Citation
Simulating Nerve-Tissue Heating Due To An Implantable Neuroprosthetic Device

Material Information

Title:
Simulating Nerve-Tissue Heating Due To An Implantable Neuroprosthetic Device
Series Title:
19th Annual Undergraduate Research Symposium
Creator:
Kitts, Daniel
Language:
English
Physical Description:
Undetermined

Subjects

Subjects / Keywords:
Center for Undergraduate Research
Center for Undergraduate Research
Genre:
Conference papers and proceedings
Poster

Notes

Abstract:
One way to improve control and acceptance of sensorized prosthetic limbs is with the implementation of a bi-directional interface for peripheral nerve stimulation as well as recording. Stimulation provides sensory feedback for future implementations in a prosthetic arm. The implantable multimodal peripheral recording and stimulation system (IMPRESS) is an intraneural interface technology supporting a high-density transverse intrafascicular multichannel electrode (hd-TIME). In order to become available for human testing the electrode cannot cause the surrounding nerve and muscular tissue to have a temperature change of more than ~1% of the initial temperature. Using COMSOL’s AC/DC and heat transfer modules the current output of the hd-TIME electrode was simulated to determine the temperature increase through the surrounding nervous tissue. This is done through electrothermal coupling allows for the simulation of the joule heating caused by the current injection into the surrounding tissue. We determined that the temperature would only change by ~0.001%. This model can be used for predictive modeling of tissue heating through various nerve-electrode configurations. ( en )
General Note:
Research authors: Daniel Kitts, Erin Patrick, - University of Florida
General Note:
Emerging Scholars Program
General Note:
Faculty Mentor: One way to improve control and acceptance of sensorized prosthetic limbs is with the implementation of a bi-directional interface for peripheral nerve stimulation as well as recording. Stimulation provides sensory feedback for future implementations in a prosthetic arm. The implantable multimodal peripheral recording and stimulation system (IMPRESS) is an intraneural interface technology supporting a high-density transverse intrafascicular multichannel electrode (hd-TIME). In order to become available for human testing the electrode cannot cause the surrounding nerve and muscular tissue to have a temperature change of more than ~1% of the initial temperature. Using COMSOL’s AC/DC and heat transfer modules the current output of the hd-TIME electrode was simulated to determine the temperature increase through the surrounding nervous tissue. This is done through electrothermal coupling allows for the simulation of the joule heating caused by the current injection into the surrounding tissue. We determined that the temperature would only change by ~0.001%. This model can be used for predictive modeling of tissue heating through various nerve-electrode configurations. - Center for Undergraduate Research, Emerging Scholars Program

Record Information

Source Institution:
University of Florida
Rights Management:
Copyright Daniel Kitts. Permission granted to University of Florida to digitize and display this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.

Downloads

This item is only available as the following downloads:


