and families.
Led by David Janicke, Ph.D., an assistant professor in the department of clinical
and health psychology in the College of Public Health and Health Professions, the
UF Healthy Lifestyles Program for Families team will work with children and their

parents in Levy and Gilchrist counties. The researchers also plan to conduct groups
over the next 16 months in three other rural counties in north central Florida.
The work is supported by a $435,000 grant awarded to Janicke from the National
Institute for Diabetes and Digestive and Kidney Disorders, with supplemental
funding from the Institute for Child and Adolescent Research and Evaluation.
More than 30 percent of American children and adolescents meet the criteria for
obesity or are considered at-risk for obesity. Overweight children and adults are at
increased risk for diabetes, high blood pressure and cardiovascular problems.
Moreover, children who struggle with weight issues are often the victims of teasing
from peers.
"Given the scope and seriousness of obesity in America and the limited access to
services for children in rural settings, there is a pressing need for the development
and assessment of intervention programs that target children at greatest risk for the
long-term negative health consequences of obesity," Janicke said. "Many families
want to develop healthier patterns of eating and exercise that may positively impact
weight and health, but making these types of changes is often hard."
The UF Healthy Lifestyles Program is designed to help children and parents
modify their dietary and physical activity in order to promote a healthy lifestyle,
positive self-image and effective weight management. The program helps families
work together to learn how to manage real-life situations and make gradual, modest
changes in their lifestyle.
"An important emphasis in our program is helping parents and children to
support each other to make positive changes," he said. "The group format is also a
very positive way to build a strong support network."
The four-month, group-based program includes weekly sessions at the Cooperative
Extension office in Bronson, with groups composed of about six to 10 families. Q


Rehabilitation counseling offers new care management service for seniors

By Jill Pease

Managing the tasks of daily living can be
overwhelming for some seniors. Following
prescription instructions, juggling medical
appointments and locating resources for
1 medical equipment, transportation and
meals can be particularly difficult for frail
elders living on their own.
SBut a new service from the department
of rehabilitation counseling at the College
,.h.....' of Public Health and Health Professions is
'" .e- helping seniors get a handle on the myriad
issues that arise with aging.
Aging Resources and Care Management
E is now offering geriatric care management
services to clients in Gainesville and Ocala
under the direction of Linda Shaw, Ph.D., an associate professor in the department
of rehabilitation counseling.
"Seniors can and do fall through the cracks," said Keith Meneskie, the service's
senior care management coordinator. "They need resources, support and
information. There are local, state and federal services that can help, but seniors
don't always know how to access them."
Aging Resources and Care Management staff may see clients once or several
times on a long-term basis, depending on the clients' needs. Meneskie is often
employed by the family of older parents who live out of state and want a local

professional to monitor all aspects of their parents' well-being and provide feedback
on emotional, physical, medical and environmental concerns.
Clients sometimes initiate geriatric care management in anticipation of long-term
needs, but managers are also called upon during crisis situations.
"We may get a call saying 'My mother fell, she's in the hospital and I don't know
what to do next,'" Meneskie said.
The geriatric care managers provide a wide range of services, including:

Coordination of care in collaboration with physicians and other health-care
professionals to manage clients' ongoing health-care situations, such as high
blood pressure, diabetes and other medical concerns.
Support in the transition to a different level of care, such as in-home services or
a move to a long-term care facility.
Resources for volunteer and community support and help with tasks of daily
living, such as driving and shopping.
Evaluation of the client's psychosocial status and counseling for seniors and
their families.
Assistance with legal and financial issues such as powers of attorney and
advance directives, including living wills, health care surrogates and health
care proxies.

For more information on Aging Resources and Geriatric Care Management, call 273-
6745 in Gainesville or (352) 291-7662 in Ocala, or e-mail ARCM@phhp.ufl.edu. Q



Stuart Klein directs the ne\\ institute


Stuart Klein, director of UF's $110 million Florida Proton Therapy Institute, poses in a gantry room of the proton therapy center in Jacksonville. The
only center of its kind in the Southeast, FPTI is scheduled to open in July. Ion Beam Application (IBA), the Belgian manufacturer of the proton beam
equipment, supplied Klein's hardhat.

