Front Cover
 Table of Contents
 Post it
 The HSC libraries
 Molar man
 Polar polution
 Making good sense
 HIV-related dementia
 Forensics goes global
 Leaving New Orleans
 Steeve Giguere's foal care
 Dr. George Wilson
 Grants: oral cancer awareness
 Grants: stroke rehabilitation


The Post
Full Citation
Permanent Link: http://ufdc.ufl.edu/UF00073869/00002
 Material Information
Title: The Post
Uniform Title: Post (Gainesville, Fla. 2001)
Physical Description: v. : ill. ; 28 cm.
Language: English
Creator: University of Florida -- Health Science Center
University of Florida -- Health Science Center. -- Office of Public Information
Publisher: HSC Office of Public Information
Place of Publication: Gainesville Fla
Creation Date: November 2005
Publication Date: 2001-
Frequency: biweekly
Subjects / Keywords: Health occupations schools -- Periodicals -- Florida   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
periodical   ( marcgt )
serial   ( sobekcm )
Statement of Responsibility: The University of Florida Health Science Center.
Dates or Sequential Designation: July 27, 2001-
General Note: Title from caption.
 Record Information
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 47826372
lccn - 2001229452
System ID: UF00073869:00002
 Related Items
Preceded by: Friday evening post (1989)


This item has the following downloads:

00001 ( PDF )

Table of Contents
    Front Cover
        Page 1
    Table of Contents
        Page 2
    Post it
        Page 3
    The HSC libraries
        Page 4
    Molar man
        Page 5
        Page 6
        Page 7
    Polar polution
        Page 8
        Page 9
    Making good sense
        Page 10
        Page 11
    HIV-related dementia
        Page 12
    Forensics goes global
        Page 13
    Leaving New Orleans
        Page 14
    Steeve Giguere's foal care
        Page 15
    Dr. George Wilson
        Page 16
        Page 17
    Grants: oral cancer awareness
        Page 18
    Grants: stroke rehabilitation
        Page 19
        Page 20
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0 COVER Making good sense
@ RESEARCH HIV-related dementia
O EDUCATION Forensics goes global
@ COMMUNITY Leaving New Orleans
Q PROFILE Steeve Giguere's foal care

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n the building

Estelita Winkel, a building services
employee, has an Elvis sighting in an
HSC hallway.
The King is visiting the HSC to
spread the word about the Nov. 4
Faculty & Staff 50th Anniversary
Appreciation Luncheon.
All HSC and Shands employees are
invited to attend the picnic on the HPNP
plaza, where hamburgers and hot dogs
will be served as 1950s tunes play.
Elvis says come celebrate 50 years at
the appreciation luncheon with Albert
and Alberta and the Gator Dazzlers from
11:30 a.m. to 1:30 p.m.
Bring your orange and blue suede
shoes and come out for a good time.

2Visit us online



S ',,


S@ http://news.health.ufl.edu/ for the latest news and HSC events

is i

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If you think folding a full-sized road map into a tiny rectangle borders on
astonishing, consider this: If the DNA in your body were put end to end, it would
reach to the sun and back more than 600 times. This amazing feat of packaging is
possible because of a substance called chromatin.
Two national speakers who are experts in chromatin studies will be featured at Florida
Genetics 2005, a symposium scheduled from Nov. 30 to Dec. 1 at the Reitz Union.
Karolin Luger, Ph.D., an assistant professor of biochemistry and molecular biology at
Colorado State University and an expert in the use of X-ray crystallography in chromatin
analysis, has been added to the symposium lineup for a 9 a.m. session Dec. 1.
Gary Felsenfeld, Ph.D., chief of the physical chemistry section and the molecular
biology lab at the National Institute of Diabetes & Digestive & Kidney Diseases, will
discuss the relationship between chromatin and gene expression during the opening
session at 2:30 p.m. Nov. 30.
In keeping with this year's theme of "epigenetics," Eric J. Richards, Ph.D., a
professor of molecular genetics and plant biology at Washington University, will give
a presentation after Felsenfeld about epigenetic variation and inheritance.
The symposium is sponsored by the UF Genetics Institute, the Center for
Mammalian Genetics, the Plant Molecular and Cellular Biology Program and Health
Science Center Libraries. Visit the UFGI Web site at www.ufgi.ufl.edu for more
information, or call the Genetics Institute at 846-2782.

October was National Medical Librarians Month.
The HSC celebrated with a new series of RxEAD
posters featuring representatives from various
interdisciplinary institutes and centers. Dennis
Steindler, executive director of the McKnight Brain
Institute, chose Merchants of Immortality: Chasing
the Dream of Human Life Extension by Steven S.
Hall as his favorite read. Come see the others in the
display case in front of the library and at
www.library.health.ufl.edu/pub/RxEAD thumbsl.html.

How can health-care workers prevent the transmission of avian flu from animals to
humans? Is the health-care system ready to tackle the challenges of the growing
elderly population? These public health concerns and more will be addressed at the
2006 Winter Public Health Institute, sponsored by the College of Public Health and
Health Professions and the University of Minnesota School of Public Health. Additional
topics include behavioral health in disasters; risk communication and food safety;
international health; and theory and methods in public health disability research.
Courses can be taken for graduate level credit or continuing education hours.
For more information, including a complete schedule and registration form, visit

Beginning immediately, the allhsc-I@lists.ufl.edu email listserv can only be used
to send official business messages. Three alternative methods for HSC-wide
communications regarding conferences, workshops, news and more are available.
For details about these methods and instructions for sending official business
messages, see http://www.health.ufl.edu/allhsc.
The Bridges Advisories will no longer be sent via email. Please bookmark the
following Web site and visit weekly to read the advisories: www.bridges.ufl.edu/


A handful of dental students had to weigh in to help faculty as they
battled the sophomore dental class in a tug-of-war contest during the
Oct. 1 Mighty Molar event. Nonetheless, the sophomores won the
friendly match, easily overpowering dental professors Marc Davis
(left) and Amer Afif Abu-Hanna, who teamed-up with Dean Teresa
Dolan (center in black) and daughter Tori, 10. The American Student
Dental Association hosts the College of Dentistry's annual Mighty
Molar event, held every year since the college's first class entered the
college in 1972, as a fundraiser for ASDA activities.

Students arriving after 5:30 p.m. may park for free at the Health Science Center's
west visitor and patient garages only by taking the following steps:
Stop when you enter the garage after 5:30 p.m., present your student parking
decal to the cashier and receive a "free exit" permit valid for the same day only.
Present the permit to the cashier in lieu of the $3 parking fee when you exit the
garage between 5:30 p.m. and 9:30 p.m. Currently, there is no charge for
vehicles exiting after 9:30 p.m.
Please call Transportation and Parking Services for additional information at

Joyce Conners, a program assistant in
the department of molecular genetics
and microbiology, won a week's worth of
free priority parking in the HSC 50th
Anniversary Trivia Contest. She used her
16 years of personal history at the HSC
to correctly answer the question, Which
of the six colleges now in the Health
Science Center was the first to open (on
campus) and in what year? The answer?
Pharmacy in 1923. To participate in the
trivia challenge visit, http://50years.

Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events

BB p S 3

--II L-~-l -L I



Library changes with the times

By April Frawley Birdwell
here were no laptops, online medical journals or medical reference Web sites
when Mark Barrow, M.D., entered medical school in 1956.
The library tucked in the back of the University of Florida's new Medical
Sciences Building was the only place students could find the research they needed
to prepare for class and clinical rotations. Barrow and his classmates were there
every day to thumb through medical journals and search through the stacks.
The library was so crucial to the health center that founding dean George T.
Harrell, M.D., hired librarian Fred Bryant before he recruited faculty members
and department chairs.
"It was absolutely essential to have a good library," said Barrow, a graduate of
UF's first medical school class.
But the library is no longer the place where Barrow searched the stacks. The
main library is not even in the same building, but that's the least of the ways the
Health Science Center Libraries has changed in the past five decades.
The books and journals are still there, 355,827 of them to be exact. But the way
today's librarians get information to students, researchers and faculty members is
not as simple as stamping a card in the back of a book. Now users access most
journal articles from their computers or pocket PCs.
"We're changing," said Faith A. Meakin, M.L.S., director of the Health Science
Center Libraries. "Some people are upset about it. They love the smell of the books.
They love the library. We don't want to lose that either. It's part of our identity. But
it's not our only identity.
"The librarian's role has evolved."
In 1954, when Bryant was hired, the librarian's role was chief collector. Bryant
had two years to build a core collection, often traveling to Europe to track down
hard-to-find journals from publishers and medical societies, Meakin said.
"You could really build a core collection," Meakin said, "but it was not an easy
job. It was a huge undertaking."
Somehow, Bryant did it. By 1955, he had amassed 22,000 volumes of journals,
monographs and 144 subscriptions, which he kept in the main library while the
Health Science Center was being built, according to a Bulletin of the Medical Library
Association article Bryant wrote. By the time students arrived in 1956, there were
nearly 50,000 volumes in the HSC library.
"He amassed an incredible collection," Barrow said. "Dean Harrell played a
significant role. He wanted to have a (good) library as quickly as possible. And it
was an excellent library."
But seeds of change were surfacing by 1967 when Ted Srygley was hired to head
the library. The library was already outgrowing its space and then-Provost Sam
Martin wanted Srygley to introduce computer automation to the library's system.
With computers, the card catalog was obsolete and researching journal articles
grew easier. But it wasn't until after Srygley left in 1993 that the Internet
revolutionized the library.
"(Technology) has changed the delivery of information significantly," Srygley
said. "Everything shifted from collection development to information delivery.
The days of having everything under one roof are gone."
Now, state universities collaborate to share online resources, providing HSC
users access to twice as many online journals in the past few years, said Lenny
Rhine, Ph.D., the library's assistant director for collection management.
And instead of collecting as they did decades ago, or searching as they did in the
1980s, HSC librarians now show students and researchers how to find information
themselves. The library even partnered with the Genetics Institute and the College
of Nursing to teach students and researchers how to find resources.
Despite the technology, Meakin says the number of people using the library has
jumped. But they're coming for different reasons than Barrow and his classmates

