Group Title: Animal science mimeograph report - University of Florida Agricultural Experiment Station ; AN65-4
Title: A combination of chlortetracycline, sulfamethazine and penicillin as a feed additive for growing-finishing swine
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 Material Information
Title: A combination of chlortetracycline, sulfamethazine and penicillin as a feed additive for growing-finishing swine
Series Title: Animal science mimeograph report
Physical Description: 5 p. : ; 28 cm.
Language: English
Creator: Wallace, H. D ( Harold Dean )
Crum, Roger Clark, 1938-
Combs, G. E ( George Ernest ), 1927-
University of Florida -- Agricultural Experiment Station
Publisher: Florida Agricultural Experiment Station
Place of Publication: Gainesville Fla
Publication Date: 1964
 Subjects
Subject: Swine -- Feeding and feeds -- Florida   ( lcsh )
Antibiotics in animal nutrition -- Florida   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
bibliography   ( marcgt )
non-fiction   ( marcgt )
 Notes
Bibliography: Includes bibliographical references (p. 5).
Statement of Responsibility: H.D. Wallace, R.E. Crum, Jr., and G.E. Combs.
General Note: Caption title.
General Note: "August, 1964."
Funding: Animal Science Department mimeograph report ;
 Record Information
Bibliographic ID: UF00072957
Volume ID: VID00001
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 77538213

Full Text




Animal Science Florida Agricultural
Mimeograph Report AN65-4 Experiment Station
August, 1964 Gainesville, Florida


A COMBINATION OF CH.LORTETRAC I NES e AM HAZINE AND
PENICILLIN AS A FEED ADDITIVE R 6WiNG-FINISHING SWINE

H. D. Wallace, R. E. Crum, an dG. mEbs /


Previous work at this station, with both young pigs and growing-finishing
pigs, has demonstrated the effectiveness of a combination of chlortetracycline,
sulfamethazine and penicillin as a feed additive (L, 2, 3).

The present experiment was undertaken.to compare two levels of this preparation
and to study the effect of withdrawing the additive during the finishing period.


Experimental

Thirty-six purebred Duroc and forty-eight crossbred pigs (Duroc-Landrace x
Hampshire) were allotted to four treatment groups from outcome groups formed on
the basis.of breed, weight, sex and Ilitter. The treatments were as follows:

Lot I Basal

Lot II Basal + 100 gm. chlortetracycline, 100 gm. sulfamethazine and
50 gm. procaine penicillin (5 Ibs. Aureo S-P 250) per ton of
feed for the entire feeding period.

Lot III Same as Lot II initially. When pigs reached an average liveweight
of 125 Iks. the additive was withdrawn from the ration.

Lot IV Basal + 50 gm. chlortetracycline, 50 gm. sulfamethazine and 25 gm.
procaine penicillin (2.5 Ibs. Aureo S-P 250) per ton of feed for
the entire feeding period.

The basal feed mixture is presented in Table I. All lots were self-fed
ad lihitum in concrete confinement. Pigs were weighed off experiment individually
at a final weight approximating 200 lbs.








J/ Wallace, Animal Nutritionist; Crum, Graduate Assistant, and Combs, Assoc.
Animal Nutritionist, Animal Science Department. The assistance of B. R.
Cannon and L. S. Taylor, Swine Herdsmen is gratefully acknowledged. This
study was supported in part by American Cyanamid Co.





-2-


Table I. Composition of Basal Ration




Ingredients Lbs.

Ground yellow corn 78.35
Soybean oilmeal (50%) 19.00
Ground limestone -1.00
Steamed bonemeal 1.00
Iodized salt. 0.50
Trace mineral supplemi2t" 0.05
B-vitamin supply ent- 0.05
B2 supplement'- 0.05

100.00


J/ Adds in p.p.m.: Manganese (29.6), iron (36.5), cop-
per (2.5), cobalt (.83), zinc (42.0) and potassium
(3.9).

2/ Contained 8,000, 14,720, 36,000 and 40,000 mg./lb.
respectively of riboflavin, pantothenic acid, niacin
and choline chloride.

3/ Contained a minimum of 20 mg. vitamin B12 per Ib.



Results and Discussion

A summary of the performance data is presented in Table 2 and a summary of
the statistical study of gains is presented in Table 3.

A.Al.of the supplemented lots (2, 3, and 4) gained significantly faster
(P < .01) than the control lot during the first four weeks of the experiment.
Lots 2 and 3 (5 Ibs. Aureo S-P 250 per ton) gained faster than Lot 4 (2.5 Ibs.
Aureo S-P 250 per ton) but the difference was not statistically significant.
Feed consumption was increased considerably by the supplementation but feed con-
version was not markedly affected.

