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 Experiment
 Results
 Bibliography
 Figure 1 - Mean EPG values for...














Group Title: Department of Animal Science research report - University of Florida Dept. of Animal Science ; AL-1985-1
Title: Comparison of two different formulations of Ivermectin when administered orally in horses
CITATION PAGE IMAGE ZOOMABLE
Full Citation
STANDARD VIEW MARC VIEW
Permanent Link: http://ufdc.ufl.edu/UF00073164/00001
 Material Information
Title: Comparison of two different formulations of Ivermectin when administered orally in horses
Series Title: Department of Animal Science research report
Physical Description: 3 leaves : ill. ; 28 cm.
Language: English
Creator: Asquith, Richard L
Henderson, W. B
Lane, Thomas J.
University of Florida -- Dept. of Animal Science
University of Florida -- Agricultural Experiment Station
Publisher: Florida Agricultural Experiment Station
Place of Publication: Gainesville Fla
Publication Date: 1985
 Subjects
Subject: Horses -- Parasites -- Control -- Florida   ( lcsh )
Ivermectin   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
non-fiction   ( marcgt )
 Notes
Bibliography: Includes bibliographical references (leaf 2).
Statement of Responsibility: R.L. Asquith, W.B. Henderson and T.J. Lane.
General Note: Caption title.
General Note: "April, 1985."
Funding: Animal science research report (University of Florida. Dept. of Animal Science) ;
 Record Information
Bibliographic ID: UF00073164
Volume ID: VID00001
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 82196689

Table of Contents
    Experiment
        Page 1
    Results
        Page 2
    Bibliography
        Page 2
    Figure 1 - Mean EPG values for mares treated with both ivermectin paste/solution and control mares
        Page 3
Full Text

Department of Animal Science Florida Agricultural
IC1) Research Report AL-1985-1 .~-* Experiment Station
Crp3n91- April, 1985 Gainesville, Florida



COMPARISON OF TWO DIFFERENT FORMULATIONS
OF IVERMECTIN WHEN ADMINISTERED ORALLY IN HORSES

R.L. Asquithl, W.B. Henderson and T.J. Lane2


Ivermectin (22,23 dihydroavermectin.B1) is a chemical derivative of
structurally related compounds produ edghy;the actinomycete, Streptomyces
avermitilis. This compound has been extensively tested i.n;fr r search trials
all over the world. Early experiment s indicated that iverme tin was a po-
tent anthelmintic and also had insec icidal!.it~i~ity/of considerable im-
portance (1,3-11). Both an oral paste and an injectible formulation have
been used in horses (2,12). The lat r i no }pnger being ma keted for
horses. It was the purpose of this tiial MoitdA ib~-ndiKCompare an oral
solution with the oral paste formulation.
Experiment

Animals Thirteen Thoroughbred and Quarter Horse mares from the
University of Florida Horse Research Center were used in this trial. The
mares were from 8 21 years old and were from 179 225 days pregnant
based upon the date of ovulation determined by sequential rectal palpations.
After a two week acclimation period similar to the expected conditions of
the trial, the animals were weighed on day 0 prior to dosing. They ranged
in weight from 532 kg to 694 kg with a mean of 589 kg. All mares were weighed
again 30 days after dosing. Fecal samples were obtained from the rectum of
all animals and again at weekly intervals. The mares were assigned to treat-
ment as follows: one mare was selected by a blind drawing to serve as an
untreated control (Group A), the remaining twelve were randomized to form six
replicates and two treatment groups, Group B animals then received a single
dose of ivermectin oral paste (1.87%) at 200 mcg/kg orally and the animals in
Group C were given a single dose of ivermectin oral micelle solution (1.0%)
at 200 mcg/kg via naso-gastric intubation.
Laboratory Procedures The number and type of parasitic eggs per gram
of feces (EPG) was determined by both a modified McMaster technique and the
Wisconsin centrifugation method.

