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Methodological Challenges in Observational Research: A Pharmacoepidemiological Perspective.
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Permanent Link: http://ufdc.ufl.edu/IR00001440/00001
 Material Information
Title: Methodological Challenges in Observational Research: A Pharmacoepidemiological Perspective.
Series Title: Ali AK. Methodological Challenges in Observational Research: A Pharmacoepidemiological Perspective. British Journal of Pharmaceutical Research. 2013;3(2):161-175.
Physical Description: Journal Article
Creator: Ayad K. Ali
Publisher: SCIENCEDOMAIN International
Place of Publication: United Kingdom
Publication Date: March 4, 2013
 Notes
Abstract: Pharmacoepidemiology is the science of studying the effects of utilizing pharmaceutical and biological products in the population, and in most cases this science is conducted in observational epidemiological designs, including retrospective database analysis. Observational pharmacoepidemiology is associated with a myriad of methodological challenges that affect study conclusions and related causal inferences. However, if these challenges are addressed and effectively dealt with, observational studies can have important and impactful clinical, regulatory, and public health outcomes. This article examines common challenges in retrospective database analysis and serves as an introductory text to important methodological concepts in research involving medication use, including confounding by indication, time-dependent confounding, informative censoring, depletion of susceptibles, and immortal time bias.
Acquisition: Collected for University of Florida's Institutional Repository by the UFIR Self-Submittal tool. Submitted by Ayad K Ali.
Publication Status: Published
 Record Information
Source Institution: University of Florida Institutional Repository
Holding Location: University of Florida
Rights Management: Applicable rights reserved.
System ID: IR00001440:00001

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