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 Experimental
 Results and discussion
 Summary
 Reference
 Table 1 - Composition of diets...
 Table 2 - Composition of diets...
 Table 3 - Summary of data (Experiment...
 Table 4 - Summary of data (Experiment...














Group Title: Department of Animal Science research report - Florida Agricultural Experiment Station ; AL-1977-6
Title: Flavomycinª (bambermycins) for young swine
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Full Citation
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Permanent Link: http://ufdc.ufl.edu/UF00073097/00001
 Material Information
Title: Flavomycinª (bambermycins) for young swine
Series Title: Department of Animal Science research report
Physical Description: 5 p. : ; 28 cm.
Language: English
Creator: Monegue, Harold James, 1951-
University of Florida -- Dept. of Animal Science
University of Florida -- Agricultural Experiment Station
Publisher: Florida Agricultural Experiment Station
Place of Publication: Gainesville Fla
Publication Date: 1977
 Subjects
Subject: Swine -- Feeding and feeds -- Florida   ( lcsh )
Antibiotics in animal nutrition   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
bibliography   ( marcgt )
non-fiction   ( marcgt )
 Notes
Bibliography: Includes bibliographical references (p. 2).
Statement of Responsibility: H.J. Monegue ... et al..
General Note: Caption title.
General Note: "August, 1977."
Funding: Animal science research report (University of Florida. Dept. of Animal Science) ;
 Record Information
Bibliographic ID: UF00073097
Volume ID: VID00001
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 80548529

Table of Contents
    Experimental
        Page 1
    Results and discussion
        Page 2
    Summary
        Page 2
    Reference
        Page 2
    Table 1 - Composition of diets (Experiment 1)
        Page 3
    Table 2 - Composition of diets (Experiment 2)
        Page 4
    Table 3 - Summary of data (Experiment 1)
        Page 5
    Table 4 - Summary of data (Experiment 2)
        Page 5
Full Text



Department of Animal Science Florida Agricultural
-- Research Report AL-1977-6 / Experiment Station
August, 1977 Gainesville, Florida

is" /,-, ," (
FLAVOMYCIP (BAMBERMYOt S) FOR YOUNG INE1

H. J. Monegue, C. A. Ducsay, G. E. Combs'ad H. D. Wallace2


Bambermycins is an antibiotic for use as a non-therapeutic feed additive.
Streptomyces bambergiensis and other gray-green streptomyces produce bamber-
mycins. This antibiotic is primarily effective against gram-positive patho-
genic bacteria, but has shown an inhibitory effect on certain gram-negative
bacteria (E. coli and Salmonella).

Dealy and Moeller (1977) reported bambermycins to be effective against
S. typhimurium infection of calves. Bambermycins reduced the number of sal-
monella in the feces and reduced the number of salmonella resistant to other
antibiotics, streptomycin, ampicillin and oxytetracycline.

Dealy and Moeller (1976) found that 4.4 mg bambermycins per kg of diet
reduced the duration and prevalence of Salmonella infection of weanling pigs
infected with S. typhimurium. The number of Salmonella resistant to other
antibiotics were significantly reduced by feeding bambermycins in the diet.

The purpose of this study was to determine the efficacy of bambermycins
as a growth promotant for swine.

Experimental

Two experiments involving 72 weanling pigs and 126 growing pigs were con-
ducted.

In experiment 1, 126 barrows and gilts averaging 83.76 Ibs. were allotted
to three treatments: (1) Control-no antibiotic (2) Bambermycins (2 gm/ton)
and (3) Baciferm-40 (10 gm/ton). The trial lasted 72 days.

Experiment 2 consisted of 72 weanling barrows and gilts averaging 20.18
lbs. allotted to four treatments: (1) Control-no antibiotic (2) Bambermycins
(2 gm/ton) (3) ASP-250 (5 Ibs./ton) and (4) Baciferm-40 (40 gm/ton). The
trial lasted 56 days.

The composition of the diets is shown in tables 1 and 2. Feed and water
were supplied ad libitum. The animals were housed in confinement. Animal
weight and feed consumption were recorded biweekly. All pens were terminated
simultaneously to maintain a constant experimental period for all treatments.

The statistical analyses involved a simple analysis of variance.


1Swine Research Unit Experiments 255 and 255 A. Supported in part by Hoechst-
Roussel Pharmaceuticals, Inc., Sommerville, New Jersey 08876.
2Monegue and Ducsay, graduate students; Combs, Animal Nutritionist and Wallace,
Chairman, Animal Science Department.







-2-


Results and Discussion

The data for these experiments are summarized in tables 3 and 4.

The average daily gain (ADG), feed consumption and feed efficiency of
growing-finishing swine were not influenced by bambermycins at 2 gm/ton or
baciferm-40 at 10 gm/ton.

