Group Title: Department of Animal Science mimeograph series -University of Florida Agricultural Experiment Station ; 61-11
Title: The effects of a new antibiotic, tylosin, on the performance of growing-finishing swine
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 Material Information
Title: The effects of a new antibiotic, tylosin, on the performance of growing-finishing swine
Series Title: Department of Animal Science mimeograph series
Physical Description: 2, 3 p. : ; 28 cm.
Language: English
Creator: O'Bannon, Robert Harold, 1938-
Wallace, H. D ( Harold Dean )
Combs, G. E ( George Ernest ), 1927-
University of Florida -- Agricultural Experiment Station
Publisher: Florida Agricultural Experiment Station
Place of Publication: Gainesville Fla
Publication Date: 1961
 Subjects
Subject: Antibiotics in animal nutrition -- Florida   ( lcsh )
Swine -- Feeding and feeds -- Florida   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
non-fiction   ( marcgt )
 Notes
Statement of Responsibility: R.H. O'Bannon, H.D. Wallace and G.E. Combs.
General Note: Caption title.
General Note: "June, 1961."
 Record Information
Bibliographic ID: UF00072911
Volume ID: VID00001
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 77080034

Full Text





Department of Animal Science Florida Agricultural
Mimeograph Series No. t--II Experiment Station
June, 1961 / Gainesville, Florida


THE EFFECTS OF A NEW ANTIBIOTIC TYLOSIN ON THE PERFORMANCE
OF GROWING-FINISHING SWINE I/

R. H. O'Bannon, H. D. Wallace and G. E. Combs 2/

Tylosin is effective essentially against Gram-positive bacteria.
A few feeding trials have been conducted in which tylosin has been fed
to swine. The results have been promising and suggested that further
testing was desirable.

The work herein reported was designed to determine:

(1) the effectiveness of tylosin for improving rate and
efficiency of gain With growing-finishing swine.

(2) the most effective level of.tylosin relative to stage of
body'development.

(3) the relative effectiveness of tylosin when compared to
other antibiotics.

Experimental

Experiment I This experiment consisted of three trials conducted at
different times of the year but under similar feeding and management
conditions. Each trial involved 25 weanling pigs of mixed breedng-' --.
The pigs were allotted to five treatment groups, with five pigs per ''
group, according to litter, breed, sex and weight. The five, treatments
were as follows: 1..

Ration Feeding Period / /

I, Basal Weaning .to market weight i ---Y- -
2. Basal + 40 gm. tylosin/ton feed Weaning to 100 Ib. weighf"- '-'
Basal + 20 gm. 100 Ib. weight to market weight
3. Basal + 20 gm. Weaning to 100 lb. weight
Basal + 10 gm. 100 lb. weight to market weight
4. Basal + 10 gm. Weaning to 100 Ib. weight
Basal + 5 gm, 100 lb. weight to market weight
5. Basal + 20 gm. Weaning to 100 Ib. weight
Basal 100 Ib. weight to market weight

I/ This study was svpportdd in part by a grant-in-aid from Eli Lilly
and Company, Indianapolis, Indiana.

/ O'Bannon, Wallace and Combs, Interim Assistant, Associate Animal
Nutritionist and Assistant Animal Nutritionist, Department of Animal
Science. The assistance of W. E. Collins and L. S. Taylor, Swine Herds-
men is gratefully acknowledged.










Experiment 2 In this experiment 32 weanling pigs of mixed breeding were
allotted to eight pens of four pigs each according to litter; breed, sex
and weight. Two pens were assigned to each of the following feeding
treatments:


Ration


Feeding Period


I. Basal
2. Basal
Basal
3. Basal
Basal
4. Basal
Basal


tylosin/ton feed
II 11 II
aureomycin/ton feed
: 1 tt II
oleandomycin/ton feed
II 11 11


Weaning
Weaning
100 lb.
Weaning
100 Ib.
Weaning
100 lb.


to market weight
to 100 Ib. weight
weight to market weight
to 100 lb. weight
weight to market weight
to 100 lb. weight
weight to market weight


The composition of the basal feed mixture used in the two
is presented in Table 1. Pigs in both experiments were fed in
confinement by means of self feeder and had access to water at


experiments
concrete
all times.


Table I. Composition of Basal Ration I/


Ingredient


Ground yellow corn
Soybean oilmeal (50%)
Ground limestone
Steamed bonemeal
Iodized salt
Trace minerals 2/
B-vitamin supplement ./
B12 supplement 4/


Percent


78.30
19.00
1.00
1.00
0.50
0.05
0.10
0.05
100.00


I/ The ration contained approximately 16.59 crude protein.

2/ Calcium Carbonate Co. trace mineral mixture for swine: Supplied the
following to the ration (p.p.m,); manganese-30, iron-36, copper-2.5,
cobalt-0.83, zinc-42 and potassium-3.9.