Feed and Housing The mares were fed similarly and in sufficient quan-
tity appropriate for the physical status of each animal. All animals were
housed for six hours each day for 30 days and given approximately the same
duration of pasture exercise each day.


R.L. Asquith, D.V.M., Associate Professor of Equine Health, Department of
Animal Science.
2W.B. Henderson, D.V.M. and T.J. Lane, D.V.M., College of Veterinary Medicine.







Results

All of the mares gained weight during the trial and showed an average
increase of 14.5kg over the 30 day period. No abortions occurred during or
after this trial nor any change of clinical condition in any of the animals.
Both the oral paste and the oral solution of ivermectin were easily admin-
istered and appeared to be well tolerated by the mares.

All mares except one demonstrated positive EPG counts (McMaster's method)
with a range of 0 3200 strongyle ova from the sample obtained prior to
treatment. The fecal egg count one week after dosing showed all mares nega-
tive except the untreated control animal. The treated mares in both groups
remained negative until the 5th week post-dosing, when one mare in each treat-
ment group was found to have 50 EPG's. (Fig. 1)

The results of this trial suggest that there is no difference in the
effectiveness of one formulation of ivermectin over the other in its anti-
parasitic activity. Treatment with oral solution then provides the clini-
cian another safe and effective mode of administration of ivermectin to horses.
Bibliography

1. Asquith, R.L. and Kulwich, R.(1981) Safety and Therapeutic Activity of
Ivermectin as an Equine Anthelmintic. J. Equine Vet.Sci. 1:18-20.
2. Asquith, R.L., Plue, R.E. and Seward, R.L. (1983) Field Performance of
the Equine Parasiticide Ivermectin in an Oral Paste. J.Eq.Vet.Sci.3:90-92:
3. Bello, T.R. and Norfleet, C.M. (1981) Critical Antiparasitic Efficacy of
Ivermectin Against Equine Parasites. J. Equine Vet. Sci. 1:14-17.
4. Craig, T.M. and Kunde, J.M. (1981) Controlled Evaluation of Ivermectin
in Shetland Ponies. Am. J. Vet. Res. 42:1422-1424.
5. DiPietro, J.A., Todd, K.S., Lock, T.F. and McPherron, T.A. (1982)
Anthelmintic Efficacy of Ivermectin Given Intramuscularly in Horses.
Am. J. Vet. Res. 43:145-148.
6. Egerton, J.R., Brokken, E.S., Suhayda, D., Eary, C.H., Wooden, J.W. and
Kilgore, R.L. (1981) The Antiparasitic Activity of Ivermectin in Horses.
Vet. Parasitol. 8:83-88.
7. Klei, T.R. and Torbert, B.J. (1980) Efficacy of Ivermectin (22,23-Dihydro-
avermectin Bl) Against Gastrointestinal Parasites in Ponies. Am,,J.Vet.
Res. 41:1747-1750.
8. Klei, T.R., Torbert, B.J. and Ochoa, R. (1980) Efficacy of Ivermectin
(22,23-Dihydroavermectin B1) Against Adult Setaria equina and micro-
filariae of Onchocerca cervicalis in Ponies. J. Parasitol. 66:859-861.
9. Lyons, E.T., Drudge, J.H. and Tolliver, S.C. (1980) Antiparasitic Activity
of Ivermectin in Critical Tests in Equids. Am. J. Vet. Res. 41:2069-2072.
10. Slocombe, J.O.D. and McCraw, B.M. (1980) Evaluation of Pyrantel Pamoate,
Nitramisole, and Avermectin B1 a Against Migrating Strongyles vulgaris
larvae. Can. J. Comp. Med. 44:93-100.
11. Slocombe, J.O.D. and McCraw, B.M. (1981) Controlled Tests of Ivermectin
Against Migrating Strongyles vulgaris in Ponies. Am. J. Vet. Res. 42:
1050-1051.
12. Torbert, B.J., Dramer, B.S. and Klei, T.R. (1982) Efficacy of Injectable
and Oral Paste Formulations of Ivermectin Against Gastrointestinal Para-
sites in Ponies. Am. J. Vet. Res. 43:1451-1453.