The performance of the weanling pigs was not significantly (P<.01)
affected by the addition of 2 gm/ton bambermycins, 5 Ibs./ton ASP-250 or
40 gm/ton baciferm-40. The pigs receiving antibiotic in the diet consumed
0.39 to 0.46 Ibs. of feed more per day than the controls, resulting in a
slightly lower feed per gain ratio for the control pigs.

Although bambermycins and the other antibiotics did not act as growth pro-
moting feed additives under these experimental conditions, it is possible that
with different bacterial populations that bambermycins may afford some bene-
ficial response.

Summary

Two experiments were conducted involving 72 weanling pigs and 126 growing
pigs. The growth promoting effects of bambermycins was compared to other anti-
biotics, ASP-250 and Baciferm-40. In both experiments the additions of anti-
biotic did not significantly improve growth rate. A possible explanation for
these results could be that the bacteria concentration under these experimental
conditions was not high enough to affect animal growth.

References

Dealy, J. and M. W. Moeller. 1976. Influence of bambermycins on Salmonella
infection and antibiotic resistance in swine. J. Anim. Sci. 42:1331.

Dealy, J. and M. W. Moeller. 1977. Influence of bambermycins on Salmonella
infection and antibiotic resistance in calves. J. Anim. Sci. 44:734.

Moeller, M. W. 1976. Bambermycins, a new antibiotic feed additive for swine.
Proceedings International Pig Veterinary Society, Ames, Iowa.







-2-


Results and Discussion

The data for these experiments are summarized in tables 3 and 4.

The average daily gain (ADG), feed consumption and feed efficiency of
growing-finishing swine were not influenced by bambermycins at 2 gm/ton or
baciferm-40 at 10 gm/ton.

The performance of the weanling pigs was not significantly (P<.01)
affected by the addition of 2 gm/ton bambermycins, 5 Ibs./ton ASP-250 or
40 gm/ton baciferm-40. The pigs receiving antibiotic in the diet consumed
0.39 to 0.46 Ibs. of feed more per day than the controls, resulting in a
slightly lower feed per gain ratio for the control pigs.

Although bambermycins and the other antibiotics did not act as growth pro-
moting feed additives under these experimental conditions, it is possible that
with different bacterial populations that bambermycins may afford some bene-
ficial response.

Summary

Two experiments were conducted involving 72 weanling pigs and 126 growing
pigs. The growth promoting effects of bambermycins was compared to other anti-
biotics, ASP-250 and Baciferm-40. In both experiments the additions of anti-
biotic did not significantly improve growth rate. A possible explanation for
these results could be that the bacteria concentration under these experimental
conditions was not high enough to affect animal growth.

References

Dealy, J. and M. W. Moeller. 1976. Influence of bambermycins on Salmonella
infection and antibiotic resistance in swine. J. Anim. Sci. 42:1331.

Dealy, J. and M. W. Moeller. 1977. Influence of bambermycins on Salmonella
infection and antibiotic resistance in calves. J. Anim. Sci. 44:734.

Moeller, M. W. 1976. Bambermycins, a new antibiotic feed additive for swine.
Proceedings International Pig Veterinary Society, Ames, Iowa.







-2-


Results and Discussion

The data for these experiments are summarized in tables 3 and 4.

The average daily gain (ADG), feed consumption and feed efficiency of
growing-finishing swine were not influenced by bambermycins at 2 gm/ton or
baciferm-40 at 10 gm/ton.

The performance of the weanling pigs was not significantly (P<.01)
affected by the addition of 2 gm/ton bambermycins, 5 Ibs./ton ASP-250 or
40 gm/ton baciferm-40. The pigs receiving antibiotic in the diet consumed
0.39 to 0.46 Ibs. of feed more per day than the controls, resulting in a
slightly lower feed per gain ratio for the control pigs.

Although bambermycins and the other antibiotics did not act as growth pro-
moting feed additives under these experimental conditions, it is possible that
with different bacterial populations that bambermycins may afford some bene-
ficial response.

Summary

Two experiments were conducted involving 72 weanling pigs and 126 growing
pigs. The growth promoting effects of bambermycins was compared to other anti-
biotics, ASP-250 and Baciferm-40. In both experiments the additions of anti-
biotic did not significantly improve growth rate. A possible explanation for
these results could be that the bacteria concentration under these experimental
conditions was not high enough to affect animal growth.

References

Dealy, J. and M. W. Moeller. 1976. Influence of bambermycins on Salmonella
infection and antibiotic resistance in swine. J. Anim. Sci. 42:1331.

Dealy, J. and M. W. Moeller. 1977. Influence of bambermycins on Salmonella
infection and antibiotic resistance in calves. J. Anim. Sci. 44:734.

Moeller, M. W. 1976. Bambermycins, a new antibiotic feed additive for swine.
Proceedings International Pig Veterinary Society, Ames, Iowa.








Table 1. Composition of Diets (Experiment 1).


