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 Front Cover
 Table of Contents
 Dietary guidelines
 Dental delay
 Physician retires
 Cough medicine/pain relief
 Prenatal cocaine
 Inner space
 Technology transfer
 Dental implant success
 Distinctions
 Humanitarian award
 Dentistry's dynamic duo
 Living wills
 Back Cover


UF



The Post
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Permanent Link: http://ufdc.ufl.edu/UF00073869/00003
 Material Information
Title: The Post
Uniform Title: Post (Gainesville, Fla. 2001)
Physical Description: v. : ill. ; 28 cm.
Language: English
Creator: University of Florida -- Health Science Center
University of Florida -- Health Science Center. -- Office of Public Information
Publisher: HSC Office of Public Information
Place of Publication: Gainesville Fla
Creation Date: June 2005
Publication Date: 2001-
Frequency: biweekly
regular
 Subjects
Subjects / Keywords: Health occupations schools -- Periodicals -- Florida   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
periodical   ( marcgt )
serial   ( sobekcm )
 Notes
Statement of Responsibility: The University of Florida Health Science Center.
Dates or Sequential Designation: July 27, 2001-
General Note: Title from caption.
 Record Information
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 47826372
lccn - 2001229452
System ID: UF00073869:00003
 Related Items
Preceded by: Friday evening post (1989)

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Table of Contents
    Front Cover
        Page 1
    Table of Contents
        Page 2
    Dietary guidelines
        Page 3
    Dental delay
        Page 4
    Physician retires
        Page 5
    Cough medicine/pain relief
        Page 6
        Page 7
    Prenatal cocaine
        Page 8
    Inner space
        Page 9
    Technology transfer
        Page 10
        Page 11
    Dental implant success
        Page 12
        Page 13
    Distinctions
        Page 14
        Page 15
    Humanitarian award
        Page 16
    Dentistry's dynamic duo
        Page 17
    Living wills
        Page 18
        Page 19
    Back Cover
        Page 20
Full Text











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TABLE OF CONTENTS


O POST IT Dietary Guidelines
PATIENT CARE Dental Delay
O PROFILE Physician Retires
@ RESEARCH Cough Medicine/Pain Relief


RESEARCH Prenatal Cocaine
RESEARCH Inner Space
@ COVER FEATURE Technology Transfer
O EDUCATION Dental Implant Success








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DISTINCTIONS
@ JACKSONVILLE Humanitarian Award
Q EXTRAORDINARYY PERSON Dynamic Duo
FIVE QUESTIONS Living Wills










17


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Don't try this at home

Nina Mayer, a first-year medical
student, balances a blade as she
performs a belly dance during the
College of Medicine's talent show
May 14 at P.K. Yonge's Performing
Arts Center. Mayer began dancing
when she was 6 years old. Twenty-
one medical students, three faculty
members and two staff members
performed at the show, which was
held in remembrance of Caroline
Cody, a medical student who died in
May 2000. Proceeds from this event
will go toward funding students'
spring break mission trips.


C2








POST IT


Pharmacy research facilities
completed at Health Science Center
The College of Pharmacy held a ribbon-cutting ceremony in
May to celebrate the completion of a five-year project that
remodeled and improved 45,500 square feet of research
space at the UF Health Science Center. This is the first
remodeling effort of the pharmacy wing since the building's
completion in 1962. The renovated seven-story wing yields
an increase of more than 37 percent in total usable space for
college researchers. The ground floor facility includes improved
laboratory research space for the department of pharmacy
practice and clinical facilities for asthma studies.
"This renovation provides a dramatic improvement in the
quality of the research space for pharmacy practice, including
dedicated space for conducting clinical research studies,
as well as laboratory space specifically designed to meet
the needs of the Center for Pharmacogenomics," said Julie
Johnson, Pharm.D., chair of the department of pharmacy
practice.
Funding for the $14.4 million project included $8 million
in privately raised funds, $5.5 million in state funds and a
$900,000 construction grant from the National Institutes of
Health.
Linda Homewood


mypyramid.gov
The federal government issued updated dietary
guidelines in February and now a new MyPyramid.
gov Web site lets users download tailored dietary
recommendations. Individuals key in their age,
gender and physical activity level so they can
get a personalized recommendation on their
daily calorie level, based on the 2005 Dietary
Guidelines for Americans.


1 ;


Representing each department in the College of Pharmacy,
ribbon cutters are: (from left) Reginald Frye, Ph.D., Dean
William Riffee, Ph.D., Maureen Keller-Wood, Ph.D., Margaret
James, Ph.D., and Guenther Hochhaus, Ph.D.


Curious About Your Vital Signs?
One Day Soon, Check Your Laptop
The cameras and MP3 players are fun, but the next wave of add-
ons for cell phones and laptops may help users keep track of their
health.
A UF engineer has built a working prototype for a small,
portable system that can monitor a person's breathing and heart
rate automatically via wireless signal, with no need for cords
or plugs. The goal is to make it easy for people to check their
own vital signs, and then transmit them in real time to medical
personnel through a cell phone or Internet connection, all with little
more than a press of a button.
"The initial idea is that elderly people who may have difficulty
getting around -they won't need to go to the hospital or the
doctor's office every time they need a checkup, they can just
send in their data and talk to the doctor," said Jenshan Lin, a UF
electrical and computer engineering associate professor who
pioneered the technology with colleagues at Stanford University
and the University of Hawaii.
The system is a fresh development in a growing trend aimed at
tapping the latest technology to improve home health care, widely
acknowledged as an important solution to rising health care costs.
Drivers of the trend include increased research funding from the
National Institutes of Health as well as the emergence of private
companies seeking to capitalize early on a new market for the
nation's growing elderly population, experts say.
Aaron Hoover
UF News & Public Affairs


3


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PATIENT CARE


Delaying dental visits can be a pain


By Lindy McCollurn-Brounley


ural residents are nearly twice as likely as
their urban counterparts to postpone
timely trips to the dentist, seeking help
only after they develop a problem and oral pain is
severe, UF researchers report.
The delay results in widespread dissatisfaction
with treatment and less than optimal outcomes.
"What we found is there is a group of people
who wait until their condition is of sufficient
painful intensity and duration before deciding
that it's bad enough to pick up the phone and call
the dentist," said study investigator Joseph Riley,
Ph.D., an assistant professor of public health
services and research at the College of Dentistry.
"There is evidence that these people assume this
problem-oriented approach to oral health because
of low access to care, whether that be due to an
inability to pay or the lack of dentists practicing
in rural areas."
UF researchers, writing in the April issue of
Public Health Reports, noted similar trends among
blacks and women, though men with painful
symptoms were the group most likely to entirely
avoid dental visits, possibly attempting to self-
medicate their pain at home to avoid going to the
dentist.
Over a four-year period, the researchers studied
patterns in access to dental care among 703
randomly selected people aged 45 years and older
living in rural or urban counties in North
Florida.
Researchers interviewed each participant and
conducted an oral examination at the beginning
of the study. They then conducted follow-up
telephone interviews at six-month intervals to
track financial status, symptoms of oral pain and
usage of dental services and treatment. Study
participants were also interviewed in person and
underwent additional oral examinations two and
four years into the study.
Study investigators found rural residents and
people who take a problem-oriented rather than
preventive approach to oral health care were more
likely to need emergency dental care for oral pain.
People who live in rural areas and opt to wait
until oral discomfort worsened were at the highest
risk of anyone for needing pain-related emergency
treatment.
Overall, men were 20 percent less likely to seek
and receive dental care at all, even when suffering
from severe oral pain.
"What we found is that patients who had urgent


dental visits because of pain were less likely to be
satisfied by the time it took to be seen, the dental
treatment they received and by the actual outcome
of the visit," said Riley.
Riley said there is nothing unique about the


population has never visited a dentist. The report
also calls the oral cavity the "mirror of health and
disease." More than 90 percent of systemic
diseases such as diabetes, leukemia,
cardiovascular disease and anemia have oral


Dr. Joseph Riley found patients who postponed seeking treatment until their dental problem was
too painful to be ignored were significantly less satisfied with their dental visit experience.


dental choices people in rural North Florida make
compared with residents living elsewhere. The
UF study findings are consistent with data
gathered by the National Center for Health
Statistics, wherein minority and poor populations
carry the burden of oral health problems, he said.
The U.S. Surgeon General's landmark 2000
report on the country's oral health outlines
substantial access to care barriers, such as ability
to pay and a shortage of dentists in certain areas,
and notes 11 percent of the nation's rural


manifestations, and people who have neglected
their oral health are more likely to also have other
medical problems.
Riley said he believes that access to care is not
the only factor at play in determining why people
with oral pain delay seeking dental treatment.
"Dentistry is really about social and
psychological factors; it's perspective, and the
preventive versus problem-oriented approach to
dental care is an attitudinal belief," he said.
"Therefore, it's something that can be changed." O