C41. IVisit us online @ http://news.health.ufl



Students sit by a picture window in the Health Science Center's
original library, which was located in the Medical Sciences Building. In
1974 the library moved to the Communicore Building, where it is still
housed. Library staff members spent an entire weekend moving boxes
of books and journals to the new three-story library.

did 50 years ago. Many students seek study rooms and space to work with their
As technology evolves, services could change in the library, Meakin said. Some
of the stacks could be cleared out for seating room and more electronic classrooms
and simulation labs could be added. Even with online access, Meakin thinks the
library still needs a physical space.
"(Even) if we are going to be all electronic, the need for the library is still there,"
she said. "We just envision this library as a place. That may be our most important
function." Q

L.edu/ for the latest news and HSC events

_ _____



Molar Man

By Adrianna Rodriguez

When man and suit combine, it's Molar
Man time.
Although more commonly known as
the College of Dentistry's "molar mascot," the cavity-
free tooth suit currently worn by Charbel Klaib, 25,
brings kids a smile under any name.
"It's kind of like Power Rangers but not nearly as
cool," said Klaib, a third-year dental student.
For more than two years, when Molar Man is
needed, Klaib has left his scrubs behind to don the
Lycra undergarment he calls a "ballerina outfit" and
the molar body.
Sometimes mistaken for a girl but never for an
incisor, Molar Man can be trusted to make
appearances at most dentistry events. It's impossible
to see who is inside the costume, but everyone knows
Klaib and his Molar Man alter ego are one and the
same. Mainly because he and the mascot are never
seen together, said Klaib.
"You never see Superman and Clark Kent in the
same room," he laughed.
Yes, but can Molar Man change in a phone booth?
Klaib doesn't mind people knowing his true
identity. At the same time, though, he doesn't correct
rumors of others being the true Molar Man.
"As long as there's a little doubt," Klaib said.
Like Her Majesty's Secret Agent 007, Klaib was
tapped to join the college's mascotting service after
the dental senior who previously wore the costume
He jokes that he was chosen because he doesn't mind
getting sweaty in the airless suit and walking around
showing his boxers through the Lycra undergarment.
From his first time inside the costume, Klaib took
mascotting to a higher level. He created the Molar
Man persona and his signature trademark greeting of
a handshake, high-five and mini-jump.
"I've been told I have quite the matching
personality for it," Klaib said.
When in the suit, the tall Klaib can only stick out
his arms to his elbows and see straight ahead. The
molar might be a little bit too big and the Lycra a little
bit too small, but the shoes, Klaib said, are just right.
"Dr. Scholl's has nothing on these shoes," Klaib
said about the molar's big blue clown shoes. "They're
not the best for football, though."
Although not headed for the gridiron Hall of
Fame, that doesn't stop Molar Man from playing a
little football at dental student gatherings. Molar


Charbel Klaib, 25, a student in the College of Dentistry, is caught in the same room with the molar mascot!

Man can pass sideways and skip "at a faster pace"
when running the ball.
Of all the dentistry events in which he's performed,
the college's annual "Give Kids a Smile" is Klaib's
favorite mascotting adventure.
"That was a lot of fun for me because it was all kids
and you're at their level," Klaib said.
According to Klaib, kids have one of three
reactions to Molar Man: They either love him from
the start, fear and then come to love him, or just flat
out cry in terror. They also tend to either hug, dance
with his cuspids and roots, or beat up Molar Man.
That's where it gets tricky, as Klaib said he has to be
careful not to get punched in the furcationn," or the

area between the roots of the tooth.
Ouch, talk about tooth sensitivity.
Despite the challenges and dangers of wearing the
college's mascot outfit, Klaib said performing as
Molar Man has been one of his most memorable
dental school experiences. He considers his stint as a
tooth to be a unique way to participate in college
activities and he plans to continue cultivating his
Molar Man alter ego... at least until graduation.
After that, another brave agent will assume the
Molar Man identity, and the legend in big blue clown
shoes will carry on.
Adrianna Rodriguez is a communications student
assistant in the College of Dentistry. 0

Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events

--II -L-~-l ~ I




Enrollment opens for innovative

CHOICES Health Services program

W ho's eligible?

v Aged 18 to 64
v U.S. citizen or permanent resident
v Alachua County resident
v Employed 32 hours a week or more
v Limited household income
v Not eligible for health insurance such as
private insurance, Medicaid, Medicare or
Veterans Administration benefits
v Some qualifying low-income seniors aged
65 and older may be eligible for assistance
with prescriptions and dental care

For more information about the CHOICES
Health Services program, visit

Dental junior Dan Stewart provides oral health counseling to dentistry booth visitors during the Oct. 15 CHOICES Health Services kickoff at
Gainesville's Martin Luther King Jr. Community Center. Stewart and classmate John Schaefer, with sophomore Pam DeTrolio assisting, provided
free oral cancer and oral health screenings to more than 20 people. They also distributed free toothbrushes, toothpaste and antimicrobial
mouthwash, and provided oral health counseling to about 150 event-goers. (Photo by Mike Fara, Alachua County Communications Office)

By Lindy McCollum-Brounley

Imagine yourself to be a hardworking person who brings home a paycheck
but has no access to health insurance. What happens when you get sick or
have a painful toothache? What will you do if you can't afford prescription
medicine necessary to control a chronic disease like high blood pressure or
diabetes? What choices will you have?
The CHOICES are easy for thousands of Alachua County residents eligible for
the innovative Community Health Offering Innovative Care and Educational
Services program. With the new CHOICES Health Services program, Alachua
County workers can visit a doctor or dentist for a nominal co-pay of $10.
That was the message nearly 200 people came to hear during the CHOICES
Health Services Oct. 15 enrollment kickoff at Northside Park's Martin Luther
King Jr. Community Center. Community health organizations, including the
ACORN Clinic, the Alachua County Health Department, UF Shands Eastside
Community Practice, Archer Family Healthcare, the UF Family Practice
Medical Group and the College of Dentistry, provided free health screenings
and educated event-goers on how their programs will extend health-care services
to the community through CHOICES.
CHOICES is a new program designed to provide health care to working
Alachua County residents who do not have access to health insurance through
work, Medicaid, Medicare or Veterans Administration benefits. Eligible residents
must be ages 18 to 64, employed 32 or more hours per week and have a limited
household income. Those who qualify enroll in the program may choose to visit
doctors or dentists from a list of program providers, paying only a $10 co-pay for

C6 1J Visit us online @ http://news.health.t

each visit. In addition to facilitating access to medical and dental care providers,
other major emphases of CHOICES include disease prevention and management
as well as health education. Some elderly, low-income residents may also be
eligible to receive prescription and dental care services through the program.
"The CHOICES Health Services program is a local solution targeting those in
our community who are working hard, but do not have access to affordable health
care," said Candice King, director of the CHOICES Health Services program.
"We believe that when working people are able to address their own health-care
needs, it positively affects their health and the health of the whole community."
Championed by City Commissioner Cynthia Moore Chestnut, CHOICES is
one of a handful of progressive local health services programs in the nation
seeking to provide health-care coverage for low-income workers. With an annual
budget of $7 million funded by a quarter-cent sales tax, the program has the
potential to affect thousands of Alachua County residents who are uninsured
and live in poverty, earning incomes 150 percent or less of the Federal Poverty
Level-that's $14,355 for a single person or $24,135 for a family of three.
Alachua County voters passed the tax last year, and the county began
collecting it in January. The CHOICES quarter-penny increase in sales tax is
estimated to cost the average consumer's pocketbook less than $20 each year.
"CHOICES is not a complete solution," said King. "But it's is a well-
considered and compassionate approach developed by a broad cross-section of
community citizens concerned about the lack of access to health care in our
"Healthy workers contribute to the economic and social vitality of the
community," she said. Q

Ifl.edu/ for the latest news and HSC events

- '-'''