Results

All of the mares gained weight during the trial and showed an average
increase of 14.5kg over the 30 day period. No abortions occurred during or
after this trial nor any change of clinical condition in any of the animals.
Both the oral paste and the oral solution of ivermectin were easily admin-
istered and appeared to be well tolerated by the mares.

All mares except one demonstrated positive EPG counts (McMaster's method)
with a range of 0 3200 strongyle ova from the sample obtained prior to
treatment. The fecal egg count one week after dosing showed all mares nega-
tive except the untreated control animal. The treated mares in both groups
remained negative until the 5th week post-dosing, when one mare in each treat-
ment group was found to have 50 EPG's. (Fig. 1)

The results of this trial suggest that there is no difference in the
effectiveness of one formulation of ivermectin over the other in its anti-
parasitic activity. Treatment with oral solution then provides the clini-
cian another safe and effective mode of administration of ivermectin to horses.
Bibliography

1. Asquith, R.L. and Kulwich, R.(1981) Safety and Therapeutic Activity of
Ivermectin as an Equine Anthelmintic. J. Equine Vet.Sci. 1:18-20.
2. Asquith, R.L., Plue, R.E. and Seward, R.L. (1983) Field Performance of
the Equine Parasiticide Ivermectin in an Oral Paste. J.Eq.Vet.Sci.3:90-92:
3. Bello, T.R. and Norfleet, C.M. (1981) Critical Antiparasitic Efficacy of
Ivermectin Against Equine Parasites. J. Equine Vet. Sci. 1:14-17.
4. Craig, T.M. and Kunde, J.M. (1981) Controlled Evaluation of Ivermectin
in Shetland Ponies. Am. J. Vet. Res. 42:1422-1424.
5. DiPietro, J.A., Todd, K.S., Lock, T.F. and McPherron, T.A. (1982)
Anthelmintic Efficacy of Ivermectin Given Intramuscularly in Horses.
Am. J. Vet. Res. 43:145-148.
6. Egerton, J.R., Brokken, E.S., Suhayda, D., Eary, C.H., Wooden, J.W. and
Kilgore, R.L. (1981) The Antiparasitic Activity of Ivermectin in Horses.
Vet. Parasitol. 8:83-88.
7. Klei, T.R. and Torbert, B.J. (1980) Efficacy of Ivermectin (22,23-Dihydro-
avermectin Bl) Against Gastrointestinal Parasites in Ponies. Am,,J.Vet.
Res. 41:1747-1750.
8. Klei, T.R., Torbert, B.J. and Ochoa, R. (1980) Efficacy of Ivermectin
(22,23-Dihydroavermectin B1) Against Adult Setaria equina and micro-
filariae of Onchocerca cervicalis in Ponies. J. Parasitol. 66:859-861.
9. Lyons, E.T., Drudge, J.H. and Tolliver, S.C. (1980) Antiparasitic Activity
of Ivermectin in Critical Tests in Equids. Am. J. Vet. Res. 41:2069-2072.
10. Slocombe, J.O.D. and McCraw, B.M. (1980) Evaluation of Pyrantel Pamoate,
Nitramisole, and Avermectin B1 a Against Migrating Strongyles vulgaris
larvae. Can. J. Comp. Med. 44:93-100.
11. Slocombe, J.O.D. and McCraw, B.M. (1981) Controlled Tests of Ivermectin
Against Migrating Strongyles vulgaris in Ponies. Am. J. Vet. Res. 42:
1050-1051.
12. Torbert, B.J., Dramer, B.S. and Klei, T.R. (1982) Efficacy of Injectable
and Oral Paste Formulations of Ivermectin Against Gastrointestinal Para-
sites in Ponies. Am. J. Vet. Res. 43:1451-1453.














- Ivermectin paste/solution
t-H-4- Control


WEEKS POST TREATMENT

Fig. 1 Mean EPG values for mares treated with both ivermectin
paste/solution and control mares.


2000.





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1000-


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