During the final period, from four weeks to termination of the experiment,
Lots 2, 3 and 4 continued to gain more rapidly than Lot I (P <.01). However,
withdrawal of the additive (Lot 3) slowed gains significantly (P <.01) when
compared to Lots 2 and 4 which continued to receive the additive. Feed intake







Table 2. The influence of level and withdrawal of a combination of chlortetracycline,
sulfamethazine and penicillin on the feedlot performance of growing-finishing pigs.


Lot Number I 2 3 4


5 lbs. Aureo S-P
250 per ton of
feed for entire
feeding period


Same as Lot 2
initially, addi-
tive withdrawn I
at 125 Ibs. wt. -


2.5 Ibs. Aureo S-P
250 per ton of feed
for entire feeding
period


Number of pigs
Av. initial wt., Ibs.
Av. final wt., Ibs.


21
73.0
201.6


First 4 Weeks


Av. daily gain, Ibs.
Av. daily feed, Ibs.
Feed required per lb. gain


1.54
4.82
3.13


After First 4 Weeks


Av. daily gain, Ibs.
Av. daily feed, Ibs.
Feed required per lb. gain


1.84
6.11
3.32


Entire Period


Av. daily gain, lbs.
Av. daily feed, Ibs.
Feed required per lb. gain


1.73
5.63
3.26


from the ration of this lot at the end of the first four weeks.


Treatment


Basal


21
73.0
203.4


21
73.1
201.1


21
73.0
202.3


1.68
5.36
3.19


1.73
5.30
3.06


1.63
5.26
3.26


2.03
6.79
3.33


1.91
6.13
3.22


2.09
6.45
3.08


1.89
6.2.1
3.28


1.84
5.80
3.16


1.90
. 5.96
3.13


I/ Aureo S-P 250 withdrawn













Table 3. Summary of statistical analyses for average daily gains.


Per iod of Experiment Lot Comparisons

I vs. 2. 3 & 4 2 & 3 vs. 4 3 vs. 2 & 4 2 vs. 3 2 vs. 4

First 4 Weeks N* N.S. --- N.S

After First 4 Weeks -, --- N.S.

Entire Period N.S. --- *


S-Significantly different (P< .01)

N.S.-Not Significant

--- Comparison not made









- 5 -


was also reduced in Lot 3. During the first several days after withdrawal of the
additive pigs in Lot 3 showed a tendency toward mild scours and required several
days to adjust to the withdrawal. Lot 4, fed the low level of additive over the
entire period, gained most rapidly of any group during the finishing period and
was extremely efficient in feed conversion. In fact the data show this lot to be
more efficient during the finishing period than during the early growing period.
Normally this would not be expected. The exceptionally good gains of the pigs
may be the explanation.

For the entire experiment all treated lots (2, 3 and 4) gained significantly
faster (P <.01) than the control lot. There was a significant advantage (P <.01)
for Lot.2 over Lot 3 in overall rate of gain, indicating that withdrawal of the
antibiotic produced an adverse effect. The pigs that received the lower level of
additive (Lot 4) gained just as rapidly and more efficiently than pigs that re-
ceived the high-level of additive (Lot 2).


Summary

Eighty-four pigs were fed in concrete confinement to determine the influence
of level and withdrawal of a feed additive consisting of chlortetracycline, sulfa-
methazine and penicillin on feedlot performance.

All treated lots, irregardless of level or withdrawal, gained significantly
faster than the control group (P <.01).

Pigs fed the equivalent of 125 gm. total additive per ton of feed gained
just as fast and more efficiently than pigs fed 250 gm. of total additive. Com-
plete removal of the additive at 125 pounds liveweight caused a moderate adverse
effect on performance.




Literature Cited

1. Wallace, H. D., G. E. Combs and R. H. O'Bannon. 1963. The value of Ampher-
tericin fed singly or in combination with other feed additives to growing-
finishing swine. Fla. An. Sci. Mimeo. Series No. 63-15

2. Wallace, H. D., G. E. Combs, R. L. Shirley and R. H. O'Bannon. 1963. High
level copper for growing-finishing swine. Fla. An. Sci. Mimeo. Series
No. 63-17.

3. Combs, G. E., H. D. Wallace and T. H. Berry. 1964. Antibiotics and copper
in pig starter rations. Fla. An. Sci. Mimeo. Rpt, AN65-2.



HDW:gem
8/10/64
1000 copies




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