Full Text

PAGE 1

Simulating Nerve Tissue Heating due to an Implantable Neuroprosthetic Device Daniel Kitts 1 Erin Patrick 1 "#$%&'(#)'*+,*-.#/'&0/%.*%)1*2+($3'#&*-)40)##&0)45*6)07#&80'9*+,*:.+&01%5*;%0)#870..#5*:.+&01%5*6<= IMPRESS Pre recorded data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d TIME JKA3,(59$*,(%+A *+2AKLA'".%'2(+/A 3(,"3 MNOP ?EN=: JQA3,(59$*,(%+A *+2ALRA'".%'2(+/A 3(,"3 ?,(59$*,(%+A3(,"FAJQSA8AJQSAT5 =".%'2(+/A3(,"FAKSA8ALSAT5 H9$$0A2(--"'"+,(*$A,(5" 7 59$,(&$"8"2A*+*$%/A %9,&9,A H9$$0A2(--"'"+,(*$AJKA(+3,'95"+,A*5&$(-("'3A 1(,)A&'%/'*55*6$"A/*(+A <'%6"A.)*++"$3A-%'A.%+-(/9'*6$"A+"9'*$A 3,(59$*,(%+A U ;%+% 7 &)*3(.A*+2AV( 7 &)*3(.A&9$3"AAA U <9$3"A1(2,)FAST3A W QSLXST3A&9$3"A1(2,)ACJST3A'"3%$9,(%+DA U Y9''"+,A*5&$(,92"FAZ[JQ\TGA W LSSTGAAA U \A]A39&&$0A Conclusions G-,"'A,"3,(+/A,)"A59$,(&$"A5%2"$3A%-A,)"A"$".,'%2"A(,A(3A*&&*'"+,A,)*,A,)"A'"39$,3A #*'0A/'"*,$0A2"&"+2(+/A%+A,)"A*''*+/"5"+,A%-A,)"A(+,"'+*$A-*3.(.$"3[ !G=A"$".,'%2"[A `(,)A*A#*'(*6$"A.9''"+,A%-A2(--"'(+/A&9$3"A1(2,)3A*+2A*5&$(,92"3A%-A+%A/'"*,"'A ,)*+AaSA GA1"A"8&".,A-%'A%9'A&"'."+,*/"3A,%A2".'"*3"A3(/+(-(.*+,$0[ ?"+3%'0A-""26*.BA ;%,%'A(+,"+,(%+ Y;N? E2 7 :4;>AJL55 >8,"+3(%+A.*6$"AQS 7 LS55 (E96 QK55 (/)A ( "+3(,0A ) '*+3#"'3"A +,'*-*3.(.9$*'A 9$,(.)*++"$A % $".,'%2" Y;N?A#*'(*+ ,3 Modeling the nerve Methods Z 7 "8,'*."$$9$*' #%$,*/"3 *+2 ,"5&"'*,9'" #*$9"3 1"'" .*$.9$*,"2 60 YN;?NMb3 -(+(," 7 "$"5"+, *+*$03(3 3%$#"' [ :)" +"'#" )*3 59$,(&$" &*',3 1(,) #*'0(+/ "$".,'(.*$ .%+29.,(#(,("3 [ 4+ %'2"' ,% ,"3, )%1 ,)"3" .%+29.,(#(,("3 (+,"'*.,"2 1(,) "*.) %,)"' *+2 ,% /", *+ *..9'*," '"&'"3"+,*,(%+ %,)" ,"5&"'*,9'" 2(3,'(69,(%+ 1(,)(+ ,)" +"'#" [ Control Acknowledgements !"#$ %&'( #$ $)&*$&'+, -. /"+ 0+1+*$+ 2,34*5+, 6+$+4'5" 7'&8+5/$ 29+*5. :02672; <#&=&9#54= !+5"*&=&9#+$ >11#5+ :; ?4*, 7'&)'#&5+)/#&* 4*, !&@5" A*/+'145+$ :?27!AB; )'&9'4C @*,+' /"+ 4@$)#5+$ &1 0' D 0&@9 E+-+' /"'&@9" /"+ F)45+ 4*, G434= E4'14'+ F.$/+C$ H+*/+'I 745#1#5 J'4*/KH&*/'45/ G& D G LLMMN O NP O H O QMNR /& /"+ S*#3+'$#/. &1 T=&'#,4 D !"#$ /+U/ #$ 4))'&3+, 1&' 7@-=#5 6+=+4$+ -. 02672I 0#$/'#-@/#&* S*=#C#/+, D !"#$ ", O !AVW 5"#) %4$ )'&,@5+, /"'&@9" #C+5 D Future Work :)"A+"8,A3,"&A(3A,%A6"/(+A'9++(+/A,)"A3(59$*,(%+3A1(,)A#*'(*6$"A.9''"+,A&9$3"3@A *+2A2(--"'(+/A*''*03A%-A"$".,'%2"3A'9++(+/[ `"A.9''"+,$0A2%+b,AB+%1A,)"A2(--"'"+,A,)"'5*$A.%+29.,(#(,("3A%-A,)"A#*'0(+/A &*',3A%-A,)"A+"9'*$A*+*,%50[A4+A%'2"'A,%A,'9$0A3(59$*,"A,)"A"--".,3A%-A,)"A "$".,'%2"A%+A,)"A,"5&"'*,9'"A%-A,)"A39''%9+2(+/A+"'#%93A,(339"A1"A+""2A,%A 2","'5(+"A,)"A#*'0(+/A,)"'5*$A.