Center to help women with urinary incontinence

By April Frawley Birdwell

Urinary incontinence isn't a problem most women
want to discuss. But more women struggle with this
chronic condition than with depression, diabetes and
That's why a team of UF health care providers has
made seeking treatment for urinary incontinence even
easier for women who need help.
The Incontinence Center at Magnolia Parke was
opened in August at Women's Health at Magnolia
Parke to consolidate the treatment options available to
women who have urinary incontinence.
"As the retiree population increases, we're seeing
more patients with these problems," said John Davis,
M.D., an associate professor and director of the
gynecology division who sees patients in the
incontinence clinic along with I. Keith Stone, M.D.,
chairman of the obstetrics and gynecology
Although men can develop urinary incontinence,
women are twice as likely to face this problem. And
many women avoid seeking treatment for years and
often stop taking part in activities they enjoy because
they're too worried about having an accident, said

Cancer hospital

planned for hotel site

By Tom Fortner

Officials of Shands HealthCare and the UF Health
Science Center announced plans to establish a new
cancer hospital on the medical center campus in
Gainesville Oct. 4.
The cancer hospital will be located in a new patient
tower planned for the south side of Archer Road where
the vacant University Centre Hotel is now located.
The hotel will be demolished.
The new tower will provide 200 additional private
rooms and a variety of health-care services, including
diagnostic and therapeutic oncology care. Completion of
the facility is expected in 2009. Services provided in the
new hospital will complement existing oncology services
provided at the UF Shands Cancer Center in Gainesville.
The tower, which will include a tunnel and
skybridge connecting to the main hospital across the
street, will cost between $250 million and $300
million to construct, according to Shands CEO Tim
As tall as eight stories, the tower will also include
general medicine and surgery beds and a new
emergency department that will be four to five times
larger than the current ED, Goldfarb said.
That extra bed capacity should help relieve pressure
on the inpatient units at UF and Shands, where on a

Patty McKey, M.S.N., A.R.N.P, coordinator of the
UF Urogynecology Clinic.
Many women also do not realize the condition can
be treated, McKey said.
The center offers urodynamic testing to more
accurately pinpoint the condition and treatments like
physical therapy, minimally invasive surgery,
medication, biofeedback training and even behavior
modification techniques, McKey said.
"Women are so thankful because they can go back
to doing things they love," she said. "(Incontinence)
definitely limits their quality of life. It is socially
embarrassing for them."
Vaginal childbirth is the biggest risk factor for
urinary incontinence, Davis said.
"When a woman delivers a baby, her pelvic support
tissue can be stretched out," he said. "The more
children a woman has, the more prone she is."
Obesity, smoking and pulmonary disease are also
risk factors. But urinary incontinence can also be a
symptom of another condition.
Although not all women take urinary incontinence
seriously, sometimes living with it because they think
it is a normal part of aging, McKey said the problem
can usually be treated.

Dr. John Davis is one of two doctors who sees
patients at the Incontinence Center at
Magnolia Parke.

And now, women can find treatment under one
roof, McKey said.
"We're establishing this center because we would
like to have one place where we can combine the
skills of a nurse and physicians to tackle the
problem," she said. O


- ; i :.



. "s-. ".- -, _o,
--.j i lL lm ~ l~

An artist's depiction of the new cancer hospital planned for the medical center campus shows a
skybridge crossing Archer Road. The patient tower will be built on the site of a vacant hotel.

recent day, he said, the census was at 98 percent.
The new facility will add to the UF and Shands
vision of a comprehensive cancer program that
integrates basic cancer research, translational research
that produces novel therapies and clinical care for the
patients who can benefit from those treatments.
Completion of the Cancer-Genetics Research Building

on the Gainesville campus next spring will represent a
huge step toward that goal.
"Our care truly is 'bench to bedsides," said UF
Shands Cancer Center Director William Stratford
May, M.D., Ph.D. "We are in the business of putting
cancer out of business, and having this hospital will
allow us to do just that." 0

Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events

--II -L-~-l ~ I




Polar bears hold key to understanding health

risk of environmental pollutants

By Linda Homewood


AUF researcher aiming to better understand
just how dangerous industrial pollutants in
arctic ecosystems might be to humans has
zeroed in on how effectively polar bears are able to
rid themselves of environmental toxins consumed in
the food they eat.
It turns out the bears can completely eliminate
only one of five of the classes of industrial
contaminants they are exposed to, a finding that's
bad news for the bears and other species who share
their environment, according to Margaret James,
Ph.D., an environmental toxicologist at UF.
"The polar bear has quite an efficient system for
metabolizing these pollutants," said James. "If they
can't do it, then it's unlikely that other animals or
persons can."
The UF study, published in the October issue of
the journal Drug Metabolism and Disposition, could
help researchers learn more about the effects of
pollutants on humans living in the Arctic who share
the same staple diet as the bears. Because polar bears
are mammals with a diet similar to the native Inuit,
they may serve as good surrogates for studying
human populations also exposed to the pollutants.
James studied liver tissue samples obtained from
the bears and found that the animals were
surprisingly efficient at metabolizing one of the five
types of industrial chemicals studied those
produced by a burning process, which are similar to
the compounds that form when meat is cooked on a
grill. The other four pollutants, she determined,
could not be fully excreted.
"This suggests that other species will metabolize
the pollutants more slowly," said James. "When they
are not sufficiently excreted the levels go up."
James, chair of the department of medicinal
chemistry at UF's College of Pharmacy, became
interested in studying pollutants nearly 30 years ago.
Around that time researchers first began to
understand that industrial byproducts were carried
to the Arctic by trade winds and then settled in the
subzero temperatures, making them more likely to
accumulate in the food chain.
One obstacle James faced in her research: how a
Florida researcher might obtain a polar bear for
scientific study. Her break came in 2003, when
Canadian colleagues Stelvio Bandiera, Ph.D.,
professor of biomolecular and pharmaceutical
chemistry at the University of British Columbia in
Vancouver, and Robert Letcher, Ph.D., at
Environment Canada in Ottawa, donated liver tissue

i .

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UF researchers have found trace amounts of environmental pollutants in the livers of arctic
polar bears.

samples from three adult male bears to UF. The
bears came from a legally controlled hunt in 1993 by
the Inuit people native to the Canadian Arctic.
In her research, James concentrated on five types of
chemical contaminants known by the acronym POP,
for persistent organic pollutants. They include
compounds produced by a burning process; a
compound used as a substitute for the pesticide DDT
when it was banned, and which itself was subsequently
banned in 2004; TCPM, an industrial compound
found in the Arctic but of unknown origin and
toxicity; PCP, used as a wood preservative; and PCBs,
industrial chemicals used for many years in electrical
applications. All these substances, with the exception
of TCPM, are regulated or banned, but they persist in
the environment.
Polar bears break down these fat-soluble chemicals
in two steps, each of which makes the substances
more water-soluble and therefore easier to excrete,
said James. The first step, however, results in a
compound that is more chemically reactive and

therefore more harmful to living cells, with the
potential for reproductive or neurological damage.
The second phase, often slower than the first,
determines how successfully the animals eliminate
the toxins, she said.
In 2001, the world population of polar bears was
estimated to be between 21,500 and 25,000, of which
some 15,000 were in Canada. James said experts have
observed a worldwide decline in their population,
which some blame on environmental pollution.
People throughout the world continue to be
exposed to chemical pollutants long after they are
created and released into the atmosphere, James said.
Her immediate research goal is to help scientists gain
a better understanding of exactly how these
compounds are eliminated from the body. Her long-
range goal is to provide governments and regulatory
agencies with scientific findings regarding the safety
or potential risks of the environmental chemical
pollutants that will guide future decisions about the
use and the disposal of these compounds. Q

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CT scan can spare some head

and neck cancer patients surgery

By Denise Trunk

Some patients with head and neck cancer can be safely spared the risk and expense of surgery by undergoing a
CT scan to predict whether the disease is in check after radiation therapy, according to study findings UF
doctors released at the annual meeting of the American Society for Therapeutic Radiology and Oncology.
Researchers with the UF Shands Cancer Center have identified criteria doctors can use to evaluate CT scans
four weeks after patients undergo initial treatment. If these criteria are met, there is a 94 percent likelihood a
patient's lymph nodes are cancer free, said Stanley L. Liauw, M.D., a resident in radiation oncology. Using a
CT scan was found to be much more accurate than relying on a physical exam to assess response to treatment.
Radiation therapy is commonly used to treat the more than 40,000 U.S. patients a year who develop
advanced head and neck cancer. After radiation therapy, doctors often operate to remove affected lymph
nodes. But UF physicians say in some cases surgery is unnecessary, and can increase recovery time, lead to
infection and possibly compromise a patient's quality of life.
The current study builds on previous research involving 95 head and neck cancer patients. In two-thirds of
the patients who underwent surgery after radiotherapy, the removed lymph nodes turned out to be cancer free,
noted UF radiologist Anthony Mancuso, M.D. Mancuso collaborated with UF radiation oncologists Robert
Amdur, M.D., Christopher Morris, M.S., and William Mendenhall, M.D.
By comparing nodes visualized on a CT scan with the same nodes after they were removed, the researchers
developed criteria doctors could use to examine nodes using a non-invasive CT scan to identify with 94
percent accuracy whether the disease was knocked out. Nodes deemed to be clear of cancer were 1.5
centimeters or smaller and had borders that were sharply defined on the CT scan, rather than fuzzy.
Liauw said, "I think it would be great if doctors could look at this data and feel comfortable with just doing
a CT scan after radiation in order to know if a neck dissection is necessary. If these data are understood and
accepted, we could limit the risk of side effects for some patients." Q

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Dr. Stan Liauw, a resident in radiation oncology,
examines the progress of patient Fred Watson,
who is recovering from head and neck cancer.
Many patients like Watson can be spared an
additional surgery by the use of CT scans,
according to data gathered by radiation
oncologists in the UF Shands Cancer Center.