By Patricia Bates McGhee

W hen Stuart Klein's neighbors ask what he
does for a living, he tells them he's opening
a new cancer center for UF.
"If I get more clinical or technical than that, I start
getting blank stares," he said. "Even my mother doesn't
have a clue what I do!"
Klein, the director of UF's $110 million Florida
Proton Therapy Institute, which is slated to open next
summer, admits that he, too, didn't have a clue about
proton therapy when he first heard about it. It was 1993
and Klein had been administrator of radiation oncology
at the University of Pennsylvania since 1990.
"At Penn we recruited a physician who originally
was supposed to head up the clinical side of the super
collider project at the University of Southwest Texas,
but their funding was pulled, so he joined our faculty,"
Klein said.
As a result of the new physician on board, a company
that wanted to get involved in proton therapy contacted
Penn. Klein said it wasn't until he toured Loma Linda
University's proton therapy center in 1994 that he
really understood the technique.
"It was phenomenal," he said. "Proton therapy is at a
whole different level," he said. "I had a strong background
in radiation therapy in general, so proton therapy was the
next logical area I became involved in."
For the next 11 years Klein worked on bringing proton
therapy to Penn. He visited proton therapy centers all
over the world from Cape Town, South Africa, to Japan
- and attended international meetings to learn more
about the technique. He served as Penn's representative to

the Proton Consortium, a group of institutions interested
in or actually doing proton therapy.
Heading up a proton therapy facility became his
goal. When he heard UF was considering one, he
jumped at the opportunity.
"Nancy Mendenhall, UF's chair of radiation
oncology, was very good friends with my boss at Penn
and communicated regularly with him and other vice
chairs in the department remember, the community
of proton therapy centers worldwide is very small,"
Klein said. "I actually met her at a proton conference
in England two or three years ago and became very
interested in UF's plans then."
From the start, Klein's been impressed with the
commitment of UF's project leaders, C. Craig Tisher,
M.D., and Mendenhall.
"I know from a firsthand basis how difficult it is to
pull these projects off, and clearly Dr. Tisher and Dr.
Mendenhall have had the vision, despite all the
stumbling blocks and odds against them, to pull it off,"
he said. "There are literally only a handful of places
that have done that, so UF is one of the exceptions and
not the rule."
Klein says such a complex project requires big-
picture leaders to champion the cause from an
institutional standpoint.
"You need someone on Dr. Tisher's level to spearhead
this type of project," he said. "At Penn our department
was continually pushing this forward, but there was
nobody at a higher, institutional level to promote it, and
that's why it basically never happened."

When offered the FPTI directorship, Klein says no
hard sell was needed. UF's foresight and leadership
brought him here. "This is something that I've been
trying to do for years at Penn, and now I have the
opportunity to do it and work with the most respected
leaders in the field."
As director, Klein said his workday activities span
the entire spectrum.
"Within a one-day period I could be working on
anything from marketing to putting together a contract
on housekeeping services to dealing with managed-
care issues and payers, and I really enjoy that variety,"
he said. "For example, I was putting together a
description for a social worker this morning, going
over to the building to do a tour, having pictures taken
and then dealing with some personnel issues, so it
really does go all over the place, but it's fun."
Personally, the move has been challenging. Klein
left Penn in January and started at UF Feb. 7. Because
of work and school commitments, his family wife
Catherine, daughters, Hannah, 15, and Haley, 13, and
son, David, 10 couldn't move to Jacksonville until
July. Until then Klein had a three-city commute each
week, working three days in Gainesville, two days in
Jacksonville and traveling home to Philadelphia every
weekend to be with his family.
Slowly, everyone's starting to settle in.
"It's still challenging to explain to my kids what I
do," said Klein. "My oldest daughter has really caught
on now, but when I try to explain what I do to the other
two I get an 'uh, okay' and the blank stare." Q

D 1

II, r rs



D.D.S., F.A.C.P., has been
appointed a clinical associate
professor of prosthodontics
and program director of
graduate prosthodontics.
O'Neill comes to UF from
the Naval Health Clinic in
Millington, Tenn., where
he served as department
head of prosthodontics and chair of the implant
committee. His areas of special interest and
expertise are in implant dentistry and full-
mouth reconstruction. A Navy man since 1976,
O'Neill earned his dental degree from Loyola
University School of Dentistry, and his Master
of Science from George Washington University.
He is a diplomat of the American Board of
Prosthodontics, and a fellow of the American
College of Prosthodontics. He also holds a
certificate of advanced prosthodontic education
from the U.S. Naval Postgraduate School in
Bethesda, Md.


college's associate dean for
graduate medical education,
has been appointed to two
prestigious posts with the L
Accreditation Council for
Graduate Medical Education
and the American Board of
Flynn will serve on the board of directors for
the ACGME, the organization that accredits
and evaluates medical residency programs,
beginning in October. He also was elected to
serve as vice chairman-elect of the American
Board of Surgery. In June 2006 he will assume
the role of vice chairman and in 2007 he will
become the American Board of Surgery's
Flynn, who is also the president of the Alachua
County Medical Society, has been with the
college since 1984.