%+29.,(#(,("3[ :)"A5%2"$A,)*,A4A)*#"A.%+3,'9.,"2A,)(3A,(5"A$*.B3A*A-9+.,(%+(+/A)"*,A3(+B[AN+"A 1*0A,%A3(59$*,"A)%1A)"*,A1($$A2(33(&*,"A(3A60A(+3"',(+/A6$%%2A#"33"$3A(+,%A,)"A 3(59$*,"2A+"'#"3A1(,)A3(59$*,"2A-$9(2A-$%1A,%A&'"#"+,A,)"A)"*,A-'%5A69($2(+/A9&A (+3(2"A%-A,)"A+"'#"A(,3"$-[ :)(3A5%2"$A(3A*$3%A+%,A,*B(+/A(+,%A*..%9+,A,)"A*8%+3A,)"53"$#"3@A*+2A,)"A*8%+3A &'"3"+,A*+%,)"'A#*'(*6$"A-%'A,)"A5%2"$A,%A3%$#"A-%'[A4,A(3A+"."33*'0A,%A&9'39"A -9',)"'A3,920A,%A2","'5(+"A(-A,)"A*8%+3A,)"53"$#"3A(5&*.,A,)"A,"5&"'*,9'"A .)*+/"3A29"A,%A,)"('A"$".,'(.*$A.%+29.,(#(,0@A%'A(-A1"A.*+A*#"'*/"A,)*,A .%+29.,(#(,0A(+A1(,)A,)"A"$".,'(.*$A.%+29.,(#(,0A%-A,)"A >+2%+"9'(95 [ References XMMRYJ'#*-+'9YT4$5#5@=4'Z 7+'#*+@'#@C !"#5(*+$$IZF#[+IZ4*,Z7&$#/#&*Z211+5/ZV&,+=Z 7'+,#5/#&*$Z&1ZG+@'4=ZWU5#/4/#&* XMM\YF/+%4'/Y7+'#)"+'4=ZG+'3+ZT4$5#5=+$]Z2*4/&C.Z4*,ZH=#*#54=Z6+=+34*5+ XMNXY^&@5=4YV&,+=#*9ZWU/'45+==@=4'ZW=+5/'#54=ZG+@'4=ZF/#C@=4/#&*]ZT'&CZ<4$#5Z S*,+'$/4*,#*9Z/&ZVW2 O -4$+,Z2))=#54/#&*$ XMNNY64$)&)&3#5Y2ZH&C)@/4/#&*4=ZV&,+=Z1&'Z/"+ZF/#C@=4/#&*Z&1Z64/ZF5#4/#5Z G+'3+ZS$#*9Z4Z!'4*$3+'$+Z A*/'414$5#5@=4' V@=/#5"4**+=ZW=+5/'&,+ Tightly Packed Fascicles Spread out Fascicles O"'#" >&(+"9'(*$ >&(+"9'(95 C?*$(+"A(+A3(59$*,(%+D <"'(+"9'(95 >+2%+"9'(95 >&(-*3.(.9$*' >&(+"9'(95 Results G8%+3 Control Tightly Packed Fascicles Spread out Fascicles #*+*,-.-+ %/-0.+10*/2 345670.181.9 Y%+,'%$ S[QA?c5 >&(-*3.9$*' >&(+"9'(95 S[SRQKA?c5 <"'(+"9'(95 S[SSQJA?c5 >+2%+"9'(95 S[SRQKA?c5 ?*$(+"A?%$9,(%+ QA?c5 "46-/ #-+0-5.23:*5;-2152)-,<-+*.7+Y%+,'%$ S[LLZ_ ?&'"*2AN9,AH*3.(.$"3 S[LR\_ :(/),$0A<*.B"2AH*3.(.$"3 J[LRJ_ .)(&c"$".,'%2"3 +"'#" M*'/"A "$".,'%2"3AdA 3,(59$*,(%+ ?5*$$A "$".,'%2"3AdA '".%'2(+/ ZA55 Abstract N+" 1*0 ,% (5&'%#" .%+,'%$ *+2 *.."&,*+." %3"+3%'(e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f3(+/ YN;?NMb3 GYc!Y *+2 )"*, ,'*+3-"' 5%29$"3 ,)" .9''"+, %9,&9, %,)" )2 7 :4;> "$".,'%2" 1*3 3(59$*,"2 ,% 2","'5(+" ,)" ,"5&"'*,9'" (+.'"*3" ,)'%9/) ,)" 39''%9+2(+/ +"'#%93 ,(339" [ :)(3 (3 2%+" ,)'%9/) "$".,'%,)"'5*$ .%9&$(+/ *$$%13 -%' ,)" 3(59$*,(%+ %,)" g%9$" )"*,(+/ .*93"2 60 ,)" .9''"+, (+g".,(%+ (+,% ,)" 39''%9+2(+/ ,(339" [ `" 2","'5(+"2 ,)*, ,)" ,"5&"'*,9'" .)*+/" (3 2"&"+2"+, 9&%+ ,)" *''*+/"5"+, %,)" (+,"'+*$ -*3.(.$"3@ *+2 ,)"(' (+,"'+*$ "$".,'(.*$ .%+29.,(#(,("3 [ :)(3 5%2"$ .*+ 6" 93"2 -%' &'"2(.,(#" 5%2"$(+/ %,(339" )"*,(+/ ,)'%9/) #*'(%93 +"'#" 7 "$".,'%2" .%+-(/9'*,(%+3 [