Biomarker test may give
early warning of brain woes
A way to detect fragments of broken brain cells that leak into the
bloodstream may help doctors more quickly and precisely treat people
with severe head injuries or brain diseases, say researchers at UF's
McKnight Brain Institute.
UF scientists have discovered they can use an approach similar to
one commonly used in HIV or pregnancy testing to find bits of axons
-nerve fibers that help brain cells communicate -in the blood and
spinal fluid of laboratory rats modeling human spinal cord or traumatic
brain injuries.
The discovery could lead to tests for the clinic or battlefield
to diagnose ailments with just a few drops of blood, bypassing
cumbersome and expensive CT or MRI brain scanning equipment. The
researchers report their findings in the online edition of Biochemical and
Biophysical Research Communications.
The cellular debris, derived from a protein called NF-H, was not
found in the blood or other fluids of healthy animals and humans. That
leads researchers to believe it is a biomarker, a substance in blood that
signals the presence of disease or injury.
"We could easily see that this particular protein is detectable very
soon after a disease starts or an injury occurs," said Gerry Shaw, Ph.D.,
a professor of neuroscience in the College of Medicine. "A lot more of it
is then released in the two or three days following a brain or spinal cord
injury, which is interesting because it signals a kind of brain cell death
that you could potentially do something about therapeutically."
The test would be helpful in emergency rooms or in combat situations
if it could be developed into a simple handheld device that could
confirm brain or spinal injury.
John Pastor

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Researchers kill resistant bugs one bandage at a time
UF researchers have led the development of a new type of wound dressing that could
keep dangerous antibiotic-resistant bacteria from spreading in hospitals, a problem that
leads to thousands of deaths in the United States each year.
This microbicidal coating, which can be chemically bonded to gauze bandages, socks
and even hospital bedding and gowns, kills the two most common and harmful types of
antibiotic-resistant bacteria that cause infections in hospitals, the researchers said.
According to the National Institutes of Health, each year nearly 2 million Americans
contract infections while hospitalized.
Antibiotic-resistant bacteria, such as methicillin-resistant staphylococcus aureus and
vancomycin-resistant enterococci, cause about 70 percent of those infections.
"Those are the two classes of bacteria that are now epidemic in the U.K.," said
Gregory Schultz, Ph.D., director of UF's Institute for Wound Research and one of the
inventors who joined with a Gainesville-based company to develop the coating. "It's a
huge problem there."
A patent is pending on the researchers' method of chemically bonding the substance
to fabrics and other materials. This method allows the substance to be efficiently mass
produced and permanently adhered to wound dressings or ready-to-wear clothing to
make antifungal and microbicidal socks and underwear.
"What we developed in the lab has to be able to be adapted into industrial
manufacturing, and the breakthrough came when we figured out how to do that,"
Schultz said.
Clothing that kills athlete's foot and other fungi could help U.S. soldiers in the field,
and the substance also could be added to hospital gowns and bedding to stop the
spread of resistant bugs, said Schultz, who also serves as the company's vice president of
clinical research and development.
UF researchers and scientists from the company presented their findings at the Wound
Healing Society's annual meeting earlier this year, and the coating's ability to wipe out
harmful bacteria and fungi was later confirmed in independent laboratory tests.
-April Frawley Birdwell

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" '''--


Dr. Linda Bartoshuk (right) discovered that a quarter of the population, dubbed supertasters, has an unusually high number of taste buds. Here, a microscopic
image, seen in the background, provides a close-up view of graduate student Derek Snyder's tongue. Blue food coloring swabbed on the tongue makes it
easier to see the tiny structures that house taste buds.

n Linda Bartoshuk's world there is accounting for
taste. With a simple test, Bartoshuk can measure the
number of taste buds a person has and classify them
as supertasters, medium tasters or nontasters.
When supertasters place a small filter paper saturated
with a chemical called 6-n-propylthiouracil in their
mouths, they taste an intense bitterness. Nontasters taste
nothing and medium tasters are somewhere in between.
But beyond explaining why for some people coffee is
too bitter to tolerate (supertaster) or why some people
can't get enough of four-alarm chili (nontaster),
Bartoshuk's work has implications for the treatment of
taste disorders.
Now a newly launched clinical service of UF McKnight
Brain Institute's Center for Smell and Taste joins only a
handful of such clinics in the United States. Housed in
the College of Dentistry, the clinic is the only one in the
Southeast to treat chemosensory disorders, which affect
approximately 2 million Americans.
"There are enormous numbers of people who walk around

with smell and taste disorders," said the center's director,
Barry Ache, Ph.D., who studies the biological chain of
events that allows the brain to process odors. "These
problems may be considered minor by others, but these
disorders are debilitating for the people who have them."

Bartoshuk, who recently joined the UF faculty as a
visiting professor in the department of clinical and health
psychology in the College of Public Health and Health
Professions, began exploring genetic variations in taste
perception in the 1970s. She describes supertasters as
living in a "neon taste world," experiencing three times
the sensation of bitterness, sweetness or spiciness in foods
compared with nontasters.
Twenty-five percent of the population are supertasters,
25 percent are nontasters and 50 percent fall into the
medium taster category.

"Your taster status not only influences your food
choices, but it also affects your health," said Bartoshuk, a
member of the prestigious National Academy of Sciences
and the first female academy member at UF.
Supertasters are less drawn to sweets and fatty foods,
which explains why they have superior cardiovascular
profiles and tend to be thinner than nontasters. But they
are less likely to eat bitter green vegetables, putting them
at increased risk for colon cancer.
"Supertasters are also more susceptible to oral pain,"
Bartoshuk said. "Because each taste bud is surrounded by
a basket of pain nerves, more taste buds equals more pain
nerves, causing supertasters to experience three times
the burn that nontasters experience."
Bartoshuk was the first to discover that burning mouth
syndrome, a condition predominantly experienced by
postmenopausal women, is caused by damage to the taste
buds at the front of the tongue and is not a psychosomatic
condition, as many believed. She will join College of
Dentistry faculty members Donald Cohen, D.M.D.,

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C ,I*

Frank Catalanotto, D.M.D., and Carol Stewart, D.D.S.,
in developing effective treatments for the disorder.
Working with Patrick Antonelli, M.D., chairman of the
department of otolaryngology in the College of Medicine,
Bartoshuk and her graduate student Derek Snyder are also
studying a particular nerve that
runs from the tongue and
through the middle ear on its
way to the brain. They have
found that when this nerve is
damaged, either by injury or
chronic ear infections, taste
sensation is impaired.
"Dr. Bartoshuk's research in
the area of taste disorders and Frank Catalanotto, D.M.D.
oral pain is extremely well-known
and well-regarded among her colleagues," said UF
President Bernie Machen. "Her work with 'supertasters' is
especially intriguing and speaks to the innovative approach
she takes in her work. UF is fortunate to have someone the
caliber of Dr. Bartoshuk in our midst. The university will
gain immensely from her presence on the faculty."

Patients with taste and smell disorders in the Southeast
also stand to benefit from the work of Bartoshuk and
others associated with the center, including Catalanotto,
the center's clinical director and director of the new
Smell and Taste Clinic, who was one of many people
instrumental in attracting Bartoshuk to UF and
establishing the clinical initiative.
Many of the patients, especially those with smell
disorders, will have ear, nose and throat problems, such
as nasal sinus disease, nasal polyps or congestion caused
by allergies, said Catalanotto, adding that these patients
will also be evaluated by Savita Collins, M.D., a UF ear,
nose and throat surgeon.
"We will also hear from patients who have had some head
trauma," said Catalanotto, a professor in the College of
Dentistry's department of pediatric dentistry. "Rarer will
be patients with a true taste complaint of unknown origin.
"Taste and smell problems are poorly understood by
the health-care community," he added. "Our role is to
better understand these problems, counsel patients on
how to deal with these issues and look for effective
treatments. In addition, we believe that looking at taste
and smell function in other systemic diseases can be
helpful in understanding such diseases."