assistant professor in the
pediatrics and psychiatry
departments, was awarded
a $39,011 grant from the
Foundation for his research on
obsessive-compulsive disorder.
Storch and his team of
researchers will use the money
to continue studying exposure response prevention
therapy, which has been shown to help adults with
OCD. Storch's team is trying to determine if a
specific drug treatment enhances the therapy.


an assistant professor
in the department of
pharmacodynamics, has
received a two-year grant
for $90,000 from the
American Health Assistance
Foundation's National
Glaucoma research program.
She examines nitric oxide's role
in regulating intraocular pressure in the human
eye. High intraocular pressure causes glaucoma,
a leading cause of blindness in the world.

and an associate professor
in the department of
pharmacodynamics, has
received a three-year grant
for $752,250 from the
National Institute of Alcohol f ": "
Abuse and Alcoholism. Her '
research focuses on the
neurochemical mechanisms
of ethanol addiction and how neurotransmission
is altered in brain regions that are highly
implicated in the alcohol addiction process when
alcohol consumption escalates.

assistant professor in the
department of pharmaceutics,
has received a two-year
grant for $363,750 from the
National Institutes of Health's
National Heart, Lung, Blood
Institute. His research goal
is to develop a gene therapy

approach to correct the mutation of the alpha 1
antitrypsin gene for treatment of lung and liver
diseases associated with AAT gene deficiency.


assistant professor in the
department of physical
therapy, received a two-year
$150,000 grant from the
National Institutes of Health
to study the effect of female
sex hormones on functional
recovery of breathing after
high cervical spinal cord injury.
These experiments will help establish if gender
hormones should be considered an important
variable in basic science research, and if hormone
therapy is an effective means of promoting
recovery of breathing ability after a cervical spinal
cord injury.

EMILY KUHL, a graduate
student in the department of
clinical and health psychology,
received a travel grant
to attend the 9th Annual
Scientific Meeting of the Heart
Failure Society of America
held in this September in
Boca Raton. She presented
a research poster on the
psychological benefits of exercise for patients with
late-stage heart failure.

Know someone who has e
E-al00 ukuf~d


UF nursing classroom dedicated in honor of
retired educator and alumna's mother

... When BETTY WARNER returned to college at age 51 to earn her Master
of Education degree from UF, she had no idea that almost 40 years later
|- :I a classroom to educate future nurses would bear her name. Yet in a
September ceremony, a classroom in the College of Nursing was named
Sfor the retired teacher as a tribute from her family in honor of her 90th
S The naming of the Betty Warner Classroom resulted from a $30,000
SI gift from the Harman and Aiken families to support the Dorothy M. Smith
S -1 1 Professorship. The professorship, named in honor of the College of
. i'" Nursing's founding dean, will help educate the next generation of the best
and brightest nursing professionals. Ms. Warner's daughter, Linda H. Aiken,
Ph.D., R.N., F.A.A.N., is an alumna of the UF College of Nursing and was
closely mentored by Dean Smith as a student.
"The College of Nursing is honored to have received such generous support from Dr. Aiken and her family,"
said Kathleen Ann Long, Ph.D., A.P.R.N., F.A.A.N., dean of the UF College of Nursing. "This is a testament
to Ms. Warner's impact as a mother and a teacher as well as to the impact Dean Smith played in shaping Dr.
Aiken's career as an internationally renowned nurse educator and researcher. We are proud to count the Aiken
and Harman families as true Gators." Tracy Brown Wright


New training program develops pain researchers of the future

Robert P. Yezierski directs the Comprehensive Center for Pain
Research based in the College of Dentistry, and is the lead on a new
$1.3 million pain training grant awarded to the college by the
National Institutes of Health. The six-year grant will fund an
interdisciplinary, post-doctorate training program to develop
researchers and clinicians in the areas of orofacial, acute, visceral,
psychosocial and musculoskeletal pain.

By Adrianna C. Rodriguez

Robert P. Yezierski, Ph.D., a professor of orthodontics at UF's College of
Dentistry and director of the Comprehensive Center for Pain Research, has
received a $1.3 million grant from the National Institute of Dental and
Craniofacial Research/National Institutes of Health. The six-year grant will fund
an interdisciplinary postdoctoral training program focusing on training
researchers in pain mechanisms, diagnoses, treatment and management.
The program's goal is to produce pain researchers for the future equipped to
develop clinical and/or basic science research programs and to instill in these