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C4








PROFILE



Physician who puts the & in UF&Shands retires

By Denise Trunk


Some patients are anchored in Dr. Nicholas Cassisi's mind.
Fixed in his memory is a girl from the Dominican Republic with a huge
tumor in her jawbone.
He'll never forget a teenager from Georgia who lost part of his face in a firearms
accident, and a young boy who was hit by a car while riding his bike in
Jacksonville and was presumed dead.
Each of them needed the help of a specialist in head and neck surgery. Each
found it in Dr. Cassisi's care.
"Throughout your career you remember many patients, and then there are the
standouts," Cassisi says, reflecting on 30 years as a physician, administrator and
researcher at UF. "They are not always the ones that turn out the best, but they
are the ones that have made the biggest impact on my life."
The little girl came with her parents to UF&Shands from a village where her
neighbors thought she was a witch. She found treatment from a man considered by
his peers to be an innovator in the fight against cancer.
Cassisi and his team treated the girl by removing her jawbone and replacing it.
The surgery was complicated, but what Cassisi remembers is the girl's strength,
simplicity and sweetness.
"We took her to an ice cream shop," he says. "With 40 odd flavors to choose
from, she picked vanilla."
A medical doctor who began his career as a dentist, Cassisi became department
chair of otolaryngology, senior associate dean of clinical affairs for the
College of Medicine, Shands' chief of staff and UF faculty
representative to the National Collegiate Athletic Association and
to the Southeastern Conference over the course of his career. In
addition, Cassisi created with Rodney R. Million. M A a new
interdisciplinary standard of treating patien- ',. ih i iali .. n
prior to surgery for head and neck cancer. H, h rj h,,n
repeatedly named in national lists as one of t he nra i.. n',
best doctors. Cassisi will retire on June 30, al i
years at UF.
Before he came to UF, Cassisi earned his
bachelor's degree and his D.D.S. from Weste n
Reserve University in Cleveland. After
finishing his dental degree, he and his wife.
Elayne, moved to Miami to jointly attend( J
medical school at the University of Miami
School of Medicine. He earned his M.D.
in 1965.
In 1973, Cassisi joined the UF
College of Medicine surgery faculty.
Since then he has followed his
philosophy throughout his career to
make an impression on patients,
clinicians and the Health Science
Center itself with his personal,
friendly, caring approach to his
profession.
"My wife and I went to medical
school together," he says. "I was the
youngest of five, and from parents
who came from Sicily and couldn't
even read and write. To go to
medical school was beyond my
wildest dreams. But once I became a


physician, the one thing I tried to remember, if I were sitting where the patient
were sitting, what would I want? How would I feel? What would be my thoughts?
Fears? Concerns? Questions? And I have always tried to keep that in mind when
treating patients."
While his passion for helping people fueled his growth as a physician, a love of
sports and the persistence of William Elmore, then UF's vice president for
administrative affairs, eventually drew him into an administrative role on the
University Athletic Association board.
"I was trying to further my career as a surgeon and academician and I had no
interest in being an administrator, but I picked it up when I was asked to be on the
athletic board," Cassisi said. "It was there that I began to learn about budgets and
how to deal with the administration and things of that sort. I guess I developed a
knack for it."
In 1975 he took the reins of what was then the College of Medicine's division of
otolaryngology, which received departmental status in 1991. In 1994 he was
awarded the Kenneth W. Grader professor of otolaryngology/head and neck
surgery endowed chair. He then was appointed senior associate dean for clinical
affairs in 1997.
When he became chief of staff at Shands in 1999-2000 and served a second term
in 2003-04, he united both academic and clinical aspects of his field. Because he
was surgeon and seeing patients himself, he had a real understanding of the wrok
environment for Shands physicians, and in his clinical affairs position worked
with doctors in the College of Medicine's various clinics to make their jobs easier.
"I like to meet one on one, doing things that are hopefully beneficial, putting
out fires, planning, meeting with faculty, chairs and try and mentor them. Because
I have been here a long time and I have seen them come and go and I've seen
F. hii hcrp, p,..pkl i.. hLe uLLL. lul and I have seen what pitfalls there are,"
( amI!! a\
\ hIn heI i'mI Ii. irrm hi, full-time position and appointments at
S he nJ .. i he mrrnrih. he will no longer do surgery, but he will
-ni inu i. L, pjal ents on two half-days a week "for as
I, ,nr a j I can h, of service helping with patients."
I I !I J u nique perspective from which to view
i he i .%vth of the HSC over the past 35 years -
Ih ai of a participant-observer to its
expansion.
"The biggest satisfaction to me is to
see how many talented people are here,
and they are here because they love
Gainesville, they love the University of
Florida," he says. "They could be
anywhere, but they choose to stay
here. And I think that to me is a huge
change from the way it was, to where
we are now. And I think we have
come a long way."
In his free time, he plans to travel
.more with his wife of 47 years, visit
1.. ^his out-of-town children and four
grandchildren and pick up a hobby
he put down in dental school.
"I want to make jewelry again,"
S. he says, "I like to work with my
S hands and I want to continue to
do that." 0


5








RESEARCH


Fibromyalgia patients may benefit

from cough remedy, UF study finds

By Tom Nordlie


An over-the-counter medication that silences
coughs may help fibromyalgia patients quiet
over-reacting nerves that can amplify
ordinary touches into agony.
A UF study documents, for the first time, that
dextromethorphan temporarily reduces the intensity
of fibromyalgia "wind-up," a snowballing pain
response to minor, repetitive physical contact. The
discovery, described in the May issue of The Journal
ofPain, also enables researchers to rule out one
suspected cause of the phenomenon.
Fibromyalgia is an incurable illness that causes
widespread muscle aches, stiffness, fatigue and sleep
disturbances, according to the National
Fibromyalgia Association. An estimated 10 million
Americans suffer from the condition, most of them
women. Current treatment strategies include pain
medication, exercise, stretching, sleep management
and psychological support.
Though the UF study did not establish guidelines
for using dextromethorphan clinically, it suggests
the drug may eventually be an option for treating
fibromyalgia and other conditions involving
heightened pain sensitivity, said rheumatology
expert Roland Staud, M.D., a UF associate professor
of medicine and the study's principal author.
"I think it's one piece of the mosaic," Staud said.
"We currently have no single therapy in chronic
pain that has a big effect. So what this really means
for chronic pain patients is that they need to use a
whole host of different interventions to decrease the
pain they have. And in this, dextromethorphan may
have a role in the future."
Dextromethorphan is popular in cold remedies
because it elevates the threshold for the coughing
reflex but does not cause physical addiction,
according to the U.S. Drug Enforcement
Administration.
But fibromyalgia patients should not resort to self-
medicating by taking cough syrups for pain, Staud
cautioned.
"Like every medication, dextromethorphan has
side effects," he said. "At high doses, patients can
have problems related to memory and confusion."
The underlying cause of fibromyalgia remains
unknown, but in the past 25 years substantial
progress has been made toward understanding the
mechanisms behind specific features of
fibromyalgia, Staud said. One is central
sensitization, a feature of many chronic pain
conditions in which the central nervous system -
the brain and spinal cord somehow magnifies
pain signals to abnormally high levels, said Staud,


who is affiliated with UF's McKnight Brain
Institute.
Central sensitization is associated with wind-up, a
phenomenon in which repeated touches even
handshakes or pats on the back generate
lingering pain that increases with each new contact,
he said. A normal form of achy, lingering pain
known as secondary pain affects anyone who suffers
an injury.
The UF researchers Staud, neuroscientist
Charles Vierck, Ph.D.; psychologist Michael
Robinson, Ph.D.; and Donald Price, Ph.D. were
surprised to learn that dextromethorphan eased
fibromyalgia patients' wind-up pain to the same


Clinical research coordinator Myriam Lopez (left)
fibromyalgia patient Pamela Kennedy.


degree it soothed secondary pain induced in healthy
volunteers, Staud said. The results indicate a long-
suspected cause of wind-up may not exist.
Previous studies at other institutions had shown
that dextromethorphan blocks the action of a
chemical messenger called N-methyl-D-aspartate, or
NMDA, which relays pain impulses in the spinal
cord. Many fibromyalgia researchers have theorized
that wind-up is caused by abnormalities in the
spinal-cord structures that process NMDA.
The UF results suggest those structures function
normally but that pain impulses are more amplified


in fibromyalgia than in healthy participants, Staud
said.
"This has refocused much of our research now,"
he said. Future UF studies will attempt to pinpoint
where the pain impulses are originating.
In the current study, researchers worked with 14
women with fibromyalgia and 10 women who did
not have the disease, using mechanical devices that
tapped the participants' hands repeatedly. One part
of the study involved contact with a heated probe,
the other used a small rubber-tipped peg. The
intensity of the heat or pressure of the stimulation
was individually adjusted so that all participants
reported feeling the same degree of pain.


performs sensory testing using heat on


Researchers then gave each participant a capsule
containing 60 milligrams of dextromethorphan, 90
milligrams of dextromethorphan or a placebo
containing none of the drug, and asked them to rate
the amount of pain they experienced when the
stimulation was repeated.
With the heat stimulus, 90 milligrams of
dextromethorphan reduced wind-up pain, but 60
milligrams was no more effective than the placebo.
With the pressure stimulus, 90 milligram and 60
milligram doses were equally effective, reducing
wind-up pain. O


