Group Title: Animal husbandry and nutrition mimeograph series - Florida Agricultural Experiment Station ; no. 60-10
Title: Preliminary observations on the use of tolbutamide, triiodothyronine and hydroxyzine in young pig rations
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Permanent Link: http://ufdc.ufl.edu/UF00072894/00001
 Material Information
Title: Preliminary observations on the use of tolbutamide, triiodothyronine and hydroxyzine in young pig rations
Physical Description: 4 p. : ; 28 cm.
Language: English
Creator: Combs, G. E. ( George Ernest ), 1927-
Wallace, H. D. ( Harold Dean )
Pekas, Jerome Charles, 1936-
University of Florida -- Agricultural Experiment Station
Publisher: Florida Agricultural Experiment Station
Place of Publication: Gainesville, Fla.
Publication Date: 1960
 Subjects
Subject: Swine -- Feeding and feeds -- Florida   ( lcsh )
Antibacterial agents -- Research -- Florida   ( lcsh )
Genre: government publication (state, provincial, terriorial, dependent)   ( marcgt )
non-fiction   ( marcgt )
 Notes
General Note: Animal husbandry and nutrition mimeograph series - Florida Agricultural Experiment Station ; no. 60-10
General Note: "January, 1960."
Funding: Animal husbandry & nutrition mimeograph series ;
Statement of Responsibility: by G.E. Combs, H.D. Wallace and J.C. Pekas.
 Record Information
Bibliographic ID: UF00072894
Volume ID: VID00001
Source Institution: University of Florida
Rights Management: All rights reserved by the source institution and holding location.
Resource Identifier: oclc - 76971587

Full Text




Animal Husbandry and Nutrition Florida Agricultural
Mimeograph Series No. 60-10 Experiment Station
Gainesville, Florida
January 1960

PRELIMINARY OBSERVATIONS ON THE USE OF TOLBUTAMIDE,
TRIIODOTHYRONINE AND HYDROXYZINE IN YOUNG PIG RATIONS

by

G. E. Combs, H. D. Wallace and J. C. Pekas j/



Previous work (Mimeo Series 60-7) has demonstrated the effects
of supplementing the rations of early weaned pigs with various
antibacterial agents.

In the present study the performance of pigs fed tolbutamide,
and oral hypoglycemic agent, triiodothyronine, a metabolic stim-
ulant and hydroxyzine, a tranquilizer was evaluated. This study
was preliminary in nature and designed to determine the feasibility
of conducting more intensive studies with the compounds mentioned
above.

Experimental

Two trials were conducted with pigs weaned at 2 weeks of age.
During both trials the pigs were housed in concrete-floored pens;
bedding consisted of wood-shavings and heat lamps were used to
provide supplemental heat. The pigs were randomly allotted from
outcome groups to the various treatments and feed and water sup-
plied ad libitum. Five pigs were used per treatment. The compo-
sition of the rations fed is presented in Table I.




I/ Combs, Wallace and Pekas, Assistant Professor, Associate
Professor and Research Assistant, respectively. Department
of Animal Husbandry and Nutrition. The assistance of
W. E. Collins and L. S. Taylor, Swine Herdsmen is gratefully
acknowledged. This study was partially supported by funds
and materials supplied by Chas. Pfizer and Company, Merck
and Company, Inc. and The Upjohn Company.







-2-


Table I. COMPOSITION OF BASAL RATION I/


Ingredient Pounds

Ground yellow corn 39.14
Soybean meal 18.66
Dried skimmilk 20.00
Rolled Oats 5.00
Sugar 10.00
Lard 3.00
Ground limestone .60
Steamed bonemeal 1.00
Trace minerals a .10
Salt .50
Vitamin-antibiotic premixb 2.00

I/ During the first week of experiment this ration contained
32.60 pounds of corn and 25.20 pounds of dried skimmilk instead
of the figures shown above.

a Supplied the following in the ration (ppm): Mn. (35.5), Fe.-
(43.8), Cu. (3.0), Co. (1.0), Zn. (50.0) and K (4.7).

b .Supplied,the following vitamins and antibiotics per pound of
ration: Vitamin A, 2000 IU; vitamin D, 400 IU; niacin, 20 mg:
riboflavin, 3 mg; pantothenic acid 10 mg; choline chloride,
500 mg.; thiamine, 3 mg; pyridoxine, I mg; vitamin B. 20 mcg;
chlortetracycline 25 mg; penicillin, 6 mg. and streptomycin
9 mg.