The research component of the UF Center for Smell and
Taste was created in 1998 to integrate and promote
discovery, application and education in the chemical senses.
"Smell and taste deficits are often envisioned as subtle
compared to vision deficits or hearing deficits if you're

blind or deaf," said Ache, a member of the advisory
council of the National Institute on Deafness and Other
Communication Disorders. "But indeed, the quality of
life is constrained significantly for people who can't smell
or taste."
Among its research initiatives, the center is working with
the Department of Psychology and the College of Liberal
Arts and Sciences to establish a national facility to assess
smell and taste function in rodents, which is important in
efforts to cure human diseases, especially considering that
most mouse genes have a direct human counterpart.
Ultimately, the only way to understand the smell or taste
capacities of animals is to study their behavior whether
a rat can be conditioned to press a lever after tasting a
specific chemical stimulus, such as salt, for example.
"In order to understand the brain mechanisms
underlying normal and abnormal smell and taste
function, it is important to be able to manipulate the
nervous system genetically, pharmacologically or
anatomically and then assess the perceptual
consequences in the animal model," said Alan Spector,
Ph.D., a professor of psychology and assistant director of
the UF Center for Smell and Taste. "Because perception
cannot be measured directly, it must be inferred by the
animal's performance on various smell and taste tasks.
Using this approach we can learn about the smell and
taste world of animals and link it to brain function."
Eventually, UF's Chemosensory Test Facility is intended
to give researchers throughout the world an opportunity to
test animals that are serving as models of disease for their
ability to smell and taste. Such experiments can contribute
to developing treatments and management strategies for a
multitude of disorders, obesity among them.
"Obesity is a problem in the United States," Spector
said. "A lot of different factors likely contribute to the
disorder, among them smell and taste. Everything a
person eats must first pass the scrutiny of the nose and
the taste buds, and thus smell and taste may be complicit
in many nutritional and eating disorders."
An impaired sense of smell is one of the first signs of
Alzheimer's disease. In addition, diabetes, hypertension,
malnutrition, Parkinson's disease, multiple sclerosis,
Korsakoff's psychosis and even psychological disorders
such as depression are all accompanied or signaled by
chemosensory problems like smell disorders.

Imagine sitting in a kitchen. An open bottle of wine is on
the table, steaks are broiling, onions are frying and a
fresh cut lawn is just outside the open window.
Using millions of receptor cells, our noses are able to
detect subtle differences in smell in complex mixtures
against equally complex backgrounds.
Imagine now trying to duplicate that process with
The UF Center for Smell and Taste works with the
Whitney Laboratory, the Interdisciplinary Center for

Supermarket blue food coloring provides an easy
way to determine taster status. Pink, circular
fungiform papillae, each home to several taste
buds, stand out against the blue background.
The tongue of a supertaster boasts more than 25
papillae within a quarter-inch circle.

Biotechnology and the colleges of Medicine, Engineering
and Liberal Arts and Sciences to foster development of
mechanical biosensors, also known as e-noses, to detect
chemical substances.
The objective is the use of molecular recognition
molecules such as olfactory receptor proteins immobilized
on nanoscale surfaces to provide the sensing element of
an electronic "nose on a chip."
The initiative addresses a growing demand for chemical
biosensors for clinical, industrial and defense applications.
Chemical biosensors detect chemical signatures of
compounds of interest, such as illicit drugs or explosives.
In medical applications, biosensors may be created to
detect so-called smell of disease, a phenomenon spoken
of since Aristotle's time. For example, there is evidence
certain cancers give off chemical signatures.
But the task to develop e-noses is formidable because
an odor may be a single chemical or a mixture of hundreds
to thousands of chemicals. Making that process even
more complex, some chemicals may block the sensory
detection of other chemicals.
More research will tell us how it all works. Just as there
are supertasters, there are people who have heightened
senses of smell. Why that is, or whether the extraordinary
smell and taste abilities are linked, are questions in need
of answers.
Tasteful answers, of course.
For more information about the UF Smell and Taste Clinic,
call (352) 294-0199. Q

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--II L-~-l -L I




Scavenger cells could be key

to treating HIV-related dementia

By April Frawley Birdwell

Bacteria-eating cells that generally fight
infection may cause dementia in HIV
patients, UF and University of California at
San Francisco researchers have found.
Macrophages, long-living white blood cells often
considered the scavengers of the immune system,
actually may damage a part of the brain where
many memories are stored in their attempt to attack
the virus there, according to findings reported in
the Journal of Virology this fall.
Nearly 15 percent of HIV patients develop
dementia as their disease progresses.
Understanding the routes macrophage cells take in
the brain could help researchers find ways to block
the migration and prevent HIV-associated
dementia, said Marco Salemi, a UF assistant 4 _
professor of pathology and immunology in the
College of Medicine and an author of the study.
Researchers found that HIV-infected
macrophages in the brain continuously travel to the
temporal lobe, a part of the brain Alzheimer's
disease often damages. Because the virus mutates
nearly 100 times faster in the temporal lobe than
other parts of the brain, attacking macrophages
migrate there in a constant stream, causing harmful
"In a way, it's not the virus that directly causes
the dementia," Salemi said. "It's the fact that there
is this continuous migration of infected

macrophages to the temporal lobe. The virus
mutates much faster there, the macrophages keep
accumulating and keep creating this inflammation
that leads to dementia."
Macrophages also may explain why current drugs
cannot kill the virus that causes AIDS.
Researchers have known for years how HIV
replicates in T cells, also part of the immune
system. But most are just beginning to understand
how the virus affects macrophages, said Dr.
Michael S. McGrath, a UCSF professor of pathology
and laboratory medicine who co-authored the study.
"It's likely the oldest (form of the) virus lives in a
macrophage in the brain and most virus strains
evolve from that," McGrath said. "Imagine having
cells, already infected, that live as long as you do."
Current antiretroviral drugs block HIV from
replicating in new T cells, but don't kill the virus in
infected macrophages. And the drugs cannot stop
the virus from evolving into new forms, McGrath
said. Because the virus mutates faster than other
cells in the body, it also can develop resistance to

Marco Salemi, a UF assistant professor of laboratory medicine, has teamed with researchers
from the University of California at San Franscisco and other institutions to find out what causes
dementia in the brains of HIV-infected patients.

these drugs, Salemi said.
Developing drugs that target macrophages as well
as T cells is important. These drugs could provide
better treatments for dementia and potentially lead to
a way to "eradicate HIV-1 infection," the study states.
Even the HIV already in an infected person's
brain is not one single virus, but rather populations
of slightly different viruses that infect different
parts of the brain, the findings show.
To obtain their findings, the researchers studied
different regions of the brain of a person who died
with HIV-associated dementia using specimens
from the AIDS and Cancer Specimen Resource at
UCSF. They also used a new computer-based
research tool to study the results. Dubbed

phylodynamic analysis, this new method links
traditional ways of studying the virus to give
researchers a more comprehensive understanding,
which Salemi says is crucial to analyzing the ever-
changing disease.
"If we really want to understand what happens to
a person infected with this disease, we need to
develop new tools," he said. "We can put together
all these different resources and describe how the
virus changes over time and try to understand why
this particular damage happens."
But these results are just a first step, Salemi said.
The team is now analyzing brains from 10 people,
some who died with HIV-associated dementia and
others who did not. 0

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Next stop, Asia:

UF leads globalization effort

in forensic education

By Linda Homewood
he University of Florida is leading scientific forces from Scotland and
Australia on an Asian tour one that calls for a new alliance of Eastern and
Western educators to advance forensic science capabilities worldwide
through education.
Ian Tebbett, Ph.D., director of the UF Global Forensic Science Program, sees a
need for countries to work together to help meet a great forensic demand, from
body identification resulting from natural disasters and war crimes to educating
much-needed scientists.
"Global Forensic Education is a perfect example of the UF 'Gator Nation'
strategic mission to develop international outreach and education with respect to
cultural differences," Tebbett said.
The UF online forensic science program, which offers master's programs in
forensic DNA and serology, drug chemistry, and toxicology, also offers a graduate
certificate option. Next spring, there are plans to launch a new certificate program
in death investigation that will involve collaboration across campus and
internationally, Tebbett said.
In August, Donna Wielbo, Ph.D., an associate professor at UF's College of
Pharmacy, launched the Asian tour. Working in collaboration with The University
of Edinburgh and the University of Canberra, the forensic educators began with an
international workshop in Thailand. Shortly after the Thai conference, Tebbett,
also a College of Pharmacy professor and UF associate dean of distance learning,
was off to Hong Kong for the International Association of Forensic Sciences
conference, before ending his travels in Beijing.
The first stop on the tour, the "Forensic Analysis of DNA" workshop, was
organized in response to efforts of the Thai government to improve their body
identification capabilities afer the tsunami disaster. The University of Silpakorn,
located about 20 miles west of Bangkok, hosted the workshop, which addressed
theory and practical applications of crime scene processing, traditional forensic
serology, basic genetics and DNA analysis used for identification, Wielbo said.
Lectures were presented by Silpakorn pharmacy faculty, UF and Edinburgh
faculty and an officer from the Institute of Forensic Medicine and the Royal Thai
Police, who presented tsunami case studies.
The forensic field, although gaining more acceptance after last year's tsunami, is
traditionally considered taboo to the Thai people, who culturally view the spirit
world differently than westerners, Wielbo said. Wielbo added that the Thai
university has requested UF's support in developing four workshops next year, an
indication that the workshop was well-received.
"It shows that the UF Global Forensic Education program is making an impact
on forensic practices worldwide," Wielbo said.
The nearly 40 workshop attendees consisted of students and practitioners in the
medical fields and members of Thai law enforcement. Surawut Watana, Ph.D.,
associate dean at Silpakorn University, said he wants to advance forensic science
education in his country. He plans to continue the Silpakorn-UF partnership by
bringing Tebbett's curriculum in forensic toxicology to Thai students.
"We have translated the UF course materials into our native language so that
we can teach the master's program online to students throughout Thailand,"
Watana said.
In mid-August, Tebbett met up with his forensic colleagues in China. Held once
every three years, the international conference in Hong Kong gave the global