C6








RESEARCH


Doctors miss depression

diagnosis in many heart patients

By Melanie Fridl Ross

When it comes to heart disease, many patients are singing the blues yet too few doctors
recognize it, UF researchers warn.
A growing number of studies link heart disease and depression, a powerful risk factor
equivalent to smoking or high blood pressure that hikes the risk of heart attack or death two to
three times above normal. Conversely, those who are depressed are more likely than their
cheerful counterparts to develop heart disease.
"It's very common, and physicians both primary care physicians and cardiologists -
should be proactively screening patients in their office for depression to at least attempt to
identify it," cautions UF cardiologist David S. Sheps, M.D., writing in a depression-themed
supplement of Psychosomatic Medicine. "Many patients are coming to see their primary care
doctor or cardiologist for other reasons. Most of them are not aware they are depressed, and
these physicians are not trained to detect depression or to screen for it. Most often the diagnosis
is missed."
As many as a third of heart disease patients are depressed, Sheps said. And doctors now also
suspect the drugs used to treat high blood pressure may intensify feelings of depression as much
as other risk factors, such as stroke or prior history of depression, according to findings from a
large international study published in the main issue of Psychosomatic Medicine.
"If a person is already depressed, a physician might want to consider a choice of one drug or
the other for that patient if they are clinically equivalent if the cardiovascular results and the
blood pressure effects are the same," said L. Douglas Ried, Ph.D., a professor of pharmacy
health care administration at the College of Pharmacy and a research health scientist in the
Rehabilitation Outcomes Research Center at the Malcom Randall Veterans Affairs Medical
Center.
The new findings stem from a substudy of a UF-led trial that tracked 2,317 of more than
22,500 patients randomly assigned to one of two blood pressure-lowering treatment strategies: a
sustained-release form of the calcium antagonist verapamil or the beta-blocker atenolol and
diuretics. Both groups also could receive an angiotensin-converting enzyme, or ACE, inhibitor.
Researchers compared self-reported symptoms of depression after one year of treatment. On
average, after one year of treatment the mood of patients on verapamil SR improved. Overall
mood did not improve among patients whose treatment included atenolol. Seventeen percent of
patients taking verapamil SR reported being highly depressed, compared with 22 percent of
those taking atenolol.
Future research should involve a more rigorous measure of depression, Ried said.
Practitioners could easily check for depression using standardized questionnaires. Screening
for depression is worthwhile, Sheps said, even if it turns out that treatment of depression doesn't
reverse the adverse prognosis for heart disease. Q


61


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A woman undergoes an imaging exam designed to evaluate
heart function at the Malcom Randall Veterans Affairs
Medical Center.


Rat studies show what mom eats may predispose offspring to diabetes, obesity


You are what your mom ate.
That could someday prove to be the latest twist
on a well-worn adage, say UF researchers. As alarm
rises over soaring rates of obesity, diabetes and high
blood pressure, scientists are eager to determine
whether nature or nurture -or some combination
spurs development of these conditions.
One possible answer: What mothers eat when
they are pregnant could alter the function of key
genes in their offspring, even without changing the
genes' fundamental DNA sequence. The notion is
part of a new field known as epigenetics.
"There are many people around the world
who don't have enough protein in their diets, and
malnutrition is a major cause of babies being born
small around the world," said Donald Novak,
M.D., a professor with the division of pediatric


gastroenterology at the College of Medicine. "There
is a lot of evidence that when infants are born small,
compared to their counterparts, they have a higher
risk of these specific disorders. We are trying to sort
out why that might be."
At the recent annual meeting of the Pediatric
Academic Societies, UF researchers released
preliminary findings from ongoing animal studies
that reveal a high-protein maternal diet predisposes
offspring to health problems such as insulin
resistance in adulthood, a precursor to diabetes.
Other early findings, published in the conference
proceedings, show that protein deprivation during
pregnancy also is linked to the development of
larger body type in rats -a tendency that persisted
for two generations.
Babies who are fed formula tend to take in higher


protein levels than those who are fed breast milk.
But researchers don't yet know what the long-term
consequences of this increased protein intake might
be, said Josef Neu, M.D., a professor of pediatrics
in the division of neonatology at the College of
Medicine.
"Human babies who are fed their mother's milk
tend to get a lower protein intake than babies who
are fed formula," Neu said. "There is a higher
incidence of obesity when the kids get older in the
formula-fed babies. So it's possible that there's
something about the composition of the formulas,
like the protein composition, that causes obesity
later on in life. Some of it might have something to
do with the increase in type 2 diabetes that we're
seeing."
Melanie Fridl Ross


7








RESEARCH


Prenatal cocaine exposure exerts

subtle effects on schoolchildren


By Melanie Fridl Ross


Children exposed to cocaine before birth
show subtle but discernible differences in
their ability to plan and problem-solve
once they reach school age, UF researchers report.
Still, most fare far better in the first few years
after birth than many experts once predicted,
contradicting the notion that as a rule, cocaine-
exposed infants would be born with devastating
birth defects or miss major developmental
milestones.
"I think the early information we had was that
these children might be irreversibly damaged-
that they would potentially have lots of problems in
school, that they might have lots of behavior
problems, that they might have problems thinking
and learning," said Dr. Marylou Behnke, a UF
neonatologist.
Instead, UF researchers wrote in the April
online issue of the Journal of Pediatric Psychology,
prenatal cocaine exposure is linked to smaller head
circumference at birth and to less optimal home
environments, which in turn have direct yet mild
effects on developmental outcome at 3 years of age.
Those effects persist at ages 5 and 7, once more
demands are placed on the children during the
formal school years, according to related findings
the researchers presented at the recent annual
meeting of the Society for Research in Child
Development.
"We have found that at age 3, the more cocaine
the child was exposed to, the smaller the head
circumference at birth, and the smaller the head
circumference at birth, the worse the
developmental or cognitive outcomes," said
Behnke, adding that head circumference at birth is
an important measure because generally the head
grows as brain size increases. "We think that head
circumference may be some sort of a marker for
what is going on in the prenatal environment."
Each year, about 45,000 infants who were
exposed to cocaine in the womb are born,
according to the National Institute on Drug Abuse.
UF researchers began studying crack and cocaine
users and their offspring about 13 years ago,
launching a study funded by NIDA that assesses
physical and developmental outcomes among 300
children from birth on. Half the study participants
were exposed to cocaine in utero, half were not.
Average daily cocaine use among the 154
mothers who used drugs throughout pregnancy
was $32.70, the cost equivalent of approximately
three rocks of crack cocaine. Of that group, one


quarter were considered "heavy
users."
"We have found in our
developmental studies of our
newborns that there were some
subtle differences between the
groups, not the kind of things
that moms and dads would
notice particularly, not the
kinds of things that family
members might suspect if they
saw the baby," said Behnke, a
professor of pediatrics at UF's
College of Medicine. "As the
children have started to get
older, we have begun to see a
few more subtle effects."
Cocaine-exposed children
were assessed at age 3 in part by
using the Bayley Scales of Infant
Development, which assesses a
child's ability to perform age-
appropriate functions such as
following simple directions and
completing puzzles and other
problem-solving tasks. At 5 and
7, more extensive
neuropsychological and
intelligence testing was done.
"Some kids just have trouble
getting going, getting
started, and once they get
going they do a little better,"
said co-researcher Fonda
Davis Eyler, a UF professor
of pediatrics. "Others have
trouble maintaining their
attention and they respond


'4


UF research is helping to dispel inaccurate predictions that
stigmatized children exposed to cocaine before birth. The
importance of positive environmental influences in promoting
toddler development, regardless of prenatal cocaine exposure, is
among the key findings of a recent study.


to other cues and not what
they're supposed to be
targeting on and doing, or they only have simple
strategies, not more complex ones."
The quality of the home environment was even
more likely than smaller head size to influence
outcome, Eyler said. UF researchers analyzed
measures of depression and self-esteem among
caregivers and studied their views on parenting
and child development. Children living in
nurturing environments with supportive,
competent caregivers scored higher on
developmental measures, even when they had been
exposed to cocaine before birth.


Study participants are now entering the pre-teen
years. As their academic responsibilities and social
pressures increase, other, more serious effects may
surface, Eyler said.
In the next arm of the study, all will undergo
intelligence and achievement tests, including
assessments of language ability, attention, problem-
solving and abstract thinking, Eyler said.
Researchers also will ask the youngsters about
their attitudes, behavior, family relationships and
friendships. In addition, they will assess the
children's home environment and interview their
caregivers and schoolteachers. O


8








RESEARCH


Inner Space

NASA software goes intra-oral to analyze durability of dental ceramics


By Lindy McCollum-Brounley


Here's a trick question: "What do dental crowns and bridges have in common with the Space Shuttle?"
Answer: "Ceramics, expense and software."
It seems dentistry is a lot like rocket science in that the ceramic materials used to construct dental prostheses
such as crowns and bridges are very similar to that of the more than 20,000 ceramic thermal tiles installed on
the Space Shuttle. Just as with shuttle tiles, ceramic crowns and bridges are exposed to drastic changes in
temperatures (depending on how hot you like your coffee or cold your tea) and must routinely withstand
extreme shearing, crushing and grinding forces.
When they fail, dental prostheses are also pricey to replace, sometimes nearly as
expensive as the roughly $10,000 per shuttle tile price tag.
Fortunately, research at the College of Dentistry is taking a Space Age approach to
analyzing survivability of ceramic crown and bridge materials to determine which
ceramics work best, for how long and under which conditions. Kenneth Anusavice, D.
M.D., Ph.D., a professor and chair of dental biomaterials and associate dean for
research with a joint appointment in the College of Engineering's department of
materials science and engineering, has just received the latest installment of $350,000 for one of the Health
Science Center's longest-running National Institutes of Health grant awards, a project totaling about $4.6
million over the past 23 years.
In its last phase of study, Anusavice's NIH-funded research to predict survivability of ceramic dental bridge
and crown prostheses spans a total of 25 years and now uses NASA software developed to analyze durability of
shuttle tiles under extreme conditions. The software, Ceramic Analysis and Reliability Evaluation of
Structures/Life, analyzes ceramic dental materials to predict length of service (how long you can expect to keep
your crown before it wears out) and fatigue data (why it fractured). The ultimate goal of the study is to identify
ceramic materials and processing methods that will provide longer-lasting service lives for dental prostheses,
leading to lower failure rates and reduced expense for the wearer.
Not surprisingly, this achievement will represent one small step for dentistry and one giant leap for mankind.O