Treatmentsi
15% Crude Protein 13% Crude Protein
Ingredient (%) Control Bambermycins Baciferm Control Bambermycins Baciferm

Yellow corn meal 77.10 77.10 77.088 81.60 81.60 81.59
Soybean meal (49%) 15.00 15.00 15.000 10.50 10.50 10.50
Dynafos 1.70 1.70 1.700 1.70 1.70 1.70
Limestone 0.80 0.80 0.800 0.80 0.80 0.80
Iodized salt 0.25 0.25 0.250 0.25 0.25 0.25
Trace minerals (CCC)2 0.10 0.10 0.100 0.10 0.10 0.10
Vitamin premix (UF)3 0.05 0.05 0.050 0.05 0.05 0.05
Swine base supplement4 5.00 --- 5.000 5.00 --- 5.00
Swine base supplement F5 --- 5.00 ---- ---- 5.00
Baciferm-406 ---- ---- 0.012 ---- --- 0.012


115% protein diet fed from initial weight to 125 Ibs.; 13% protein diet fed from 125 lbs. to termination of
.experiment.
2Supplied by Calcium Carbonate Company, Quincy, Illinois. Contained 20% zinc, 5.5% manganese, 1.1% copper, 10%
iron, 0.15% iodine, 0.10% cobalt and 2% calcium.
3Contained 6,000 mg riboflavin, 20,000 mg niacin, 12,000 mg pantothenic acid, 80,000 mg choline chloride, 10,000
mcg Vitamin B12, 2,500,000 IU Vitamin A, 400,000 ICU Vitamin D and 10,000 IU Vitamin E per lb. of premix.
Supplied by Hoechst-Roussel Pharmaceuticals; contained 12% protein.
SContains 40 gm bambermycins per ton in addition to other ingredients.
6Produced by Commercial Solvents Co., Terre Haute, Indiana. Contains 40 gm zinc Bacitracin per lb. premix.











Table 2. Composition of Diets (Experiment 2).


Treatments1


Ingredient (%) Control Bambermycins ASP-250 Baciferm


Yellow corn meal 67.05 67.05 66.80 67.00
Soybean meal (49%) 25.0 25.0 25.0 25.0
Dynafos 1.70 1.70 1.70 1.70
Limestone 0.80 0.80 0.80 0.80
Iodized salt 0.25 0.25 0.25 0.25
Trace mineral mix (CCC)2 0.10 0.10 0.10 0.10
Vitamin premix (UF)3 0.10 0.10 0.10 0.10
Swine base supplement4 5.00 --- 5.00 5.00
Swine base supplement F5 --- 5.00 --
Baciferm-406 --- --- --- 0.05
ASP-2507 --- --- 0.25 ---


1Approximately 18.8% protein diet.
2,3,4,5,6 Same as Table 1.

produced by American Cyanamid Co., Princeton, New Jersey. Contains 20 gm/lb. premix of chlortetracycline
and sulfamethazine and 10 gm/lb. premix of penicillin.






-5-


Table 3. Summary of Data (Experiment 1).


Treatments

Criteria Control Bambermycins Baciferm

Average initial weight, (lb.) 83.80 83.70 83.70
Average-final weight, (lb.) 203.00 203.55 205.80
Average daily gain, (lb.)1 1.66 1.67 1.68
Average daily feed, (lb.) 5.86 5.74 5.81
Average feed/gain1 3.53 3.44 3.46


IDifferences non-significant (P<.05).












Table 4. Summary of Data (Experiment 2).



Treatments

Criteria Control Bambermycins ASP-250 Baciferm

Average initial weight, (lb.) 20.17 20.17 20.20 20.17
Average final weight, (lb.) 95.43 100.40 100.30 97.63
Average daily gain, (lb.)1 1.34 1.43 1.43 1.38
Average daily feed, (lb.)1 3.25 3.70 3.71 3.64
Average feed/gain1 2.43 2.59 2.59 2.64


IDifferences non-significant (P<.01).






-5-


Table 3. Summary of Data (Experiment 1).


Treatments

Criteria Control Bambermycins Baciferm

Average initial weight, (lb.) 83.80 83.70 83.70
Average-final weight, (lb.) 203.00 203.55 205.80
Average daily gain, (lb.)1 1.66 1.67 1.68
Average daily feed, (lb.) 5.86 5.74 5.81
Average feed/gain1 3.53 3.44 3.46


IDifferences non-significant (P<.05).












Table 4. Summary of Data (Experiment 2).



Treatments

Criteria Control Bambermycins ASP-250 Baciferm

Average initial weight, (lb.) 20.17 20.17 20.20 20.17
Average final weight, (lb.) 95.43 100.40 100.30 97.63
Average daily gain, (lb.)1 1.34 1.43 1.43 1.38
Average daily feed, (lb.)1 3.25 3.70 3.71 3.64
Average feed/gain1 2.43 2.59 2.59 2.64


IDifferences non-significant (P<.01).




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