Visit us online @ http://news.health.ufl.edu,

S mtfliiQ r l,(1XA ZIM .1
- -

Presenters AnnMarie Clark, of UF, (fourth from left); Alex Graham
(blond woman in tan suit), of The University of Edinburgh; and UF's
Donna Wielbo, of UF, (eighth from left), stand in the second row among
University of Silpakorn faculty and workshop attendees. The DNA
workshop announcement is posted in Thai behind the group.

forensic partners UF, Edinburgh and Canberra a chance to talk one-on-one to
forensic scientists from China and other Asian countries. During her conference
seminar, Jennelle Kyd, Ph.D., a professor from the University of Canberra,
explained the universities' coordinated efforts and the advantages of teaching
forensic science through distance education.
After the Hong Kong conference, Tebbett traveled to the UF International
Center in Beijing, where UF professor Sherman Bai, Ph.D., the center director and
a native of China, had arranged meetings with three universities. Tebbett toured
the University of Traditional Chinese Medicine, Capital University School of
Medical Sciences and Beijing University.
Ironically, professor Wei Wang, M.D., Ph.D., of Capital University, had been
called back from the IAFS conference in Hong Kong to meet with the visiting
UF professor of forensic science. After the meeting, Wang, a highly regarded
professor in the Chinese forensic science community, was enthusiastic about the
UF programs.
"Our students are very smart and they learn English from the time they first
start school," Wang said. "We are confident that our students will be able to meet
your university's requirements for admission."
Capital University hosted a dinner for its pharmacy faculty to meet with Tebbett
and other UF representatives for an opportunity to talk about mutual education
interests and future possibilities for collaboration in teaching, exchange students
and distance learning.
Tebbett credits Bai and his staff at the UF International Center in Beijing for
making important contacts with the schools and with China's Ministry of
Education that have paved the road for future developments in the globalization of
forensic education.
"The UF-Beijing center was key to our successful meetings in China," Tebbett
said. "They assisted us with basic things like language interpretation and
cultural understanding that are imperative when beginning new relationships in
another country."
The meetings were so successful that Tebbett hopes to return to Beijing before
the end of the year to sign early agreements with Capital University to offer UF
master's degrees in China. O

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__ _____


Leaving New Orleans:

LSLU medical student spending senior vear at UF

Christian Fauria, a medical student from Louisiana State University School
Hurricane Katrina swamped the Gulf Coast city.

of Medicine in New Orleans, will spend most of her senior year at UF after

By April Frawley Birdwell

Christian Fauria's Thanksgiving Day wedding won't take place on her parents'
lawn as she had planned. The groomsmen's suits were lost in floodwaters
and the order for the bridesmaids' dresses has been canceled, too.
Most brides-to-be would be crushed. Fauria just feels lucky.
Her family has a house and her relatives are all alive. That's more than many New
Orleans families have in the wake of Hurricane Katrina, which caused several of the
under-sea-level city's levees to break when it struck Aug. 29, flooding the city and
killing nearly 1,000 people.
Fauria, a fourth-year medical student from the Louisiana State University School
of Medicine in New Orleans, now will spend most of her last year of medical school
at UF. The New Orleans native will spend five months at UF until she returns to
LSU to match in a residency program in March.
"I'm very lucky compared to most of the people in New Orleans," she said. "A lot of
people in medical school with me lost their houses. You have guilt for being so lucky."
Fauria hasn't been back since the day before Katrina hit, when she, her fiance and
her parents finally decided to evacuate.
They watched the chaos and destruction unfold in the city on television, like the
rest of the country. Fauria could only think of how crazy it all seemed, that houses
would be knocked down and some people would never be back, and yet, how
inevitable it was, too. New Orleanians had talked for years about what would happen
if "the big one" hit, she said.
Fauria's relatives, many of whom lost their homes, are now scattered across the
country, but she and her parents have been able to track them down. Friends have not
been as easy to find, although she did spot one fellow medical student on "Dr. Phil."
She doesn't know what happened to her on-campus apartment either. Her father,
a coastal engineer who is working in the city, tried to get to her apartment to grab her
books and clothes, but school officials weren't letting anyone in yet, she said.
She had to buy all new clothes, but she shrugs it off. It's nothing compared to what

14 4 j1 TI Visit us online @ http://news.health.ufl.

her friends and other evacuees are going through, she said. And frankly, Fauria is
too busy to worry about her own troubles.
"I have to do my applications. I have to take tests. I have to get into a residency
program. I have to finish medical school," she said. "I'm just trying to keep going."
Although she was able to complete a family medicine rotation in Louisiana after
evacuating, Fauria decided to come to UF after talking to a close family friend and UF
faculty member, Mary Ann Burg, Ph.D, an associate professor of community health
and family medicine and the director of the UF Women's Health Research Center.
Still technically an LSU student, Fauria will take five clinical rotations while she
is here to match the LSU curriculum.
Two third-year LSU medical students are also coming to UF this month for eight-
week medicine rotations, said Patrick Duff, M.D., associate dean for student and
alumni affairs.
The school should reopen in January, Fauria said, but she is not sure if that will
happen, particularly since two LSU-run hospitals were declared unsalvageable in
She would like to go back to New Orleans, but she doesn't know when that will
happen. She had planned to try to get into a residency program in New Orleans, but
UF is her first choice now, she said. Her fiance found a job with a local biotechnology
company and the couple has been able to establish a home base here.
And the wedding is still on for Thanksgiving, even if they can't have it in New
Orleans. The couple plans to marry on a Destin beach.
"She is someone who feels things will work out," said Burg, who has known
Fauria's family since her parents were graduate students in New York. "She's got a
Vera Wang dress and she's going to wear it somewhere."
Fauria does wonder what will happen to her native city, though. And she worries
that leaders won't do enough to bring back the city's poor, who she says "create what
people love about New Orleans."
"I don't think it will ever be the same," she said. "I think it will always be referred
to as 'pre- and post-Katrina.' But I hope it gets close to normal." Q

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Bringing up baby

Vet Steeve Giguere has a passion for foal care

Dr. Steeve Giguere with a foal in UF's Hofmann Intensive Care Unit.
(Photo by Kristin Bartlett, UF News & Public Affairs.)

By Cindy Spence

hen he was a boy, the formula seemed simple to UF researcher
Steeve Giguere: become a veterinarian, own a horse, keep riding.
Today, his research into equine neonatology brings him into
contact with plenty of horses, although he doesn't own them or ride them. But
that's OK with Giguere, who says he has found a new mission in helping frail
foals survive. And he likes knowing his work makes a difference.
"If you do clinics, you deal with horses and their problems every day,"
Giguere said. "That way you know what kinds of research really will help, as
opposed to something that is interesting but not really helpful clinically."
Since the mid-1980s, the UF College of Veterinary Medicine has built up its
neonatology program, publishing the first equine neonatal text in 1990,
Giguere said. The university long has been a top referral center for clinical care
of neonates and is playing a key role in equine neonatology research.
"The discipline of equine neonatology started here," Giguere said. "Every
project helps in understanding better ways to treat equine neonatal diseases."
A big part of Giguere's research is focused on an anomaly that makes
newborn horses highly susceptible to Rhodococcus equi, which causes
pneumonia, while adult horses largely are immune to it.
"With Rhodococcus, we are trying to discover why only the babies get it, not
adults. What is different in the immune system of the babies?" Giguere said.
Rhodococcus is the leading cause of illness and death in foals in the United
States and the leading cause of pneumonia in foals from 3 weeks to 5 months of
age. It is financially devastating for horse breeders, who sometimes see 40
percent of their foals contract the disease. Foals that do recover are much less
likely to race as adults.
Giguere says a long-term goal is to develop a vaccine to protect foals from
Rhodococcus. But first he needs to find the reason for foals' peculiar
susceptibility to the infection.
In his work in UF clinics, Giguere found himself faced with a need to
measure blood pressure and cardiac output in critically ill foals, but with few
well-standardized, non-invasive ways to perform those tests. So he embarked on
studies to find more precise and less invasive ways to take the measurements.
In one study, he looked at the accuracy of blood pressure monitors and foals
and he evaluated the effect of the site of cuff placement on measurement accuracy.
He found that most blood pressure monitors commonly used worked well but
found that the best placement for the cuffs was on a foal's tail. The non-invasive
monitors are portable and easily used on the farm or in a veterinary office.
To improve methods to measure cardiac output in critically ill foals, Giguere
decided to evaluate many non-invasive methods. He found that ultrasound
examination of the heart was very accurate in measuring cardiac output and
easily used without causing distress to the sick foals.
Giguere also evaluated kits commonly used on horse farms to measure
concentrations of antibodies in newborn foals. He found the kits varied widely
in accuracy and made his results available to veterinarians and farm managers.
Giguere also has been studying multiple antibiotics for use in foals in an
attempt to improve treatment of bacterial infections. Systemic bacterial
infection is the leading cause of mortality in foals.
Giguere's work has been funded by the Morris Animal Foundation and
Florida's Pari-Mutuel Trust Fund as well as the Florida Thoroughbred
Breeders' and Owners' Association. In fact, support from the association
allowed the college to establish a breeding herd of 17 mares that provide foals
each year for research. Once the research is completed, the foals are adopted,
Giguere said.
"We can change the way we practice, discover better therapies," Giguere said.
"I see my mission as improving equine health."
Cindy Spence is a freelance writer for the College of Veterinary Medicine. Q