New online journal explores molecular pain on a

global scale

By Lindy McCollum Brounley MC LECULAR

Molecular Pain is an open access, peer-reviewed journal that PA IN
hit the online community this January. The journal, located
at www.molecularpain.com, publishes research that explores
pain at the cellular, subcellular and molecular levels.
Sponsored by the UF College of Dentistry, Molecular Pain is the brainchild of Jianguo Gu, a pain
neuroscientist in the college with ties to the McKnight Brain Institute. Gu views molecular pain research as a
rapidly growing area of study bringing clinicians and patients into a new era of pain research and medicine, but
he was frustrated by the dearth of molecular pain research printed in traditional pain journals.
He decided to launch a journal specifically dedicated to molecular pain research to provide a valuable forum
for molecular pain scientists to communicate their research findings to others with pain research interests that
integrate molecular biology, genomics, proteomics, modern electrophysiology and neurobiology.
Gu and colleague Min Zhuo, a professor of physiology at the University of Toronto, Canada, are co-editors-
in-chief of the journal, which boasts an editorial board of respected neuroscientists from across the globe,
including UF Center for Comprehensive Pain Research Director Robert Yezierski. The editorial board
members work together to peer review report submissions for the e-journal, assuring high-quality research
reports are published. Reports published in Molecular Pain are listed in PubMed for citation by the molecular
pain research community.
"Thousands of researchers and clinicians have become readers of Molecular Pain since its launch at the
beginning of 2005," Gu said. "Molecular Pain has already demonstrated itself as an impact journal in the pain
research society, and its influence will continue to grow through the support of the best pain researchers
around the world as they continue to submit and publish top research papers in Molecular Pain," said Gu. 0


Epilepsy by the numbers

New brain monitoring method would pinpoint
babies at risk for seizures

By John Pastor

Confusion and speech problems are frequent
signs of seizures, but babies offer few such clues
as to what ails them.
Now scientists at the Evelyn F. and William
L. McKnight Brain Institute of UF report they
have found a mathematical way to translate
complicated brain wave readings into simple
terms to help doctors and nurses more easily
identify babies at risk for epilepsy.
Epilepsy describes a group of disorders that
occur when bursts of electrical activity in the
brain cause seizures. It strikes more than 2
million people in the United States, according
to the National Institute of Neurological
Diseases and Stroke. Newborn children have the
highest risk.
But it is difficult to tell whether babies are
epileptic because they are often asleep. Nor can
their movements or speech provide clues.
An electroencephalogram, or EEG, which
monitors electrical activity through electrodes
placed on a patient's scalp, can detect a seizure
in an infant. But the test is expensive, requires a
high level of training to interpret and often isn't
readily available in hospitals.
"An EEG provides a squiggly line readout of
brain activity," said Paul Carney, M.D., chief of
pediatric neurology at the College of Medicine
and a professor at the B.J. and Eve Wilder Center
for Excellence in Epilepsy Research. "Our goal
is to take our findings and develop a tool that
can run in real time right next to the blood
pressure and other monitoring devices in a
hospital. If successful, it would be one of the first
brain function monitors for clinical use in the
neonatal intensive care unit."
UF researchers reviewed the EEGs of 35
babies up to a month old, 23 of whom had
normal brain function. They were able to
pinpoint the newborns at risk for seizures
through differences in key statistical values of
brain activity.
"An experienced pediatric neurologist and
electroencephalographer could certainly
distinguish abnormal from normal newborns by
reviewing their EEGs," said Deng-Shan Shiau,
an assistant research neuroscientist at UF's
Brain Dynamics Laboratory. "However, from
my understanding, for abnormal neonates with
lower degrees of severity, abnormal EEG
patterns may only be obvious in a few segments
in the entire recording. Quantitative EEG
analysis may help doctors quickly identify these
segments and determine if a neonate is normal."
J


0 0 9















technoj


A crazy, glorious game at which

the Health Science Center excels


By Tom Fortner
On a recent Wednesday in May, a classroom in the McKnight Brain Institute
filled to capacity with 60 or so attentive listeners. These weren't fresh-faced
students. Instead picture a diverse collection of students, staff and faculty-
all would-be inventors eager to learn what it takes to start their own companies.
It was a display of entrepreneurial spirit that might have made Thomas Edison
proud.
The interest in technology transfer converting a novel idea into a useful product
available to the masses is almost as ubiquitous on the University of Florida campus
as reddish-orange bricks. From seminars like the ones at the Brain Institute, to the
recent Corporate Leaders Summit that showcased UF medical technology, to hard
investments such as the Sid Martin biotechnology incubator, some facet of the
university tech transfer effort is never far from view.
By just about any measure, the Health Science Center is a major player in that effort.
Many HSC faculty have licensed their discoveries to the private sector. A few have
started successful companies. Their achievements are all the more striking because
despite the many resources available to support tech transfer, it is by nature a long and
often frustrating process, filled with ups and downs and no guarantees of success.
Fortunately, HSC inventors have a powerful incentive working in their favor the
prospect their discoveries will help patients.
"I like to think of technology transfer as a kind of virtuous circle a process that
creates many winners," said Douglas Barrett, M.D., senior vice president for health
affairs. "Obviously, our faculty, our university and our state benefit from the financial
returns that flow from licensing technology, and that's a good thing. But the process
begins and ends at the same place: a patient with a problem. To be able to help solve
that problem is ultimately what it's all about."


HSC LOOMS LARGE
Beyond patient care, the benefits of university tech transfer to society are substantial.
UF's Economic Development Administration University Center recently
commissioned a study that showed companies with UF roots contribute nearly half a
billion dollars annually to the state's economy and account for 2,000 new jobs. It's
estimated as many as three-quarters of these companies are built in part on technology
created at the HSC.
In terms of revenues from UF-licensed technologies, the "gator's share" also has an
HSC flavor to it.
Gator as in Gatorade, that is.
In its long, storied history, the sports beverage invented by Robert Cade, M.D., has
produced millions in licensing income for UF and is still going strong. Less visible but
even more profitable has been Trusopt, the anti-glaucoma drug developed by the late
College of Medicine ophthalmologist Thomas Maren, M.D., and marketed by Merck.
Those two products, combined with income from other HSC-licensed technologies,
accounted for two-thirds of UF's $36.6 million in licensing revenue in 2003-04 alone.
As those two giants of tech transfer mature, there is a natural interest in cultivating
their successors. Fortunately, the pipeline is full, even crowded.
"We're going gangbusters," said Jane Muir, associate director of UF's Office of
Technology Licensing. "Six years ago, we issued eight licenses. We went from eight to
25 to 37 to 59 to 64 licenses and options, and we're on track to do that or better again
this year. The majority are coming from the life sciences."



G Oi


As busy as it has been, the competition for
technology transfer success is intense. For example,
after breaking into the ranking of top 10
universities receiving U.S. patents in 2003 with 59
(up from 42 in '02), UF slipped out of that elite group
by tallying 41 patents in calendar '04, good for a tie for No.
13. Still, the university produced a record 278 invention
disclosures in fiscal year '03, with the HSC accounting for 127.
The HSC tech transfer portfolio is as diverse as you would expect from six
distinct colleges representing hundreds of disciplines. The technology includes
assistive devices like those associated with the Gator-Tech Smart House, a project
involving faculty of the College of Public Health and Health Professions. At the other
end of the spectrum are technologies spawned in the burgeoning field of genetics. Well
down the road to market are Applied Genetic Technologies Corp. out of the College
of Medicine, with gene therapies for inherited diseases, and Oragenics Inc., now
testing a treatment for lifelong protection against tooth decay, the brainchild of a
College of Dentistry faculty member.
In between are a bevy of pharmaceuticals, techniques, procedures and devices
promoting human and animal health. The technologies represent a variety of
business approaches, from licensing of technology to existing firms, to new
company startups with faculty or staff playing key roles, to some blend of
these two.
It was only 25 years ago that federal law essentially created the
technology transfer movement by giving universities and their employees
rights to the intellectual property they create. Indeed, the law obligates
schools that receive federal grants to
proactively protect and market
inventions generated by that
money or else forfeit them to
funding agencies.
The HSC has taken that
message to heart, with the help
of an OTL operation that has
grown dramatically in the past
five years. Overall, UF has
licensed 568 HSC technologies


Proceeds from Ray
Bergeron's inventions paid
for this nuclear magnetic
resonance spectrometer for
the College of Pharmacy.
The equipment, which aids
the process of drug
discovery for COP faculty
members, cost about
$400,000.


COVER STORY


I


- '-'''












to private industry, and HSC faculty hold 356 U.S. patents, about half of the UF
total.
Although inventors who have experienced tech transfer have much to learn
from each other, it's fair to say that everyone's "game" unfolds uniquely. Here
just three perspectives.