IT; &
P. L

The National Institutes of Health recognizes UF

medicinal chemist with $3 million award

Ray Bergeron, Ph.D., a graduate research professor of
medicinal chemistry and Duckworth Eminent Scholar of
Drug Development in the College of Pharmacy, received a
$3 million NIH MERIT award to continue his research on
blood and liver-related disease.
Acknowledging his "consistent and excellent
contributions to scientific knowledge," the award, from the
National Institutes of Health's National Diabetes and
Digestive and Kidney Diseases Advisory Council, gives
Bergeron the opportunity to extend his current grant for an

additional five years.
"This is a well-deserved honor and one that the College of Pharmacy should
be very proud of on his behalf," said Dean William H. Riffee, Ph.D, in a
congratulatory speech.
Investigating ways to better treat iron-overload diseases, Bergeron currently
has two drugs in clinical trials with Genzyme. One drug is used for treatment of
liver cancer. The other was developed for the treatment of children with
thalassemia, also called Cooley's anemia, a rare disease in which iron builds up
in the system, causing an overload that cannot be effectively eliminated.
-Linda Homewood



individuals an appreciation for the benefits of collaborative, multidisciplinary
programs in meeting present and future challenges in the field of pain research.
Yezierski said the two- to three-year program provides a well-balanced core
curriculum for four postdoctorate trainees entered into the program each year.
The training program contains provisions for the recruitment of
underrepresented minorities, a required component dealing with the ethical
conduct of research, and steps to ensure the program meets the needs of trainees
in areas of research, education and professional development.
Conducted by an interdisciplinary group of 15 core faculty members with
expertise in neuroscience and psychosocial issues of pain mechanisms, the
program offers training opportunities in five designated tracks that represent the
faculty's research interests. These include the following areas:

Orofacial pain associated with the head and neck, including trigeminal
neuralgia, temporomandibular joint disorder and migraine;
Acute and chronic pain mechanisms, the neurobiology of the pain system,
including the anatomy, physiology, pharmacology, molecular biology of
peripheral and central pain pathways;
Sex, gender and ethnic differences, psychosocial issues of pain and how those
factors impact the experience of pain;
Visceral pain associated with dysfunction of the gastrointestinal tract; and
Musculoskeletal pain, one of the most common types of chronic pain
conditions, including back pain and fibromyalgia.

These tracks represent established research programs of core faculty and will
provide structure, guidance and a diverse training environment for the program,
Yezierski said. Additionally, each trainee will receive mentoring from the
program's advisory committee to enrich their training experiences.
Trainees will use facilities throughout the Health Science Center for their
research training. Although trainees will select one track of training emphasis,
they will be required to participate in a two-week research rotation in each of the
five tracks.
For more information about the pain training grant, contact Yezierski at
ryezierski@dental.ufl.edu or call the Comprehensive Center for Pain Research at
(352) 392-3032. Q



Pat Siter is the administrative assistant to the senior associate
dean for educational affairs in the College of Medicine.

Published by
UF Health Science Center
Office of News & Communications
Senior Vice President for Health Affairs
Douglas J. Barrett, M.D.
Director, News & Communications
Tom Fortner
Denise Trunk
Senior Editors
Melanie Fridl Ross, John Pastor
Mickey Cuthbertson
Staff Writers
Tracy Brown, Sarah Carey, Tom Fortner,
April Frawley Birdwell, Linda Homewood,
Lindy McCollum-Brounley, Patricia McGhee,
John Pastor, Jill Pease, Melanie Fridl Ross,
Denise Trunk
UF Health Science

Nurse Donna Waldron (left) and Ginny Profumo, a guest services specialist, bring Sox
to visit children on a recent Friday morning.

Support Staff
Cassandra Jackson, Beth Powers, Kim Smith

The POST is the monthly internal newsletter
for the University of Florida Health Science
Center, the most comprehensive academic
health center in the Southeast, with campuses
in Gainesville and Jacksonville and affiliations
throughout Florida. Articles feature news
of interest for and about HSC faculty, staff
and students. Content may be reprinted
with appropriate credit. Ideas for stories are
welcome. The deadline for submitting items
to be considered for each month's issue is the
15th of the previous month. Submit to the editor
at dtrunk@ufl.edu or deliver to the Office of
News & Communications in the Communicore
Building, Room C3-025.


Physician and

community leader dies

obert L. Brown, M.D., a 1984
graduate of the College of
Medicine and a leader in
Jacksonville's black community, died
Sept. 1 after suffering a cerebral
hemorrhage. He was 55.
Dr. Brown served as director of the
Soutel Family Practice Center in
Jacksonville, which is part of the UF
Health Science Center there. Brown,
who committed himself to giving back
Brown after medical school, established his

practice in a medically underserved part of town and helped
bring a grocery store to the area.
Brown is survived by his wife, Gloria, four children, one
grandchild, seven brothers and one sister.
Brown was quoted in the September 2005 issue of the POST
in a remembrance of the late Dr. Hugh "Smiley" Hill, longtime
associate dean for education for the College of Medicine.