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UFIR



Southeast Center for Integrated Metabolomics (SECIM)
http://www.ufl.edu ( Publisher's URL )
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Permanent Link: http://ufdc.ufl.edu/IR00001407/00001
 Material Information
Title: Southeast Center for Integrated Metabolomics (SECIM)
Physical Description: Conference Poster
Creator: Edison, Arthur
Yost, Rick
McIntyre, Lauren
Garrett, Tim
Conlon, Michael
Smith, Steven
Gardell, Stephen
Publisher: University of Florida
Sanford-Burnham Medical Research Institute
Place of Publication: Miami, Florida
Publication Date: 2013-02-27
 Notes
Abstract: The Southeast Resource Center for Integrated Metabolomics (SECIM) integrates existing strengths to create a comprehensive resource for basic and clinical scientists to obtain state-of-the-art metabolomics data and analyses. SECIM offers services in MS- and NMR-based metabolomics with partner Sanford- Burnham Medical Research Institute (Orlando, Fla.)
Acquisition: Collected for University of Florida's Institutional Repository by the UFIR Self-Submittal tool. Submitted by Michael Conlon.
Publication Status: Published
General Note: Presented at CaneSearch, University of Miami CTSI Research Day, at the University of Miami, Wednesday, February 27, 2013.
 Record Information
Source Institution: University of Florida Institutional Repository
Holding Location: University of Florida
Rights Management: All rights reserved by the submitter.
System ID: IR00001407:00001

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Southeast Center for Integrated Metabolomics (SECIM) Arthur Edison, Rick Yost, Lauren McIntyre, Tim Garrett, Michael Conlon University of Florida; Steven Smith, Stephen Gardell Sanford Burnham Medical Research Institute SECIM is supported in part from grant 1UL1TR000066 the University of Florida CTSI, from the National Center for Advancing Translational Sciences The Southeast Resource Center for Integrated Metabolomics (SECIM) integrates existing strengths to create a comprehensive resource for basic and clinical scientists to obtain state of the art metabolomics data and analyses SECIM offers services in MS and NMR based metabolomics with partner Sanford Burnham Medical Research Institute (Orlando Fla ) SECIM will offer a fully integrated platform for statistical analysis created by our Bioinformatics Core Biomarkers will be identified by NMR and MS, with new methods for de novo structure prediction with the Brschweiler lab at Florida State University and joint NMR/MS analysis with the Nicholson group at Imperial College, London A service will be provided to SECIM users by the Prestegard lab at the University of Georgia for dynamic nuclear polarization (DNP) substrates that will be used by our partner, the AMRIS Facility at UF, for monitoring of metabolism in living animals SECIM users will also be able to conduct isotopic ratio outlier analysis (IROA) experiments to measure global metabolomic changes in response to external perturbations or mutations using LC/MS through our partnership with NextGen Metabolomics and Thermo Fisher SECIM will provide ex vivo tissue analysis using MALDI imaging (MS) and HRMAS (NMR) techniques, and users can also access an extensive tissue and blood bank through the UF Clinical and Translational Science Institute Biorepository SECIM technical cores include : 1. Mass Spectrometry Services for global and targeted metabolomics (Garrett and Gardell Co PIs) 2. NMR spectroscopy for global metabolomics and biomarker identification (Edison, PI) 3. Advanced MS for biomarker identification, imaging mass spectrometry, and IROA (Yost, PI) 4. Bioinformatics for SECIM pipeline development and analysis (McIntyre, PI) The Promotion & Outreach Core (Conlon and Smith, Co PIs) brings everything together by expanding the user base and providing education and training in SECIM capabilities The Administrative Core coordinates all activities and will develop and implement a sustainable business model that will be self supporting in years 6 and beyond