Ration treatments were as follows:

Experiment I

I. Basal
2. Basal + 100 mg. tolbutamide daily
3. Basal + 60 mcg. triiodothyronine/lb. of ration
4. Basal + 100 mg. tolbutamide daily + 60 mcg.
triiodothyronine/lb. of ration.

Experiment 2

1. Basal
2. Basal + 0.2 mg. hydroxyzine/lb. of ration
3. Basal + 10.0 mg. tolbutamide/Ib. of ration
4. Basal + 30.0 mcg. triiodothyronine/Ib. of ration
5. Basal + combination of treatments 2 and 3
6. Basal + combination of treatments 2, 3 and 4






- 3 -


Results and Discussion

A summary of the results is presented in Table 2. In
Experiment I the daily gains of.the treated groups were comparable
and were less than the basal fed pigs. This decrease may have
resulted from feeding excessive quantities of tolbutamide or
triiodothyronine; therefore in Experiment 2 considerably lower
levels of thesecompounds were fed.

In addition the tranquilizer hydroxyzine was evaluated for
both growth promoting and tranquilizing properties. Early weaned
pigs often appear extremely nervous for several days following
weaning; Hydroxyzine was used in an attempt to correct or alleviate
this condition.

Both daily gain and feed efficiency data indicate that in
Experiment 2 none of the compounds tested significant-ly-affected
performance. It was also observed that the use of hydroxyzine
had little if any influence on relieving the stress imposed by
weaning.

Summary

Pigs weaned at 2 weeks of age were fed rations supplemented
with tolbutamide, triiodothyronine and hydroxyzine.

Performance as measured by rate and efficiency of gain was
not materially influenced by these compounds when fed singly or
in combination. The stress of early weaning was not noticeable
relieved by hydroxyzine.






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Table 2. EVALUATION OF VARIOUS FEED ADDITIVES
IN-YOUNG PIG RATIONS


Experiment I .I


Basal Tolbutamide


Treatment


Triiodo-
thyronine


Tolbutamide
+ triiodo-
+h roni ne


Av. initial wt., Ibs. 10.0 10.0 10.4 10.0
Av. final wt.,ilbs. 52.8 47.0 .47.8 48;3
Av. daily gain, lbs. 1.02 .88 .89 .91
Av. daily feed, Ibs. 2.22 1.79 1.92 1.90
Lb. feed/lb. gain, Ibs. 2.18 2.03 2.15 2.08
Days on test 42 42 42.. 42


Experiment 2 I/

Basal Hydroxy- Tolbuta- Triiodo- Combi- Combi-
zine mide thyronine nation nation
Treatment 2 & 3 2, 3
and 4
Av. initial wt., Ibs. 10.2 10.3 10.3 10.2- 10.3- 10.2
Av. final wt., Ibs. 51.5 51.9 52.5 49.5 49.9 49.9.
Av. daily gain, Ibs. .98 .99. 1.01 .94 .94 .94
Av. daily feed, Ibs. 1.94 2.04 1.91 1.95 2.00 1.89
Lb. feed/lb. gain Ib 1.97 2.06 1.90 2.08 2.12 2.00
Days on test 42 42 42 42 42 42


J/ Tolbutamide is sold
Hydroxyzine is sold
name of Tran-Q.


by the Upjohn Company under the trade name Orinase.
by the Chas. Pfizer and Company under the trade




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