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--II -L-~-l ~ I




UF study looks for undiagnosed

dementia in long-term care environments

By Patricia Bates McGhee

While following the cases of hundreds of patients with dementia for
the last 15 years, George Wilson, M.D., has identified many
unanswered questions about the disease.
Now he can answer one of them.
Thanks to an $86,500 grant from Pfizer, Wilson will be the first to study
the incidence of undiagnosed dementia in long-term care.
Treatment of dementia as a disease has evolved slowly and with few
breakthroughs, said Wilson, associate chair of community health/family
medicine at UF HSC Jacksonville.
"Even as long as 20 years ago, there were really no therapies for dementias.
Some could be prevented, but there was no treatment for the disease," he said.
"We, being physicians in primary care, used various anecdotal treatments but
none showed true efficacy. Then, about 10 years ago, several drugs were
developed that seemed to have a positive effect on dementia and physicians
started using them to treat moderate-to-severe dementia."
Over the next several years the data showed two things, Wilson said. First,
the drugs seemed to slow down dementia but did not arrest it. Second, they
were most effective in early dementia and had almost no effect in moderate-
to-severe dementia.
"So the problem now becomes who should get the drug," Wilson said.
"Most of us intuitively or from observation know who has moderate-to-severe
dementia, but how do we know who has early dementia?"
That question prompted Wilson to find out how many people admitted to
nursing homes for reasons other than dementia actually had early dementia.
"The obvious benefit of knowing this is that those people might benefit
most from the new drugs, but if you don't know if someone has dementia
until they're moderate to severe, then it's too late to treat them," Wilson
He also was led to believe that because of a difference in patients' daily
routines, most people don't recognize dementia progression in nursing home
residents as quickly as in those living at home.
"The dementia can be fairly far advanced before somebody one day says,
'You know, I think Granny is demented,'" he said.
The UF study, which will evaluate 80 to 100 residents and track them over
time, involves two questions: What is the incidence of unrecognized early
dementia in individuals who are admitted to nursing homes regardless of why
they're admitted and what is the progression rate of dementia in nursing
homes that is unrecognized?
The first part of the study looks at how many already living in a nursing
home are unrecognized.
"I'm working with River Garden Hebrew Home in Jacksonville and
identifying all current residents who do not have a diagnosis of either
dementia or minimum cognitive impairment and screening them to see how
many actually screen positive," Wilson explained. "I'm not going to screen
those already on treatment for dementia because I don't know what that
would mean relative to the question.
"The second part of the study involves screening all new admissions -
again, those without a diagnosis for dementia over the next three years
who enter River Garden to find out how many have early dementia that's
unrecognized," he said. "Then over those same three years I'll re-screen to

16 61j 1B Visit us online @ http://news.health.ul

Dr. George Wilson, associate chair of community health/family
medicine at UF HSC Jacksonville, leads research to study how
often dementia goes undiagnosed in nursing home patients.

see what the progression rate is and how that correlates with the staff's
appreciation of progression."
Wilson's premise is that there will be more people who enter the nursing
home who have dementia that nobody's recognized, that there will be more
individuals already living in the nursing home who have unappreciated early
dementia and that the progression rate will be more significant than the
clinical staff has recognized.
"If these theories prove out," Wilson said, "then the research becomes
extremely important because it would suggest screening all nursing home
residents and admissions for early dementia because those individuals would
benefit most from starting drug therapy."
Wilson is principal investigator of the three-year study. Co-investigators
are Fern Webb, Ph.D., a UF epidemiologist and assistant professor, and Sue
Leger-Krall, Ph.D., River Garden research director. The study is being
conducted at River Garden Hebrew Home and is under the umbrella of UF's
Center for Geriatric Medicine at River Garden. 0

fl.edu/ for the latest news and HSC events

- --~--



M.D., a professor and
chairman of the department
of radiology, was awarded
the 2005 Gold Medal from
the American Society of 'i
Head and Neck Radiology
on Sept. 23 at the society's
39th annual meeting in San Mancuso
Francisco. The group's most
prestigious award is presented each year to a
member who has provided dedicated service to
the society and to the science and education of
head and neck radiology.


junior students, were recently awarded Alumni
Book Awards by the College of Nursing Alumni
Council to enhance their educational experience
and assist them in purchasing textbooks during
the fall 2005 semester. Each student received
$200 to offset textbook costs and was chosen
for demonstrating commitment to nursing and
community involvement.

STELLING were awarded
scholarships from the
Association of Perioperative
Registered Nurses Foundation
for the 2005-06 academic
year. They were among
100 students nationwide
Floetke Elliott
chosen from more than 340 Floetke Elliott

Doctoral student Amanda Floetke Elliott, part
of the college's accelerated B.S.N. to Ph.D.
program, was one of the 44 graduate student
awardees, and Jennifer Stelling, a senior B.S.N.
student, was one of 56 undergraduate student
Elliott has been an active member of AORN,
sitting on a national task force and attending
the AORN Congress meeting last year. Stelling
showed a strong interest and commitment to
perioperative nursing and hopes to pursue a
career in operating room nursing.

F.A.A.N., has been named
the Annabel Davis Jenks
Endowed Professor for
Teaching and Research in
Clinical Nursing Excellence.
Roberts, a nationally known
researcher on older adults
and exercise, served as a Roberts
nursing faculty member for 23
years at Case Western Reserve University, most
recently as the Arline H. and Curtis F. Garvin
Professor of Nursing.
The Annabel Davis Jenks Endowed
Professorship for Teaching and Research in
Clinical Nursing Excellence is in recognition of
Mrs. Annabel Jenks, a committed and caring
nurse who had strong connections to the College
in the 1970s and '80s. This professorship
was made possible by a gift to the College
of Nursing from the Thomas M. and Irene B.
Kirbo Charitable Trust. The Kirbo Trust donated
$600,000 to establish the professorship, which
was eligible for state-matching funds. Mr. Murray
Jenks, a trustee of the Kirbo Trust, was the
husband of the late Annabel Jenks.
Roberts has built a long program of NIH-
funded research exploring factors that contribute
to function and independence in daily activities,
specifically exercise from a physical and
psychosocial standpoint. Her most current
research study examines how a low-intensity

muscle strength program could aid function
and recovery of elderly adults who have been
hospitalized for a medical condition. She has
written more than 50 books, book chapters and
articles in refereed publications.
While at Case Western, she also helped garner
more than $1 million in funding for programs
and scholarships in geriatric nursing.
Roberts is a research and clinical practice
fellow of the Gerontological Society of America
and was given the Outstanding Researcher
award from the Midwest Nursing Research
Society in 2003. She is an abstract reviewer for
the Gerontological Society of America, Sigma
Theta Tau International and the Midwest Nursing
Research Society.
Roberts is now a member of the UF Institute on
Aging's Executive Committee, and notes that it is
collaborations such as these that attracted her to
UF, she said.
"There are so many at UF with research interests
in aging that align with mine, and entities like the
Institute on Aging focus on bringing us together
and encouraging collegiality and networking for
the greater good," Roberts said. "I am excited to
further build these relationships."


Ph.D., an associate professor,
an assistant professor, are
two new faculty members
recently welcomed to
the medicinal chemistry
Booth comes to UF from Booth
the University of North Carolina at Chapel
Hill where he was an associate professor
of medicinal chemistry and toxicology. He
received a Ph.D. in pharmaceutical chemistry
at the University of California at San Francisco,
and completed a postdoctoral fellowship in

Dentistry dedicates Philanthropy

Center honoring college donors

Five dentistry deans joined the College of Dentistry during the Sept. 10 Dental Fall Weekend alumni
homecoming and Philanthropy Center dedication activities in the West Lobby of the Dental Sciences Building.
The Philanthropy Center represents cumulative gifts from alumni and friends to the college in excess of $20
million since the college's inception in 1966. The permanent display, which will be updated annually, was made
possible through the support of the college's Zeta, Omicron and Epsilon classes, the Academy of Alumni and
Friends, and Drs. Paul Mevoli and Paul Heidrich.

Front row, from left to right, sit deans Jose E. Medina, (1969-73) and Teresa A. Dolan, (interim
2003-04, dean 2004 to present). Back row from left to right, Donald L. Allen, (interim 1973-74,
dean 1974-82), Frank A. Catalanotto, (1994-2003) and Donald M. Legler, (1983-94).

Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events

--II -L~- l 17




neuroscience at Harvard Medical School.
Booth's research focuses on specific protein
molecules in the brain that can be targeted
by new drugs to treat the progression of a
disease and its associated impairments in
neurodegenerative diseases such as Alzheimer's
and Parkinson's and neuropsychiatric disorders,
with the goal of developing new drug treatment
for brain injury or diseases.
Luesch recently
completed a postdoctoral
fellowship at the Scripps
Research Institute in La
Jolla, Calif. He received a
diploma in chemistry from
the University of Siegen
in Germany, and a Ph.D. '-
from the University of Luesch
Hawaii at Manoa. Luesch's
research focus is in small molecules that may
have biomedical utility for treatment of diseases
such as cancer and neurological disorders. His
studies include marine natural products, such as
blue-green algae, which may prove useful in the
discovery of new drugs to fight cancer. He also
uses genomics to identify and characterize genes
associated with disease processes.


graduate student in the
department of clinical and
health psychology, has
received a Neuroscience
Scholars Fellowship from the
Society for Neuroscience. The
three-year award offers a
stipend, assistance with travel Dotson
costs to attend the society's
annual meeting, enrichment programs and
mentoring opportunities.

The three-member team of TERIKA
DONNA THOMPSON, students in the
master's in health administration program in
the department of health services research,
management and policy, reached the finals
of the annual student case competition
sponsored by the National Association of
Health Services Executives.

MICHAEL ROBINSON, Ph.D., a professor in
the department of clinical and health psychology,
was recognized for the second consecutive year
as the college's Teacher/Scholar of the Year. The
director of the Center for Pain Research and
Behavioral Health, Robinson was recognized for
his clinical and research supervision, as well as
his classroom teaching.

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0a 0itncin Please 0esn w
0-ai dtrnk ufled


Selling Survival

Social marketing brings oral cancer awareness and prevention message home

By Lindy McCollum-Brounley

Most people with a head for business are familiar
with the four Ps of marketing Product, Price, Place
and Promotion. Now, University of Florida public
dental health researchers are adding a fifth P -
Prevention to the equation in their social
marketing efforts to stem the rising tide of deaths
from oral and throat cancers in Florida.
Spurred by a $1.25 million, five-year grant from
the National Institute of Dental and Craniofacial
Research, these scientists plan to use advertising to
raise awareness of the role of prevention in the early
detection of oral cancer in people most at risk of
dying from the disease.
Study investigator Scott L. Tomar, D.M.D.,
Dr.P.H., an associate professor of public health
services and research in the College of Dentistry, is
taking a novel, science-based social marketing
approach to sell survival to African-American men
over the age of 40 the segment of Florida's
population at greatest risk for oral and pharyngeal
cancer incidence and mortality. The project
coordinators are developing an advertising campaign
in the greater Jacksonville area, in which 28 percent
of the area's approximately 800,000 residents are
African-American. The campaign aims to increase

awareness of the signs and symptoms of oral cancer,
the major risk factors of tobacco and alcohol use and
the benefits of early detection, which offers a cure
rate of 90 percent.
Focus groups and telephone surveys of African-
American residents in the Jacksonville and outlying
area have been conducted to establish baseline data
about current behaviors and attitudes, level of
awareness, information and media sources and
message preferences in the targeted population.
Telephone surveys of African-American respondents
in Miami-Dade have also been conducted to establish
baseline data.
This fall, a public relations/media agency will be
hired to develop the advertising campaign, which is
expected to roll out in early 2006. The campaign will
involve African-American actors and models to help
the message resonate with its targeted audience.
Radio public service announcements, billboards,
printed brochures and exam vouchers are expected to
be developed and distributed during the campaign by
mass media and through the health networks of the
IFAS health and nutrition extension program and
the Duval County Health Department.
Evaluation of the campaign's effectiveness in
achieving its goals of raising awareness and
increasing oral cancer exams in the targeted audience

Scott L. Tomar studies the role advertising
plays in raising oral health awareness.

will be conducted using follow-up telephone surveys.
The hypothesis is that a greater change in health
beliefs and behaviors will be seen in the targeted
community of Jacksonville/Duval County than in the
general community. Q

Visit us online @ http://news.health.ufl.edu/ for the latest news and HSC events

r18 J-*


UF researchers awarded $13.5 million

to study stroke rehabilitation

By Denise Trunk I

UF scientists have been awarded a five-year,
$13.5 million federal grant to lead a national
group of researchers who will study
rehabilitation techniques designed to improve
walking in the first year after stroke.
"These are critical questions that are very
important as we address the needs of aging
patients," said Pam Duncan, Ph.D., the study's
principal investigator and associate director of the
UF Institute on Aging.
The study, known as the Locomotor Experience
Applied Post-Stroke trial, or LEAPS, is funded by
the National Institute of Neurological Disorders
and Strokes and the National Center for Medical
Rehabilitative Research. UF and University of
Southern California researchers will study 400
stroke patients ages 18 and older in partnership
with clinicians at The Brooks Center for
Rehabilitation Studies in Jacksonville; Florida
Hospital in Orlando; Long Beach Memorial
Hospital in Long Beach, Calif.; Centinela Freeman
Memorial Hospital in Inglewood, Calif.; and Sharp
Rehabilitation Hospital in San Diego.
Difficulty walking is the most common disability
associated with stroke, said Duncan, who is also a
professor of aging and geriatric research in the UF
College of Medicine and a research career scientist
for the Department of Veterans Affairs. The focus
of the trial is a clinic-based program in which
patients practice walking on a treadmill.
The multisite, randomized trial will assess
whether there is a difference in the proportion of
subjects who successfully recover walking ability
using this therapy versus a group given a therapist-
supervised, home-based exercise program.
Researchers will divide the patients into study
groups based on the severity of their strokes and
their level of walking impairment. They also will
gauge whether initiating the therapy two months
after stroke versus six months after stroke makes a
difference in its effectiveness, and will seek to
identify the optimal duration of therapy. Patients
will be reassessed one year after treatment.
"Timing the intervention is important," Duncan
said. "For example, after a stroke, a patient will
experience some spontaneous recovery. Should we
provide therapy during this period of recovery or
later, when recovery has stabilized?"
The study will evaluate the success of the
therapeutic methods tested by measuring how much
walking ability study subjects regain, and whether

F :'' -I -

.3 .& C \ .. ,' .'*'z

UF researchers are leading a five-year, $13.5 million federal research grant to study
rehabilitation techniques to improve walking abilities and quality of life for stroke patients.

that improvement is great enough to help them act
Co-principal investigators Katherine Sullivan,
Ph.D., P.T., and Andrea Behrman, Ph.D., P.T.,
helped develop and design the study.
Sullivan, an assistant professor of clinical
physical therapy in the department of
biokinesiology and physical therapy at USC, has led
multisite clinical trials comparing different
therapeutic interventions such as strength training,
endurance training, locomotor training and
combined modalities to improve function after

stroke. Behrman, an assistant professor in the
department of physical therapy at UF's College of
Public Health and Health Professions, is the leader
of a combined UF and VA research program to
improve walking recovery after neurological
injuries involving stroke and spinal cord injury.
Scott Janis, NINDS spokesman, said although
other scientists have studied the new therapy, no one
has completed a definitive study to show it works.
"By investigating potential therapeutic
interventions for stroke victims, we are looking to
improve outcomes and quality of life," Janis said. O

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--II -L~- l 19



Martha Cheatham (left), a program assistant, and Ginny Leap, an office
assistant, are unsung heroes in the division of nephrology, hypertension and

Michelle Griffin (left), a senior secretary in the College of Medicine,
gets out of the office for a quick lunch break with Dr. Christine
Nielson, a clinical assistant professor in the College of Medicine.

Published by
UF Health Science Center
Office of News & Communications
Senior Vice President for Health Affairs
Douglas J. Barrett, M.D.
Director, News & Communications
Tom Fortner
Denise Trunk
Senior Editors
Melanie Fridl Ross, John Pastor
Mickey Cuthbertson
Staff Writers
Tracy Brown, Sarah Carey, Tom Fortner,
April Frawley Birdwell, Linda Homewood,
Lindy McCollum-Brounley, Patricia McGhee,
John Pastor, Jill Pease, Melanie Fridl Ross,
Denise Trunk
UF Health Science

Support Staff
Cassandra Jackson, Beth Powers, Kim Smith

The POST is the monthly internal newsletter
for the University of Florida Health Science
Center, the most comprehensive academic
health center in the Southeast, with campuses
in Gainesville and Jacksonville and affiliations
throughout Florida. Articles feature news
of interest for and about HSC faculty, staff
and students. Content may be reprinted
with appropriate credit. Ideas for stories are
welcome. The deadline for submitting items
to be considered for each month's issue is the
15th of the previous month. Submit to the editor
at dtrunk@ufl.edu or deliver to the Office of
News & Communications in the Communicore
Building, Room C3-025.




Professor Leslie Hendeles (left), gets a pie in the face from pharmacy
student Fiadora Avramidis at the annual College of Pharmacy Alumni
Reunion. The Kappa Epsilon student organization raised $100
through $1 donations in which the bidder chooses from six faculty
finalists. Professor Doug Ried tied with Hendeles in the bids, and also
got a pie in the face. A record 750 alumni and guests attended the
college's homecoming barbecue reunion.