A LONG, WINDING ROAD
Whether you've invented the next Trusopt or a technology destined to take its
place beside a long line of forgettable thingamabobs in the annals of the U.S.
Patent Office, it's safe to say that the road to commercial success will not be
without its share of potholes.
Raymond Bergeron, Ph.D., has been getting it right for a long time, and yet he's
the first to say that the experience has been like "laughing through tears." The
graduate research professor in the College of Pharmacy holds an astounding 91
U.S. patents, with another 104 patents pending.
But a patent is just a piece of paper. Far more important, he says, are what those
papers represent, including the two drugs that he now has in clinical trials and the
patients they may help. The new compounds, licensed to Genzyme, target liver
cancer and Cooley's anemia, a genetic blood disorder for which the current
treatment is so unpalatable that some patients forego it even though the disease
can be fatal.
Bergeron is typical of most UF faculty with intellectual
property, in that he has chosen to license his inventions
rather than be directly involved in a company. But that
doesn't mean he's been able to sit back in his lab and wait for
the royalty checks to come rolling in.
"Filing a patent," he said, "it doesn't stop there. That's when
the game is just beginning. You have to make up your mind that
what you just patented is important enough that you're willing to
put in the extra time to bring it forward to society."
SJob 1? To find a partner with the know-how and the money to get
S the product to market. There are many resources out there to help,
S especially from OTL, but as the inventor it will be up to you to persuade
others to get behind your idea, Bergeron said, particularly when you're
involved with a startup company that lacks a track record.
"You're expected to give, it seems at least, endless presentations to the VC
(venture capital) group and to their stockholders, explaining continually why it
is you're doing what you're doing," he said.
Once a solid partner is on board, he sees three major hurdles that have to be
negotiated. The first is scientific and involves refining the technology to make it
work properly. The second involves helping the
company avoid mistakes in
the development process. ___
The third involves "board
room decisions" that can
sometimes seem irrational
when viewed through the
eyes of a scientist.
"They say, 'You know, I
just don't think we want ..
to be in this area,"'
Bergeron said. ,
"'We'd like to be in ,
plastics."'
Asked what the
secret of his
enormous inventive
output is, Bergeron, a
chemist by training, PHOTO BY LISA BALTOZER


didn't hesitate.
"My secret is being in this health center," he said, rapping his knuckle on his
desk for emphasis. "Having an opportunity to interact with the docs, that's my
secret. It's the Holy Grail. Because you listen to what they have to say, and you say,
'Geez, I know how to solve that problem.'"


SOMETIMES, A DETOUR
Meredeth Rowe, Ph.D., an associate professor in the College of Nursing, has had a
different experience. Her good idea went without a corporate sponsor for seven
years. Then, "just by serendipity," she said, it found a home and will soon be
helping families who provide care to a member with a major cognitive impairment
such as Alzheimer's disease.
About half these individuals are prone to sleep disturbances that cause them to
get out of bed at night. Awake but disoriented, they may turn on the stove, flood
the bathroom or leave the house and wander off, possibly to die from exposure.
"Caregivers' strategy to deal with this is they sleep with an open ear," said
Rowe. "This is very taxing on their sleep quality."
Ultimately, the family member caring for the patient can become physically and
emotionally exhausted, with no choice but to place the patient in an institution.
Rowe's idea was to develop a monitoring system to alert the caregiver when the
patient gets out of bed. The development of the system, which she dubbed
CareWatch, was initially funded with a small business tech transfer grant from the
National Institute of Nursing Research.
But contacts with approximately 200 businesses produced no takers.
"I had gone down so many avenues but they were all dead ends," said Rowe.
Finally, through a chance acquaintance with a home security specialist, she got
her idea in front of the home security division of corporate giant Honeywell. They
agreed to develop the device and take it through clinical trials, where it's now in
phase II development.
As the incidence of Alzheimer's increases, the system promises to help tens of
thousands of patients and their families. But Rowe likely won't realize any
financial benefit. Her good idea, conceived when she was a faculty member
elsewhere, was not considered novel enough to be patentable. Still, the project has
provided her with a rich source of research, and she's learned a lot about topics far
removed from her expertise, such as business plans and electronics.
But overall, she said, "It's been very difficult."

THE PATH LEAST TRAVELED
Feeling adventurous? You could always start your own company. The
timing is good, according to industry experts, with capital "coming
off the sidelines" following the dot-corn debacle.
But tread carefully. Only those few who are risk-tolerant, oozing
with self-confidence, and willing to do whatever it takes to be
'LuL--.'C lul in lud ing getting out of the way- need apply.
IDn )r Ru, h.. heads an investment fund and was the
..... Ia uiiicJ peak .e for OTL's kickoff seminar,


Meredeth Rowe's CareWatch
system, based on home
security technology, will soon
be helping families keep track
of their loved ones who have
Alzheimer's disease. Rowe is a
faculty member in the College
of Nursing.


*V__








EDUCATION


General dentistry residents

have high implant success rate


By Lindy McCollum Brounley


When it comes to successfully placing tooth implants, they have the
right stuff.
In fact, first-year general dentistry residents at the UF College of
Dentistry Jacksonville Clinic have a success rate of 98 percent exceeding the
90 to 95 percent average survival rate of implants placed by experienced
clinicians, according to the American Dental Association.
A UF study reported the findings regarding the ability of general dentistry
residents to learn complex implant procedures and successfully place implants in
a mixed patient population in the Journal of Oral Implantology.
"Really, the success rate of the residents, although much higher than expected,
was not the emphasis of the report," said Clifford Starr, D.M.D., clinical associate
professor of community based programs at UF College of Dentistry and director
of the college's Jacksonville dental clinic. "What we wanted to show is that dental
residents can place dental implants with success it's something that residents
can be taught, it's not too difficult to do and general dentists can learn to place
implants and succeed with it."

S- I ......... .


.r*3L 4


I


Jacksonville clinic advanced education in general dentistry
resident, Dr. Bill Stephenson (left), who graduated last year,
and dental assistant Theresa Buford (right), prepare to
examine the implant Stephenson placed in patient Bonita Ross'
mouth. Coincidentally, Ross is also a dental assistant at the
Jacksonville Clinic.


Dental implants, which look and feel like natural teeth, are the latest hi-tech
alternative to dentures and fixed prosthetics like bridges and crowns. Patients are
fitted with a metal post implanted directly in the bone to which a prosthetic tooth
is affixed. The implant tooth provides its own support and does not rely on
adjacent teeth for support or anchorage. Implants are also used to anchor denture
plates, giving the patient a better fit and helping to preserve the patient's
supporting bone.
These advantages have fueled increased patient demand for implants and the
placement of dental implants by dentists has tripled since 1986. Although some
sources state 65 percent of general dentists offer implant restorations as a routine
service of their practices, the ADA reports only 8 percent of general dentists are
doing the actual surgical placement of the implants. The majority of surgical
implants are placed by specialists in oral surgery and periodontology working in
conjunction with general dentists.
Cases of 108 UF patients who received 279 dental implants by residents under
the supervision of the Jacksonville clinic faculty between the years 1998 to 2002



"What we wanted to show is that dental

residents can place dental implants with

success it's something that residents can

be taught, it's not too difficult to do and

general dentists can learn to place implants

and succeed with it."

Clifford Starr, D,M,D,



were reviewed for the study. Patient gender was roughly 60 percent female and 40
percent male, and the majority of patients fell within the ages of 50 to 59 years.
One implant system, SteriOss, was used in 94 percent of the cases, and about 30
percent of the patients required bone grafts to augment the bony ridges of the jaw
or to fill-in the space between the implants and the sockets of extracted teeth.
Of the 279 implants placed, only five failed, resulting in an implant success rate
of 98 percent over the course of four years.
"Five years would be the gold standard for reporting implant success rates,"
said Starr. "That's not what we reported our cases ranged from six months to
four years because we haven't done implants for five years. However, I think the
overall summary of our report is that we have quality faculty and residents using
good implant systems to complete complex cases with great success.
"It would be very valuable to the literature if other residency programs doing
implant dentistry would publish their results so we can learn from each other's
experiences," said Starr. "This would be of great benefit for undergraduate and
graduate programs in the process of introducing implant dentistry into their
curriculum." 0


CI~


/ ii








EDUCATION


What would you put in a time capsule?

By Nina Stoyen-Rozenzweig

When the founders of the Health Science Center put together their historic capsule, they tried to think
of materials that represented the most important and influential materials documenting the planning
process for the center, and materials that would, at some point in the future, allow for dating of the
materials and the building. They lived in a time 1955-when radioactivity seemed the wave of the


HEALTH SCIENCE CENTER



JoOE


YEARS
UNIVERSITY OF FLORIDA
vision M innovation U continuity


future, when it offered unlimited promise for medical research and
healing, so they included facilities for radioactive research in their
plans and a radioactive vial in their time capsule. They knew,
perhaps, that their efforts were indeed unprecedented and
visionary, and they took seriously the job of passing on to a distant
posterity the scope of their efforts.
Today, with the Health Center firmly indeed monumentally
established, we may approach the generation of a time capsule a
little differently. Now we want to document for future generations
the ebb and flow of everyday life. What is it like to come to work
every day? What do we need to make the journey through the
hallways, to communicate with co-workers, keep track of time?
What events preoccupy us? What pieces of information are unique
to our time and likely to have changed dramatically in 50 years?