3/ Pfizer Vitamin Supplement No. 2: contains 4,000 mg. riboflavin, 4,000
mg. per;othenic acid, 24,000 mg. niacin and 104,000 mg. choline chloride
per pound.

4/ Pfizer B12 Supplement (9+): contains approximately 9 mg. vitamin
B12 per pound.


-2-









Results and Discussion


Results of the three trials of Experiment I were combined and
summarized in Table 2. The addition of tylosin at all levels resulted
in some improvement in daily gains and feed conversion over the controls
but this difference was not statistically significant (P<0.05). On
the basis of these data it appears that the lower levels of tylosin
supplementation (20-10 and 10-5) were more feasible than the higher level
(40-20). Overall performance indicated that withdrawal of the antibiotic
at 100 pounds body weight had little effect on daily gains and feed con-
version. The reduction of the level of tylosin supplementation at 100
pounds body weight in groups 2, 3 and 4 had no adverse effect on pig
performance.

The results of Experiment 2 are summarized in Table 3. It can be
noted that all antibiotic treatments increased daily gains. During.the
early part of the experiment (60-100 pounds live weight) the tylosin
supplemented pigs gained fastest (1.64) followed by oleandomycin (1.58)
aureomycin (1.50) and the controls (1.44). Feed consumption was increased
by all of the antibiotic treatments, but the feed required per unit of
gain was essentially the same for all treatments. Oleandomycin supple-
mented pigs gained very well during the entire trial (1.79) and especially
well from 100 pounds to market weight (1.92).

Summary

Two experiments were conducted to evaluate the growth-promoting
properties of tylosin, a new antibiotic, for growing-finishing swine.

The first experiment involving 75 pigs demonstrated the feasibility
of using relatively,low levels and reducing the level or withdrawing
tylosin at 100 pounds liveweight. Levels of 20-10, 10-5 and 20-0 gm.
per ton (first level reduced to second level at 100 lb. body weight)
were slightly more effective than the 40-20 gm. level.

The second experiment involving 32 pigs demonstrated that tylosin
and aureomycin were similarly effective while oleandomycin was slightly
more effective than either tylosin or aureomycin for stimulating gains.












Table 2. The Effects of Reducing and Discontinuing Tylosin Supplementation on
the Growth Rate and Feed Efficiency of Growing-Finishing Swine


Treatment I 2 3 4 5
gm/ton 1/ 0-0 40-20 20-10 10-5 20-0


Number of pigs 15 15 15 142/ 15
Average initial weight, lb. 47.2 47.3 47.0 47.4 47.1
Average final weight, Ib. 189.5 191.7 194.1 198.0 194.0
Average daily gain, lb.
Initial 100 Ib. 1.49 1.53 1.56 1.64 1.58
100 lb. market weight 1.68 1.69 1.73 1.73 1.71
Initial market weight :.60 1.63 1.66 1.69 1.66
Average daily feed, lb.
Initial 100 lb. 4.62 .4.38 4.44 4.53 4.64
100 Ib. market weight 6.03 5.82 6.15 6.37 6.09
Initial market weight 5.48 5.25 5.47 5.52 5.48
Feed per Ib. of gain, lb.
Initial 100 lb. 3.10 2.86 2.85 2.75 2.93
100 Ib. market weight 3.60 3.44 3.55 3.69 3.55
Initial market weight 3.41 3.24 3.30 3.26 3.31


I/ First level was reduced to second level at 100 Ib. body weight.


2/ One pig removed with umbilical hernia.













Table 3. The Comparative Effectiveness of Tylosin, Aureomycin and
in Promoting Gains and Feed Efficiency of Growing-Finishing


Oleandomycin
Swine


Treatment Basal Tylosin Aureomycin Oleandomycin
gm/ton 1/ 0-0 20-10 20-10 20-10


Number of pigs 8 8 8 8
Average initial weight, lb. 60.9 61.1 60.5 60.5
Average final weight, lb. 169.9 178.1 177.1 185.9
Average daily gain, lb.
Initial 100 lb. 1.44 1.64 1.50 1.58
100 Ib. market weight 1.64 1.70 1.77 1.92
Initial market weight 1.55 1.67 1.67 1.79
Average daily feed, Ib.
Initial 100 Ib. 3.91 4.12 4.66 4.64
100 lb. market weight 5.82 6.26 6.22 6.82
Initial market weight 5.06 5.41 5.60 5.94
Feed per pound of gain, Ib.
Initial 100 Ib. 2.72 2.54 3.10 2.93
100 Ib. market weight 3.57 3.68 3.51 3.53
Initial market weight 3.24 3.24 3.36 3.32
Days on experiment 70 70 70 70


I/ First level was reduced to second level at 100 Ib. body weight.




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