Citation
Post-polymerization Modification of Polyesters via Suzuki Coupling and Dynamic Light Scattering Study of Zwitterionic Amphiphilic Homopolymers

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Title:
Post-polymerization Modification of Polyesters via Suzuki Coupling and Dynamic Light Scattering Study of Zwitterionic Amphiphilic Homopolymers
Creator:
Latty, Tristin Shikakura
Publication Date:
Language:
English

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Abstract:
Functional polyesters have been used in the field of medicine in the delivery of various therapeutic agents. However, the functionalization of polyesters has been met with challenges due to the lack of reactive handles of the polyester backbone for post-polymerization modification strategies. This study focuses on the application of Suzuki coupling as a method of post-polymerization modification of polylactides due to its tolerance for various functional groups and avoidance of harsh reaction conditions. We have successfully applied the Suzuki reaction in the post-polymerization modification of polylactide in order to afford polymers with various functionalities. The second portion of this report focuses on the dynamic light scattering analysis of two triazine-containing zwitterionic amphiphilic homopolymers. The two homopolymers used only differ in length of their hydrophobic side chain. The size of the nanoparticles formed by these two homopolymers was analyzed under various concentrations of NaBr. We have found that an increase in the ionic strength of an aqueous solution results in an initial decrease in nanoparticle diameter. However, a further addition of NaBr results in an increase in nanoparticle diameter. Both studies focus on the construction of functional homopolymers that form nanoparticles in aqueous solution. The modification of homopolymers through Suzuki coupling may be used to add zwitterionic groups through post-polymerization modification. This may be a focus for future studies. ( en )
General Note:
Awarded Bachelor of Science, summa cum laude, on May 8, 2018. Major: Chemistry. Emphasis/Concentration: Biochemistry
General Note:
College or School: College of Liberal Arts and Sciences
General Note:
Advisor: Alexander Angerhofer. Advisor Department or School: Chemistry

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Source Institution:
University of Florida
Holding Location:
University of Florida
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Copyright Tristin Shikakura Latty. Permission granted to the University of Florida to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.

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