What do we or our children collect in our off-hours? How do we fund our projects, conduct
research, treat our patients? What treatment is most likely to have changed radically by 2056?
Now, our ideas about what should go into the time capsule not only provide a picture of our lives today
but also represent our predictions as to how life will change and what will be most dramatically
different.
To capture the moment amid the upcoming 50th anniversary celebrations, officials with the College of
Nursing, College of Medicine, Health Center Library and Health Science Center are planning to create
time capsules. They are actively seeking suggestions for objects to go into the capsule and committees
will weigh suggestions and select a range of materials for preservation. Please send in suggestions and
include the reason why you think your suggestion captures an important and perhaps unique part of
everyday life!
Stoyen-Rozenzweig is the archivist for the College of Medicine.
Send your suggestions to her at Nstoyan@vpha.health.ufl.edu





UF department of physical therapy to offer clinical doctoral degree
The UF department of physical therapy has received approval from the Florida
Board of Governors to offer the entry-level clinical doctoral degree, the Doctor of
Physical Therapy, or D.P.T., beginning in fall 2005.
S The UF physical therapy department at the College of Public Health and Health
Professions is one of only two Florida public universities to offer the D.P.T. degree.
SThe department will admit 50 students to the inaugural class.
The D.P.T. degree will eventually replace the master's degree as the entry-level
degree for clinical practice in physical therapy, said Jane Day, Ph.D., P.T., a clinical
Day associate professor and assistant chair of the physical therapy department. The
American Physical Therapy Association recommends that the D.P.T. be the standard
physical therapy degree granted by educational programs by 2020.
"The goal of the D.P.T. program is to prepare graduates to be autonomous practitioners and the
authoritative practitioner in the diagnosis and treatment of movement disorders," Day said. "These are
graduates capable of evaluation and patient treatment ideally prepared to work in collaboration with
other health professionals."
As with the master's degree, a baccalaureate degree is the prerequisite for admission into the three-
year D.P.T. program. The D.P.T. curriculum augments the content of the current master's program by
including additional coursework in areas such as diagnosis, pharmacology, radiology and imaging,
health-care management, and prevention and wellness, as well as additional clinical internship time.
The UF department's future plans call for the development of a transitional D.P.T. program for practicing
physical therapists who would like to earn this doctoral degree.


University of Florida students build
smaller, smarter heart pump
A miniaturized heart pump designed by a team of
University of Florida engineering students could
become a life-saving alternative for patients
waiting in long lines for scarce donor hearts.
The UF team, advised by College of Medicine
faculty, is creating a device with a novel pumping
technology that makes it smaller and smarter than
currently available ventricular assist devices, which
are too large to be implanted in many patients.
The pump's small size means also it would be the
first such device in the United States that could be
used in children.
"Current (heart pumps) are really large and
complicated, so we're aiming to build one that's
smaller and allows more types of applications,"
said mechanical and aerospace engineering
student Ella Kinberg, the project's team leader.
Ventricular assist devices, or VADs, are
connected to a patient's diseased heart, internally
or externally, and help it to pump blood. Although
most VADs are used to sustain a patient's life
until a donor heart becomes available, they also
can help patients recover from trauma such as
open heart surgery, eliminating the need for a
transplant. VADs also are being developed to act
as long-term replacement hearts, a process known
as destination therapy.
The UF student team designed the device as
part of the College of Engineering's yearlong
Integrated Process and Product Design, or
IPPD, program, a government- and corporate-
sponsored research and education program. The
team's goal was to design a smaller, more efficient
version of an innovative prototype pump originally
conceived by UF biomedical engineering doctoral
student Mattias Stenberg, who acted as a project
adviser.
Stenberg designed the original device in
1999 while working with UF mechanical and
engineering professor Roger Tran-Son-Tay.
Stenberg returned to UF in 2004 to develop
and test the prototype with Tran-Son-Tay and UF
College of Medicine assistant professor Charles
Klodell. Both Tran-Son-Tay and Klodell were
faculty advisers on the IPPD project.
"The one thing that (this pump) has that no
other pump has is continuous inflow with pulsating
outflow," Klodell said. "It has a continuous pre-
filling chamber, something that nobody else has
come up with."
"Currently we do about 2,200 heart transplants
per year, but we have about 5,000 people on
the donor waiting list," Stenberg said. "If you
take a look at how many patients have end-stage
heart failure, that figure goes up to 50,000 in the
United States alone."
"This device could save their lives," Kinberg
agreed.
Carolyn Gramling
UF News & Public Affairs


-Jill Pease

13
mwao








DISTINCTIONS


DENTISTRY

ABIMBOLA O. ADEWUMI,
B.D.S., has been appointed
an assistant professor of
pediatric dentistry. Adewumi
earned her dental degree
from the University of Ibadan,
Nigeria. Prior to coming to UF,
Adewumi served as a specialist
registrar in pediatric dentistry
at St. George's Hospital, King's
Dental Institute, Chelsea and Westminster Hospital,
London. She also earned her master's degree in
pediatric dentistry from the University of London.
She is a fellow of the Royal College of Surgeons
of England and the Royal College of Physicians of
Glasgow, Scotland. Adewumi's research interests
include dental traumatology, aesthetic dentistry for
children, and law and ethics in dentistry.

MADHU K. NAIR, B.D.S.,
D.M.D., Ph.D., has been
appointed associate professor
of oral and maxillofacial surgery
and diagnostic sciences.
Nair comes to UF from the
University of Pittsburgh School
of Dental Medicine, where he
served as director and tenured
associate professor of oral
and maxillofacial radiology. His research interests
include tuned aperture computed tomography,
radiology informatics, computer-aided diagnostic
techniques, digital imaging/image processing and
advanced imaging including cone beam computed
tomography.

MEDICINE

MICHAEL L. GOOD, M.D., has
beenappointedseniorassociate
dean for clinical affairs in the
College of Medicine. He will
succeed Dr. Nicholas Cassisi,
who is retiring, effective July 1.
A professor of anesthesiology,
Good joined the faculty of the
college in 1988. A graduate of
the University of Michigan and
its medical school, he completed his residency in
anesthesiology at UF. During his residency and
later as a faculty member, he was instrumental in
developing the Human Patient Simulator that is
now widely used in medical education.
In 1994 Good became chief of anesthesiology
at the Veterans Affairs Medical Center and later
served as chief of staff of the VA, returning to
the UF anesthesiology faculty in 2003. Last year
he was appointed senior associate dean for VA
affiliations.
Good, who said his new job is to "assure the
success of the clinical enterprise," was appointed
following an internal search.


C. PARKER GIBBS, M.D., an associate professor in
the department of orthopaedics and rehabilitation,
was awarded a Pfizer Inc. inSCOPE (Innovative
Scientific Centers of Orthopedic and Pain
Excellence) award. Gibbs will use the award to
provide SEAN MCGARRY, M.D., an orthopedic
research fellowship to join his efforts to identify
tumor stem cells in human and dog bone cancer.

NURSING

ROSE NEALIS, Ph.D., A.R.N.P.,
a clinical associate professor
at the College of Nursing,
was invited to participate in
the 2005 National Institutes l
of Health/National Institute
of Nursing Research Summer
Genetics Institute, designed
to provide advanced nurses
with a foundation in molecular
genetics for clinical practice and the research
laboratory.
Nealis will participate in the two-month summer
research training program held on the NIH campus
in Bethesda, Md. More than 35 genetics experts
from the NIH and universities in the Washington,
D.C. area serve as course faculty for the institute,
which includes a select group of nursing students
and faculty, most of them either doctorally prepared
faculty or Ph.D. students. Graduates will receive
12 hours of doctoral level graduate credit from
the Georgetown University School of Nursing and
Health Studies.

ROSALYN REISCHMAN,
D.S.N., A.R.N.P., a clinical
assistant professor on the
UF Health Science Center's
Jacksonville campus, was
recognized as one of the 2005
Great 100 Nurses of Northeast
Florida.
The Great 100 Nurses
of Northeast Florida Inc. is
a volunteer group of professional nurses that
provides funding for nursing scholarships, supports
research studies to improve patient care and
recognizes outstanding nurses and their successes.
Honorees are selected based on their professional
contributions and how well these contributions are
known and recognized in the community.


Reischman has been a UF nursing faculty
member since 1999 and is a certified adult
nurse practitioner and critical care nurse. She
has authored various publications and given
national and local presentations on critical care
topics, especially related to cardiovascular and
respiratory conditions. She is the Jacksonville
clinical coordinator of the college's acute care
nurse practitioner master's degree track.

JOANNE RICHARD, Ph.D.,
A.R.N.P., an associate professor
and interim department chair of
women's, children's and family
nursing, has been named
associate dean for academic
and student affairs. Richard,
who is also president of the
faculty organization, has had a
distinguished career in nursing
education and practice, including service as dean
of the College of Liberal Arts and Sciences and
director of the division of nursing at the University
of Tampa.

PUBLIC HEALTH & HEALTH PROFESSIONS

A research poster by LINDSEY
KIRSCH, a graduate student
in the department of clinical
and health psychology, was
selected as one of the top
posters at the annual meeting
of the American Academy of
Neurology, held in April in
Miami. Her research focused
on the dissociation between
apathy and depression in Parkinson's disease.

WILLIAM MKANTA, a doctoral
student in the department of
health services research, man-
agementand policy, received the
2005 dissertation completion
grant from the Sherri Aversa
Memorial Foundation. His
dissertation research addresses
health services use among HIV-
infected patients with prolonged
survival.







e wo
ha are


C1








DISTINCTIONS 8 GRANTS




Neubert awarded Pfizer grant
John Neubert, D.D.S., Ph.D., an assistant professor of orthodontics in the College of
Dentistry with a joint appointment in the department of neuroscience, has been awarded
the $130,000 Pfizer's Scholars Grant in Pain Medicine. Neubert was one of two awardees
of Pfizer's nationally competitive pain medicine grant program, which aims to support the
career development and research activities of junior faculty exploring pain medicine.
The grant will fund Neubert's research of orofacial pain as outlined in his winning
proposal, "Mechanisms of orofacial neuropathic pain." The goal of his research is to
explore pain of the face, head and neck caused by trauma to one of the head's largest t i I
nerves, the trigeminal nerve, which enters the brainstem at the base of the cranium.
Some patients who have experienced trigeminal nerve trauma, such as that caused by an
injury or disease, will become hyper-sensitive to temperatures or touch. The slightest cool
breeze against the skin of the cheek may cause extreme spasms of pain, as could the soft '-
touch of cloth or brush of fingertips.
The reasons for these painful responses to normal sensory stimuli are not well-
understood, but Neubert's research goal is to develop behavioral animal models that could
help physicians assess abnormal facial pain in people.
Neubert's grant application was selected by Pfizer's independent academic advisory t
board based on his professional achievement and potential, the innovation and feasibility of
his research proposal, and the credibility and commitment of UF as his mentoring institution.
Lindy McCollum-Brounley












Steindler to collaborate

with California stem cell project HSC faculty named UF Research
An internationally regarded authority on adult stem cells at UF will Foundation Professors for 2005
help oversee research spending at the newly established California Seven HSC faculty were chosen as the University
Institute of Regenerative Medicine, a landmark initiative to supply of Florida Research Foundation Professors for
$3 billion for stem cell research at California universities and 2005 08. In total, 33 UF faculty members who
research institutions. have a distinguished current record of research
Dennis Steindler, executive director of UF's Evelyn F. and and a strong research agenda that is likely to lead
William L. McKnight Brain Institute, was named to the institute's to continuing distinction in their fields were given
Scientific and Medical Research Funding Working Group. He will the award.
serve for six years in an unpaid advisory capacity with 14 of the The UFRF professors Mark Atkinson, Ph.D.; A.
world's top stem cell scientists, seven patient advocates and Robert Daniel Martin, Ph.D.; Terence Flotte, M.D.; Carrie
Klein, chairman of the institute's Independent Citizens Oversight Haskell-Luevano, Ph.D.; Kenneth Heilman, M.D.;
Committee. His duties at UF will not change. Steindler Ann Progulske-Fox, Ph.D., and John Wingard,
"This company of scientists is quite humbling to me," said Steindler, a professor of M.D. were recommended by their college deans
neuroscience and neurosurgery and a member of the Program in Stem Cell Biology and on the basics of nominations from their department
Regenerative Medicine at the College of Medicine. "All of the other scientists are truly chairs, a personal statement and an evaluation of
fantastic investigators." their recent research accomplishments.
The group, chaired by blood-disease expert Stuart Orkin of Harvard University, will help The three-year award provides a $5,000 annual
provide oversight as the institute disburses $3 billion for stem cell research over the next 10 salary supplement and a $3,000 grant. The
years. Broadly defined, regenerative medicine seeks to help natural healing processes work professorships are funded from the university's
better and faster. Stem cell research looks at ways to make use of undifferentiated cells that share of royalty and licensing income on UF-
have the potential to produce any kind of cell in the body. generated products.
"This may be one of the more important service activities that any of our folks could do,"
said Douglas Barrett, M.D., senior vice president for health affairs at the UF Health Science
Center. "In addition, Dr. Steindler will have a unique view of the California initiative."
John Pastor



II15








JACKSONVILLE


A philosophy of involvement wins

Dr. Benrubi a humanitarian award

By Patricia Bates McGhee


Just reading about a typical workday in the life of Guy Benrubi, M.D.,
clinician, professor and researcher, is exhausting for most of us.
He leaves home by 6:15 a.m., scrubs for surgery by 7:15, then checks in to
his departmental office to review e-mail and address administrative problems and
before seeing private patients from 10 a.m. to noon. Lunch, usually over
conferences or meetings, ends by 1:30 p.m., when he returns to surgery or attends
budget or administrative meetings. At 4:30 p.m., he conducts lectures for medical
students and at 5:30 returns to his office in the dean's suite, where he discusses
the day's events with Jacksonville's head administrator. Benrubi finally leaves
campus around 6:30 p.m. Whew, you say! Wait, there's a catch. When he leaves
campus he returns directly home only about 50 percent of the time the other
50 percent he attends professional and philanthropic meetings in Jacksonville.
"I do this for self-preservation," Benrubi says with a smile. "There's some


Dr. Benrubi is a gynecological oncologist at UF&Shands Jacksonville.


excellent research out there that shows that the more involved we are, the fewer
illnesses and colds we suffer, and in the last 10 years I've probably had only two
sick days."
This incredible, nonstop involvement in career and community earned
Benrubi the prestigious Silver Medallion at the 35th Humanitarian Awards
dinner of the National Conference for Community and Justice, held May 26 in
Jacksonville. Also honored were the late Tillie Fowler, Toni Crawford and Ronnie
Ferguson.
Founded in 1927 as the National Conference of Christians and Jews, NCCJ is a
human relations organization dedicated to promoting understanding and respect


and fighting bias, bigotry and racism. The Jacksonville group has been honoring
local humanitarians since 1970.
During his 23 years in Jacksonville, Benrubi has served his family, his faith,
UF, the Jacksonville community and his profession. Community involvement,
leadership and service are part of him, his family and his beliefs.
"My parents taught me that you feel better when you feel that you're
accomplishing something," he explains. "I strongly believe that the more
involved all of us are in our communities, the more freedom we have in our
society."
Benrubi earned his bachelor's and master's degrees from New York University
and his medical degree from the State University of New York/Downstate
Medical Center. He and his wife, Patti, have one son, Daniel. He started his
medical and UF career in 1975 as an intern reporting to Robert Nuss, M.D., now
College of Medicine senior associate dean and associate vice president for health
affairs, Jacksonville.
"Dr. Benrubi is a physician, educator and community leader of multiple talents
with a cosmopolitan view and humanitarian goals," Nuss said. "He's been a credit
to our profession from the time I first met him in 1975, when he was one of my
interns, until now, as my associate. He is most deserving of the NCCJ
Humanitarian Award."
A gynecologic oncologist, Benrubi has trained more than 150 physicians in the
specialty of obstetrics and gynecology while operating his own practice with UF
at Shands Jacksonville. He was named OB/GYN chair in 1996 and became
associate dean for clinical affairs of the Jacksonville campus in 2002.
In fact, Benrubi has trained the majority of all OB/GYN doctors practicing in
the Jacksonville area. Former residents and other physicians frequently contact
him regarding his expertise in the care of OB/GYN patients with complex
clinical problems and for his insights in the area of medical ethics, a field in
which he formally trained and has achieved a reputation as an authority. The
North Florida Ethics Council also seeks his advice.
His commitment to education has earned him numerous awards, including the
Robert J. Thompson Award for Excellence in Teaching (1984 and 2000) and the
UF College of Medicine Outstanding Student Teaching in OB/GYN Award for
the consecutive years spanning from 1992 (when the award was created) to the
present. In 2003, the UF College of Medicine Jacksonville awarded him the Louis
S. Russo Award for Outstanding Professionalism in Medicine.
He also serves as president of both the Academy of Medicine of Duval County
and the Florida Obstetrical & Gynecological Society and is a past president of the
Duval County Medical Society. A member of Leadership Jacksonville Class of
1993, he served on Leadership Jacksonville's board of directors from 2000-03 as
well as president of Jewish Family and Community Services from 1994 to 1996.
He was responsible for JFCS becoming the region's lead adoption agency and the
lead agency for Ryan White funds. He's also serving his second year as president
of the Jacksonville Jewish Federation. He also served as board member of the
Jacksonville Jewish Center from 1999 to 2002.
For his many accomplishments and his tireless devotion to bettering himself,
his profession, his community and his world, Guy Benrubi takes home this year's
NCCJ Humanitarian Award and a sense of personal satisfaction.
"I'm humbled and proud to accept this award," Benrubi says, "especially from
the NCCJ, an organization that strives to keep this country committed to its
ideals." 0


16
II~








EXTRAORDINARYY PEOPLE


Dentistry's Dynamic Duo


By Lindy McCollum-Brounley


Walk into the College of Dentistry's Office of Research, and you may
feel as if you've entered the eye of the storm. Volumes of research
proposals, contracts and letters of correspondence are organized for
filing, phones ring off the hook, and fingers click a staccato on computer
keyboards. Yet despite this busy energy, the two women who staff the office
exude a sense of calm and friendly efficiency.
Jane Moore and Kathy Galloway may be two of the hardest-working women
in dentistry, teaming up to manage the growing tide of grants and awards
funneled through the college's Office of Research. That's no easy task,
considering federal funding has increased nearly 150 percent since 1997,
elevating the college to No. 4 among the nation's 56 dental schools in terms of
federally funded research in 2004.
Moore and Galloway divide and conquer to keep the grant machinery
running smoothly. As office manager, Moore provides support for the pre-award
processing of grant applications, and Galloway, the college's assistant director of
research, manages post-award implementation and monitoring. With $14
million in sponsored research flowing through the office, things can get a little
crazy, but Moore and Galloway take pleasure in maintaining the office's
productivity with a smile.
"Grant application processing is actually a small part of what I do," said
Moore. She juggles grant processing with special projects such as the college's
Summer Research Program, UFCD Research Day and scheduling the speakers
for the dean's Seminar Series. "I love my job, and part of the reason I love it is
because it is so varied and it's never boring."
Galloway takes the lead in monitoring awards after they've been made,
making sure the college stays in compliance with the stipulations of the award
contract, the sponsoring agency and the university. A big part of her job is
training and assisting departmental staff in setting up and monitoring the fiscal
accounting for the award.
Both women feel serving others is a critical component of their jobs, and they
take a proactive, teaching approach to helping students, faculty and staff
navigate the complex and confusing landscape of award regulations and
requirements.
"I think anytime we can help people, we should be willing to do that with a
good spirit," said Moore. "It makes you grow and makes you a better employee."
Maintaining this service excellence in a demanding office is a tall ticket for a
staff of two, especially when one considers the college's goal is to expand the
already burgeoning program of sponsored research by another 50 percent over
the next five years. But Moore and Galloway are committed to the ethic.
"I'd like to see our office expand, hire more personnel so that we can give
better service to our faculty and staff. But I have to give credit to the
departmental staff I work with, because they're on the front line and have to do
the work every day," said Galloway. "If it wasn't for their hard work, we
wouldn't be as good as we are." 0


'K, Z r~;
-r a .r 1e


Jane Moore (seated) and Kathy Galloway staff the College of Dentistry's
Office of Research, keep the college's $14 million sponsored research
enterprise moving forward efficiently. Each demonstrate outstanding and
uncomplaining service ethics in the fulfillment of their job responsibilities.


0 0 17
9X*V~







FIVE QUESTIONS


Planning health care

in advance
As the media covered the case of Terri Schiavo, who died March 31 -
in a hospice in Florida after a court ordered the removal of her
feeding tube, almost everyone agreed on one aspect of the situation
- it would have been better if she had written her wishes regarding
end-of-life care in a living will. Bill Allen, J.D., director of the
program in bioethics, law and medical professionalism at the
College of Medicine, discusses the importance of living wills and
advance directives.




What is an advance directive?
An advance directive is a witnessed
written document or oral statement by
which a person expresses her choices
on any aspect of her health care, including designation of a health-care surrogate, a living will, pre-hospital do-
not-resuscitate order, or anatomical gift. The purpose of an advance directive is to enable a person to direct her
medical decision-making during a time when the person has lost the ability to make decisions directly, whether
temporarily or permanently. Any of these types may be used alone or combined into a single, comprehensive
advance directive.

What are the advantages and limitations of a living will?
A living will allows you to express in your own words such choices as whether you want to die in a hospital, at home
or in hospice care, under what circumstances you want to be sustained on life support or have life support withheld
or withdrawn, and what you consider to be the minimally acceptable quality of life for which you are willing to
accept aggressive therapy or life support.
Although a living will provides important direction about your end-of-life choices, most people cannot specifically
anticipate all of the medical situations and choices that may need to be made toward the end of life. That is why
the designation of a health-care surrogate is needed to supplement your living will.

What are the advantages of designating a health-care surrogate?
You can give authority for health-care decisions to someone who is in the best position to say what you would
choose when you are incapacitated. The language of living wills usually refers only to end-of-life decision-making,
but health-care surrogates can make medical decisions for you at any time, even when you are only temporarily
incapacitated, such as during periods of illness or surgery.

How can one obtain an advance directive?
Hospitals, nursing homes and hospices all have ready-made forms that you can complete, as well as many Web
sites that can be found by a Google search. An even better approach is to use these forms to select the features
and language you like best to construct your own advance directive, uniquely expressing your values. There is no
magic legal language that is required, so you do not need a lawyer. It is perfectly valid to write your own directive
or to orally express it to your physician and have her record it in your medical chart.

What if you change your mind?
You may change what is in your advance directive at any time simply by modifying it at will. Be sure to give the
updated version to your surrogate and your physician, so that they can replace the old one. In fact, as your
life changes by divorce or death of your surrogate or changes in your medical conditions, you should make
appropriate changes in your advance directive. 0













Annual Multidisciplinary Symposium on Breast Disease

Since 1995, the Annual Multidisciplinary Symposium on
Breast Disease, a program of UF's Health Science Center in
Jacksonville founded by Shahla Masood, M.D., has promoted
breast cancer education and pioneered a multidisciplinary
approach to breast cancer research, diagnosis and treatment.
To celebrate the event's 10th anniversary, this year's
symposium -set for June 30 through July 3 -will be held
in Paris.
"Our symposium was one of the first in the world to bring
together all the specialties involved in the study and treatment
of breast disease and allow them to share their experience,"
says Masood, meeting founder and director. "Our event has
become a national and international model for institutions




"So You Want to Start a Business," said the entrepreneurial approach is less about
science and more about business.
"It's not all about the whiz-bang mousetrap that you created," said Rua, who
holds degrees in law and business from the University of North Carolina. "There
are a lot of talented people in this room, but it's probably on the science side."
Reasons for starting companies include the desire to be involved in all aspects of
the business and making more money than might be possible through licensing to
others. But Rua said the prospect of personal financial gain shouldn't be the
primary motivator.
"There are so many ups and downs in this business," he said. If you are in it
mainly for the money, "you're not going to stick to it, which is really what makes
the winners."
In fact, investors will expect a business founder to tap into his own cash, as well
as that of "family, friends and fools," before they chip in additional funds.
Jeffrey Leismer thinks he has what it takes to start his own business. A doctoral
student in mechanical and aerospace engineering, Leismer attended the seminar
on entrepreneurship and has an air of quiet confidence as he discusses his plans.


Jeff Leismer, a UF doctoral candidate in mechanical and aerospace
engineering, hopes to patent biomedical technology he developed and
start his own company.


that value the significance of a multidisciplinary and integrated
approach to breast health care to better serve our patients."
This year's meeting -in association with the Institut Curie,
Institute Gustave Roussy and Centre Rene Huguenine and with
funding from the Susan G. Komen Breast Cancer Foundation
will feature a public forum in French, designed to further
extend the event's outreach goals by providing scientific
knowledge to the general public.
This is the second time the symposium has been held
outside the United States, with the first being in Rome in
2000. The event has grown from 129 participants in 1995
to more than 500 in recent years, with as many as 123
international speakers.




When he was a master's degree student in Michigan, Leismer came up with the
notion of strengthening muscle and bone with a non-invasive vibrational stimulus.
The handheld device could be used by astronauts and others whose muscle and
bone atrophy from lack of use or are damaged by disease.
When he arrived at UF to pursue his Ph.D., the Office of Technology Licensing
thought enough of his idea to absorb the cost of filing a patent application on his
behalf. His utility patent application is due to be reviewed in October.
In the meantime, he's writing an NIH small business technology transfer grant
to finance development of his product, and he's talking to venture capitalists,
attending seminars and connecting with faculty from other disciplines to improve
his idea. He says he's bootstrappingg."
"I'm learning a lot of things out of necessity," said Leismer. "That's the way the
business world works."
His early contact with venture capitalists, he said, "may have been a little
premature, but it was great to let them hear about my plan and what they thought
of it. It provided me with some of the critical information that I needed to
proceed, to make my business sound like something they'd want to invest in."
For Leismer, starting his own company puts him in the driver's seat, better able
to determine his destiny.
"I have my own ideas," he said. "If I am in charge of what I'm doing it will be
easier to bring those ideas to life." 0


Want to play Biotechnopoly? Call OTL

Got a killer idea for an invention? Make a beeline to UF's Office
of Technology Licensing. The expert staff can help an inventor take
the first critical steps in protecting intellectual property, evaluating
its marketability and identifying the best way to get an invention to
market.
In addition to helping inventors stay in step with various legal
requirements, OTL provides a host of educational programs that
can acquaint them with what it takes to license technology or start a
business. The office also sponsors events that showcase university-
developed technologies to investors, and regularly connects inventors
with its network of entrepreneurs, venture capitalists, and corporate
research and development contacts.
Want to learn more? A good place to start is the OTL Web site at
www.otl.ufl.edu. Or call the staff at 392-8929. It's the smart play.


U.19








LOOKING' AT YOU


[ r.J


Sidney Gorden keeps
the HSC looking sharp
as a custodial worker.
He has worked for UF
for 20 years.


Published by
UF Health Science Center
Office of News & Communications
Senior Vice President for Health Affairs
Douglas J. Barrett, M.D.
Director, News & Communications
Tom Fortner
Editor
Denise Trunk
Senior Editors
Melanie Fridl Ross, John Pastor
Designer/Photographer
Lisa Baltozer
Staff Writers
Tracy Brown, Sarah Carey, Tom Fortner,
Linda Homewood, Lindy McCollum-Brounley,
Patricia McGhee, John Pastor, Jill Pease,
Melanie Fridl Ross, Denise Trunk


Support Staff
Cassandra Jackson, Beth Powers, Kim Smith
Intern
Leah Cochran
The POST is the monthly internal newsletter for
the University of Florida Health Science Center,
the most comprehensive academic health center
in the Southeast, with campuses in Gainesville
and Jacksonville and affiliations throughout
Florida. Articles feature news of interest for and
about HSC faculty, staff and students. Content
may be reprinted with appropriate credit.
Ideas for stories are welcome. The deadline
for submitting items to be considered for each
month's issue is the 15th of the previous month.
Submit to the editor at dtrunk@ufl.edu or
deliver to the Office of News & Communications
in the Communicore Building, Room C3-025.

www.news.health.ufl.edu


UF Health Science
CENTER


Chuck Robertson, a
library technical
assistant, and Gloria
London, a senior
clerk, take their shift
handling the returns
and checkouts at the
HSC Libraries main
desk.















Susan Gardner, a
program assistant for
the office of graduate
education, takes a
break from her work in
the office of the dean
of the College of
Medicine.